Chemistry and biology of Phellinus linteus

BioMedicine (Netherlands)

Volumn 3, Issue 3, 2013, Pages 106-113

  Hsieh, Pei Wen ^a   Wu, Jin Bin ^b   Wu, Yang Chang ^b,c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Anti inflammatory; Anticancer; Bioactive compounds; Fruiting body; Phellinus linteus

Indexed keywords

5 HYDROXYMETHYLFURFURAL; ANTIALLERGIC AGENT; ANTIDIABETIC AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; ANTIRHEUMATIC AGENT; CARBOXYMETHYLCELLULOSE; CEREBROSIDE B; FUNGAL EXTRACT; HISPIDIN; IMMUNOMODULATING AGENT; LIVER PROTECTIVE AGENT; PHELLINUS LINTEUS EXTRACT; PHELLINUSFURANS; PHELLINUSFURANS A; POLYSACCHARIDE; PROTOCATECHUALDEHYDE; UNCLASSIFIED DRUG;

ANTIDIABETIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTHRITIS; BIOLOGICAL ACTIVITY; BRAIN PROTECTION; DIABETES MELLITUS; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; LIVER PROTECTION; MOLECULAR WEIGHT; MYCELIUM; NONHUMAN; PERITONITIS; PHELLINUS LINTEUS; PRIORITY JOURNAL; REVIEW; SKIN MANIFESTATION;

BASIDIOMYCOTA; INONOTUS LINTEUS;

EID: 84881374212     PISSN: 22118020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomed.2013.01.002     Document Type: Review

References (74)

1. Bai D. Traditional Chinese medicines and new drug development. Pure Appl Chem 1993, 65:1103-1112.
2. Alves R.R.N., Rosa I.M.L. Biodiversity, traditional medicine and public health: where do they meet?. J Ethnobiol Ethnomed 2007, 3:14-22.
3. Fabricant D.S., Farnsworth N.R. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 2001, 109:69-75.
4. Zhu T., Kim S.H., Chen C.Y. A medicinal mushroom: Phellinus linteus. Curr Med Chem 2008, 15:1330-1335.
5. Smith J.E., Rowan N.J., Sullivan R. Medicinal mushrooms: a rapidly developing area of biotechnology for cancer therapy and other bioactivities. Biotechnol Lett 2002, 24:1839-1845.
6. Rathee S., Rathee D., Rathee D., Vikash K., Rathee P. Mushrooms as therapeutic agents. Rev Bras Farmacogn Braz J Pharmacogn 2012, 22:459-474.
7. Vojdani A., Erde J. Regulatory T cells, a potent immunoregulatory target for CAM researchers: modulating allergic and infectious disease pathology (II). Evid Based Complement Alternat Med 2006, 3:209-215.
8. Ramberg J.E., Nelson E.D., Sinnott R.A. Immunomodulatory dietary polysaccharides: a systematic review of the literature. Nutr J 2010, 9:54-75.
9. Donatini B. Basics on mycotherapy: preliminary concepts on the medicinal use of mycelia. Phytotherapie 2010, 8:191-197. in French.
10. Lull C., Wichers H.J., Savelkoul H.R.I. Antiinflammatory and immunomodulating properties of fungal metabolites. Media Inflam 2005, 2005:63-80.
11. Lee I.K., Yun B.S. Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg Med Chem 2007, 15:3309-3314.
12. Lee I.K., Yun B.S. Styrylpyrone-class compounds from medicinal fungi Phellinus and Inonotus spp., and their medicinal importance. J Antibiot 2011, 64:349-359.
13. Park I.H., Jeon S.Y., Lee H.J., Kim S.I., Song K.S. A β-secretase (BACE1) inhibitor hispidin from the mycelia cultures of Phellinus lintrus. Planta Med 2004, 70:143-146.
14. Jang J.S., Lee J.S., Lee J.H., Kwon D.S., Lee K.E., Lee S.Y., et al. Hispidin produced from Phellinus linteus protects pancreatic β-cells from damage by hydrogen peroxide. Arch Pharm Res 2010, 33:853-861.
15. Jung J.Y., Lee I.K., Seok S.J., Lee H.J., Kim Y.H., Yun B.S. Antioxidant polyphenols from the mycelia culture of the medicinal fungi Inonotus xeranticus and Phellinus lintrus. J Appl Microbiol 2008, 104:1824-1832.
16. Min B.S., Yun B.S., Lee H.K., Jung H.J., Jung H.A., Choi J.S. Two novel furan derivatives from Phellinus linteus with anti-complement activity. Bioorg Med Chem Lett 2006, 16:3255-3257.
17. Lee Y.S., Kang Y.H., Jung J.Y., Kang I.J., Han S.N., Chung J.S., et al. Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm Bull 2008, 31:765-768.
18. Lee Y.S., Jang Y.H., Jung J.Y., Lee S., Ohuchi K., Shin K.H., et al. Protein glycation inhibitors from the fruiting body of Phellinus linteus. Biol Pharm Bull 2008, 31:1968-1972.
19. Nagatsu A., Itoh S., Tanaka R., Kato S., Haruna M., Kishimoto K., et al. Identification of novel substituted fused aromatic compounds, meshimakobnol A and B, from natural Phellinus linteus fruit body. Tetrahedron Lett 2004, 45:5931-5933.
20. Kojima K., Ohno T., Inoue M., Mizukami H., Nagatsu A. Phellifuropyranone A: a new furopyranone compound isolated from fruit bodies of wild Phellinus linteus. Chem Pharm Bull 2008, 56:173-175.
21. Yang K.L., Chang W.T., Chuang C.C., Hung K.C., Li E.I.C. Antagonizing TGF-β induced liver fibrosis by a retinoic acid derivative through regulation of ROS and calcium influx. Biochem Biophys Res Comm 2008, 365:484-489.
22. Yeo W.H., Hwang E.I., So S.H., Lee S.M. Phellinone, a new furanone derivative from the Phellinus linteus KT&G PL-2. Arch Pharm Res 2007, 30:924-926.
23. Kang H.S., Choi J.H., Cho W.K., Park J.C., Choi J.S. A sphingolipid and tryrosinase inhibitors from the fruiting body of Phellinus linteus. Arch Pharm Res 2004, 27:742-750.
24. Lu T.L., Huang G.J., Lu T.J., Wu J.B., Wu C.H., Yang T.C., et al. Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food Chem Toxicol 2009, 47:2013-2021.
25. Huang G.J., Yang C.M., Chang Y.S., Amagaya S., Wang H.C., Hou W.C., et al. Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways. J Agric Food Chem 2010, 58:9468-9475.
26. Chang H.Y., Sheu M.J., Yang C.H., Lu T.C., Chang Y.S., Peng W.H., et al. Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice. Evid Based Complement Alternat Med 2011, 2011:478246.
27. Cho J.Y., Kwon Y.J., Sohn M.J., Seok S.J., Kim W.G. Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus. Bioorg Med Chem Lett 2011, 21:1716-1718.
28. Suzuki S., Kawamata T., Okada Y., Kobayashi T., Nakamura T., Hori T. Filtrate of Phellinus linteus broth culture reduces infarct size significantly in a rat model of permanent focal cerebral ischemia. Evid Based Complement Alternnat Med 2011, 8:1-7.
29. Seo J.H., Sung Y.H., Kim K.J., Shin M.S., Lee E.K., Kim C.J. Effects of Phellinus linteus administration on serotonin synthesis in the brain expression of monocarboxylate transporters in the muscle during exhaustive exercise in rats. J Nutr Sci Vitaminol 2001, 57:95-103.
30. Juel C., Halestrap A.P. Lactate transport in skeletal muscle-role and regulation of the monocarboxylate transporter. J Physiol 1999, 517:633-642.
31. Kim H.M., Kang J.S., Kim J.Y., Park S.K., Kim H.S., Lee Y.J., et al. Evaluation of antidiabetic activity of polysaccharide isolated from Phellinus linteus in non-obese diabetic mouse. Int Immnunopharmacol 2010, 10:72-78.
32. Choi S.B., Park C.H., Choi M.K., Jun D.W., Park S. Improvement of insulin resistance in insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats. Biosci Biotechnol Biochem 2004, 68:2257-2264.
33. Kim S.H., Song Y.S., Kim S.K., Kim B.C., Lim C.J., Park E.H. Anti-inflammatory and related pharmacological activities of the n-BuOH subfraction of mushroom Phellinus linteus. J Ethnopharmacol 2004, 93:141-146.
34. Kim B.C., Choi J.W., Hong H.Y., Lee S.A., Hong S., Park E.H., et al. Heme oxygenase-1 mediates the anti-inflammatory effectof mushroom Phellinus linteus in LPS-stimulated RAW264.7 macrophages. J Ethnopharmacol 2006, 106:364-371.
35. Kim B.C., Jeon W.K., Hong H.Y., Jeon K.B., Hahn J.H., Kim Y.M., et al. The anti-inflammatory activity of Phellinus linteus (Berk. &M.A. Curt.) is mediated through the PKCδ/Nrf2/ARE signaling to up-regulation of heme oxygenase-1. J Ethnopharmacol 2007, 113:240-247.
36. Kim H.G., Yoon D.H., Lee W.H., Han S.K., Shrestha B., Kim C.H., et al. Phellinus linteus inhibits inflammatory mediators by suppressing redox-based NFκ-B and MAPKs activation in lipopolysaccharide-induced RAW264.7 macrophage. J Ethnopharmacol 2007, 114:307-315.
37. Kim G.Y., Kim S.H., Hwang S.Y., Kim H.Y., Park Y.M., Park S.K., et al. Oral administration of proteoglycan isolated from Phellinus linteus in the prevention and treatment of collagen-induced arthritis in mice. Biol Pharm Bull 2003, 26:823-831.
38. Kim G.Y., Roh S.I., Park S.K., Ahn S.C., Oh Y.H., Lee J.D., et al. Alleviation of experimental septic shock in mice by acidic polysaccharide isolated from the medicinal mushroom Phellinus linteus. Biol Pharm Bull 2003, 26:1418-1423.
39. Bae J.S., Ahn S.J., Yim H., Jang K.H., Jin H.K. Prevention of intraperitoneal adhesions and abscesses by polysaccharides isolated from Phellinus spp in a rat peritonitis model. Ann Surg 2005, 241:534-540.
40. Bae J.S., Jang K.H., Jin H.K. Comparison of intraperitoneal anti-adhesive polysaccharides derived from Phellinus mushrooms in a rat peritonitis model. World J Gastroenterol 2005, 11:810-816.
41. Bae J.S., Jin H.K., Jang K.H. The effect of polysaccharides and carboxymethylcellulose combination to prevent intraperitoneal adhesion and abscess formation in a rat peritonitis model. J Vet Med Sci 2004, 66:1205-1211.
42. Park S.K., Kmi G.Y., Lim J.Y., Kwak J.Y., Bae Y.S., Lee J.D., et al. Acidic polysaccharides isolated from Phellinus linteus induce phenotypic and functional maturation of murine dendritic cells. Biochem Biophys Res Commun 2003, 312:449-458.
43. Kim G.Y., Choi G.S., Lee S.H., Park Y.M. Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-α from peritoneal macrophages. J Ethnopharmacol 2004, 95:69-76.
44. Kim G.Y., Park S.K., Lee M.K., Lee S.H., Oh Y.H., Kwak J.Y., et al. Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosin kinase. Int Immunopharmacol 2003, 3:1281-1292.
45. +DC and type I helper T cell-dominant immune state. FEBS Lett 2004, 576:391-400.
46. Kim G.Y., Han M.G., Song Y.S., Shin B.C., Shin Y.I., Lee H.J., et al. Proteoglycan isolated from Phellinus linteus induces toll-like receptors 2- and 4-mediated maturation of murine dendritic cells via activation of ERK, p38, and NFκB. Biol Pharm Bull 2004, 27:1656-1662.
47. Huang H.Y., Chieh S.Y., Tso T.K., Chien T.Y., Lin H.T., Tsai Y.C. Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice. J Ethnopharmacol 2011, 133:460-466.
48. Li Y.G., Ji D.F., Zhong S., Zhu J.X., Chen S., Hu G.Y. Anti-tumor effects of proteoglycan from Phellinus lintenus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carvinoma. Int J Bio Macromol 2011, 48:511-517.
49. Collins L., Zhu T., Guo J., Xiao Z.J., Chen C.Y. Phellinus linteus sensitises apoptosis induced by doxorebisin in prostate cancer. Br J Cancer 2006, 95:282-288.
50. Zhu T., Collins L., Kelly J., Xiao Z.J., Kim S.H., Chen C.Y. Phellinus linteus activates different pathways to induce apoptosis in prostate cancer cells. Br J Cancer 2007, 96:583-590.
51. Tsuji T., Du W., Nishioka T., Chen L., Yamamoto D., Chen C.Y. Phellinus linteus extract sensitizes advanced prostate cancer cells to apoptosis in athymic nude mice. PLoS One 2010, 5:e9885.
52. 1 cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Phytother Res 2010, 24:1019-1026.
53. 2/M phase arrest and apoptosis in SW480 human colon cancer cells. Cancer Lett 2004, 216:175-181.
54. Park H.J., Han E.S., Park D.K. The ethyl acetate extract of PGP (Phellinus linteus grown on Panax ginseng) suppresses B16F10 melanoma cell proliferation through inducing cellular differentiation and apoptosis. J Ethnopharmacol 2010, 132:115-121.
55. Chen W., He F.Y., Li Y.Q. The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells. J Ethnopharmacol 2006, 105:280-285.
56. Guo J., Zhu T., Collins L., Xiao Z.H.J., Kim S.H., Chen C.Y. Modulation of lung cancer growth arrest and apoptosis by Phellinus linteus. Mol Carcinogen 2007, 46:144-154.
57. Sliva D., Jedinak A., Kawasaki J., Harvey K., Slivova V. Phellinus linteus suppresses growth, angiogenesis and invasive behavior of breast cancer cells through the inhibition of AKT signaling. Br J Cancer 2008, 98:1348-1356.
58. Han S.B., Lee C.W., Kang J.S., Yoon Y.D., Lee K.H., Lee K., et al. Acidic polysaccharide from Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion. Int Immunopharmacol 2006, 6:697-702.
59. Shon Y.H., Nam K.S. Antimutagenicity and induction of anticarcinogenic phase II enzymes by basidiomycetes. J Ethnopharmacol 2001, 77:103-109.
60. Song Y.S., Kim S.H., Sa J.H., Jin C., Lim C.J., Park E.H. Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus. J Ethnopharmacol 2003, 88:113-116.
61. Lim B.O., Yamada K., Cho B.G., Jeon T., Hwang S.G., Park T., et al. Comparative study on the modulation of IgE and cytokineproduction by Phellinus linteus grown on germinated brown rice, Phellinus linteus and germinated brown rice in murine splenocytes. Biosci Biotechnol Biochem 2004, 68:2391-2394.
62. Lim B.O., Jeon T.I., Hwang S.G., Moon J.H., Park D.K. Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1/Th2 balance in murine mesenteric lymph node lymphocytes. Biotechnol Lett 2005, 27:613-617.
63. Inagaki N., Shibata T., Itoh T., Suzuki T., Tanaka H., Nakamura T., et al. Inhibition of IgE-dependent mouse triphasic cutaneous reaction by a boiling water fraction separated from mycelium of Phellinus linteus. Evid Based Complement Alternat Med 2005, 2:369-374.
64. Choi Y.H., Yan G.H., Chai O.H., Lim J.M., Sung S.Y., Zhang X., et al. Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biol Pharm Bull 2006, 29:1360-1365.
65. Matsuba S., Matsuno H., Sakuma M., Komatsu Y. Phellinus linteus extract augments the immune response in mitomycin C-induced immunodeficient mice. Evid Based Complement Alternat Med 2008, 5:85-90.
66. Harikrishnan R., Balasundaram C., Heo M.S. Diet enriched with mushroom Phellius linteus extract enhances the growth, innate immune response, and disease resistance of kelp grouper, Epinephelus bruneus against vibriosis. Fish Shellfish Immunol 2011, 30:128-134.
67. Shon Y.H., Nam K.S. Inhibition of cytochrome P450 isozymes in rat liver microsomes by polysaccharides derived from Phellinus linteus. Biotechnol Lett 2003, 25:167-172.
68. Jeon T.I., Hwang S.G., Lim B.O., Park D.K. Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats. Biotechnol Lett 2003, 25:2093-2096.
69. Lim S.H., Lee H.S., Lee S., Cho J., Ze K., Sung J., et al. Mycelial culture of Phellinus linteus protects primary cultured rat hepatocytes against hepatotoxins. J Ethnopharmacol 2004, 95:367-372.
70. Ye S.F., Hou Z.Q., Zhang Q.Q. Protective effects of Phellinus linteus extract against iron overload-mediated oxidative stress in cultured rat hepatocytes. Phytother Res 2007, 21:948-953.
71. Hur J.M., Yang C.H., Han S.H., Lee S.H., You Y.O., Park J.C., et al. Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia 2004, 75:603-605.
72. Park B.J., Lim Y.S., Lee H.J., Eum W.K., Park J., Han K.H., et al. Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage. BMB Rep 2009, 42:500-505.
73. Mukai M., Kasai A., Hiramatsu N., Hayakawa K., Okamura M., Tagawa Y., et al. Blockade of the aryl hydrocarbon receptor pathway triggered by dioxin, polycyclic aromatic hydrocarbons and cigarette smoke by Phellinus linteus. Biol Pharm Bull 2008, 31:1888-1893.
74. Ichinohe T., Ainai A., Nakamura T., Akiyama Y., Maeyama J., Odagiri T., et al. Induction of cross-protective immunity against influenza A virus H5N1 by and intranasal vaccine with extracts of mushroom mycelia. J Med Virol 2010, 82:128-137.