Synthesis and biological evaluation of amino analogs of Ludartin: Potent and selective cytotoxic agents

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 17, 2013, Pages 4931-4934

  Lone, Shabir H ^a   Bhat, Khursheed A ^a   Shakeel U Rehman, ^a   Majeed, Rabiya ^a   Hamid, Abid ^a   Khuroo, Mohd A ^b  

^a CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

^b UNIVERSITY OF KASHMIR   (India)

Author keywords

Amino analogs; Cytotoxicity; Ludartin; Michael addition

Indexed keywords

(11 ) 13 (6 NITROINDAZOLE) 11,13 DIHYDROLUDARTIN; (11 ) 13 (DIETHYL AMINE) 11,13 DIHYDROLUDARTIN; (11 ) 13 (PIPERIDINE) 11,13 DIHYDROLUDARTIN; (11) 13 (MORPHOLINE) 11,13 DIHYDROLUDARTIN; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; EXOCYCLIC DOUBLE BOND; NATURAL PRODUCT; SULFORHODAMINE B; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HCT116; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE;

AMINO ANALOGS; CYTOTOXICITY; LUDARTIN; MICHAEL-ADDITION;

AMINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOTOXINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881375742     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.068     Document Type: Article

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