Rapid modifications of N-substitution in iminosugars: Development of new β-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5021-5028

  Cheng, Wei Chieh ^a,b   Weng, Chen Yi ^a,b   Yun, Wen Yi ^a   Chang, Shang Yu ^a   Lin, Yu Chun ^a   Tsai, Fuu Jen ^c   Huang, Fu Yung ^b   Chen, Yun Ru ^a  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Chemical chaperone; Gaucher disease; GCase inhibitor; Glycosidases; Iminosugar

Indexed keywords

2 (3,4 DICHLOROPHENOXY) N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL]ACETAMIDE; 2 (6 METHOXY 2,3 DIHYDRO 1H INDEN 1 YL) N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL]ACETAMIDE; 2 (9H FLUOREN 9 YL) N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL]ACETAMIDE; 2 [3,5 BIS(TRIFLUOROMETHYL)PHENYL] N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL]ACETAMIDE; 2,5 DIDEOXY 2,5 IMINO MANNITOL DERIVATIVE; 3,3,3 TRIPHENYL N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL]PROPANAMIDE; ALPHA GLUCOSIDASE; BETA GLUCOCEREBROSIDASE INHIBITOR; CARBOXYLIC ACID DERIVATIVE; GLYCOSIDASE INHIBITOR; IMINOSUGAR; N [4 [2 ETHYL 3,4 DIHYDROXY 5 (HYDROXYMETHYL)PYRROLIDIN 1 YL]BUTYL] 2 (9H FLUOREN 9 YL)ACETAMIDE; N [4 [3,4 DIHYDROXY 2,5 BIS(HYDROXYMETHYL)PYRROLIDIN 1 YL]BUTYL] 2 (9H FLUOREN 9 YL)ACETAMIDE; N [4 [3,4 DIHYDROXY 2,5 BIS(HYDROXYMETHYL)PYRROLIDIN 1 YL]BUTYL] 3,3,3 TRIPHENYLPROPANAMIDE; N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL] 1,2,3,4-TETRAHYDRONAPHTHALENE 2 CARBOXAMIDE; N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL] 2 (9H FLUOREN 9 YL)ACETAMIDE; N [4 [3,4,5 TRIHYDROXY 2 (HYDROXYMETHYL)PIPERIDIN 1 YL]BUTYL] 3,3,3 TRIPHENYLPROPANAMIDE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG POTENCY; DRUG RESEARCH; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; FIBROBLAST; GAUCHER DISEASE; HUMAN; HUMAN CELL; INHIBITION KINETICS; MOLECULAR DOCKING;

CHEMICAL CHAPERONE; GAUCHER DISEASE; GCASE INHIBITOR; GLYCOSIDASES; IMINOSUGAR;

BINDING SITES; CELL LINE; ENZYME INHIBITORS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; IMINO SUGARS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 84881374684     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.054     Document Type: Article

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