Design, synthesis and evaluation of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 15, 2011, Pages 4460-4472

  Crocetti, Letizia ^a   Giovannoni, Maria Paola ^a   Schepetkin, Igor A ^b   Quinn, Mark T ^b   Khlebnikov, Andrei I ^c   Cilibrizzi, Agostino ^a   Piaz, Vittorio Dal ^a   Graziano, Alessia ^a   Vergelli, Claudia ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b MONTANA STATE UNIVERSITY   (United States)

^c ALTAI STATE TECHNICAL UNIVERSITY   (Russian Federation)

Author keywords

1 Benzoylindazoles; Human neutrophil elastase; Indazoles; Inhibitors; Structure activity relationship

Indexed keywords

1 (2 METHOXYBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID PHENYLAMIDE; 1 (3 AMINOBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (3 AMINOBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID PHENYLAMIDE; 1 (3 METHOXYBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (3 METHOXYBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID METHYL ESTER; 1 (3 METHOXYBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID PHENYLAMIDE; 1 (3 METHYLBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID METHYL ESTER; 1 (3 METHYLBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID PROPYL ESTER; 1 (3 TERT BUTOXYCARBONYLAMINO BENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (3,4,5 TRIMETHOXYBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (4 CYANOBENZOYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (NAPHTHALENE 1 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (PYRIDINE 4 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (PYRIDINE 4 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID PHENYLAMIDE; 1 (THIOPHENE 3 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 (THIOPHENE 3 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID METHYL ESTER; 1 (THIOPHENE 3 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID PHENYLAMIDE; 1 (THIOPHENE 3 CARBONYL) 1H INDAZOLE 3 CARBOXYLIC ACID PROPYL ESTER; 1 BENZOYL 1H INDAZOLE 3 CARBOXYLIC ACID METHYL ESTER; 1 BENZOYL 1H INDAZOLE 3 CARBOXYLIC ACID PHENYLAMIDE; 1 BUTYRYL 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 CYCLOPENTANECARBONYL 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1 PROPIONYL 1H INDAZOLE 3 CARBOXYLIC ACID ETHYL ESTER; 1H INDAZOLE 3 CARBOXYLIC ACID 2,2,2 TRIFLUOROETHYL ESTER; [3 (3 PHENYLCARBAMOYL INDAZOLE 1 CARBONYL)PHENYL]CARBAMIC ACID TERT BUTYL ESTER; INDAZOLE DERIVATIVE; LEUKOCYTE ELASTASE INHIBITOR; N BENZOYLINDAZOLE DERIVATIVE; SIVELESTAT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING SITE; BIOLOGICAL ACTIVITY; CONCENTRATION RESPONSE; DRUG DESIGN; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; IC 50; MOLECULAR DOCKING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDAZOLES; INHIBITORY CONCENTRATION 50; LEUKOCYTE ELASTASE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960558163     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.036     Document Type: Article

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