Organometallic ruthenium anticancer complexes inhibit human glutathione-S-transferase π

Journal of Inorganic Biochemistry

Volumn 128, Issue , 2013, Pages 77-84

  Lin, Yu ^a,b   Huang, Yongdong ^c   Zheng, Wei ^a,b   Wang, Fuyi ^a,b   Habtemariam, Abraha ^d   Luo, Qun ^a,b   Li, Xianchan ^a,b   Wu, Kui ^a,b   Sadler, Peter J ^d   Xiong, Shaoxiang ^a,b  

^a PEKING UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c INSTITUTE OF PROCESS ENGINEERING   (China)

^d UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Anticancer; Enzyme inhibition; Glutathione S transferase; Mass spectrometry; Organometallic ruthenium complex

Indexed keywords

ANTINEOPLASTIC METAL COMPLEX; CYSTEINE; GLUTATHIONE TRANSFERASE P1; METHIONINE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; RUTHENIUM COMPLEX;

ARTICLE; BINDING SITE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROPHILICITY; IC 50; METAL BINDING; MOLECULAR MODEL; OXIDATION;

ANTICANCER; ENZYME INHIBITION; GLUTATHIONE-S-TRANSFERASE; MASS SPECTROMETRY; ORGANOMETALLIC RUTHENIUM COMPLEX;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; BINDING SITES; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTATHIONE S-TRANSFERASE PI; HUMANS; INDANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RUTHENIUM; RUTHENIUM COMPOUNDS;

EID: 84881135953     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2013.07.029     Document Type: Article

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