Medicinal chemistry of dihydropyran-based medium ring macrolides related to aspergillides: Selective inhibition of PI3Kα

Journal of Medicinal Chemistry

Volumn 56, Issue 15, 2013, Pages 6122-6135

  Lambu, Mallikharjuna R ^a,b   Kumar, Suresh ^b   Yousuf, Syed K ^b   Sharma, Deepak K ^a,b   Hussain, Altaf ^a,b   Kumar, Ajay ^b   Malik, Fayaz ^b   Mukherjee, Debaraj ^a,b  

^a ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ASPERGILLIDE A; ASPERGILLIDE B; ASPERGILLIDE C; CASPASE 3; CYTOCHROME C; FLUDARABINE; MACROLIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

AMELANOTIC MELANOMA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HL 60; CELL STRESS; COMPETITIVE INHIBITION; COMPUTER MODEL; CONTROLLED STUDY; CYCLIZATION; CYTOSOL; CYTOSOLIC FRACTION; DOSE RESPONSE; DRUG SYNTHESIS; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IC 50; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; NONHUMAN; PROSTATE CANCER; PROTEIN SUBUNIT; PROTEIN TARGETING; RING CLOSING METATHESIS; SIGNAL TRANSDUCTION; STEREOCHEMISTRY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CLASS IA PHOSPHATIDYLINOSITOL 3-KINASE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MACROLIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR DOCKING SIMULATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRANS; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881414821     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400515c     Document Type: Article

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