Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential

Environmental Health Perspectives

Volumn 119, Issue 11, 2011, Pages 1539-1546

  Gangwa, Sumit ^a   Brown, James S ^b   Wang, Amy ^a   Houck, Keith A ^a   Dix, David J ^a   Kavlock, Robert J ^a   Cohen Hubal, Elaine A ^a  

^a National Center for Computational Toxicology   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

ExpoCast; Human particle deposition and retention; In vitro nanomaterial concentration; Multiple path particle dosimetry (MPPD); Occupational exposure; ToxCast

Indexed keywords

CARBON NANOTUBE; NANOMATERIAL; SILVER NANOPARTICLE; TITANIUM DIOXIDE;

AEROSOL; ALVEOLAR MASS; BREATHING PATTERN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSIMETRY; HIGH THROUGHPUT SCREENING; HUMAN; IN VITRO STUDY; LIFESPAN; LUNG; LUNG ALVEOLUS; METHODOLOGY; MULTIPLE PATH PARTICLE DOSIMETRY; OCCUPATIONAL EXPOSURE; PARTICLE SIZE; PRIORITY JOURNAL; REVIEW; TOXCAST METHOD;

AEROSOLS; AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; CARBON; COMPUTER SIMULATION; HUMANS; INHALATION EXPOSURE; MODELS, BIOLOGICAL; NANOPARTICLES; NANOTUBES; OCCUPATIONAL EXPOSURE; PULMONARY ALVEOLI; SENSITIVITY AND SPECIFICITY; SILVER; TITANIUM; TOXICITY TESTS; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 80455140278     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1103750     Document Type: Review

References (55)

1. Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol 28(1):41-50.
2. Asgharian B, Hofman W, Bergmann R. 2001. Particle deposition in a multiple-path model of the human lung. Aerosol Sci Technol 34(4):332-339.
3. Asgharian B, Price OT. 2007. Deposition of ultrafine (NANO) particles in the human lung. Inhal Toxicol 19:1045-1054.
4. Baron PA, Deye GJ, Chen BT, Schwegler-Berry DE, Shvedova AA, Castranova V. 2008. Aerosolization of single-walled carbon nanotubes for an inhalation study. Inhal Toxicol 20(8):751-760.
5. Bello D, Hart AJ, Ahn K, Hallock M, Yamamoto N, Garcia EJ, et al. 2008. Particle exposure levels during CVD growth and subsequent handling of vertically-aligned carbon nanotube films. Carbon 46(6):974-977.
6. Bello D, Wardle BL, Yamamoto N, deVilloria RG, Garcia EJ, Hart AJ, et al. 2009. Exposure to nanoscale particles and fibers during machining of hybrid advanced composites containing carbon nanotubes. J Nanopart Res 11(1):231-249.
7. Bergamaschi E. 2009. Occupational exposure to nanomaterials: present knowledge and future development. Nanotoxicology 3(3):194-201.
8. Brown JS, Wilson WE, Grant LD. 2005. Dosimetric comparisons of particle deposition and retention in rats and humans. Inhal Toxicol 17(7-8):355-385.
9. Choi HS, Ashitate Y, Lee JH, Kim SH, Matsui A, Insin N, et al. 2010. Rapid translocation of nanoparticles from the lung airspaces to the body. Nat Biotechnol 28(12):1300-1303.
10. Cohen Hubal EA. 2009. Biologically relevant exposure science for 21st century toxicity testing. Toxicol Sci 111(2):226-232.
11. Cohen Hubal EA, Richard A, Aylward L, Edwards S, Gallagher J, Goldsmith MR, et al. 2010. Advancing exposure characterization for chemical evaluation and risk assessment. J Toxicol Environ Health B 13(2-4):299-313.
12. Dix DJ, Houck KA, Martin MT, Richard AM, Setzer RW, Kavlock RJ. 2007. The ToxCast program for prioritizing toxicity testing of environmental chemicals. Toxicol Sci 95(1):5-12.
13. Farkas A, Balashazy I, Szocs K. 2006. Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods. J Aerosol Med 19(3):329-343.
14. Geiser M, Kreyling WG. 2010. Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol 7:2; doi:10.1186/1743-8977-7-2 [Online 20 January 2010].
15. Hameri K, Lahde T, Hussein T, Koivisto J, Savolainen K. 2009. Facing the key workplace challenge: assessing and preventing exposure to nanoparticles at source. Inhal Toxicol 21(suppl 1):17-24.
16. Hinderliter PM, Minard KR, Orr G, Chrisler WB, Thrall BD, Pounds JG, et al. 2010. ISDD: a computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies. Part Fibre Toxicol 7(1):36; doi:10.1186/1743-8977-7-36 [Online 30 November 2010].
17. Hoet PH, Bruske-Hohlfeld I, Salata OV. 2004. Nanoparticles - known and unknown health risks. J Nanobiotechnology 2(1):12; doi:10.1186/1477-3155-2-12 [Online 8 December 2004].
18. ICRP (International Commission on Radiological Protection). 1994. Human respiratory tract model for radiological protection: a report of a task group of the International Commission on Radiological Protection. Publ no. 66. Ann ICRP 24(1-3):1-482.
19. Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, et al. 2010. In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project. Environ Health Perspect 118:485-492.
20. Judson R, Richard A, Dix DJ, Houck K, Martin M, Kavlock R, et al. 2009. The toxicity data landscape for environmental chemicals. Environ Health Perspect 117:685-695.
21. Kessler R. 2011. Engineered nanoparticles in consumer products: understanding a new ingredient. Environ Health Perspect 119:A120-A125.
22. Klaine SJ, Alvarez PJ, Batley GE, Fernandes TF, Handy RD, Lyon DY, et al. 2008. Nanomaterials in the environment: behavior, fate, bioavailability, and effects. Environ Toxicol Chem 27(9):1825-1851.
23. Lee JH, Lee SB, Bae GN, Jeon KS, Yoon JU, Ji JH, et al. 2010. Exposure assessment of carbon nanotube manufacturing workplaces. Inhal Toxicol 22(5):369-381.
24. Maynard AD, Aitken RJ. 2007. Assessing exposure to airborne nanomaterials: current abilities and future requirements. Nanotoxicology 1(1):26-41.
25. Maynard AD, Baron PA, Foley M, Shvedova AA, Kisin ER, Castranova V. 2004. Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 67(1):87-107.
26. Methner M, Hodson L, Dames A, Geraci C. 2010b. Nanoparticle emission assessment technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials-part B: results from 12 field studies. J Occup Environ Hyg 7(3):163-176.
27. Methner M, Hodson L, Geraci C. 2010a. Nanoparticle emission assessment technique (NEAT) for the identification and measurement of potential inhalation exposure to engineered nanomaterials-part A. J Occup Environ Hyg 7(3):127-132.
28. Miller A, Drake PL, Hintz P, Habjan M. 2010. Characterizing exposures to airborne metals and nanoparticle emissions in a refinery. Ann Occup Hyg 54(5):504-513.
29. Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, et al. 2006. Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am J Respir Crit Care Med 173(4):426-431.
30. Möller W, Felten K, Sommerer K, Scheuch G, Meyer G, Meyer P, et al. 2008. Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am J Respir Crit Care Med 177(4):426-432.
31. Morrow PE. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam Appl Toxicol 10(3):369-384.
32. Mutlu GM, Budinger GR, Green AA, Urich D, Soberanes S, Chiarella SE, et al. 2010. Biocompatible nanoscale dispersion of single-walled carbon nanotubes minimizes in vivo pulmonary toxicity. Nano Lett 10(5):1664-1670.
33. Nanostructured & Amorphous Materials Inc. 2010. Nanostructured & Amorphous Materials Inc. Homepage. Available: http://www.nanoamor.com/ [accessed 1 September 2010].
34. National Nanotechnology Initiative. 2008. Strategy for Nanotechnology-Related Environmental, Health, and Safety Research. Washington, DC:Executive Office of the President, Office of Science and Technology Policy, National Nanotechnology Initiative. Available: http://www.nano.gov/NNI_EHS_Research_Strategy.pdf [accessed 14 March 2010].
35. National Research Council. 2007. Toxicity Testing in the 21st Century: A Vision and a Strategy. Washington, DC:National Academies Press.
36. NIOSH (National Institute for Occupational Safety and Health). 2005. NIOSH Current Intelligence Bulletin: Evaluation of Health Hazard and Recommendations for Occupational Exposure to Titanium Dioxide. Cincinnati, OH:NIOSH. Available: http://www.cdc.gov/niosh/review/public/tio2/pdfs/tio2draft.pdf [accessed 19 September 2010].
37. NIOSH (National Institute for Occupational Safety and Health). 2008. Final Report: A Predictive Model of Inhaled Nanofibers/Nanotubes Deposition in the Human Lung. CDC/NIOSH 211-2007-M-22959. Research Triangle Park, NC:The Hamner Institutes for Health Sciences.
38. NIOSH (National Institute for Occupational Safety and Health). 2010. NIOSH Current Intelligence Bulletin: Occupational Exposure to Carbon Nanotubes and Nanofibers. Public Review Draft. Cincinnati, OH:NIOSH. Available: http://www.cdc.gov/niosh/docket/review/docket161A/pdfs/carbonNanotubeCIB_PublicReviewOfDraft.pdf [accessed 19 September 2010].
39. Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823-839.
40. Ono-Ogasawara M, Serita F, Takaya M. 2009. Distinguishing nanomaterial particles from background airborne particulate matter for quantitative exposure assessment. J Nanopart Res 11(7):1651-1659.
41. Park J, Kwak BK, Bae E, Lee J, Kim Y, Choi K, et al. 2009. Characterization of exposure to silver nanoparticles in a manufacturing facility. J Nanopart Res 11(7):1705-1712.
42. Pauluhn J. 2010. Multi-walled carbon nanotubes (Baytubes): approach for derivation of occupational exposure limit. Regul Toxicol Pharmacol 57(1):78-89.
43. Schulte PA, Murashov V, Zumwalde R, Kuempel ED, Geraci CL. 2010. Occupational exposure limits for nanomaterials: state of the art. J Nanopart Res 12(6):1971-1987.
44. Seipenbusch M, Binder A, Kasper G. 2008. Temporal evolution of nanoparticle aerosols in workplace exposure. Ann Occup Hyg 52(8):707-716.
45. Sigma-Aldrich. 2010. Sigma-Aldrich Homepage. Available: http://www.sigmaaldrich.com [accessed 1 September 2010].
46. Takenaka S, Karg E, Kreyling WG, Lentner B, Möller W, Behnke-Semmler M, et al. 2006. Distribution pattern of inhaled ultrafine gold particles in the rat lung. Inhal Toxicol 18(10):733-740.
47. Tsai SJ, Ada E, Isaacs JA, Ellenbecker MJ. 2009. Airborne nanoparticle exposures associated with the manual handling of nanoalumina and nanosilver in fume hoods. J Nanopart Res 11(1):147-161.
48. Toxic Substances Control Act of 1976. 1976. 15USC2601 et seq. Public Law 94-469.
49. U.S. EPA (U.S. Environmental Protection Agency). 2004. What Is the TSCA Chemical Substance Inventory? Washington, DC:U.S. EPA. Available: http://www.epa.gov/oppt/newchems/pubs/invntory.htm [accessed 14 March 2010].
50. U.S. EPA (U.S. Environmental Protection Agency). 2009. Integrated Science Assessment for Particulate Matter (Final Report). EPA/600/R-08/139F. Washington, DC:U.S. EPA.
51. U.S. EPA (U.S. Environmental Protection Agency). 2010. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen (Final). EPA/600/R-09/057F. Washington, DC:U.S. EPA.
52. Wang J, Shin WG, Mertler M, Sachweh B, Fissan H, Pui DYH. 2010. Measurement of nanoparticle agglomerates by combined measurement of electrical mobility and unipolar charging properties. Aerosol Sci Technol 44(2):97-108.
53. Warheit DB, Sayes CM, Reed KL. 2009. Nanoscale and fine zinc oxide particles: can in vitro assays accurately forecast lung hazards following inhalation exposures? Environ Sci Technol 43(20):7939-7945.
54. Wiebert P, Sanchez-Crespo A, Falk R, Philipson K, Lundin A, Larsson S, et al. 2006. No significant translocation of inhaled 35-nm carbon particles to the circulation in humans. Inhal Toxicol 18(10):741-747.
55. Yeh HC, Schum GM. 1980. Models of human lung airways and their application to inhaled particle deposition. Bull Math Biol 42(3):461-480.