The nucleotide sugar UDP-glucose mobilizes long-term repopulating primitive hematopoietic cells

Journal of Clinical Investigation

Volumn 123, Issue 8, 2013, Pages 3420-3435

  Kook, Sungho ^a,c   Cho, Joonseok ^a   Lee, Sean Bong ^b   Lee, Byeong Chel ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CD11B ANTIGEN; CD150 ANTIGEN; CD48 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GRANULOCYTE COLONY STIMULATING FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PURINERGIC P2X7 RECEPTOR; SUPEROXIDE; URIDINE DIPHOSPHATE GLUCOSE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELLULAR STRESS RESPONSE; COLONY FORMING UNIT; CONTROLLED STUDY; ENGRAFTMENT; EXTRACELLULAR FLUID; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL MOBILIZATION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CHEMOTAXIS; GRANULOCYTE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MITOCHONDRIA; OSTEOCLASTS; SUPEROXIDES; URIDINE DIPHOSPHATE GLUCOSE;

EID: 84881263256     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI64060     Document Type: Article

References (61)

1. Hartmann O, et al. Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. A randomized, controlled trial. Ann Intern Med. 1997;126(8):600-607.
2. Tricot G, et al. Peripheral blood stem cell transplants for multiple myeloma: identification of favorable variables for rapid engraftment in 225 patients. Blood. 1995;85(2):588-596.
3. Neben S, Marcus K, Mauch P. Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony- stimulating factor. Blood. 1993;81(7):1960-1967.
4. Majolino I, Aversa F, Bacigalupo A, Bandini G, Arcese W, Reali G. Allogeneic transplants of rhG-CSF-mobilized peripheral blood stem cells (PBSC) from normal donors. GITMO. Gruppo Italiano Trapianto di Midollo Osseo. Haematologica. 1995;80(1):40-43.
5. Platzbecker U, et al. Spleen enlargement in healthy donors during G-CSF mobilization of PBPCs. Transfusion. 2001;41(2):184-189.
6. Yeoh JS, Ausema A, Wierenga P, de Haan G, van Os R. Mobilized peripheral blood stem cells provide rapid reconstitution but impaired long-term engraftment in a mouse model. Bone Marrow Transplant. 2007;39(7):401-409.
7. Borgerding JN, et al. G-CSF treatment induces hematopoietic stem cell quiescence but loss of repopulating activity. Presented at: American Society of Hematology 54th Annual Meeting December 2012; Atlanta, Georgia, USA. 8. Hill GR, et al. Stem cell mobilization with G-CSF induces type 17 differentiation and promotes scleroderma. Blood. 2010;116(5):819-828.
8. Pulliam AC, et al. AMD3100 synergizes with G-CSF to mobilize repopulating stem cells in Fanconi anemia knockout mice. Exp Hematol. 2008;36(9):1084-1090.
9. D'Addio A, et al. The addition of plerixafor is safe and allows adequate PBSC collection in multiple myeloma and lymphoma patients poor mobilizers after chemotherapy and G-CSF. Bone Marrow Transplant. 2011;46(3):356-363.
10. Broxmeyer HE, et al. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med. 2005;201(8):1307-1318.
11. Wright DE, Cheshier SH, Wagers AJ, Randall TD, Christensen JL, Weissman IL. Cyclophosphamide/ granulocyte colony-stimulating factor causes selective mobilization of bone marrow hematopoietic stem cells into the blood after M phase of the cell cycle. Blood. 2001;97(8):2278-2285.
12. Mollee P, et al. Cyclophosphamide, etoposide and G-CSF to mobilize peripheral blood stem cells for autologous stem cell transplantation in patients with lymphoma. Bone Marrow Transplant. 2002;30(5):273-278.
13. Lapid K, Vagima Y, Kollet O, Lapidot T. Egress and mobilization of hematopoietic stem and progenitor cells. In: StemBook. Cambridge, Massachusetts, USA: Harvard Stem Cell Institute; 2008.
14. Di Virgilio F, et al. Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood. 2001;97(3):587-600.
15. Sak K, Boeynaems JM, Everaus H. Involvement of P2Y receptors in the differentiation of haematopoietic cells. J Leukoc Biol. 2003;73(4):442-447.
16. Linden J. Cell biology. Purinergic chemotaxis. Science. 2006;314(5806):1689-1690.
17. Chen Y, et al. ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science. 2006;314(5806):1792-1795.
18. Rossi L, et al. The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration. Blood. 2007;109(2):533-542.
19. Lemoli RM, et al. Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo. Blood. 2004;104(6):1662- 1670.
20. Abbracchio MP, Burnstock G. Purinergic signalling: pathophysiological roles. Jpn J Pharmacol. 1998;78(2):113-145.
21. Lazarowski ER, Shea DA, Boucher RC, Harden TK. Release of cellular UDP-glucose as a potential extracellular signaling molecule. Mol Pharmacol. 2003;63(5):1190-1197.
22. Arase T, et al. The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8. J Immunol. 2009;182(11):7074-7084.
23. Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R. Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog. 1992;3(1-2):91-115.
24. He S, Kim I, Lim MS, Morrison SJ. Sox17 expression confers self-renewal potential and fetal stem cell characteristics upon adult hematopoietic progenitors. Genes Dev. 2011;25(15):1613-1627.
25. Roberts AW, Foote S, Alexander WS, Scott C, Robb L, Metcalf D. Genetic influences determining progenitor cell mobilization and leukocytosis induced by granulocyte colony-stimulating factor. Blood. 1997;89(8):2736-2744.
26. Park CY, Majeti R, Weissman IL. In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood. Nat Protoc. 2008;3(12):1932-1940.
27. de Kruijf EJ, Hagoort H, Velders GA, Fibbe WE, van Pel M. Hematopoietic stem and progenitor cells are differentially mobilized depending on the duration of Flt3-ligand administration. Haematologica. 2010;95(7):1061-1067.
28. Purton LE, Scadden DT. Osteoclasts eat stem cells out of house and home. Nat Med. 2006;12(6):610-611.
29. Liu F, Wu HY, Wesselschmidt R, Kornaga T, Link DC. Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity. 1996;5(5):491-501.
30. Steinman RA. Cell cycle regulators and hematopoiesis. Oncogene. 2002;21(21):3403-3413.
31. Tesio M, et al. Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling. Blood. 2011;117(2):419-428.
32. Dar A, et al. Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells. Leukemia. 2011;25(8):1286-1296.
33. Bai XC, et al. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem. 2005;280(17):17497- 17506.
34. Barsony J, Sugimura Y, Verbalis JG. Osteoclast response to low extracellular sodium and the mechanism of hyponatremia-induced bone loss. J Biol Chem. 2011;286(12):10864-10875.
35. Kollet O, et al. Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med. 2006;12(6):657-664.
36. Calvi LM, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-846.
37. Miyamoto K, et al. Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med. 2011;208(11):2175-2181.
38. Takamatsu Y, Simmons PJ, Moore RJ, Morris HA, To LB, Levesque JP. Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization. Blood. 1998;92(9):3465-3473.
39. Yoshida H, et al. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. 1990;345(6274):442-444.
40. Ke HZ, et al. Deletion of the P2X7 nucleotide receptor reveals its regulatory roles in bone formation and resorption. Mol Endocrinol. 2003;17(7):1356-1367.
41. Levesque JP, Hendy J, Takamatsu Y, Williams B, Winkler IG, Simmons PJ. Mobilization by either cyclophosphamide or granulocyte colony-stimulating factor transforms the bone marrow into a highly proteolytic environment. Exp Hematol. 2002;30(5):440-449.
42. Peled A, et al. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science. 1999;283(5403):845-848.
43. Fricks IP, et al. UDP is a competitive antagonist at the human P2Y14 receptor. J Pharmacol Exp Ther. 2008;325(2):588-594.
44. Schmitz N, et al. Randomised trial of filgrastimmobilised peripheral blood progenitor cell transplantation versus autologous bone-marrow transplantation in lymphoma patients. Lancet. 1996;347(8998):353-357.
45. Cottler-Fox MH, et al. Stem cell mobilization. Hematology Am Soc Hematol Educ Program. 2003:419-437.
46. Hornung RL, Longo DL. Hematopoietic stem cell depletion by restorative growth factor regimens during repeated high-dose cyclophosphamide therapy. Blood. 1992;80(1):77-83.
47. Chitteti BR, Liu Y, Srour EF. Genomic and proteomic analysis of the impact of mitotic quiescence on the engraftment of human CD34+ cells. PLoS One. 2011;6(3):e17498.
48. Micklem HS, Anderson N, Ross E. Limited potential of circulating haemopoietic stem cells. Nature. 1975;256(5512):41-43.
49. Schwarzenberger P, et al. Il-17 mobilizes peripheral blood stem cells with short- and long-term repopulating ability in mice. J Immunol. 2001;167(4):2081-2086.
50. Li JM, Giver CR, Lu Y, Hossain MS, Akhtari M, Waller EK. Separating graft-versus-leukemia from graft-versus- host disease in allogeneic hematopoietic stem cell transplantation. Immunotherapy. 2009;1(4):599-621.
51. Lekli I, Gurusamy N, Ray D, Tosaki A, Das DK. Redox regulation of stem cell mobilization. Can J Physiol Pharmacol. 2009;87(12):989-995.
52. Pruijt JF, et al. Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice. Proc Natl Acad Sci U S A. 2002;99(9):6228-6233.
53. Brautigam VM, Dubyak GR, Crain JM, Watters JJ. The inflammatory effects of UDP-glucose in N9 microglia are not mediated by P2Y14 receptor activation. Purinergic Signal. 2008;4(1):73-78.
54. Scrivens M, Dickenson JM. Pharmacological effects mediated by UDP-glucose that are independent of P2Y14 receptor expression. Pharmacol Res. 2005;51(6):533-538.
55. Liu F, Poursine-Laurent J, Link DC. Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF. Blood. 2000;95(10):3025-3031.
56. Greenbaum AM, Link DC. Mechanisms of G-CSFmediated hematopoietic stem and progenitor mobilization. Leukemia. 2011;25(2):211-217.
57. Lee BC, et al. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Genes Dev. 2003;17(13):1592-1604.
58. Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med. 2005;202(11):1599-1611.
59. Ko H, Fricks I, Ivanov AA, Harden TK, Jacobson KA. Structure-activity relationship of uridine 5'-diphosphoglucose analogues as agonists of the human P2Y14 receptor. J Med Chem. 2007;50(9):2030-2039.
60. Ploemacher RE, van der Sluijs JP, Voerman JS, Brons NH. An in vitro limiting-dilution assay of long-term repopulating hematopoietic stem cells in the mouse. Blood. 1989;74(8):2755-2763.
61. Cho J, et al. Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence. Blood. 2011; 117(4):1156-1166.