Synthesis and antitumor activity of 17-carboxylic acid modified amide derivatives of 23-hydroxy betulinic acid

Records of Natural Products

Volumn 7, Issue 4, 2013, Pages 254-265

  Bi, Yi ^a   Xu, Jin Yi ^b   Sun, Fei ^b   Wu, Xiao Ming ^c   Ye, Wen Cai ^d   Sun, Yi Jun ^e   Meng, Qing Guo ^a   Huang, Wen Wen ^a  

^a YANTAI UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c Center for Drug Discovery   (China)

^d Pharmaceutical University   (China)

^e Drug Screening Center   (China)

Author keywords

23 hydroxy betulinic acid; Amide derivatives; Antitumor activity; Structure modification; Structure activity relationship

Indexed keywords

23 HYDROXY BETULIC ACID; 23 HYDROXY BETULIC ACID DERIVATIVE; AMIDE; BETULIC ACID; BETULIC ACID DERIVATIVE; CARBOXYLIC ACID; DIMETHYL N [3BETA,23 DIACETOXYLUP 20[29] EN 28 OYL] GLUTAMATE; DIMETHYL N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINO 2 BENZYL ETHANOYL] LGLUTAMATE; METHYL N [3BETA,23 DIACETOXYLUP 20[29] EN 28 OYL] ALALINATE; METHYL N [3BETA,23 DIACETOXYLUP 20[29] EN 28 OYL] GLYCINATE; METHYL N [3BETA,23 DIACETOXYLUP 20[29] EN 28 OYL] LEUCINATE; METHYL N [3BETA,23 DIACETOXYLUP 20[29] EN 28 OYL] PHENYLALANINATE; METHYL N [3BETA,23 DIACETOXYLUP 20[29] EN 28 OYL] VALINATE; METHYL N' [N [ 3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINO 2 [2' ISOBUTYL]ETHANOYL] GLUCINATE; METHYL N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINO 2 BENZYL ETHANOYL] GLUCINATE; METHYL N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINO 2 BENZYL ETHANOYL] LEUCINATE; METHYL N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINOETHANOYL] GLUCINATE; METHYL N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINOETHANOYL] LEUCINATE; METHYL N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINOETHANOYL] PHENYLALANINATE; N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] ALANINE; N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] GLUTAMIC ACID; N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] GLYCINE; N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] LEUCINE; N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] PHENYLALANINE; N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] VALINE; N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINO 2 BENZYL ETHANOYL] LEUCINE; N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINOETHANOYL] GLUCINE; N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINOETHANOYL] LEUCINE; N' [N [3BETA,23 DIHYDROXYLUP 20[29] EN 28 OYL] 2 AMINOETHANOYL] PHENYLALANINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

A549 CELL; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BEL 7402 CELL; BRAIN TUMOR; CELL STRAIN HL 60; CHEMICAL MODIFICATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CELL CARCINOMA; LUNG CARCINOMA; MELANOMA B16; NONHUMAN; SF 763 CELL; STRUCTURE ACTIVITY RELATION; TUMOR CELLS AND CELL LINES;

EID: 84881282317     PISSN: None     EISSN: 13076167     Source Type: Journal    
DOI: None     Document Type: Article

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