Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification

Journal of Bone and Mineral Research

Volumn 26, Issue 11, 2011, Pages 2647-2655

  Pignolo, Robert J ^a   Xu, Meiqi ^a   Russell, Elizabeth ^a   Richardson, Alec ^a   Kaplan, Josef ^a   Billings, Paul C ^a   Kaplan, Frederick S ^a   Shore, Eileen M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Albright hereditary osteodystrophy (AHO); GNAS Gnas; Heterotopic ossification; Osteoblast differentiation; Osteoma cutis (OC); Progressive osseous heteroplasia (POH); Pseudohypoparathyroidism (PHP)

Indexed keywords

STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; EXON; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; HETEROTOPIC OSSIFICATION; HETEROZYGOSITY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCYTE; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL; SUBCUTANEOUS FAT; UPREGULATION;

ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; GENE SILENCING; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HETEROZYGOTE; HUMANS; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELLS; MICE; MODELS, BIOLOGICAL; OSSIFICATION, HETEROTOPIC; OSTEOBLASTS; OSTEOGENESIS; RNA, MESSENGER; STROMAL CELLS;

EID: 80055002539     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.481     Document Type: Article

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