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Volumn 8, Issue 7, 2013, Pages

Targeting Proliferating Cell Nuclear Antigen and Its Protein Interactions Induces Apoptosis in Multiple Myeloma Cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ATX 101; CASPASE; CELL PENETRATING PEPTIDE; CYCLINE; MELPHALAN; PROCASPASE 3; PROCASPASE 8; UNCLASSIFIED DRUG;

EID: 84881146571     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070430     Document Type: Article
Times cited : (78)

References (34)
  • 2
    • 41949130070 scopus 로고    scopus 로고
    • Improved survival in multiple myeloma and the impact of novel therapies
    • Kumar SK, Rajkumar SV, Dispenzieri A, Lacy MQ, Hayman SR, et al. (2008) Improved survival in multiple myeloma and the impact of novel therapies. Blood 111: 2516-2520.
    • (2008) Blood , vol.111 , pp. 2516-2520
    • Kumar, S.K.1    Rajkumar, S.V.2    Dispenzieri, A.3    Lacy, M.Q.4    Hayman, S.R.5
  • 3
    • 79955843637 scopus 로고    scopus 로고
    • Molecular Heterogeneity of Multiple Myeloma: Pathogenesis, Prognosis, and Therapeutic Implications
    • Avet-Loiseau H, Magrangeas F, Moreau P, Attal M, Facon T, et al. (2011) Molecular Heterogeneity of Multiple Myeloma: Pathogenesis, Prognosis, and Therapeutic Implications. J Clin Oncol 29: 1893-1897.
    • (2011) J Clin Oncol , vol.29 , pp. 1893-1897
    • Avet-Loiseau, H.1    Magrangeas, F.2    Moreau, P.3    Attal, M.4    Facon, T.5
  • 4
    • 34249066085 scopus 로고    scopus 로고
    • PCNA, the maestro of the replication fork
    • Moldovan GL, Pfander B, Jentsch S, (2007) PCNA, the maestro of the replication fork. Cell 129: 665-679.
    • (2007) Cell , vol.129 , pp. 665-679
    • Moldovan, G.L.1    Pfander, B.2    Jentsch, S.3
  • 6
  • 7
    • 5444275347 scopus 로고    scopus 로고
    • Expression of proliferating cell nuclear antigen (PCNA) in multiple myeloma: Its relationship to bone marrow microvessel density and other factors of disease activity
    • Alexandrakis MG, Passam FH, Pappa CA, Dambaki C, Sfakiotaki G, et al. (2004) Expression of proliferating cell nuclear antigen (PCNA) in multiple myeloma: Its relationship to bone marrow microvessel density and other factors of disease activity. Int J Immunopathol Pharmacol 17: 49-56.
    • (2004) Int J Immunopathol Pharmacol , vol.17 , pp. 49-56
    • Alexandrakis, M.G.1    Passam, F.H.2    Pappa, C.A.3    Dambaki, C.4    Sfakiotaki, G.5
  • 8
    • 78649440078 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival
    • Witko-Sarsat V, Mocek J, Bouayad D, Tamassia N, Ribeil JA, et al. (2010) Proliferating cell nuclear antigen acts as a cytoplasmic platform controlling human neutrophil survival. J Exp Med 207: 2631-2645.
    • (2010) J Exp Med , vol.207 , pp. 2631-2645
    • Witko-Sarsat, V.1    Mocek, J.2    Bouayad, D.3    Tamassia, N.4    Ribeil, J.A.5
  • 9
    • 82755186747 scopus 로고    scopus 로고
    • Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44
    • Rosental B, Brusilovsky M, Hadad U, Oz D, Appel MY, et al. (2011) Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44. J Immunol 187: 5693-5702.
    • (2011) J Immunol , vol.187 , pp. 5693-5702
    • Rosental, B.1    Brusilovsky, M.2    Hadad, U.3    Oz, D.4    Appel, M.Y.5
  • 10
    • 77957792618 scopus 로고    scopus 로고
    • Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer
    • Naryzhny SN, Lee H, (2010) Proliferating cell nuclear antigen in the cytoplasm interacts with components of glycolysis and cancer. FEBS Lett 584: 4292-4298.
    • (2010) FEBS Lett , vol.584 , pp. 4292-4298
    • Naryzhny, S.N.1    Lee, H.2
  • 11
    • 0032031972 scopus 로고    scopus 로고
    • PCNA binding through a conserved motif
    • Warbrick E, (1998) PCNA binding through a conserved motif. Bioessays 20: 195-199.
    • (1998) Bioessays , vol.20 , pp. 195-199
    • Warbrick, E.1
  • 12
    • 69949163202 scopus 로고    scopus 로고
    • Identification of a novel, widespread, and functionally important PCNA-binding motif
    • Gilljam KM, Feyzi E, Aas PA, Sousa MM, Muller R, et al. (2009) Identification of a novel, widespread, and functionally important PCNA-binding motif. J Cell Biol 186: 645-654.
    • (2009) J Cell Biol , vol.186 , pp. 645-654
    • Gilljam, K.M.1    Feyzi, E.2    Aas, P.A.3    Sousa, M.M.4    Muller, R.5
  • 13
    • 84869077981 scopus 로고    scopus 로고
    • Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA
    • Gilljam KM, Muller R, Liabakk NB, Otterlei M, (2012) Nucleotide Excision Repair Is Associated with the Replisome and Its Efficiency Depends on a Direct Interaction between XPA and PCNA. PLoS One 7: e49199.
    • (2012) PLoS One , vol.7
    • Gilljam, K.M.1    Muller, R.2    Liabakk, N.B.3    Otterlei, M.4
  • 14
    • 84861532638 scopus 로고    scopus 로고
    • Clonal competition with alternating dominance in multiple myeloma
    • Keats JJ, Chesi M, Egan JB, Garbitt VM, Palmer SE, et al. (2012) Clonal competition with alternating dominance in multiple myeloma. Blood 120: 1067-1076.
    • (2012) Blood , vol.120 , pp. 1067-1076
    • Keats, J.J.1    Chesi, M.2    Egan, J.B.3    Garbitt, V.M.4    Palmer, S.E.5
  • 15
    • 84864561961 scopus 로고    scopus 로고
    • Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides
    • Egan JB, Shi CX, Tembe W, Christoforides A, Kurdoglu A, et al. (2012) Whole-genome sequencing of multiple myeloma from diagnosis to plasma cell leukemia reveals genomic initiating events, evolution, and clonal tides. Blood 120: 1060-1066.
    • (2012) Blood , vol.120 , pp. 1060-1066
    • Egan, J.B.1    Shi, C.X.2    Tembe, W.3    Christoforides, A.4    Kurdoglu, A.5
  • 16
    • 84859765844 scopus 로고    scopus 로고
    • Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
    • Duncan JS, Whittle MC, Nakamura K, Abell AN, Midland AA, et al. (2012) Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer. Cell 149: 307-321.
    • (2012) Cell , vol.149 , pp. 307-321
    • Duncan, J.S.1    Whittle, M.C.2    Nakamura, K.3    Abell, A.N.4    Midland, A.A.5
  • 17
    • 0037456369 scopus 로고    scopus 로고
    • Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
    • Aas PA, Otterlei M, Falnes PO, Vagbo CB, Skorpen F, et al. (2003) Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature 421: 859-863.
    • (2003) Nature , vol.421 , pp. 859-863
    • Aas, P.A.1    Otterlei, M.2    Falnes, P.O.3    Vagbo, C.B.4    Skorpen, F.5
  • 19
    • 0026550033 scopus 로고
    • Fluorescence resonance energy transfer measurements on cell surfaces. A spectroscopic tool for determining protein interactions
    • Matyus L, (1992) Fluorescence resonance energy transfer measurements on cell surfaces. A spectroscopic tool for determining protein interactions. J Photochem Photobiol B 12: 323-337.
    • (1992) J Photochem Photobiol B , vol.12 , pp. 323-337
    • Matyus, L.1
  • 20
    • 33846141125 scopus 로고    scopus 로고
    • Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest
    • Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, et al. (2006) Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci 119: 5137-5146.
    • (2006) J Cell Sci , vol.119 , pp. 5137-5146
    • Otterlei, M.1    Bruheim, P.2    Ahn, B.3    Bussen, W.4    Karmakar, P.5
  • 21
    • 0034810232 scopus 로고    scopus 로고
    • Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes
    • Xia Z, Liu Y, (2001) Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophys J 81: 2395-2402.
    • (2001) Biophys J , vol.81 , pp. 2395-2402
    • Xia, Z.1    Liu, Y.2
  • 22
    • 84879474695 scopus 로고    scopus 로고
    • A Method for Measurement of Drug Sensitivity of Myeloma Cells Co-cultured with Bone Marrow Stromal Cells
    • Misund K, Baranowska KA, Holien T, Rampa C, Klein DC, et al. (2013) A Method for Measurement of Drug Sensitivity of Myeloma Cells Co-cultured with Bone Marrow Stromal Cells. J Biomol Screen.
    • (2013) J Biomol Screen
    • Misund, K.1    Baranowska, K.A.2    Holien, T.3    Rampa, C.4    Klein, D.C.5
  • 23
    • 20144367589 scopus 로고    scopus 로고
    • Structural basis for recruitment of human flap endonuclease 1 to PCNA
    • Sakurai S, Kitano K, Yamaguchi H, Hamada K, Okada K, et al. (2005) Structural basis for recruitment of human flap endonuclease 1 to PCNA. EMBO J 24: 683-693.
    • (2005) EMBO J , vol.24 , pp. 683-693
    • Sakurai, S.1    Kitano, K.2    Yamaguchi, H.3    Hamada, K.4    Okada, K.5
  • 24
    • 66149150580 scopus 로고    scopus 로고
    • CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
    • Azab AK, Runnels JM, Pitsillides C, Moreau AS, Azab F, et al. (2009) CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy. Blood 113: 4341-4351.
    • (2009) Blood , vol.113 , pp. 4341-4351
    • Azab, A.K.1    Runnels, J.M.2    Pitsillides, C.3    Moreau, A.S.4    Azab, F.5
  • 25
    • 69249087671 scopus 로고    scopus 로고
    • Environment-mediated drug resistance: a major contributor to minimal residual disease
    • Meads MB, Gatenby RA, Dalton WS, (2009) Environment-mediated drug resistance: a major contributor to minimal residual disease. Nat Rev Cancer 9: 665-A674.
    • (2009) Nat Rev Cancer , vol.9 , pp. 665-674
    • Meads, M.B.1    Gatenby, R.A.2    Dalton, W.S.3
  • 26
    • 84864946159 scopus 로고    scopus 로고
    • Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress
    • Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, et al. (2012) Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress. Mol Cell 47: 396-409.
    • (2012) Mol Cell , vol.47 , pp. 396-409
    • Ciccia, A.1    Nimonkar, A.V.2    Hu, Y.3    Hajdu, I.4    Achar, Y.J.5
  • 27
    • 33646697127 scopus 로고    scopus 로고
    • A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design
    • Warbrick E, (2006) A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design. Oncogene 25: 2850-2859.
    • (2006) Oncogene , vol.25 , pp. 2850-2859
    • Warbrick, E.1
  • 28
    • 34249941966 scopus 로고    scopus 로고
    • Translesion synthesis: Y-family polymerases and the polymerase switch
    • Lehmann AR, Niimi A, Ogi T, Brown S, Sabbioneda S, et al. (2007) Translesion synthesis: Y-family polymerases and the polymerase switch. DNA Repair (Amst) 6: 891-899.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 891-899
    • Lehmann, A.R.1    Niimi, A.2    Ogi, T.3    Brown, S.4    Sabbioneda, S.5
  • 29
    • 84868689036 scopus 로고    scopus 로고
    • Regulation of the specialized DNA polymerase eta: Revisiting the biological relevance of its PCNA- and ubiquitin-binding motifs
    • Despras E, Delrieu N, Garandeau C, Ahmed-Seghir S, Kannouche PL, (2012) Regulation of the specialized DNA polymerase eta: Revisiting the biological relevance of its PCNA- and ubiquitin-binding motifs. Environ Mol Mutagen 53: 752-765.
    • (2012) Environ Mol Mutagen , vol.53 , pp. 752-765
    • Despras, E.1    Delrieu, N.2    Garandeau, C.3    Ahmed-Seghir, S.4    Kannouche, P.L.5
  • 31
  • 32
    • 84859965553 scopus 로고    scopus 로고
    • Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication
    • Punchihewa C, Inoue A, Hishiki A, Fujikawa Y, Connelly M, et al. (2012) Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication. J Biol Chem 287: 14289-14300.
    • (2012) J Biol Chem , vol.287 , pp. 14289-14300
    • Punchihewa, C.1    Inoue, A.2    Hishiki, A.3    Fujikawa, Y.4    Connelly, M.5
  • 33
    • 84861428331 scopus 로고    scopus 로고
    • Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth
    • Tan ZQ, Wortman M, Dillehay KL, Seibel WL, Evelyn CR, et al. (2012) Small-Molecule Targeting of Proliferating Cell Nuclear Antigen Chromatin Association Inhibits Tumor Cell Growth. Mol Pharmacol 81: 811-819.
    • (2012) Mol Pharmacol , vol.81 , pp. 811-819
    • Tan, Z.Q.1    Wortman, M.2    Dillehay, K.L.3    Seibel, W.L.4    Evelyn, C.R.5
  • 34
    • 84870527677 scopus 로고    scopus 로고
    • Mitosis-targeted anti-cancer therapies: where they stand
    • Chan KS, Koh CG, Li HY, (2012) Mitosis-targeted anti-cancer therapies: where they stand. Cell Death Dis 3: e411.
    • (2012) Cell Death Dis , vol.3
    • Chan, K.S.1    Koh, C.G.2    Li, H.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.