Structure-activity relationship analysis of N-benzoylpyrazoles for elastase inhibitory activity: A simplified approach using atom pair descriptors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 6, 2008, Pages 2791-2802

  Khlebnikov, Andrei I ^a   Schepetkin, Igor A ^b   Quinn, Mark T ^b  

^a ALTAI STATE TECHNICAL UNIVERSITY   (Russian Federation)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

Atom pairs; Molecular descriptors; N Benzoylpyrazoles; Neutrophil elastase inhibitors; Structure activity relationship

Indexed keywords

ELASTASE; METHYL GROUP; PYRAZOLE DERIVATIVE;

ACCURACY; ALGORITHM; ANALYSIS OF VARIANCE; ARTICLE; ATOM; CHEMICAL STRUCTURE; COMPARATIVE STUDY; ENERGY; ENZYME INHIBITION; HUMAN; LIPOPHILICITY; METHODOLOGY; MOLECULE; PHYSICAL CHEMISTRY; QUALITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; ENZYME INHIBITORS; MODELS, MOLECULAR; PANCREATIC ELASTASE; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40949105165     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.014     Document Type: Article

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