Antiproliferative activity on human prostate carcinoma cell lines of new peptidomimetics containing the spiroazepinoindolinone scaffold

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5470-5479

  Pellegrino, Sara ^a   Ruscica, Massimiliano ^a   Magni, Paolo ^a   Vistoli, Giulio ^a   Gelmi, Maria Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Docking; Ghrelin; Peptidomimetics; Prostate cancer

Indexed keywords

1 ACYL 2' OXA 1,2,3,5,6,7 HEXAHYDROSPIRO 4H AZEPINE 4,3' 3H INDOLE; 1 ACYL 5' NITRO 2' OXA 1,2,3,5,6,7 HEXAHYDROSPIRO 4H AZEPINE 4,3' 3H INDOLE; 2' OXA 1,2,3,5,6,7 HEXAHYDROSPIRO 4H AZEPINE 4,3' 3H INDOLE; 5' NITRO 2' OXA 1,2,3,5,6,7 HEXAHYDROSPIRO 4H AZEPINE 4,3' 3H INDOLE; ETHYL 2' OXA 7 THIOOXA 1,2,3,5,6,7 HEXAHYDROSPIRO[4H AZEPINE 4,3' 3H INDOLE] 1' CARBOXYLIC ACID; IBUTAMOREN; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; ISOMER; MALE; MOLECULAR DOCKING; PROSTATE CARCINOMA; STEREOCHEMISTRY; WESTERN BLOTTING;

DOCKING; GHRELIN; PEPTIDOMIMETICS; PROSTATE CANCER;

AZEPINES; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; DIPEPTIDES; HUMANS; INDOLES; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR DOCKING SIMULATION; PEPTIDOMIMETICS; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GHRELIN; SPIRO COMPOUNDS; STEREOISOMERISM;

EID: 84881374494     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.006     Document Type: Article

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