The Chick Transcriptional Repressor Nkx3.2 Acts Downstream of Shh to Promote BMP-Dependent Axial Chondrogenesis

Developmental Cell

Volumn 1, Issue 3, 2001, Pages 411-422

  Murtaugh, L Charles ^a   Zeng, Li ^a   Chyung, Jay H ^a   Lassar, Andrew B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; BONE MORPHOGENETIC PROTEIN; CARRIER PROTEIN; COLLAGEN TYPE 9; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; HYBRID PROTEIN; LECTIN; NOGGIN PROTEIN; PAIRED BOX TRANSCRIPTION FACTOR; PAX1 TRANSCRIPTION FACTOR; PROTEIN; PROTEOGLYCAN; REPRESSOR PROTEIN; SCLEROPROTEIN; SONIC HEDGEHOG PROTEIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; CELL STRAIN COS1; CHICK EMBRYO; CHONDROGENESIS; CULTURE MEDIUM; DRUG ANTAGONISM; EMBRYO INDUCTION; GENE EXPRESSION REGULATION; GENETICS; IN SITU HYBRIDIZATION; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION;

AGGRECANS; ANIMALS; BODY PATTERNING; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; CHICK EMBRYO; CHONDROGENESIS; COLLAGEN TYPE IX; COS CELLS; CULTURE MEDIA, SERUM-FREE; DNA-BINDING PROTEINS; EMBRYONIC INDUCTION; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; IN SITU HYBRIDIZATION; LECTINS, C-TYPE; PAIRED BOX TRANSCRIPTION FACTORS; PROTEINS; PROTEOGLYCANS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0035463255     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(01)00039-9     Document Type: Article

References (38)

1. Akazawa H., Komuro I., Sugitani Y., Yazaki Y., Nagai R., Noda T. Targeted disruption of the homeobox transcription factor bapx1 results in lethal skeletal dysplasia with asplenia and gastroduodenal malformation. Genes Cells. 5:2000;499-513.
2. Aulthouse A.L., Solursh M. The detection of a precartilage, blastema-specific marker. Dev. Biol. 120:1987;377-384.
3. Badiani P., Corbella P., Kioussis D., Marvel J., Weston K. Dominant interfering alleles define a role for c-Myb in T-cell development. Genes Dev. 8:1994;770-782.
4. Borycki A.G., Mendham L., Emerson C.P. Jr. Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development. 125:1998;777-790.
5. Burke A.C., Nelson C.E., Morgan B.A., Tabin C. Hox genes and the evolution of vertebrate axial morphology. Development. 121:1995;333-346.
6. Capdevila J., Johnson R.L. Endogenous and ectopic expression of noggin suggests a conserved mechanism for regulation of BMP function during limb and somite patterning. Dev. Biol. 197:1998;205-217.
7. Chiang C., Litingtung Y., Lee E., Young K.E., Corden J.L., Westphal H., Beachy P.A. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 383:1996;407-413.
8. Denisenko O.N., Bomsztyk K. The product of the murine homolog of the Drosophila extra sex combs gene displays transcriptional repressor activity. Mol. Cell. Biol. 17:1997;4707-4717.
9. Ebensperger C., Wilting J., Brand-Saberi B., Mizutani Y., Christ B., Balling R., Koseki H. Pax-1, a regulator of sclerotome development is induced by notochord and floor plate signals in avian embryos. Anat. Embryol. 191:1995;297-310.
10. Fan C.M., Tessier-Lavigne M. Patterning of mammalian somites by surface ectoderm and notochord. evidence for sclerotome induction by a hedgehog homolog Cell. 79:1994;1175-1186.
11. Fan C.M., Porter J.A., Chiang C., Chang D.T., Beachy P.A., Tessier-Lavigne M. Long-range sclerotome induction by sonic hedgehog. direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway Cell. 81:1995;457-465.
12. Healy C., Uwanogho D., Sharpe P.T. Regulation and role of Sox9 in cartilage formation. Dev. Dyn. 215:1999;69-78.
13. Huang R., Zhi Q., Schmidt C., Wilting J., Brand-Saberi B., Christ B. Sclerotomal origin of the ribs. Development. 127:2000;527-532.
14. Hughes S.H., Greenhouse J.J., Petropoulos C.J., Sutrave P. Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J. Virol. 61:1987;3004-3012.
15. Jaynes J.B., O'Farrell P.H. Active repression of transcription by the engrailed homeodomain protein. EMBO J. 10:1991;1427-1433.
16. Jegalian B.G., De Robertis E.M. Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene. Cell. 71:1992;901-910.
17. Johnson R.L., Laufer E., Riddle R.D., Tabin C. Ectopic expression of Sonic hedgehog alters dorsal-ventral patterning of somites. Cell. 79:1994;1165-1173.
18. Kawakami Y., Ishikawa T., Shimabara M., Tanda N., Enomoto-Iwamoto M., Iwamoto M., Kuwana T., Ueki A., Noji S., Nohno T. BMP signaling during bone pattern determination in the developing limb. Development. 122:1996;3557-3566.
19. Kieny M., Mauger A., Sengel P. Early regionalization of somitic mesoderm as studied by the development of axial skeleton of the chick embryo. Dev. Biol. 28:1972;142-161.
20. Lefebvre V., De Crombrugghe B. Toward understanding Sox9 function in chondrocyte differentiation. Matrix Biol. 16:1998;529-540.
21. Le Mouellic H., Lallemand Y., Brulet P. Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell. 69:1992;251-264.
22. Lettice L.A., Purdie L.A., Carlson G.J., Kilanowski F., Dorin J., Hill R.E. The mouse bagpipe gene controls development of axial skeleton, skull, and spleen. Proc. Natl. Acad. Sci. USA. 96:1999;9695-9700.
23. Munsterberg A.E., Kitajewski J., Bumcrot D.A., McMahon A.P., Lassar A.B. Combinatorial signaling by Sonic hedgehog and Wnt family members induces myogenic bHLH gene expression in the somite. Genes Dev. 9:1995;2911-2922.
24. Murtaugh L.C., Chyung J.H., Lassar A.B. Sonic hedgehog promotes somitic chondrogenesis by altering the cellular response to BMP signaling. Genes Dev. 13:1999;225-237.
25. Pizette S., Niswander L. BMPs are required at two steps of limb chondrogenesis. formation of prechondrogenic condensations and their differentiation into chondrocytes Dev. Biol. 219:2000;237-249.
26. Pollock R.A., Jay G., Bieberich C.J. Altering the boundaries of Hox3.1 expression. evidence for antipodal gene regulation Cell. 71:1992;911-923.
27. Riddle R.D., Johnson R.L., Laufer E., Tabin C. Sonic hedgehog mediates the polarizing activity of the ZPA. Cell. 75:1993;1401-1416.
28. Rodriguez Esteban C., Capdevila J., Economides A.N., Pascual J., Ortiz A., Izpisua Belmonte J.C. The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry. Nature. 401:1999;243-251.
29. Sadowski I., Ptashne M. A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17:1989;7539.
30. Sadowski I., Ma J., Triezenberg S., Ptashne M. GAL4-VP16 is an unusually potent transcriptional activator. Nature. 335:1988;563-564.
31. Schneider A., Mijalski T., Schlange T., Dai W., Overbeek P., Arnold H.H., Brand T. The homeobox gene NKX3.2 is a target of left-right signalling and is expressed on opposite sides in chick and mouse embryos. Curr. Biol. 9:1999;911-914.
32. Shinomura T., Kimata K. Proteoglycan-Lb, a small dermatan sulfate proteoglycan expressed in embryonic chick epiphyseal cartilage, is structurally related to osteoinductive factor. J. Biol. Chem. 267:1992;1265-1270.
33. Tribioli C., Lufkin T. The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen. Development. 126:1999;5699-5711.
34. Tribioli C., Frasch M., Lufkin T. Bapx1. an evolutionary conserved homologue of the Drosophila bagpipe homeobox gene is expressed in splanchnic mesoderm and the embryonic skeleton Mech. Dev. 65:1997;145-162.
35. Vortkamp A., Pathi S., Peretti G.M., Caruso E.M., Zaleske D.J., Tabin C.J. Recapitulation of signals regulating embryonic bone formation during postnatal growth and in fracture repair. Mech. Dev. 71:1998;65-76.
36. Wozney J.M., Rosen V., Celeste A.J., Mitsock L.M., Whitters M.J., Kriz R.W., Hewick R.M., Wang E.A. Novel regulators of bone formation. molecular clones and activities Science. 242:1988;1528-1534.
37. Zimmerman L.B., De Jesus-Escobar J.M., Harland R.M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 86:1996;599-606.
38. Zou H., Wieser R., Massague J., Niswander L. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage. Genes Dev. 11:1997;2191-2203.