Substrate and Metal Complexes of 3-Deoxy-D-arabino-heptulosonate-7- phosphate Synthase from Saccharomyces cerevisiae Provide New Insights into the Catalytic Mechanism

Journal of Molecular Biology

Volumn 337, Issue 3, 2004, Pages 675-690

  König, Verena ^a   Pfeil, Andrea ^a   Braus, Gerhard H ^a   Schneider, Thomas R ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

DAHP synthase; DAHP, 3 deoxy D arabino heptulosonate 7 phosphate; DAHPSSC, tyrosine regulated DAHP synthase Aro4p from Saccharomyces cerevisiae; Feedback inhibition; Metal enzyme; TIM barrel; Yeast

Indexed keywords

2 DEHYDRO 3 DEOXYPHOSPHOHEPTONATE ALDOLASE; 2 PHOSPHOENOLPYRUVATE; DEXTRO ERYTHROSE 4 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE; METAL COMPLEX; PHOSPHATE; PYRUVIC ACID DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME CONFORMATION; ENZYME PURIFICATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MUTAGENESIS; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 1542328861     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.01.055     Document Type: Article

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