Self-microemulsifying drug delivery system for improved oral bioavailability of oleanolic acid: Design and evaluation

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 2917-2926

  Yang, Rui ^a   Huang, Xin ^a   Dou, Jinfeng ^a   Zhai, Guangxi ^a   Lequn, Su ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Bioavailability; Formulation design; In vitro release; Oleanolic acid; Self microemulsifying drug delivery system

Indexed keywords

ALCOHOL; BENORILATE; CREMOPHOR; DECANOIC ACID; LABRASOL; MYRISTIC ACID ISOPROPYL ESTER; OCTANOIC ACID; OCTOXINOL; OLEANOLIC ACID; OLEIC ACID; OLEIC ACID ETHYL ESTER; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DETERMINATION; DRUG INCOMPATIBILITY; DRUG SCREENING; DRUG SOLUBILITY; DRUG STRUCTURE; ELECTRIC CONDUCTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MICROEMULSION; NONHUMAN; RAT; REFRACTION INDEX; SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM; SUSTAINED DRUG RELEASE; TABLET; TIME TO MAXIMUM PLASMA CONCENTRATION; VISCOSITY; ZETA POTENTIAL;

BIOAVAILABILITY; FORMULATION DESIGN; IN VITRO RELEASE; OLEANOLIC ACID; SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; EMULSIONS; ETHANOL; GLYCEROL; MALE; MASS SPECTROMETRY; NANOPARTICLES; OLEANOLIC ACID; OLEIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SURFACE-ACTIVE AGENTS; VISCOSITY;

EID: 84881292049     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S47510     Document Type: Article

References (31)

1. Mahato SB, Garai S. Triterpenoid saponins. Fortschr Chem Org Naturst. 1998;74:1-196.
2. Wang B, Jiang ZH. Studies on oleanolic acid. Chin Pharm J. 1992;27: 393-397.
3. Price KR, Johnson IT, Fenwick GR. The chemistry and biological significance of saponins in foods and feedingstuffs. Crit Rev Food Sci Nutr. 1987;26:27-135.
4. Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol. 1995;49:57-68.
5. Xi J, Chang Q, Chan CK, et al. Formulation development and bioavailability evaluation of a self-nanoemulsified drug delivery system of oleanolic acid. AAPS PharmSciTech. 2009;10:172-182.
6. Pollier J, Goossens A. Oleanolic acid. Phytochemistry. 2012;77:10-15.
7. Somova LI, Shode FO, Ramnanan P, Nadar A. Antihypertensive, antiatherosclerotic and antioxidant activity of triterpenoids isolated from Olea europaea, subspecies africana leaves. J Ethnopharmacol. 2003;84:299-305.
8. Assimopoulou AN, Zlatanos SN, Papageorgiou VP. Antioxidant activity of natural resins and bioactive triterpenes in oil substrates. Food Chem. 2005;92:721-727.
9. Somova LI, Shode FO, Mipando M. Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol. Phytomedicine. 2004;11:121-129.
10. Raphael TJ, Kuttan G. Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. Phytomedicine. 2003;10:483-489.
11. Ali MS, Jahangir M, Hussan SS, Choudhary MI. Inhibition of alpha-glucosidase by oleanolic acid and its synthetic derivatives. Phytochemistry. 2002;60:295-299.
12. Kim KA, Lee JS, Park HJ, et al. Inhibition of cytochrome P450 activities by oleanolic acid and ursolic acid in human liver microsomes. Life Sci. 2004;74:2769-2779.
13. Oguro T, Liu J, Klaassen CD, Yoshida T. Inhibitory effect of oleanolic acid on 12-O-tetradecanoylphorbol-13-acetate-induced gene expression in mouse skin. Toxicol Sci. 1998;45:88-93.
14. Jager S, Winkler K, Pfuller U, Scheffler A. Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L. Planta Med. 2007;73:157-162.
15. Jager S, Laszczyk MN, Scheffler A. A preliminary pharmacokinetic study of betulin, the main pentacyclic triterpene from extract of outer bark of birch (Betulae alba cortex). Molecules. 2008;13: 3224-3235.
16. Jin IJ, Ko YI, Kim YM, Han SK. Solubilization of oleanolic acid and ursolic acid by cosolvency. Arch Pharm Res. 1997;20:269-274.
17. Jeong DW, Kim YH, Kim HH, et al. Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats. Biopharm Drug Dispos. 2007;28:51-57.
18. Chen Y, Liu J, Yang X, Zhao X, Xu H. Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect. J Pharm Pharmacol. 2005;57:259-264.
19. Liu L, Wang X. Improved dissolution of oleanolic acid with ternary solid dispersions. AAPS PharmSciTech. 2007;8:E113.
20. Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12:1561-1572.
21. Shah NH, Carvajal MT, Patel CI, Infeld NH, Malick AW. Selfemulsifying drug delivery systems (SEDDS) with polyglycolized glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm. 1994;106:15-23.
22. Iwanaga K, Kushibiki T, Miyazaki M, Kakemi M. Disposition of lipidbased formulation in the intestinal tract affects the absorption of poorly water-soluble drugs. Biol Pharm Bull. 2006;29:508-512.
23. Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov. 2007;6:231-248.
24. Zhang P, Liu Y, Feng N, Xu J. Preparation and evaluation of selfmicroemulsifying drug delivery system of oridonin. Int J Pharm. 2008;355:269-276.
25. Kang BK, Lee JS, Chon SK, et al. Development of selfmicroemulsifying drug delivery systems (SMEDDS) for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm. 2004;274:65-73.
26. Wu W, Wang Y, Que L. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. EurJ Pharm Biopharm. 2006;63:288-294.
27. Khoo SM, Humberstone AJ, Porter JHC, Edwards GA, Charman WN. Formulation design and bioavailability assessment of lipidic selfemulsifying formulations of halofantrine. Int J Pharm. 1998;167: 155-164.
28. Surjyanarayan M, Snigdha MS, Naazneen S, Vandana PB, Mandal PAS. Design and development of saquinavir microemulsion for the oral bioavailability enhancement. Int J Pharm Tech Res. 2009;1:1442-1448.
29. Patel AR, Vavia PR. Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J. 2007;9:E344-E352.
30. Swenson ES, Curatolo WJ. Means to enhance penetration. Adv Drug Deliv Rev. 1992;8:39-42.
31. Hauss DJ, Mehta SC, Radebaugh GW. Targeted lymphatic transport and modified systemic distribution of CI-976, a lipophilic lipid-regulator drug, via a formulation approach. Int J Pharm. 1994;108:85-93.