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Volumn 2, Issue 1, 2008, Pages 58-63

Antimicrobial peptide precursor structures suggest effective production strategies

Author keywords

Antimicrobial peptides; Expression systems; Fusion proteins; Protein precursor structure; Recombinant polypeptide production

Indexed keywords

AMIDOPHOSPHORIBOSYLTRANSFERASE; BETA GALACTOSIDASE; BETA LACTAMASE; BINDING PROTEIN; CARRIER PROTEIN; CATHELICIDIN; CECROPIN; DEFENSIN; DERMASEPTIN; DROSOCIN; GLUCAN SYNTHASE; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; HEVEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G BINDING PROTEIN A; INDOLICIDIN; LACTOFERRICIN; MALTOSE BINDING PROTEIN; MELITTIN; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN OPRF; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN PRECURSOR; RECOMBINANT PROTEIN; THIONINE; THIOREDOXIN; UBIQUITIN; UNCLASSIFIED DRUG; XYLAN ENDO 1,3 BETA XYLOSIDASE;

EID: 42149175957     PISSN: 1872213X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221308783399261     Document Type: Review
Times cited : (34)

References (74)
  • 1
    • 0345839252 scopus 로고    scopus 로고
    • Where will new antibiotics come from?
    • Walsh C. Where will new antibiotics come from? Nat Rev Microbiol 2003; 1: 65-70.
    • (2003) Nat Rev Microbiol , vol.1 , pp. 65-70
    • Walsh, C.1
  • 2
    • 0034680167 scopus 로고    scopus 로고
    • Molecular mechanisms that confer antibacterial drug resistance
    • Walsh C. Molecular mechanisms that confer antibacterial drug resistance. Nature 2000; 406: 775-781.
    • (2000) Nature , vol.406 , pp. 775-781
    • Walsh, C.1
  • 3
    • 0037165196 scopus 로고    scopus 로고
    • Antimicrobial peptides of multicellular organisms
    • Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 2002; 415: 389-395.
    • (2002) Nature , vol.415 , pp. 389-395
    • Zasloff, M.1
  • 4
    • 14544282377 scopus 로고    scopus 로고
    • Antimicrobial peptides: Pore formers or metabolic inhibitors in bacteria?
    • Brogden KA. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Nat Rev Microbiol 2005; 3: 238-250.
    • (2005) Nat Rev Microbiol , vol.3 , pp. 238-250
    • Brogden, K.A.1
  • 5
    • 2942670459 scopus 로고    scopus 로고
    • Can innate immunity be enhanced to treat microbial infections?
    • Finlay BB, Hancock RE. Can innate immunity be enhanced to treat microbial infections? Nat Rev Microbiol 2004; 2: 497-504.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 497-504
    • Finlay, B.B.1    Hancock, R.E.2
  • 6
    • 0032007854 scopus 로고    scopus 로고
    • Cationic peptides: A new source of antibiotics
    • Hancock RE, Lehrer R. Cationic peptides: a new source of antibiotics. Trends Biotechnol 1998; 16: 82-88.
    • (1998) Trends Biotechnol , vol.16 , pp. 82-88
    • Hancock, R.E.1    Lehrer, R.2
  • 7
    • 33846894709 scopus 로고    scopus 로고
    • Optimization of protein expression systems for modern drug discovery
    • Forstner M, Leder L, Mayr LM. Optimization of protein expression systems for modern drug discovery. Expert Rev Proteomics 2007; 4: 67-78.
    • (2007) Expert Rev Proteomics , vol.4 , pp. 67-78
    • Forstner, M.1    Leder, L.2    Mayr, L.M.3
  • 8
    • 4644348208 scopus 로고    scopus 로고
    • Recombinant expression systems in the pharmaceutical industry
    • Schmidt FR. Recombinant expression systems in the pharmaceutical industry. Appl Microbiol Biotechnol 2004; 65: 363-372.
    • (2004) Appl Microbiol Biotechnol , vol.65 , pp. 363-372
    • Schmidt, F.R.1
  • 9
    • 0027445909 scopus 로고
    • Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria
    • Piers KL, Brown MH, Hancock REW. Recombinant DNA procedures for producing small antimicrobial cationic peptides in bacteria. Gene 1993; 134: 7-13.
    • (1993) Gene , vol.134 , pp. 7-13
    • Piers, K.L.1    Brown, M.H.2    Hancock, R.E.W.3
  • 11
    • 0028006717 scopus 로고
    • Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures
    • Casteels-Josson K, Zhang W, Capaci T, Casteels P, Tempst P. Acute transcriptional response of the honeybee peptide-antibiotics gene repertoire and required post-translational conversion of the precursor structures. J Biol Chem 1994; 269: 28569-28575.
    • (1994) J Biol Chem , vol.269 , pp. 28569-28575
    • Casteels-Josson, K.1    Zhang, W.2    Capaci, T.3    Casteels, P.4    Tempst, P.5
  • 12
    • 0038706380 scopus 로고    scopus 로고
    • Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain
    • Vanhoye D, Bruston F, Nicolas P, Amiche M. Antimicrobial peptides from hylid and ranin frogs originated from a 150-million-year-old ancestral precursor with a conserved signal peptide but a hypermutable antimicrobial domain. Eur J Biochem 2003; 270: 2068-2081.
    • (2003) Eur J Biochem , vol.270 , pp. 2068-2081
    • Vanhoye, D.1    Bruston, F.2    Nicolas, P.3    Amiche, M.4
  • 13
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: Antimicrobial peptides of innate immunity
    • Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 2003; 3: 710-720.
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-720
    • Ganz, T.1
  • 14
    • 0032411402 scopus 로고    scopus 로고
    • Cysteine-rich antimicrobial peptides in invertebrates
    • Dimarcq JL, Bulet P, Hetru C, Hoffmann J. Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers 1998; 47: 465-477.
    • (1998) Biopolymers , vol.47 , pp. 465-477
    • Dimarcq, J.L.1    Bulet, P.2    Hetru, C.3    Hoffmann, J.4
  • 15
    • 0020826315 scopus 로고
    • Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin
    • Vlasak R, Unger-Ullmann C, Kreil G, Frischauf AM. Nucleotide sequence of cloned cDNA coding for honeybee prepromelittin. Eur J Biochem 1983; 135: 123-126.
    • (1983) Eur J Biochem , vol.135 , pp. 123-126
    • Vlasak, R.1    Unger-Ullmann, C.2    Kreil, G.3    Frischauf, A.M.4
  • 16
    • 0028518533 scopus 로고
    • Thionins: Properties, possible biological roles and mechanisms of action
    • Florack DE, Stiekema WJ. Thionins: properties, possible biological roles and mechanisms of action. Plant Mol Biol 1994; 26: 25-37.
    • (1994) Plant Mol Biol , vol.26 , pp. 25-37
    • Florack, D.E.1    Stiekema, W.J.2
  • 17
    • 33947311685 scopus 로고    scopus 로고
    • The universal algorithm of maturation for secretory and excretory protein precursors
    • Kozlov SA, Grishin EV. The universal algorithm of maturation for secretory and excretory protein precursors. Toxicon 2007; 49: 721-726.
    • (2007) Toxicon , vol.49 , pp. 721-726
    • Kozlov, S.A.1    Grishin, E.V.2
  • 18
    • 22944458199 scopus 로고    scopus 로고
    • The role of cathelicidins in the innate host defenses of mammals
    • Zanetti M. The role of cathelicidins in the innate host defenses of mammals. Curr Issues Mol Biol 2005; 7: 179-196.
    • (2005) Curr Issues Mol Biol , vol.7 , pp. 179-196
    • Zanetti, M.1
  • 19
    • 0025940134 scopus 로고
    • Co- and post-translational processing of the hevein preproprotein of latex of the rubber tree (Hevea brasiliensis)
    • Lee HI, Broekaert WF, Raikhel NV. Co- and post-translational processing of the hevein preproprotein of latex of the rubber tree (Hevea brasiliensis). J Biol Chem 1991; 266: 15944-15948.
    • (1991) J Biol Chem , vol.266 , pp. 15944-15948
    • Lee, H.I.1    Broekaert, W.F.2    Raikhel, N.V.3
  • 20
    • 0030582631 scopus 로고    scopus 로고
    • cDNA cloning and characterization of buforin I, an antimicrobial peptide: A cleavage product of histone H2A
    • Kim HS, Park CB, Kim MS, Kim SC. cDNA cloning and characterization of buforin I, an antimicrobial peptide: a cleavage product of histone H2A. Biochem Biophys Res Commun 1996; 229: 381-387.
    • (1996) Biochem Biophys Res Commun , vol.229 , pp. 381-387
    • Kim, H.S.1    Park, C.B.2    Kim, M.S.3    Kim, S.C.4
  • 21
    • 0027465990 scopus 로고    scopus 로고
    • Yamauchi K, Tomita M, Giehl TJ, Ellison RT. 3rd. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect Immun 1993; 61: 719-728.
    • Yamauchi K, Tomita M, Giehl TJ, Ellison RT. 3rd. Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect Immun 1993; 61: 719-728.
  • 22
    • 0023903695 scopus 로고
    • The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide
    • Terry AS, Poulter L, Williams DH, et al. The cDNA sequence coding for prepro-PGS (prepro-magainins) and aspects of the processing of this prepro-polypeptide. J Biol Chem 1988, 263: 5745-5751.
    • (1988) J Biol Chem , vol.263 , pp. 5745-5751
    • Terry, A.S.1    Poulter, L.2    Williams, D.H.3
  • 23
    • 0027413860 scopus 로고
    • Apidaecin multipeptide precursor structure: A putative mechanism for amplification of the insect antibacterial response
    • Casteels-Josson K, Capaci T, Casteels P, Tempst P. Apidaecin multipeptide precursor structure: a putative mechanism for amplification of the insect antibacterial response. EMBO J 1993; 12: 1569-1578.
    • (1993) EMBO J , vol.12 , pp. 1569-1578
    • Casteels-Josson, K.1    Capaci, T.2    Casteels, P.3    Tempst, P.4
  • 24
    • 0030808656 scopus 로고    scopus 로고
    • A novel family of small cysteine-rich antimicrobial-peptides from seed of Impatiens balsamina is derived from a single precursor protein
    • Tailor RH, Acland DP, Attenborough S, et al. A novel family of small cysteine-rich antimicrobial-peptides from seed of Impatiens balsamina is derived from a single precursor protein. J Biol Chem 1997; 272: 24480-24487.
    • (1997) J Biol Chem , vol.272 , pp. 24480-24487
    • Tailor, R.H.1    Acland, D.P.2    Attenborough, S.3
  • 25
    • 0033197643 scopus 로고    scopus 로고
    • A family of antimicrobial peptides is produced by processing of a 7S globulin protein in Macadamia integrifolia kernels
    • Marcus JP, Green JL, Goulter KC, Manners JM. A family of antimicrobial peptides is produced by processing of a 7S globulin protein in Macadamia integrifolia kernels. Plant J 1999; 19: 699-710.
    • (1999) Plant J , vol.19 , pp. 699-710
    • Marcus, J.P.1    Green, J.L.2    Goulter, K.C.3    Manners, J.M.4
  • 26
    • 42149124535 scopus 로고    scopus 로고
    • Hancock, R.E.W., Piers, K.L., Brown, M.H., Kelly, N.: WO9628559 (1996).
    • Hancock, R.E.W., Piers, K.L., Brown, M.H., Kelly, N.: WO9628559 (1996).
  • 28
    • 42149148940 scopus 로고    scopus 로고
    • Hancock, R.E., Piers, K.L., Brown, M.H.: WO9404688 (1994).
    • Hancock, R.E., Piers, K.L., Brown, M.H.: WO9404688 (1994).
  • 31
    • 42149144881 scopus 로고    scopus 로고
    • Kim, J.H., Kang, M.H., Lee, J.H., Park, S.H., Lee, J.W., Hong, S.S., Lee, H.S.: WO9964611 (1999).
    • Kim, J.H., Kang, M.H., Lee, J.H., Park, S.H., Lee, J.W., Hong, S.S., Lee, H.S.: WO9964611 (1999).
  • 32
    • 0032577940 scopus 로고    scopus 로고
    • Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria
    • Zhang L, Falls T, Wu M, et al. Determinants of recombinant production of antimicrobial cationic peptides and creation of peptide variants in bacteria. Biochem Biophys Res Commun 1998; 247: 674-680.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 674-680
    • Zhang, L.1    Falls, T.2    Wu, M.3
  • 33
    • 33846383444 scopus 로고    scopus 로고
    • Expression of recombinant puroindolines for the treatment of staphylococcal skin infections (Acne vulgaris)
    • Capparelli R, Ventimiglia I, Palumbo D, et al. Expression of recombinant puroindolines for the treatment of staphylococcal skin infections (Acne vulgaris). J Biotechnol 2007; 128: 606-614.
    • (2007) J Biotechnol , vol.128 , pp. 606-614
    • Capparelli, R.1    Ventimiglia, I.2    Palumbo, D.3
  • 34
    • 33646726320 scopus 로고    scopus 로고
    • Cloning, expression, isotope labeling, and purification of human antimicrobial peptide LL-37 in Escherichia coli for NMR studies
    • Li Y, Li X, Wang G. Cloning, expression, isotope labeling, and purification of human antimicrobial peptide LL-37 in Escherichia coli for NMR studies. Protein Expr Purif 2000; 47: 498-505.
    • (2000) Protein Expr Purif , vol.47 , pp. 498-505
    • Li, Y.1    Li, X.2    Wang, G.3
  • 35
    • 33947369797 scopus 로고    scopus 로고
    • Expression and purification of a recombinant antibacterial peptide, cecropin, from Escherichia coli
    • Xu X, Jin F, Yu X, et al. Expression and purification of a recombinant antibacterial peptide, cecropin, from Escherichia coli. Protein Expr Purif 2007; 53: 293-301.
    • (2007) Protein Expr Purif , vol.53 , pp. 293-301
    • Xu, X.1    Jin, F.2    Yu, X.3
  • 36
    • 33748948233 scopus 로고    scopus 로고
    • Expression and purification of a recombinant LL-37 from Escherichia coli
    • Moon JY, Henzler-Wildman KA, Ramamoorthy A. Expression and purification of a recombinant LL-37 from Escherichia coli. Biochim Biophys Acta 2006; 1758: 1351-1358.
    • (2006) Biochim Biophys Acta , vol.1758 , pp. 1351-1358
    • Moon, J.Y.1    Henzler-Wildman, K.A.2    Ramamoorthy, A.3
  • 37
    • 33646059875 scopus 로고    scopus 로고
    • Xu Z, Peng L, Zhong Z, Fang X, Cen P. High-leve expression of a soluble functional antimicrobial peptide, human beta-defensin 2, in Escherichia coli. Biotechnol Prog 2006; 22: 382-386.
    • Xu Z, Peng L, Zhong Z, Fang X, Cen P. High-leve expression of a soluble functional antimicrobial peptide, human beta-defensin 2, in Escherichia coli. Biotechnol Prog 2006; 22: 382-386.
  • 38
    • 34248395017 scopus 로고    scopus 로고
    • High-level production of a novel antimicrobial peptide perinerin in Escherichia coli by fusion expression
    • Zhou QF, Luo XG, Ye L, Xi T. High-level production of a novel antimicrobial peptide perinerin in Escherichia coli by fusion expression. Curr Microbiol 2007; 54: 366-370.
    • (2007) Curr Microbiol , vol.54 , pp. 366-370
    • Zhou, Q.F.1    Luo, X.G.2    Ye, L.3    Xi, T.4
  • 39
    • 33646460123 scopus 로고    scopus 로고
    • Production of bioactive human beta-defensin-3 in Escherichia coli by soluble fusion expression
    • Huang L, Wang J, Zhong Z, et al. Production of bioactive human beta-defensin-3 in Escherichia coli by soluble fusion expression. Biotechnol Lett 2006; 28: 627-632.
    • (2006) Biotechnol Lett , vol.28 , pp. 627-632
    • Huang, L.1    Wang, J.2    Zhong, Z.3
  • 40
    • 3543099821 scopus 로고    scopus 로고
    • Expression of the melittin gene of Apis cerana cerana in Escherichia coli
    • Shi WJ, Xu HJ, Cheng JA, Zhang CX. Expression of the melittin gene of Apis cerana cerana in Escherichia coli. Protein Expr Purif 2004; 37: 213-219.
    • (2004) Protein Expr Purif , vol.37 , pp. 213-219
    • Shi, W.J.1    Xu, H.J.2    Cheng, J.A.3    Zhang, C.X.4
  • 41
    • 42149103457 scopus 로고    scopus 로고
    • US5646014
    • Hara, S.: US5646014 (1997).
    • (1997)
    • Hara, S.1
  • 42
    • 0037928846 scopus 로고    scopus 로고
    • EGFP as a fusion partner for the expression and organic extraction of small polypeptides
    • Skosyrev VS, Rudenko NV, Vakhnin AV, et al. EGFP as a fusion partner for the expression and organic extraction of small polypeptides. Protein Expr Purif 2003; 27: 55-62.
    • (2003) Protein Expr Purif , vol.27 , pp. 55-62
    • Skosyrev, V.S.1    Rudenko, N.V.2    Vakhnin, A.V.3
  • 43
    • 34547856210 scopus 로고    scopus 로고
    • High-level expression of the recombinant hybrid peptide cecropinA(1-8)-magainin2(1-12) with an ubiquitin fusion partner in Escherichia coli
    • Xu X, Jin F, Yu X, Ren S, Hu J, Zhang W. High-level expression of the recombinant hybrid peptide cecropinA(1-8)-magainin2(1-12) with an ubiquitin fusion partner in Escherichia coli. Protein Expr Purif 2007; 55: 175-182.
    • (2007) Protein Expr Purif , vol.55 , pp. 175-182
    • Xu, X.1    Jin, F.2    Yu, X.3    Ren, S.4    Hu, J.5    Zhang, W.6
  • 45
    • 0034943549 scopus 로고    scopus 로고
    • A simple method for the purification of an antimicrobial peptide in recombinant Escherichia coli
    • Hwang SW, Lee JH, Park HB, et al. A simple method for the purification of an antimicrobial peptide in recombinant Escherichia coli. Mol Biotechnol 2001; 18: 193-198.
    • (2001) Mol Biotechnol , vol.18 , pp. 193-198
    • Hwang, S.W.1    Lee, J.H.2    Park, H.B.3
  • 46
    • 42149108727 scopus 로고    scopus 로고
    • Jensen, E.B., Hoegenhaug, H.H.K., Hansen, P.K., Pedersen, P.E., Mygind, P.H.: WO05024002 (2005).
    • Jensen, E.B., Hoegenhaug, H.H.K., Hansen, P.K., Pedersen, P.E., Mygind, P.H.: WO05024002 (2005).
  • 48
    • 42149115926 scopus 로고    scopus 로고
    • Keeler, S.J., Hnatow, L.L.: WO05019242 (2005).
    • Keeler, S.J., Hnatow, L.L.: WO05019242 (2005).
  • 49
    • 31044435481 scopus 로고    scopus 로고
    • Cipakova I, Gasperik J, Hostinova E. Expression and purification of human antimicrobial peptide, dermcidin, in Escherichia coli. Protein Expr Purif 2006; 45: 269-274.
    • Cipakova I, Gasperik J, Hostinova E. Expression and purification of human antimicrobial peptide, dermcidin, in Escherichia coli. Protein Expr Purif 2006; 45: 269-274.
  • 50
    • 33747757981 scopus 로고    scopus 로고
    • Expression and purification of recombinant human alpha-defensins in Escherichia coli
    • Pazgier M, Lubkowski J. Expression and purification of recombinant human alpha-defensins in Escherichia coli. Protein Expr Purif 2006; 49: 1-8.
    • (2006) Protein Expr Purif , vol.49 , pp. 1-8
    • Pazgier, M.1    Lubkowski, J.2
  • 51
    • 0034597709 scopus 로고    scopus 로고
    • High-level expression of antimicrobial peptide mediated by a fusion partner reinforcing formation of inclusion bodies
    • Lee JH, Kim JH, Hwang SW, et al. High-level expression of antimicrobial peptide mediated by a fusion partner reinforcing formation of inclusion bodies. Biochem Biophys Res Commun 2000; 277: 575-580.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 575-580
    • Lee, J.H.1    Kim, J.H.2    Hwang, S.W.3
  • 52
    • 25144438913 scopus 로고    scopus 로고
    • Facilitation of expression and purification of an antimicrobial peptide by fusion with baculoviral polyhedrin in Escherichia coli
    • Wei Q, Kim YS, Seo JH, Jang WS, Lee, IH, Cha HJ. Facilitation of expression and purification of an antimicrobial peptide by fusion with baculoviral polyhedrin in Escherichia coli. Appl Environ Microbiol 2005; 71: 5038-5043.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 5038-5043
    • Wei, Q.1    Kim, Y.S.2    Seo, J.H.3    Jang, W.S.4    Lee, I.H.5    Cha, H.J.6
  • 53
    • 3042545322 scopus 로고    scopus 로고
    • A novel carrier molecule for high-level expression of peptide antibiotics in Escherichia coli
    • Rao XC, Li S, Hu JC, et al. A novel carrier molecule for high-level expression of peptide antibiotics in Escherichia coli. Protein Expr Purif 2004; 36: 11-18.
    • (2004) Protein Expr Purif , vol.36 , pp. 11-18
    • Rao, X.C.1    Li, S.2    Hu, J.C.3
  • 55
    • 3543119574 scopus 로고    scopus 로고
    • Yang YH, Zheng GG, Li G, et al. Expression of bioactive recombinant GSLL-39, a variant of human antimicrobial peptide LL-37, in Escherichia coli. Protein Expr Purif 2004; 37: 229-235.
    • Yang YH, Zheng GG, Li G, et al. Expression of bioactive recombinant GSLL-39, a variant of human antimicrobial peptide LL-37, in Escherichia coli. Protein Expr Purif 2004; 37: 229-235.
  • 56
    • 0028122314 scopus 로고
    • Expression and export in Escherichia coli of fusion proteins containing carboxy-terminally located honeybee prepromelittin
    • He M, Liu H, Austen B. Expression and export in Escherichia coli of fusion proteins containing carboxy-terminally located honeybee prepromelittin. DNA Cell Biol 1994; 13: 875-882.
    • (1994) DNA Cell Biol , vol.13 , pp. 875-882
    • He, M.1    Liu, H.2    Austen, B.3
  • 57
    • 42149176223 scopus 로고    scopus 로고
    • Kim, S.C., Lee, J.H., Kang, M.H., Kim, J.H., Hong, S.S., Lee, H.S.: WO9854336 (1998).
    • Kim, S.C., Lee, J.H., Kang, M.H., Kim, J.H., Hong, S.S., Lee, H.S.: WO9854336 (1998).
  • 59
    • 34247561353 scopus 로고    scopus 로고
    • Multimerization and fusion expression of bovine lactoferricin derivative LfcinB15-W4,10 in Escherichia coli
    • Tian ZG, Teng D, Yang YL, et al. Multimerization and fusion expression of bovine lactoferricin derivative LfcinB15-W4,10 in Escherichia coli. Appl Microbiol Biotechnol 2007; 75: 117-124.
    • (2007) Appl Microbiol Biotechnol , vol.75 , pp. 117-124
    • Tian, Z.G.1    Teng, D.2    Yang, Y.L.3
  • 60
    • 0032006495 scopus 로고    scopus 로고
    • Acidic peptide-mediated expression of the antimicrobial peptide buforin II as tandem repeats in Escherichia coli
    • Lee JH, Minn I, Park CB, Kim SC. Acidic peptide-mediated expression of the antimicrobial peptide buforin II as tandem repeats in Escherichia coli. Protein Expr Purif 1998; 12: 53-60.
    • (1998) Protein Expr Purif , vol.12 , pp. 53-60
    • Lee, J.H.1    Minn, I.2    Park, C.B.3    Kim, S.C.4
  • 61
    • 33747718706 scopus 로고    scopus 로고
    • Expression of the cationic antimicrobial peptide lactoferricin fused with the anionic peptide in Escherichia coli
    • Kim HK, Chun DS, Kim JS, et al. Expression of the cationic antimicrobial peptide lactoferricin fused with the anionic peptide in Escherichia coli. Appl Microbiol Biotechnol 2006; 72: 330-338.
    • (2006) Appl Microbiol Biotechnol , vol.72 , pp. 330-338
    • Kim, H.K.1    Chun, D.S.2    Kim, J.S.3
  • 62
    • 42149118008 scopus 로고    scopus 로고
    • Burian, J., Bartfeld, D.: WO0031279 (2000).
    • Burian, J., Bartfeld, D.: WO0031279 (2000).
  • 64
    • 42149133852 scopus 로고    scopus 로고
    • Krebs, J.F., Zorner, P.S., Tomlinson, I.A.: WO03089455 (2003).
    • Krebs, J.F., Zorner, P.S., Tomlinson, I.A.: WO03089455 (2003).
  • 66
    • 42149133310 scopus 로고
    • US3093551
    • Hall, R.H.: US3093551 (1963).
    • (1963)
    • Hall, R.H.1
  • 67
    • 27144504220 scopus 로고    scopus 로고
    • Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus
    • Mygind PH, Fischer RL, Schnorr KM, et al. Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 2005; 437: 975-80.
    • (2005) Nature , vol.437 , pp. 975-980
    • Mygind, P.H.1    Fischer, R.L.2    Schnorr, K.M.3
  • 68
    • 42149125158 scopus 로고    scopus 로고
    • Schnorr, K.M., Hansen, M.T., Mygind, P.H., Segura, D.R., Kristensen, H.H.H.: WO03044049 (2003).
    • Schnorr, K.M., Hansen, M.T., Mygind, P.H., Segura, D.R., Kristensen, H.H.H.: WO03044049 (2003).
  • 70
    • 42149116540 scopus 로고    scopus 로고
    • Spodsberg, N.: WO07068735 (2007).
    • Spodsberg, N.: WO07068735 (2007).
  • 71
    • 42149151742 scopus 로고    scopus 로고
    • Hoegenhaug, H.H.K., Schnorr, K.M., Hansen, M.T.: WO06097464 (2006).
    • Hoegenhaug, H.H.K., Schnorr, K.M., Hansen, M.T.: WO06097464 (2006).
  • 72
    • 42149118582 scopus 로고    scopus 로고
    • US2004093636
    • Daniell, H.: US2004093636 (2004).
    • (2004)
    • Daniell, H.1
  • 74
    • 42149146963 scopus 로고    scopus 로고
    • Putman, R.J., Rao, A.G.: WO9516776 (1995).
    • Putman, R.J., Rao, A.G.: WO9516776 (1995).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.