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Volumn 228, Issue 4, 2013, Pages 563-575

Efficacy of d-penicillamine, a sequestering acetaldehyde agent, in the prevention of alcohol relapse-like drinking in rats

Author keywords

Acetaldehyde sequestering agents; Alcohol deprivation effect; d Penicillamine; Ethanol relapse prevention

Indexed keywords

ACETALDEHYDE; PENICILLAMINE;

EID: 84881218221     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3065-1     Document Type: Article
Times cited : (30)

References (53)
  • 1
    • 84856100318 scopus 로고    scopus 로고
    • Novel therapeutic strategies for alcohol and drug addiction: Focus on GABA, ion channels and transcranial magnetic stimulation
    • 10.1038/npp.2011.216 22030714 10.1038/npp.2011.216 1:CAS:528: DC%2BC3MXhs1ejsrbL
    • Addolorato G, Leggio L, Hopf FW, Diana M, Bonci A (2012) Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology 37:163-177. doi: 10.1038/npp.2011.216
    • (2012) Neuropsychopharmacology , vol.37 , pp. 163-177
    • Addolorato, G.1    Leggio, L.2    Hopf, F.W.3    Diana, M.4    Bonci, A.5
  • 2
    • 19844378927 scopus 로고    scopus 로고
    • Cost of addiction in Europe
    • 10.1111/j.1468-1331.2005.01194.x 15877775 10.1111/j.1468-1331.2005.01194. x
    • Andlin-Sobocki P, Rehm J (2005) Cost of addiction in Europe. Eur J Neurol 12(Suppl 1):28-33. doi: 10.1111/j.1468-1331.2005.01194.x
    • (2005) Eur J Neurol , vol.12 , Issue.SUPPL. 1 , pp. 28-33
    • Andlin-Sobocki, P.1    Rehm, J.2
  • 4
    • 0019845989 scopus 로고
    • The pharmacokinetics of penicillamine in a female mongrel dog
    • 7334461 10.1007/BF01061028 1:CAS:528:DyaL38XnvFCitQ%3D%3D
    • Bergstrom RF, Kay RD, Wagner JG (1981) The pharmacokinetics of penicillamine in a female mongrel dog. J Pharmacokinet Biopharm 9:603-621
    • (1981) J Pharmacokinet Biopharm , vol.9 , pp. 603-621
    • Bergstrom, R.F.1    Kay, R.D.2    Wagner, J.G.3
  • 5
    • 80053635834 scopus 로고    scopus 로고
    • Acamprosate-responsive brain sites for suppression of ethanol intake and preference
    • 10.1152/ajpregu.00179.2011 21697518 10.1152/ajpregu.00179.2011 1:CAS:528:DC%2BC3MXhtlertrjO
    • Brager A, Prosser RA, Glass JD (2011) Acamprosate-responsive brain sites for suppression of ethanol intake and preference. Am J Physiol Regul Integr Comp Physiol 301:R1032-43. doi: 10.1152/ajpregu.00179.2011
    • (2011) Am J Physiol Regul Integr Comp Physiol , vol.301 , pp. 1032-1043
    • Brager, A.1    Prosser, R.A.2    Glass, J.D.3
  • 6
    • 0019807764 scopus 로고
    • Effects of voluntary short-term abstinence from alcohol on subsequent drinking patterns of college students
    • 7334801 1:STN:280:DyaL387kslSgtA%3D%3D
    • Burish TG, Maisto SA, Cooper AM, Sobell MB (1981) Effects of voluntary short-term abstinence from alcohol on subsequent drinking patterns of college students. J Stud Alcohol 42:1013-1020
    • (1981) J Stud Alcohol , vol.42 , pp. 1013-1020
    • Burish, T.G.1    Maisto, S.A.2    Cooper, A.M.3    Sobell, M.B.4
  • 7
    • 0017008967 scopus 로고
    • Mechanism of the protective action of cysteine and penicillamine against acetaldehyde-induced mitochondrial injury
    • 971330 10.1016/0006-2952(76)90130-1 1:CAS:528:DyaE2sXis1Kjsw%3D%3D
    • Cederbaum AI, Rubin E (1976) Mechanism of the protective action of cysteine and penicillamine against acetaldehyde-induced mitochondrial injury. Biochem Pharmacol 25:2179-2185
    • (1976) Biochem Pharmacol , vol.25 , pp. 2179-2185
    • Cederbaum, A.I.1    Rubin, E.2
  • 9
    • 79960010839 scopus 로고    scopus 로고
    • Current and promising pharmacotherapies, and novel research target areas in the treatment of alcohol dependence: A review
    • 21524263 10.2174/138161211796150765 1:CAS:528:DC%2BC3MXosVSkt7o%3D
    • Edwards S, Kenna GA, Swift RM, Leggio L (2011) Current and promising pharmacotherapies, and novel research target areas in the treatment of alcohol dependence: a review. Curr Pharm Des 17:1323-1332
    • (2011) Curr Pharm des , vol.17 , pp. 1323-1332
    • Edwards, S.1    Kenna, G.A.2    Swift, R.M.3    Leggio, L.4
  • 10
    • 58149352280 scopus 로고    scopus 로고
    • Acetaldehyde sequestering prevents ethanol-induced stimulation of mesolimbic dopamine transmission
    • 10.1016/j.drugalcdep.2008.10.010 19070441 10.1016/j.drugalcdep.2008.10. 010 1:CAS:528:DC%2BD1MXnslSmtQ%3D%3D
    • Enrico P, Sirca D, Mereu M, Peana AT, Lintas A, Golosio A, Diana M (2009) Acetaldehyde sequestering prevents ethanol-induced stimulation of mesolimbic dopamine transmission. Drug Alcohol Depend 100:265-271. doi: 10.1016/j.drugalcdep.2008.10.010
    • (2009) Drug Alcohol Depend , vol.100 , pp. 265-271
    • Enrico, P.1    Sirca, D.2    Mereu, M.3    Peana, A.T.4    Lintas, A.5    Golosio, A.6    Diana, M.7
  • 11
    • 1642409201 scopus 로고    scopus 로고
    • Acetaldehyde increases dopaminergic neuronal activity in the VTA
    • 10.1038/sj.npp.1300326 14973432 10.1038/sj.npp.1300326 1:CAS:528:DC%2BD2cXhtlWksbs%3D
    • Foddai M, Dosia G, Spiga S, Diana M (2004) Acetaldehyde increases dopaminergic neuronal activity in the VTA. Neuropsychopharmacology 29:530-536. doi: 10.1038/sj.npp.1300326
    • (2004) Neuropsychopharmacology , vol.29 , pp. 530-536
    • Foddai, M.1    Dosia, G.2    Spiga, S.3    Diana, M.4
  • 12
    • 23044504343 scopus 로고    scopus 로고
    • Prevention of ethanol-induced behavioral stimulation by D-penicillamine: A sequestration agent for acetaldehyde
    • 16046870 10.1097/01.ALC.0000171945.30494.AF 1:CAS:528: DC%2BD2MXmsFWksLk%3D
    • Font L, Miquel M, Aragon CM (2005) Prevention of ethanol-induced behavioral stimulation by D-penicillamine: a sequestration agent for acetaldehyde. Alcohol Clin Exp Res 29:1156-1164
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 1156-1164
    • Font, L.1    Miquel, M.2    Aragon, C.M.3
  • 13
    • 33646556412 scopus 로고    scopus 로고
    • Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine
    • 10.1016/j.bbr.2006.03.020 16621047 10.1016/j.bbr.2006.03.020 1:CAS:528:DC%2BD28XltVeksLc%3D
    • Font L, Aragon CM, Miquel M (2006a) Voluntary ethanol consumption decreases after the inactivation of central acetaldehyde by d-penicillamine. Behav Brain Res 171:78-86. doi: 10.1016/j.bbr.2006.03.020
    • (2006) Behav Brain Res , vol.171 , pp. 78-86
    • Font, L.1    Aragon, C.M.2    Miquel, M.3
  • 14
    • 29344443777 scopus 로고    scopus 로고
    • Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with D-penicillamine, an inactivation agent for acetaldehyde
    • 10.1007/s00213-005-0224-z 10.1007/s00213-005-0224-z 1:CAS:528: DC%2BD2MXhtlCrtLzL
    • Font L, Aragon CM, Miquel M (2006b) Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with D-penicillamine, an inactivation agent for acetaldehyde. Psychopharmacology (Berl) 184:56-64. doi: 10.1007/s00213-005-0224-z
    • (2006) Psychopharmacology (Berl) , vol.184 , pp. 56-64
    • Font, L.1    Aragon, C.M.2    Miquel, M.3
  • 16
    • 80054823945 scopus 로고    scopus 로고
    • Pharmacogenetic approaches to the treatment of alcohol addiction
    • 10.1038/nrn3110 22011682 10.1038/nrn3110 1:CAS:528:DC%2BC3MXhtlChtL7L
    • Heilig M, Goldman D, Berrettini W, O'Brien CP (2011) Pharmacogenetic approaches to the treatment of alcohol addiction. Nat Rev Neurosci 12:670-684. doi: 10.1038/nrn3110
    • (2011) Nat Rev Neurosci , vol.12 , pp. 670-684
    • Heilig, M.1    Goldman, D.2    Berrettini, W.3    O'Brien, C.P.4
  • 17
    • 0030791743 scopus 로고    scopus 로고
    • Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm
    • 9267526 10.1111/j.1530-0277.1997.tb03840.x 1:CAS:528:DyaK2sXlvFejs7g%3D
    • Heyser CJ, Schulteis G, Koob GF (1997) Increased ethanol self-administration after a period of imposed ethanol deprivation in rats trained in a limited access paradigm. Alcohol Clin Exp Res 21:784-791
    • (1997) Alcohol Clin Exp Res , vol.21 , pp. 784-791
    • Heyser, C.J.1    Schulteis, G.2    Koob, G.F.3
  • 18
    • 35348876023 scopus 로고    scopus 로고
    • Brain metabolism of ethanol and alcoholism: An update
    • 17979660 10.2174/138920007782109797 1:CAS:528:DC%2BD2sXhtFKjsbbO
    • Hipolito L, Sanchez MJ, Polache A, Granero L (2007) Brain metabolism of ethanol and alcoholism: an update. Curr Drug Metab 8:716-727
    • (2007) Curr Drug Metab , vol.8 , pp. 716-727
    • Hipolito, L.1    Sanchez, M.J.2    Polache, A.3    Granero, L.4
  • 19
    • 0032852217 scopus 로고    scopus 로고
    • Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats
    • 10.1007/s002130051069 1:CAS:528:DyaK1MXmtlOlsb8%3D
    • Holter SM, Spanagel R (1999) Effects of opiate antagonist treatment on the alcohol deprivation effect in long-term ethanol-experienced rats. Psychopharmacology (Berl) 145:360-369
    • (1999) Psychopharmacology (Berl) , vol.145 , pp. 360-369
    • Holter, S.M.1    Spanagel, R.2
  • 20
    • 0022372974 scopus 로고
    • Conjugation of acetaldehyde with cysteinylglycine, the first metabolite in glutathione breakdown by gamma-glutamyltranspeptidase
    • 2867670 10.1007/BF01966681 1:CAS:528:DyaL28XivF2lsg%3D%3D
    • Kera Y, Kiriyama T, Komura S (1985) Conjugation of acetaldehyde with cysteinylglycine, the first metabolite in glutathione breakdown by gamma-glutamyltranspeptidase. Agents Actions 17:48-52
    • (1985) Agents Actions , vol.17 , pp. 48-52
    • Kera, Y.1    Kiriyama, T.2    Komura, S.3
  • 21
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication
    • 10.1001/archpsyc.62.6.617 15939839 10.1001/archpsyc.62.6.617
    • Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:617-627. doi: 10.1001/archpsyc.62.6.617
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3    Merikangas, K.R.4    Walters, E.E.5
  • 22
    • 0025847455 scopus 로고
    • Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys
    • 10.1007/BF02246038 1:CAS:528:DyaK3MXkvVOgs7o%3D
    • Kornet M, Goosen C, Van Ree JM (1991) Effect of naltrexone on alcohol consumption during chronic alcohol drinking and after a period of imposed abstinence in free-choice drinking rhesus monkeys. Psychopharmacology (Berl) 104:367-376
    • (1991) Psychopharmacology (Berl) , vol.104 , pp. 367-376
    • Kornet, M.1    Goosen, C.2    Van Ree, J.M.3
  • 23
    • 0034821702 scopus 로고    scopus 로고
    • Efficacy of naltrexone and acamprosate for alcoholism treatment: A meta-analysis
    • 11584154 10.1111/j.1530-0277.2001.tb02356.x 1:CAS:528: DC%2BD3MXnt1Git7o%3D
    • Kranzler HR, Van Kirk J (2001) Efficacy of naltrexone and acamprosate for alcoholism treatment: a meta-analysis. Alcohol Clin Exp Res 25:1335-1341
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 1335-1341
    • Kranzler, H.R.1    Van Kirk, J.2
  • 24
    • 0019732010 scopus 로고
    • Rapid automated determination of D-penicillamine in plasma and urine by ion-exchange high-performance liquid chromatography with electrochemical detection using a gold electrode
    • 7320122 10.1016/S0021-9673(00)82086-5 1:CAS:528:DyaL38XivVWltQ%3D%3D
    • Kreuzig F, Frank J (1981) Rapid automated determination of D-penicillamine in plasma and urine by ion-exchange high-performance liquid chromatography with electrochemical detection using a gold electrode. J Chromatogr 218:615-620
    • (1981) J Chromatogr , vol.218 , pp. 615-620
    • Kreuzig, F.1    Frank, J.2
  • 25
    • 77955632266 scopus 로고    scopus 로고
    • Turning the clock ahead: Potential preclinical and clinical neuropharmacological targets for alcohol dependence
    • 20482506 10.2174/138161210791516369 1:CAS:528:DC%2BC3cXpsVOks7w%3D
    • Leggio L, Cardone S, Ferrulli A, Kenna GA, Diana M, Swift RM, Addolorato G (2010) Turning the clock ahead: potential preclinical and clinical neuropharmacological targets for alcohol dependence. Curr Pharm Des 16:2159-2118
    • (2010) Curr Pharm des , vol.16 , pp. 2159-2118
    • Leggio, L.1    Cardone, S.2    Ferrulli, A.3    Kenna, G.A.4    Diana, M.5    Swift, R.M.6    Addolorato, G.7
  • 26
    • 84876460541 scopus 로고    scopus 로고
    • The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats
    • 10.1007/s00213-012-2920-9
    • March SM, Abate P, Spear NE, Molina JC (2012) The role of acetaldehyde in ethanol reinforcement assessed by Pavlovian conditioning in newborn rats. Psychopharmacology (Berl). doi: 10.1007/s00213-012-2920-9
    • (2012) Psychopharmacology (Berl)
    • March, S.M.1    Abate, P.2    Spear, N.E.3    Molina, J.C.4
  • 27
    • 77956161514 scopus 로고    scopus 로고
    • Systemic administration of D-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats
    • 10.1016/j.neulet.2010.07.081 20691754 10.1016/j.neulet.2010.07.081 1:CAS:528:DC%2BC3cXhtFamsbvF
    • Marti-Prats L, Sanchez-Catalan MJ, Hipolito L, Orrico A, Zornoza T, Polache A, Granero L (2010) Systemic administration of D-penicillamine prevents the locomotor activation after intra-VTA ethanol administration in rats. Neurosci Lett 483:143-147. doi: 10.1016/j.neulet.2010.07.081
    • (2010) Neurosci Lett , vol.483 , pp. 143-147
    • Marti-Prats, L.1    Sanchez-Catalan, M.J.2    Hipolito, L.3    Orrico, A.4    Zornoza, T.5    Polache, A.6    Granero, L.7
  • 28
    • 43849106583 scopus 로고    scopus 로고
    • Drug driving and the management of risk: The perspectives and practices of a sample of problem drug users
    • 10.1016/j.drugpo.2006.12.003 18502377 10.1016/j.drugpo.2006.12.003
    • McIntosh J, O'Brien T, McKeganey N (2008) Drug driving and the management of risk: the perspectives and practices of a sample of problem drug users. Int J Drug Policy 19:248-254. doi: 10.1016/j.drugpo.2006.12.003
    • (2008) Int J Drug Policy , vol.19 , pp. 248-254
    • McIntosh, J.1    O'Brien, T.2    McKeganey, N.3
  • 29
    • 36148982668 scopus 로고    scopus 로고
    • Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system
    • 10.1111/j.1460-9568.2007.05887.x 18001279 10.1111/j.1460-9568.2007.05887. x 1:STN:280:DC%2BD2snnslOhsA%3D%3D
    • Melis M, Enrico P, Peana AT, Diana M (2007) Acetaldehyde mediates alcohol activation of the mesolimbic dopamine system. Eur J Neurosci 26:2824-2833. doi: 10.1111/j.1460-9568.2007.05887.x
    • (2007) Eur J Neurosci , vol.26 , pp. 2824-2833
    • Melis, M.1    Enrico, P.2    Peana, A.T.3    Diana, M.4
  • 30
    • 0018235520 scopus 로고
    • 2,5,5-Trimethylthiazolidine-4-carboxylic acid, a D(-)-penicillamine- directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde
    • 364061 10.1021/jm00210a019 1:CAS:528:DyaE1cXmtFSitb8%3D
    • Nagasawa HT, Goon DJ, DeMaster EG (1978) 2,5,5-Trimethylthiazolidine-4- carboxylic acid, a D(-)-penicillamine-directed pseudometabolite of ethanol. Detoxication mechanism for acetaldehyde. J Med Chem 21:1274-1279
    • (1978) J Med Chem , vol.21 , pp. 1274-1279
    • Nagasawa, H.T.1    Goon, D.J.2    Demaster, E.G.3
  • 31
    • 0018922062 scopus 로고
    • Structural requirements for the sequestration of metabolically generated acetaldehyde
    • 7359527 10.1021/jm00176a007 1:CAS:528:DyaL3cXhsVWmt7s%3D
    • Nagasawa HT, Elberling JA, DeMaster EG (1980) Structural requirements for the sequestration of metabolically generated acetaldehyde. J Med Chem 23:140-143
    • (1980) J Med Chem , vol.23 , pp. 140-143
    • Nagasawa, H.T.1    Elberling, J.A.2    Demaster, E.G.3
  • 33
    • 38349184194 scopus 로고    scopus 로고
    • Key role of ethanol-derived acetaldehyde in the motivational properties induced by intragastric ethanol: A conditioned place preference study in the rat
    • 10.1111/j.1530-0277.2007.00574.x 18162073 10.1111/j.1530-0277.2007.00574. x 1:CAS:528:DC%2BD1cXis1Squ7Y%3D
    • Peana AT, Enrico P, Assaretti AR, Pulighe E, Muggironi G, Nieddu M, Piga A, Lintas A, Diana M (2008) Key role of ethanol-derived acetaldehyde in the motivational properties induced by intragastric ethanol: a conditioned place preference study in the rat. Alcohol Clin Exp Res 32:249-258. doi: 10.1111/j.1530-0277.2007.00574.x
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 249-258
    • Peana, A.T.1    Enrico, P.2    Assaretti, A.R.3    Pulighe, E.4    Muggironi, G.5    Nieddu, M.6    Piga, A.7    Lintas, A.8    Diana, M.9
  • 34
    • 58149114844 scopus 로고    scopus 로고
    • Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine
    • 10.1111/j.1530-0277.2008.00809.x 18945224 10.1111/j.1530-0277.2008.00809. x 1:CAS:528:DC%2BD1MXhvFeqtLg%3D
    • Peana AT, Assaretti AR, Muggironi G, Enrico P, Diana M (2009) Reduction of ethanol-derived acetaldehyde induced motivational properties by L-cysteine. Alcohol Clin Exp Res 33:43-48. doi: 10.1111/j.1530-0277.2008.00809.x
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 43-48
    • Peana, A.T.1    Assaretti, A.R.2    Muggironi, G.3    Enrico, P.4    Diana, M.5
  • 35
    • 71849101018 scopus 로고    scopus 로고
    • L-Cysteine reduces oral ethanol self-administration and reinstatement of ethanol-drinking behavior in rats
    • 10.1016/j.pbb.2009.10.005 19879891 10.1016/j.pbb.2009.10.005 1:CAS:528:DC%2BD1MXhsFantb7P
    • Peana AT, Muggironi G, Calvisi G, Enrico P, Mereu M, Nieddu M, Boatto G, Diana M (2010) l-Cysteine reduces oral ethanol self-administration and reinstatement of ethanol-drinking behavior in rats. Pharmacol Biochem Behav 94:431-437. doi: 10.1016/j.pbb.2009.10.005
    • (2010) Pharmacol Biochem Behav , vol.94 , pp. 431-437
    • Peana, A.T.1    Muggironi, G.2    Calvisi, G.3    Enrico, P.4    Mereu, M.5    Nieddu, M.6    Boatto, G.7    Diana, M.8
  • 36
    • 84863099400 scopus 로고    scopus 로고
    • Effect of l-cysteine on acetaldehyde self-administration
    • 10.1016/j.alcohol.2011.10.004 22440691
    • Peana AT, Muggironi G, Fois GR, Zinellu M, Sirca D, Diana M (2012) Effect of l-cysteine on acetaldehyde self-administration. Alcohol. doi: 10.1016/j.alcohol.2011.10.004
    • (2012) Alcohol
    • Peana, A.T.1    Muggironi, G.2    Fois, G.R.3    Zinellu, M.4    Sirca, D.5    Diana, M.6
  • 39
    • 33645457489 scopus 로고    scopus 로고
    • Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking
    • 10.1158/1055-9965.EPI-05-0248 16434601 10.1158/1055-9965.EPI-05-0248 1:CAS:528:DC%2BD28XmvVSguw%3D%3D
    • Salaspuro VJ, Hietala JM, Marvola ML, Salaspuro MP (2006) Eliminating carcinogenic acetaldehyde by cysteine from saliva during smoking. Cancer Epidemiol Biomarkers Prev 15:146-149. doi: 10.1158/1055-9965.EPI-05-0248
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 146-149
    • Salaspuro, V.J.1    Hietala, J.M.2    Marvola, M.L.3    Salaspuro, M.P.4
  • 40
    • 0027193604 scopus 로고
    • The alcohol-deprivation effect in hybrid mice
    • 8508729 10.1016/0376-8716(93)80012-4 1:CAS:528:DyaK3sXltlegsrg%3D
    • Salimov RM, Salimova NB (1993) The alcohol-deprivation effect in hybrid mice. Drug Alcohol Depend 32:187-191
    • (1993) Drug Alcohol Depend , vol.32 , pp. 187-191
    • Salimov, R.M.1    Salimova, N.B.2
  • 41
    • 47049086815 scopus 로고    scopus 로고
    • Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat
    • 10.1093/alcalc/agn012 18326880 10.1093/alcalc/agn012 1:CAS:528: DC%2BD1cXnvV2qt7k%3D
    • Sanchez-Catalan MJ, Hipolito L, Guerri C, Granero L, Polache A (2008) Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat. Alcohol Alcohol 43:401-407. doi: 10.1093/alcalc/agn012
    • (2008) Alcohol Alcohol , vol.43 , pp. 401-407
    • Sanchez-Catalan, M.J.1    Hipolito, L.2    Guerri, C.3    Granero, L.4    Polache, A.5
  • 42
    • 34247229202 scopus 로고    scopus 로고
    • What we drink when we drink? The role of the acetaldehyde in the alcohol consumption
    • 17687877
    • Sanchis C, Aragon CM (2007) What we drink when we drink? The role of the acetaldehyde in the alcohol consumption. Adicciones 19:5-11
    • (2007) Adicciones , vol.19 , pp. 5-11
    • Sanchis, C.1    Aragon, C.M.2
  • 43
    • 33947733064 scopus 로고    scopus 로고
    • Liquid chromatography/tandem mass spectrometry determination of (4S,2RS)-2,5,5-trimethylthiazolidine-4-carboxylic acid, a stable adduct formed between D-(-)-penicillamine and acetaldehyde (main biological metabolite of ethanol), in plasma, liver and brain rat tissues
    • 10.1002/rcm.2951 17330215 10.1002/rcm.2951 1:CAS:528:DC%2BD2sXks1GrtLo%3D
    • Serrano E, Pozo OJ, Beltran J, Hernandez F, Font L, Miquel M, Aragon CM (2007) Liquid chromatography/tandem mass spectrometry determination of (4S,2RS)-2,5,5-trimethylthiazolidine-4-carboxylic acid, a stable adduct formed between D-(-)-penicillamine and acetaldehyde (main biological metabolite of ethanol), in plasma, liver and brain rat tissues. Rapid Commun Mass Spectrom 21:1221-1229. doi: 10.1002/rcm.2951
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 1221-1229
    • Serrano, E.1    Pozo, O.J.2    Beltran, J.3    Hernandez, F.4    Font, L.5    Miquel, M.6    Aragon, C.M.7
  • 44
    • 84055197552 scopus 로고    scopus 로고
    • Vaccines against drug abuse
    • 10.1038/clpt.2011.281 22130115 10.1038/clpt.2011.281 1:CAS:528: DC%2BC3MXhs1emtrnF
    • Shen XY, Orson FM, Kosten TR (2012) Vaccines against drug abuse. Clin Pharmacol Ther 91:60-70. doi: 10.1038/clpt.2011.281
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 60-70
    • Shen, X.Y.1    Orson, F.M.2    Kosten, T.R.3
  • 45
    • 79955477261 scopus 로고    scopus 로고
    • L-cysteine prevents ethanol-induced stimulation of mesolimbic dopamine transmission
    • 10.1111/j.1530-0277.2010.01416.x 21303385 10.1111/j.1530-0277.2010.01416. x 1:CAS:528:DC%2BC3MXnsVegtL8%3D
    • Sirca D, Enrico P, Mereu M, Peana AT, Diana M (2011) L-cysteine prevents ethanol-induced stimulation of mesolimbic dopamine transmission. Alcohol Clin Exp Res 35:862-869. doi: 10.1111/j.1530-0277.2010.01416.x
    • (2011) Alcohol Clin Exp Res , vol.35 , pp. 862-869
    • Sirca, D.1    Enrico, P.2    Mereu, M.3    Peana, A.T.4    Diana, M.5
  • 46
    • 67649985942 scopus 로고    scopus 로고
    • Alcoholism: A systems approach from molecular physiology to addictive behavior
    • 10.1152/physrev.00013.2008 19342616 10.1152/physrev.00013.2008 1:CAS:528:DC%2BD1MXkvFegu7s%3D
    • Spanagel R (2009) Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiol Rev 89:649-705. doi: 10.1152/physrev.00013.2008
    • (2009) Physiol Rev , vol.89 , pp. 649-705
    • Spanagel, R.1
  • 47
    • 0344004825 scopus 로고    scopus 로고
    • Long-term alcohol self-administration with repeated alcohol deprivation phases: An animal model of alcoholism?
    • 10344783 10.1093/alcalc/34.2.231 1:CAS:528:DyaK1MXjs1ansLo%3D
    • Spanagel R, Holter SM (1999) Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcohol 34:231-243
    • (1999) Alcohol Alcohol , vol.34 , pp. 231-243
    • Spanagel, R.1    Holter, S.M.2
  • 48
    • 39749088094 scopus 로고    scopus 로고
    • Drugs for relapse prevention of alcoholism: Ten years of progress
    • 10.1016/j.tips.2007.12.005 18262663 10.1016/j.tips.2007.12.005 1:CAS:528:DC%2BD1cXislKht70%3D
    • Spanagel R, Kiefer F (2008) Drugs for relapse prevention of alcoholism: ten years of progress. Trends Pharmacol Sci 29:109-115. doi: 10.1016/j.tips.2007.12.005
    • (2008) Trends Pharmacol Sci , vol.29 , pp. 109-115
    • Spanagel, R.1    Kiefer, F.2
  • 49
    • 84868666534 scopus 로고    scopus 로고
    • New pharmacological treatment strategies for relapse prevention
    • 10.1007/7854-2012-205
    • Spanagel R, Vengeliene V (2012) New pharmacological treatment strategies for relapse prevention. Curr Top Behav Neurosci. doi: 10.1007/7854-2012-205
    • (2012) Curr Top Behav Neurosci
    • Spanagel, R.1    Vengeliene, V.2
  • 50
    • 0031081578 scopus 로고    scopus 로고
    • Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes
    • 9090311 10.1016/S0165-6147(97)89800-8 1:CAS:528:DyaK2sXhvFyms70%3D
    • Spanagel R, Zieglgansberger W (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18:54-59
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 54-59
    • Spanagel, R.1    Zieglgansberger, W.2
  • 51
    • 16844386330 scopus 로고    scopus 로고
    • The role of the NMDA receptor in alcohol relapse: A pharmacological mapping study using the alcohol deprivation effect
    • 10.1016/j.neuropharm.2005.01.002 15829254 10.1016/j.neuropharm.2005.01. 002 1:CAS:528:DC%2BD2MXjt1WisrY%3D
    • Vengeliene V, Bachteler D, Danysz W, Spanagel R (2005) The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 48:822-829. doi: 10.1016/j.neuropharm.2005.01.002
    • (2005) Neuropharmacology , vol.48 , pp. 822-829
    • Vengeliene, V.1    Bachteler, D.2    Danysz, W.3    Spanagel, R.4
  • 52
    • 36348963529 scopus 로고    scopus 로고
    • The effects of lamotrigine on alcohol seeking and relapse
    • 10.1016/j.neuropharm.2007.09.006 17976664 10.1016/j.neuropharm.2007.09. 006 1:CAS:528:DC%2BD2sXhtlGgs7vI
    • Vengeliene V, Heidbreder CA, Spanagel R (2007) The effects of lamotrigine on alcohol seeking and relapse. Neuropharmacology 53:951-957. doi: 10.1016/j.neuropharm.2007.09.006
    • (2007) Neuropharmacology , vol.53 , pp. 951-957
    • Vengeliene, V.1    Heidbreder, C.A.2    Spanagel, R.3
  • 53
    • 33747747638 scopus 로고    scopus 로고
    • Enzymatic mechanisms of ethanol oxidation in the brain
    • 10.1111/j.1530-0277.2006.00181.x 16930212 10.1111/j.1530-0277.2006.00181. x 1:CAS:528:DC%2BD28XhtVGjurjM
    • Zimatkin SM, Pronko SP, Vasiliou V, Gonzalez FJ, Deitrich RA (2006) Enzymatic mechanisms of ethanol oxidation in the brain. Alcohol Clin Exp Res 30:1500-1505. doi: 10.1111/j.1530-0277.2006.00181.x
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1500-1505
    • Zimatkin, S.M.1    Pronko, S.P.2    Vasiliou, V.3    Gonzalez, F.J.4    Deitrich, R.A.5


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