Macamides and their synthetic analogs: Evaluation of in vitro FAAH inhibition

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 5188-5197

  Wu, Hui ^a,b   Kelley, Charles J ^a   Pino Figueroa, Alejandro ^a   Vu, Huyen D ^a   Maher, Timothy J ^a  

^a MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b ARQULE INC   (United States)

Author keywords

Anandamide; Carbamate; FAAH 3 Methoxybenzylamine; Fatty acid amide; Lepidium meyenii; Maca; Macamide; OL 135; Oleamide; PF 750; Urea

Indexed keywords

3 METHOXYBENZYLAMINE; AMIDE; ANANDAMIDE; BENZYLAMINE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; LINOLEIC ACID; LINOLENIC ACID; MACAMIDE DERIVATIVE; N (3 METHOXYBENZYL)OCTADECA 9,12 DIENAMIDE; N (3 METHOXYBENZYL)OCTADECA 9,12,15 TRIENAMIDE; N (3 METHOXYBENZYL)OLEAMIDE; N (3 METHOXYBENZYL)PALMITAMIDE; N (3 METHOXYBENZYL)TETRADECANAMIDE; N (4 CHLOROBENZYL)PALMITAMIDE; N (4 FLUOROBENZYL)PALMITAMIDE; N BENZYL 5 OXOOCTADECA 6,8 DIENAMIDE; N BENZYLLINOLEAMIDE; N BENZYLLINOLENAMIDE; N BENZYLNERVONAMIDE; N BENZYLOCTADECA 9,12 DIENAMIDE; N BENZYLOCTADECA 9,12,15 TRIENAMIDE; N BENZYLOLEAMIDE; N BENZYLPALMITAMIDE; N BENZYLSTEARAMIDE; N BENZYLTETRACOS 15 ENAMIDE; N BENZYLTETRADECANAMIDE; OLEAMIDE; OLEIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY;

LEPIDIUM MEYENII;

3-METHOXYBENZYLAMINE; ANANDAMIDE; CARBAMATE; FAAH; FATTY ACID AMIDE; LEPIDIUM MEYENII; MACA; MACAMIDE; OL-135; OLEAMIDE; PF-750; UREA;

AMIDES; AMIDOHYDROLASES; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; LEPIDIUM; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84881373921     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.034     Document Type: Article

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