Design and development of Saquinavir microemulsion for the oral bioavailability enhancement

International Journal of PharmTech Research

Volumn 1, Issue 4, 2009, Pages 1442-1448

  Surjyanarayan, Mandal ^a   Snigdha S , Mandal ^a   Naazneen, Surti ^a   Vandana B , Patel ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL; POLYSORBATE 80; SAQUINAVIR; WATER;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG RESPONSE; DRUG SOLUBILITY; DRUG STABILITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PRACTICE GUIDELINE; RAT; ZETA POTENTIAL;

EID: 77953419716     PISSN: None     EISSN: 09744304     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. K Singh, L Dickinson, A Chaikan, D Back, C Fletcher. Pharmacokinetics and Safety of Saquinavir/Ritonavir and Omeprazole in HIV-infected Subjects. Clinical Pharmacology & Therapeutics, 2008; 83(6): 867-872. (Pubitemid 351704917)
2. Molla, A., Granneman, G.R., Sue, E., Kempf, D.J. Recent developments in HIV protease inhibitor therapy. Antivir. Res, 1998; 39: 1-23.
3. Williams, G.C., Sinko, P.J. Oral absorption of the HIV protease inhibitors: a current update. Adv. Drug Deliv. Rev, 1999; 39: 211-238.
4. Noble, S., Faulds, D. Saquinavir A review of its pharmacology and clinical potential in the management of HIV infection. Drugs, 1996; 52: 93-112. (Pubitemid 126445750)
5. Charman S, Charman W, Rogge M, Wilson T, Dutko F, Pouton C. Self-emulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound. Pharm Res, 1992; 9: 87-93.
6. Constantinides P, Scalart J, Lancaster C, et al. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm Res, 1994; 11: 1385-1390. (Pubitemid 24339642)
7. Kovarik J, Muelle E, Van Bree J, Tetzloff W, Kutz K. Reduced inter- and intraindividual variability in cyclosporine pharmacokinetics from a microemulsion formulation. J Pharm Sci, 1994; 83: 444-446. (Pubitemid 24224228)
8. Shah N, Carvajal M, Patel C, Infeld M, Malick A. Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs. Int J Pharm, 1994; 106: 15-23. (Pubitemid 24110060)
9. Matuszewska B, Hettrick L, Bondi J, Storey D. Comparative bioavailability of L-683,453, a 5a-reductase inhibitor, from a self-emulsifying drug delivery system in beagle dogs. Int J Pharm, 1996; 136: 147-154.
10. Pradip Kumar Ghosh, Rita J. Majithiya, Manish L. Umrethia, and Rayasa S. R. Murthy. Design and Development of Microemulsion Drug Delivery System of Acyclovir for Improvement of Oral Bioavailability. AAPS PharmSci Tech, 2006; 7 (3): 1-6.
11. Hung-Jang G., Shou-Nan Chen, Jenn-Shyong Hwang, C. Tien, M. T. Kuo. Studies of Formation and Interface of Oil-Water Microemulsion. Chinese Journal of physics, 1992; 30 (5): 665-678.
12. A. Radomska, R. Dobrucki; The use of some ingredients for microemulsion preparation containing retinol and its esters. International journal of Pharmaceutics, 2000; 196(2): 131-134.
13. Smith P. Methods for evaluating intestinal permeability and metabolism in vitro. Pharm Biotechnol, 1996; 8: 13-34.
14. Charles M. Buchanan, Norma L. Buchanan, Kevin J. Edgar, James L. Pharmacokinetics of Saquinavir after Intravenous and Oral Dosing of Saquinavir: Hydroxybutenyl-β-Cyclodextrin Formulations. Biomacromolecules, 2008; 9 (1): 305-313.
15. †. Characterizing an Amorphous System Exhibiting Trace Crystallinity: A Case Study with Saquinavir. Cryst. Growth Des., 2008; 8 (1): 119-127.
16. McEvoy G. AHFS Drugs Information, American Society of Health System Pharmacists. Bethesda, MD: Atlantic Books, 1998; 471-480.
17. Ghosh PK, Umrethia M, Majithiya RJ, Murthy RSR. Preparation and physicochemical characterisation of caprylocapryl macrogol -8-glycerides microemulsion for oral drug delivery. Ars Pharm, 2004; 45: 353-372. (Pubitemid 41301630)
18. M. A. Campanero , M. Escolar , M. A. Arangoa , B. Sádaba , J. R. Azanza. Development of a chromatographic method for the determination of saquinavir in plasma samples of HIV patients. Biomedical Chromatography, 2001; 16(1): 7-12.
19. Gibaldi M, Perrier D. Pharmacokinetics. New York, NY: Marcel-Dekker; Volume15, second edition, 1982.
20. V. Jain, V. Prasad, P. Jadhav, P. R. Mishra. Preparation and performance evaluation of saquinavir laden cationic submicron emulsions. Drug delivery, 2009; 16(1): 37-44.
21. Dimitrios G Fatouros, Ditte M Karpf, Flemming S Nielsen, and Anette Mullertz. Clinical studies with oral lipid based formulations of poorly soluble compounds. Ther Clin Risk Manag, 2007; 3(4): 591-604.
22. Bidyut K. Paul and Satya P. Moulik. Uses and applications of microemulsions. Current Science, 2001; 80 (8): 990-1001.