Neisseria meningitidis expresses a single 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase that is inhibited primarily by phenylalanine

Protein Science

Volumn 22, Issue 8, 2013, Pages 1087-1099

  Cross, Penelope J ^a   Pietersma, Amy L ^b   Allison, Timothy M ^a   Wilson Coutts, Sarah M ^a   Cochrane, Fiona C ^b   Parker, Emily J ^a  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

^b MASSEY UNIVERSITY   (New Zealand)

Author keywords

Allostery; Aromatic amino acids; DAHPS; Shikimate

Indexed keywords

3 DEOXY ARABINO HEPTULOSONATE 7 PHOSPHATE SYNTHASE; AROMATIC CARBOXYLIC ACID; BARIUM; CADMIUM; CALCIUM; COBALT; COPPER; ENZYME VARIANT; IRON; MAGNESIUM; MANGANESE; NICKEL; PHENYLALANINE; SERINE; SHIKIMIC ACID; STRONTIUM; SYNTHETASE; TYROSINE; UNCLASSIFIED DRUG; ZINC;

ALLOSTERISM; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; BIOSYNTHESIS; BRAIN DAMAGE; CATALYSIS; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENTHALPY; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STABILITY; ENZYME STRUCTURE; HEARING IMPAIRMENT; ISOTHERMAL TITRATION CALORIMETRY; MENINGITIS; MENINGOCOCCEMIA; METABOLITE; MOLECULAR MECHANICS; NEGATIVE FEEDBACK; NEISSERIA MENINGITIDIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALLOSTERY; AROMATIC AMINO ACIDS; DAHPS; SHIKIMATE;

3-DEOXY-7-PHOSPHOHEPTULONATE SYNTHASE; ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; AMINO ACIDS, AROMATIC; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; FEEDBACK, PHYSIOLOGICAL; NEISSERIA MENINGITIDIS; PHENYLALANINE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; SCATTERING, SMALL ANGLE; TRYPTOPHAN; TYROSINE; X-RAY DIFFRACTION;

EID: 84881291432     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2293     Document Type: Article

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