Somitic disruption of GNAS in chick embryos mimics progressive osseous heteroplasia

Journal of Clinical Investigation

Volumn 123, Issue 8, 2013, Pages 3624-3633

  Cairns, Dana M ^a,b   Pignolo, Robert J ^c,d   Uchimura, Tomoya ^a,b   Brennan, Tracy A ^c   Lindborg, Carter M ^c,d   Xu, Meiqi ^c,d   Kaplan, Frederick S ^c,d   Shore, Eileen M ^c,d,e   Zeng, Li ^a,b,f  

^a Sackler School of Graduate Biomedical Sciences   (United States)

^b TUFTS UNIVERSITY   (United States)

^c Department of Medicine ^*  (United States)

^d Department of Orthopaedic Surgery   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARTILAGE; CHICK EMBRYO; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE LOCUS; GENETIC ANALYSIS; GNAS GENE; HAPLOINSUFFICIENCY; HETEROTOPIC OSSIFICATION; HETEROZYGOSITY LOSS; HUMAN; MALE; MOUSE; MUSCULOSKELETAL DISEASE; NONHUMAN; PRIORITY JOURNAL; PROGRESSIVE OSSEOUS HETEROPLASIA; SOMATIC MUTATION; STEM CELL;

ADOLESCENT; ADULT; ANIMALS; AVIAN PROTEINS; CHICK EMBRYO; CHILD; CHILD, PRESCHOOL; DISEASE MODELS, ANIMAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; LOSS OF HETEROZYGOSITY; MUTATION, MISSENSE; OSSIFICATION, HETEROTOPIC; SOMITES; YOUNG ADULT;

EID: 84881255549     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI69746     Document Type: Article

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