메뉴 건너뛰기




Volumn 7, Issue 6, 2012, Pages 1111-1119

Titanium dioxide nanoparticles activate the ATM-Chk2 DNA damage response in human dermal fibroblasts

Author keywords

ATM; DNA damage response; Environmental toxicology; Mechanistic toxicology; Nanotoxicology

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; HISTONE H2AX; NANOPARTICLE; TITANIUM DIOXIDE;

EID: 84881283681     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2012.710659     Document Type: Article
Times cited : (29)

References (55)
  • 1
    • 79952305404 scopus 로고    scopus 로고
    • Polymorph-And size-dependent uptake and toxicity of TiO nanoparticles in living lung epithelial cells
    • Andersson PO, Lejon C, Ekstrand-Hammarstrom B, Akfur C, Ahlinder L, Bucht A, et al. 2011. Polymorph-And size-dependent uptake and toxicity of TiO nanoparticles in living lung epithelial cells. Small 7(4):514-523
    • (2011) Small , vol.7 , Issue.4 , pp. 514-523
    • Andersson, P.O.1    Lejon, C.2    Ekstrand-Hammarstrom, B.3    Akfur, C.4    Ahlinder, L.5    Bucht, A.6
  • 2
    • 84855785145 scopus 로고    scopus 로고
    • Nanotoxicology and in vitro studies: The need of the hour
    • Arora S, Rajwade JM, Paknikar KM. 2012. Nanotoxicology and in vitro studies: The need of the hour. Toxicol Appl Pharmacol 258(2):151:65
    • (2012) Toxicol Appl Pharmacol , vol.258 , Issue.2 , pp. 151-165
    • Arora, S.1    Rajwade, J.M.2    Paknikar, K.M.3
  • 4
    • 77953557271 scopus 로고    scopus 로고
    • Revised genetic requirements for the decatenation G2 checkpoint: The role of ATM
    • 1628
    • Bower JJ, Zhou Y, Zhou T, Simpson DA, Arlander SJ, Paules RS, et al. 2010. Revised genetic requirements for the decatenation G2 checkpoint: The role of ATM. Cell Cycle 9(8):1617:1628
    • (2010) Cell Cycle , vol.9 , Issue.8 , pp. 1617
    • Bower, J.J.1    Zhou, Y.2    Zhou, T.3    Simpson, D.A.4    Arlander, S.J.5    Paules, R.S.6
  • 5
    • 0242497228 scopus 로고    scopus 로고
    • Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage
    • Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, et al. 2003. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature 426 (6962):87-91
    • (2003) Nature , vol.426 , Issue.6962 , pp. 87-91
    • Busino, L.1    Donzelli, M.2    Chiesa, M.3    Guardavaccaro, D.4    Ganoth, D.5    Dorrello, N.V.6
  • 7
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia A, Elledge SJ. 2010. The DNA damage response: Making it safe to play with knives. Mol Cell 40:179-204
    • (2010) Mol Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 9
    • 0035848819 scopus 로고    scopus 로고
    • The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
    • Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. 2001. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410(6830):842-847
    • (2001) Nature , vol.410 , Issue.6830 , pp. 842-847
    • Falck, J.1    Mailand, N.2    Syljuasen, R.G.3    Bartek, J.4    Lukas, J.5
  • 10
    • 85172040085 scopus 로고    scopus 로고
    • FDA (U.S. Food and Drug Administration FR 27666; codified in 21 CFR 352 Retrieved June 2 2009
    • FDA (U.S. Food and Drug Administration). 1999. Final Rule for sunscreen drug products for over-The-counter human use; 64 FR 27666; codified in 21 CFR 352. Retrieved June 2 2009. fromhttp://www. access.gpo.gov/nara/cfr/waisidx-08/ 21cfr352-08.html
    • (1999) Final Rule For Sunscreen Drug Products For Over-The-Counter Human Use , vol.64
  • 11
    • 80455140278 scopus 로고    scopus 로고
    • Informing selection of nanomaterial concentrations for toxcast In Vitro testing based on occupational exposure potential
    • Gangwal S, Brown JS, Wang A, Houck KA, Dix DJ, Kavlock RJ, et al. 2011. Informing selection of nanomaterial concentrations for toxcast In Vitro testing based on occupational exposure potential. Environ Health Perspect 119(11):1539-1546
    • (2011) Environ Health Perspect , vol.119 , Issue.11 , pp. 1539-1546
    • Gangwal, S.1    Brown, J.S.2    Wang, A.3    Houck, K.A.4    Dix, D.J.5    Kavlock, R.J.6
  • 12
    • 23944463473 scopus 로고    scopus 로고
    • Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells
    • Gurr JR, Wang AS, Chen CH, Jan KY. 2005. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213 (1-2):66-73
    • (2005) Toxicology , vol.213 , Issue.1-2 , pp. 66-73
    • Gurr, J.R.1    Wang, A.S.2    Chen, C.H.3    Jan, K.Y.4
  • 13
    • 77951910654 scopus 로고    scopus 로고
    • Intracellular distribution, geno-And cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells
    • Hackenberg S, Friehs G, Froelich K, Ginzkey C, Koehler C, Scherzed A, et al. 2010. Intracellular distribution, geno-And cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells. Toxicol Lett 195(1):9-14
    • (2010) Toxicol Lett , vol.195 , Issue.1 , pp. 9-14
    • Hackenberg, S.1    Friehs, G.2    Froelich, K.3    Ginzkey, C.4    Koehler, C.5    Scherzed, A.6
  • 14
    • 79953719052 scopus 로고    scopus 로고
    • Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes
    • Hackenberg S, Friehs G, Kessler M, Froelich K, Ginzkey C, Koehler C, et al. 2011. Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes. Environ Mol Mutagen 52(4):264-268
    • (2011) Environ Mol Mutagen , vol.52 , Issue.4 , pp. 264-268
    • Hackenberg, S.1    Friehs, G.2    Kessler, M.3    Froelich, K.4    Ginzkey, C.5    Koehler, C.6
  • 15
    • 0036892831 scopus 로고    scopus 로고
    • An ATR-And Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
    • Heffernan TP, Simpson DA, Frank AR, Heinloth AN, Paules RS, Cordeiro-Stone M, et al. 2002. An ATR-And Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol Cell Biol 22(24):8552-8561
    • (2002) Mol Cell Biol , vol.22 , Issue.24 , pp. 8552-8561
    • Heffernan, T.P.1    Simpson, D.A.2    Frank, A.R.3    Heinloth, A.N.4    Paules, R.S.5    Cordeiro-Stone, M.6
  • 18
    • 85172034906 scopus 로고    scopus 로고
    • Titanium Dioxide
    • IARC Monograph 93 (Titanium Dioxide). 2010. http://monographs. iarc.fr/ENG/Monographs/PDFs/93-Titaniumdioxide.pdf
    • (2010) IARC Monograph , vol.93
  • 19
    • 0032559794 scopus 로고    scopus 로고
    • Replicon clusters are stable units of chromosome structure: Evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells
    • Jackson DA, Pombo A. 1998. Replicon clusters are stable units of chromosome structure: Evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells. J Cell Biol 140(6):1285-1295
    • (1998) J Cell Biol , vol.140 , Issue.6 , pp. 1285-1295
    • Jackson, D.A.1    Pombo, A.2
  • 20
    • 53549131701 scopus 로고    scopus 로고
    • Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells
    • Jin CY, Zhu BS, Wang XF, Lu QH. 2008. Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells. Chem Res Toxicol 21 (9):1871-1877
    • (2008) Chem Res Toxicol , vol.21 , Issue.9 , pp. 1871-1877
    • Jin, C.Y.1    Zhu, B.S.2    Wang, X.F.3    Lu, Q.H.4
  • 21
    • 45849128316 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes
    • Kang SJ, Kim BM, Lee YJ, Chung HW. 2008. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen 49(5):399-405
    • (2008) Environ Mol Mutagen , vol.49 , Issue.5 , pp. 399-405
    • Kang, S.J.1    Kim, B.M.2    Lee, Y.J.3    Chung, H.W.4
  • 23
    • 77952297911 scopus 로고    scopus 로고
    • The human intra-S checkpoint response to UVC-induced DNA damage
    • Kaufmann WK. 2010. The human intra-S checkpoint response to UVC-induced DNA damage. Carcinogenesis 31(5):751-765
    • (2010) Carcinogenesis , vol.31 , Issue.5 , pp. 751-765
    • Kaufmann, W.K.1
  • 24
    • 55249116558 scopus 로고    scopus 로고
    • Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    • Kinner A, Wu W, Staudt C, Iliakis G. 2008. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 36(17):5678-5694
    • (2008) Nucleic Acids Res , vol.36 , Issue.17 , pp. 5678-5694
    • Kinner, A.1    Wu, W.2    Staudt, C.3    Iliakis, G.4
  • 26
    • 38849111818 scopus 로고    scopus 로고
    • Cytotoxicity of nanoparticles
    • Lewinski N, Colvin V, Drezek R. 2008. Cytotoxicity of nanoparticles. Small 4(1):26-49
    • (2008) Small , vol.4 , Issue.1 , pp. 26-49
    • Lewinski, N.1    Colvin, V.2    Drezek, R.3
  • 27
    • 80455149950 scopus 로고    scopus 로고
    • Environmental, health and safety issues: Nanoparticles in the real world
    • McCall MJ. 2011. Environmental, health and safety issues: Nanoparticles in the real world. Nat Nanotechnol 6(10):613-614
    • (2011) Nat Nanotechnol , vol.6 , Issue.10 , pp. 613-614
    • McCall, M.J.1
  • 28
    • 2442582392 scopus 로고    scopus 로고
    • Visualization of altered replication dynamics after DNA damage in human cells
    • Merrick CJ, Jackson D, Diffley JF. 2004. Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 279:19 20067-20075
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 20067-20075
    • Merrick, C.J.1    Jackson, D.2    Diffley, J.F.3
  • 30
    • 80052505577 scopus 로고    scopus 로고
    • Safety evaluationof sunscreen formulation containing titaniumdioxide and zinc oxide nanoparticles inUVB sunburned skin: An in vitro and in vivo study
    • Monteiro-Rivere NA, Wiench K, Landsiedel R, Schulte R, Inman AO, Riviere JE. 2011. Safety evaluationof sunscreen formulation containing titaniumdioxide and zinc oxide nanoparticles inUVB sunburned skin: An in vitro and in vivo study. Tox Sci 123(1):264-280
    • (2011) Tox Sci , vol.123 , Issue.1 , pp. 264-280
    • Monteiro-Rivere, N.A.1    Wiench, K.2    Landsiedel, R.3    Schulte, R.4    Inman, A.O.5    Riviere, J.E.6
  • 31
    • 44949247432 scopus 로고    scopus 로고
    • Exposure modeling of engineered nanoparticles in the environment
    • Mueller NC, Nowack B. 2008. Exposure modeling of engineered nanoparticles in the environment. Environ Sci Technol 42:4447-4453
    • (2008) Environ Sci Technol , vol.42 , pp. 4447-4453
    • Mueller, N.C.1    Nowack, B.2
  • 33
    • 0008158443 scopus 로고
    • Radiosensitivity in ataxia-Telangiectasia: A new explanation
    • Painter RB, Young BR. 1980. Radiosensitivity in ataxia-Telangiectasia: A new explanation. Proc Natl Acad Sci USA 77(12):7315-7317
    • (1980) Proc Natl Acad Sci USA , vol.77 , Issue.12 , pp. 7315-7317
    • Painter, R.B.1    Young, B.R.2
  • 34
    • 62749083701 scopus 로고    scopus 로고
    • Adverse effects of titanium dioxide nanoparticles on human dermal fibroblasts and how to protect cells
    • Pan Z, Lee W, Slutsky L, Clark RA, Pernodet N, Rafailovich MH. 2009. Adverse effects of titanium dioxide nanoparticles on human dermal fibroblasts and how to protect cells. Small 5(4):511-520
    • (2009) Small , vol.5 , Issue.4 , pp. 511-520
    • Pan, Z.1    Lee, W.2    Slutsky, L.3    Clark, R.A.4    Pernodet, N.5    Rafailovich, M.H.6
  • 35
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. 2000. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10 (15):886-895
    • (2000) Curr Biol , vol.10 , Issue.15 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 36
    • 0036055464 scopus 로고    scopus 로고
    • Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts
    • Rahman Q, Lohani M, Dopp E, Pemsel H, Jonas L, Weiss DG, et al. 2002. Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts. Environ Health Perspect 110(8):797-800
    • (2002) Environ Health Perspect , vol.110 , Issue.8 , pp. 797-800
    • Rahman, Q.1    Lohani, M.2    Dopp, E.3    Pemsel, H.4    Jonas, L.5    Weiss, D.G.6
  • 37
    • 84858994990 scopus 로고    scopus 로고
    • Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts
    • Romoser AA, Figueroa DE, Sooresh A, Scriber K, Chen PL, Porter W, et al. 2012. Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts. Tox Lett 210:293-301
    • (2012) Tox Lett , vol.210 , pp. 293-301
    • Romoser, A.A.1    Figueroa, D.E.2    Sooresh, A.3    Scriber, K.4    Chen, P.L.5    Porter, W.6
  • 40
    • 77950349125 scopus 로고    scopus 로고
    • Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and p,p'-DDT in human hepatocytes
    • Shi Y, Zhang JH, Jiang M, Zhu LH, Tan HQ, Lu B. 2010. Synergistic genotoxicity caused by low concentration of titanium dioxide nanoparticles and p,p'-DDT in human hepatocytes. Environ Mol Mutagen 51(3):192-204
    • (2010) Environ Mol Mutagen , vol.51 , Issue.3 , pp. 192-204
    • Shi, Y.1    Zhang, J.H.2    Jiang, M.3    Zhu, L.H.4    Tan, H.Q.5    Lu, B.6
  • 41
    • 0032497548 scopus 로고    scopus 로고
    • Regulation of DNA-replication origins during cell-cycle progression
    • Shirahige K, Hori Y, Shiraishi K, Yamashita M, Takahashi K, Obuse C, et al. 1998. Regulation of DNA-replication origins during cell-cycle progression. Nature 395(6702):618-621
    • (1998) Nature , vol.395 , Issue.6702 , pp. 618-621
    • Shirahige, K.1    Hori, Y.2    Shiraishi, K.3    Yamashita, M.4    Takahashi, K.5    Obuse, C.6
  • 42
    • 84872469220 scopus 로고    scopus 로고
    • TiO (2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells
    • Epub ahead of print]
    • Shukla RK, Kumar A, Gurbani D, Pandey AK, Singh S, Dhawan A. 2011a. TiO(2) nanoparticles induce oxidative DNA damage and apoptosis in human liver cells. Nanotoxicology Epub ahead of print].
    • (2011) Nanotoxicology
    • Shukla, R.K.1    Kumar, A.2    Gurbani, D.3    Pandey, A.K.4    Singh, S.5    Dhawan, A.6
  • 43
    • 78650519473 scopus 로고    scopus 로고
    • ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells
    • Shukla RK, Sharma V, Pandey AK, Singh S, Sultana S, Dhawan A. 2011b. ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells. Toxicol In Vitro 25(1):231-241
    • (2011) Toxicol In Vitro , vol.25 , Issue.1 , pp. 231-241
    • Shukla, R.K.1    Sharma, V.2    Pandey, A.K.3    Singh, S.4    Sultana, S.5    Dhawan, A.6
  • 46
    • 33845715977 scopus 로고    scopus 로고
    • ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
    • Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, et al. 2006. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J 25(24):5775-5782
    • (2006) EMBO J , vol.25 , Issue.24 , pp. 5775-5782
    • Stiff, T.1    Walker, S.A.2    Cerosaletti, K.3    Goodarzi, A.A.4    Petermann, E.5    Concannon, P.6
  • 47
    • 0035797444 scopus 로고    scopus 로고
    • Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint
    • Tercero JA, Diffley JF. 2001. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412(6846):553-557
    • (2001) Nature , vol.412 , Issue.6846 , pp. 553-557
    • Tercero, J.A.1    Diffley, J.F.2
  • 48
    • 35448973583 scopus 로고    scopus 로고
    • An investigation of the photo-clastogenic potential of ultrafine titanium dioxide particles
    • Theogaraj E, Riley S, Hughes L, Maier M, Kirkland D. 2007. An investigation of the photo-clastogenic potential of ultrafine titanium dioxide particles. Mutat Res 634(1-2):205-219
    • (2007) Mutat Res , vol.634 , Issue.1-2 , pp. 205-219
    • Theogaraj, E.1    Riley, S.2    Hughes, L.3    Maier, M.4    Kirkland, D.5
  • 49
    • 72249115549 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice
    • Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. 2009. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 69(22):8784-8789
    • (2009) Cancer Res , vol.69 , Issue.22 , pp. 8784-8789
    • Trouiller, B.1    Reliene, R.2    Westbrook, A.3    Solaimani, P.4    Schiestl, R.H.5
  • 51
    • 33847256798 scopus 로고    scopus 로고
    • 2 particles in cultured human lymphoblastoid cells
    • 2 particles in cultured human lymphoblastoid cells. Mutat Res 628(2):99-106
    • (2007) Mutat Res , vol.628 , Issue.2 , pp. 99-106
    • Wang, J.J.1    Sanderson, B.J.2    Wang, H.3
  • 52
    • 80055029446 scopus 로고    scopus 로고
    • Automated DNA fiber tracking and measurement
    • March 30 2011-April 2 2011, doi: 10.1109/ISBI.2011. 5872650]
    • Wang Y, Chastain P, Yap PT, Cheng JZ, Kaufman D, Guo L, et al. 2011. Automated DNA fiber tracking and. measurement. Proc IEEE ISBI 1349-1352 [March 30 2011-April 2 2011, doi: 10.1109/ISBI.2011. 5872650].
    • (2011) Proc IEEE ISBI , pp. 1349-1352
    • Wang, Y.1    Chastain, P.2    Yap, P.T.3    Cheng, J.Z.4    Kaufman, D.5    Guo, L.6
  • 53
    • 38149103482 scopus 로고    scopus 로고
    • How meaningful are the results of nanotoxicity studies in the absence of adequate material characterization?
    • Warheit DB 2008. How meaningful are the results of nanotoxicity studies in the absence of adequate material characterization? Toxicol Sci 101(2):183-185
    • (2008) Toxicol Sci , vol.101 , Issue.2 , pp. 183-185
    • Warheit, D.B.1
  • 54
    • 78650516786 scopus 로고    scopus 로고
    • Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells
    • Wu J, Sun J, Xue Y. 2010. Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. Toxicol Lett 199(3):269-276
    • (2010) Toxicol Lett , vol.199 , Issue.3 , pp. 269-276
    • Wu, J.1    Sun, J.2    Xue, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.