A novel combinatorial biocatalytic approach for producing antibacterial compounds effective against Mycobacterium tuberculosis (TB)

Applied Microbiology and Biotechnology

Volumn 97, Issue 16, 2013, Pages 7151-7163

  McClay, Kevin ^a   Wan, Baojie ^b   Wang, Yuehong ^b   Cho, Sanghyun ^b   Yu, Jerry ^b   Santarsiero, Bernard ^b   Mehboob, Shahila ^b   Johnson, Michael ^b   Franzblau, Scott ^b   Steffan, Robert ^a  

^a CB and I Federal Services LLC   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Antibiotic; Combinatorial biocatalysis; Indole; Oxygenase; TB; Tuberculosis

Indexed keywords

CLOSTRIDIUM ACETOBUTYLICUM; COMBINATORIAL BIOCATALYSIS; INDOLE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; OXYGENASES; STAPHYLOCOCCUS EPIDERMIDIS; TUBERCULOSIS;

ANTIBIOTICS; BACTERIA; CLONING; ORGANIC POLYMERS; POLYCYCLIC AROMATIC HYDROCARBONS; TERBIUM; X RAY CRYSTALLOGRAPHY;

DIMERS;

ANTIBIOTIC AGENT; BENZOXAZOLE DERIVATIVE; INDIRUBIN; INDOLE DERIVATIVE; ISONIAZID; RIFAMPICIN; SAB 7FR 1; SAB B 10; SAB B 11; SAB B 13; SAB B 16; SAB B 17; SAB B 18; SAB B 20; SAB B 25; SAB B 26; SAB B 27; SAB B 28; SAB B 33; SAB B 35; SAB B 7; SAB B 8; SAB C 1; SAB C 10; SAB C 11; SAB C 18; SAB C 22; SAB C 23; SAB C 4; SAB P 1; SAB R 1; UNCLASSIFIED DRUG;

ANTIBIOTICS; CATALYSIS; CLONE; CONCENTRATION (COMPOSITION); DISEASE RESISTANCE; HALOGEN; MICROBIAL ACTIVITY; PATHOGEN; POLYMERIZATION; RESPIRATORY DISEASE; SUBSTRATE; TUBERCULOSIS;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; BACILLUS SUBTILIS; BACTERIAL GROWTH; BIOCATALYSIS; CLOSTRIDIUM ACETOBUTYLICUM; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HOST; IC 50; KIDNEY CELL; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATION; POLYMERIZATION; STAPHYLOCOCCUS EPIDERMIDIS; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; CELL LINE; CELL SURVIVAL; GRAM-POSITIVE BACTERIA; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS;

EID: 84881249094     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5012-9     Document Type: Article

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