Gustatory sensory cells express a receptor responsive to protein breakdown products (GPR92)

Histochemistry and Cell Biology

Volumn 140, Issue 2, 2013, Pages 137-145

  Haid, Désirée ^a   Widmayer, Patricia ^a   Voigt, Anja ^b,d   Chaudhari, Nirupa ^c   Boehm, Ulrich ^d,e   Breer, Heinz ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e SAARLAND UNIVERSITY   (Germany)

Author keywords

GPR92; GPR93; Gustatory sensory cells; LPAR5; Protein breakdown products; Receptors; T1R1; Taste

Indexed keywords

AMINO ACID; ANTIBODY; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 92; LIPOPROTEIN RECEPTOR; METABOTROPIC RECEPTOR 4; PROTEIN HYDROLYSATE; RECEPTOR PROTEIN; UNCLASSIFIED DRUG; GPR97 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CELL TYPE; CONTROLLED STUDY; ENTEROENDOCRINE CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENSORY NERVE CELL; SENSORY STIMULATION; TASTE BUD; TASTE DISCRIMINATION; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MURINAE;

ANIMALS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; PHENOTYPE; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TASTE BUDS;

EID: 84881316077     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-013-1080-2     Document Type: Article

References (40)

1. 2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat. J Physiol 490(Pt 2):325-336
2. Breer H, Eberle J, Frick C, Haid D, Widmayer P (2012) Gastrointestinal chemosensation: chemosensory cells in the alimentary tract. Histochem Cell Biol 138(1):13-24. doi: 10.1007/s00418-012-0954-z
3. Chaudhari N, Roper SD (2010) The cell biology of taste. J Cell Biol 190(3):285-296
4. Chaudhari N, Pereira E, Roper SD (2009) Taste receptors for umami: the case for multiple receptors. Am J Clin Nutr 90(3):738S-742S
5. Choi S, Lee M, Shiu AL, Yo SJ, Aponte GW (2007a) Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes. Am J Physiol Gastrointest Liver Physiol 292(1):G98-G112
6. Choi S, Lee M, Shiu AL, Yo SJ, Halldén G, Aponte GW (2007b) GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol Gastrointest Liver Physiol 292(5):G1366-G1375
7. Clapp TR, Yang R, Stoick CL, Kinnamon SC, Kinnamon JC (2004) Morphologic characterization of rat taste receptor cells that express components of the phospholipase C signaling pathway. J Comp Neurol 468(3):311-321
8. Cuber JC, Bernard G, Fushiki T, Bernard C, Yamanishi R, Sugimoto E, Chayvialle JA (1990) Luminal CCK-releasing factors in the isolated vascularly perfused rat duodenojejunum. Am J Physiol 259(2 Pt 1):G191-G197
9. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, Jiang P, Ninomiya Y, Margolskee RF (2003) Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 301(5634):850-853
10. DeFazio RA, Dvoryanchikov G, Maruyama Y, Kim JW, Pereira E, Roper SD, Chaudhari N (2006) Separate populations of receptor cells and presynaptic cells in mouse taste buds. J Neurosci 26(15):3971-3980
11. Haid D, Jordan-Biegger C, Widmayer P, Breer H (2012) Receptors responsive to protein breakdown products in g-cells and d-cells of mouse, swine and human. Front Physiol 3:65. doi: 10.3389/fphys.2012.00065
12. Ikeda K (1909) New seasonings. J Tokyo Chem Soc 30:820-836 (in Japanese)
13. Ikeda K (2002) New seasonings. Chem Sense 27(9):847-849
14. Iwatsuki K, Uneyama H (2012) Sense of taste in the gastrointestinal tract. J Pharmacol Sci 118(2):123-128
15. Jahan-Mihan A, Luhovyy BL, El Khoury D, Anderson GH (2011) Dietary proteins as determinants of metabolic and physiologic functions of the gastrointestinal tract. Nutrients 3(5):574-603
16. Kim MR, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A (2003) Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun 312(2):500-506
17. Kim JW, Roberts C, Maruyama Y, Berg S, Roper S, Chaudhari N (2006) Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells. Chem Senses 31(3):213-219
18. Kretz O, Barbry P, Bock R, Lindemann B (1999) Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat. J Histochem Cytochem 47(1):51-64
19. Kusakabe Y, Kim MR, Miura H, Shindo Y, Ninomiya Y, Hino A (2005) Regional expression patterns of T1r family in the mouse tongue. Chem Sense 30(Suppl 1):i23-i24
20. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E (2002) Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 99(7):4692-4696
21. Maga JA (1983) Flavor potentiators. Crit Rev Food Sci Nutr 18(3):231-312
22. Maruyama Y, Pereira E, Margolskee RF, Chaudhari N, Roper SD (2006) Umami responses in mouse taste cells indicate more than one receptor. J Neurosci 26(8):2227-2234
23. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106(3):381-390
24. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS (2002) An amino-acid taste receptor. Nature 14;416(6877):199-202
25. Raksakulthai N, Haard NF (1992) Correlation between the concentration of peptides and amino acids and the flavour of fish sauce. ASEAN Food J 7(2):86-90
26. Rössler P, Kroner C, Freitag J, Noè J, Breer H (1998) Identification of a phospholipase C beta subtype in rat taste cells. Eur J Cell Biol 77(3):253-261
27. Saffouri B, DuVal JW, Makhlouf GM (1984) Stimulation of gastrin secretion in vitro by intraluminal chemicals: regulation by intramural cholinergic and noncholinergic neurons. Gastroenterology 87:557-561
28. San Gabriel A, Uneyama H (2012) Amino acid sensing in the gastrointestinal tract. Amino Acids. doi: 10.1007/s00726-012-1371-2
29. Schlichtherle-Cerny H, Amadò R (2002) Analysis of taste-active compounds in an enzymatic hydrolysate of deamidated wheat gluten. J Agric Food Chem 50(6):1515-1522
30. Striem BJ, Naim M, Lindemann B (1991) Generation of cyclic AMP in Taste Buds of the Rat Circumvallate Papilla in Response to Sucrose. Cell Physiol Biochem 1:46-54
31. Tamura M, Nakatsuka T, Tada M, Kawasaki Y, Kikuchi E, Okai A (1989) The relationship between taste and primary structure of "delicious peptide" (Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) from beef soup. Agric Biol Chem 53:319-325
32. Tomchik SM, Berg S, Kim JW, Chaudhari N, Roper SD (2007) Breadth of tuning and taste coding in mammalian taste buds. J Neurosci 27(40):10840-10848
33. Van Den Oord AHA, Van Wassenaar PD (1997) Umami peptides: assessment of their alleged taste properties. Eur Food Res Technol 205:25-130
34. Voigt A, Hübner S, Lossow K, Hermans-Borgmeyer I, Boehm U, Meyerhof W (2012) Genetic Labeling of Tas1r1 and Tas2r131 Taste Receptor Cells in Mice. Chem Sense 37(9):897-911
35. Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37(1):1-17
36. Yamaguchi S, Ninomiya K (2000) Umami and food palatability. J Nutr 130(4S Suppl):921S-926S
37. Yee CL, Yang R, Böttger B, Finger TE, Kinnamon JC (2001) "Type III" cells of rat taste buds: immunohistochemical and ultrastructural studies of neuron-specific enolase, protein gene product 9.5, and serotonin. J Comp Neurol 440(1):97-108
38. Yoshida R, Yasumatsu K, Shirosaki S, Jyotaki M, Horio N, Murata Y, Shigemura N, Nakashima K, Ninomiya Y (2009) Multiple receptor systems for umami taste in mice. Ann N Y Acad Sci 1170:51-54
39. Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003) Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112(3):293-301
40. Zhang F, Klebansky B, Fine RM, Xu H, Pronin A, Liu H, Tachdjian C, Li X (2008) Molecular mechanism for the umami taste synergism. Proc Natl Acad Sci U S A 105(52):20930-20934