Glutathione transferase P1-1: Self-preservation of an anti-cancer enzyme

Biochemical Journal

Volumn 376, Issue 1, 2003, Pages 71-76

  Ricci, Giorgio ^a   Caccuri, Anna Maria ^a   Lo Bello, Mario ^a   Parker, Michael W ^b   Nuccetelli, Marzia ^c   Turella, Paola ^a   Stella, Lorenzo ^a   Di Iorio, Ernesto E ^d   Federici, Giorgio ^c  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^d ETH ZURICH   (Switzerland)

Author keywords

Detoxification; Glutathione transferase (GST); Self preservation

Indexed keywords

CELLS; CHEMOTHERAPY; DRUG PRODUCTS; ENZYMES; TUMORS;

ANTI-CANCER ENZYMES;

BIOCHEMISTRY;

GLUTATHIONE TRANSFERASE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DETOXIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; PLACENTA; PRIORITY JOURNAL; TEMPERATURE; TUMOR CELL; ULTRAVIOLET RADIATION;

BINDING SITES; COMPUTER SIMULATION; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; MODELS, MOLECULAR; PROTEIN SUBUNITS;

PROKARYOTA;

EID: 0344393661     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20030860     Document Type: Article

References (30)

1. Armstrong, R. N. (1997) Structure, catalytic mechanism and evolution of the glutathione transferases. Chem. Res. Toxicol. 10, 2-18
2. Salinas, A. E. and Wong, M. G. (1999) Glutathione S-Transferases - a review. Curr. Med. Chem. 6, 279-309
3. Ketterer, B. (1998) Glutathione S-transferases and prevention of cellular free radical damage. Free Radical Res. Commun. 28, 647-658
4. Wang, T., Ariflogu, P., Ronai, Z. and Tew, K. D. (2001) Glutathione S-transferase P1-1 (GSTP1-1) Inhibits c-Jun N-terminal Kinase (JNK1) signaling through Interaction with the C-terminus. J. Biol. Chem. 276, 20999-21003
5. Henderson, C. J., Smith, A. G., Ure, J., Brown, K., Bacon, E. J. and Wolf, C. R. (1998) Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc. Natl. Acad. Sci. U.S.A. 95, 5275-5280
6. O'Brien, M. L. and Tew, K. D. (1996) Glutathione and related enzymes in multidrug resistance. Eur. J. Cancer 32, 967-978
7. Tew, K. D., Monks, A., Barone, L., Rosser, D., Akerman, G., Montali, J. A., Wheatley, J. B. and Schmidt, Jr, D. E. (1996) Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program. Mol. Pharmac. 50, 149-159
8. Keppler, D. (1999) Export pumps for glutathione S-conjugates. Free Rad. Biol. Med. 27, 985-991
9. Tew, K. D., Dutta, S. and Schultz, M. (1997) Inhibitors of Glutathione S-transferases as therapeutic agents. Adv. Drug Deliv. Rev. 26, 91-104
10. Oakley, A. J., Lo Bello, M., Battistoni, A., Ricci, G., Rossjohn, J., Villar, H. O. and Parker M. W. (1997) The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution. J. Mol. Biol. 274, 84-100
11. Ricci, G., Lo Bello, M., Caccuri, A. M., Pastore, A., Nuccetelli, M., Parker, M. W. and Federici, G. (1995) Site-directed mutagenesis of human glutathione transferase P1-1. Mutation of Cys 47 induces a positive cooperativity in GSTP1-1. J. Biol. Chem. 270, 1243-1248
12. Lo Bello, M., Battistoni, A., Mazzetti, A. P., Board, P. G., Muramatzu, M., Federici, G. and Ricci, G. (1995) Site-directed mutagenesis of human glutathione transferase P1-1. Spectral, kinetic and structural properties of Cys 47 and Lys 54 mutants. J. Biol. Chem. 270, 1249-1253
13. Lo Bello, M., Nuccetelli, M., Chiessi, E., Laham, P., Mazzetti, A. P., Battistoni, A., Caccuri, A. M., Oakley, A. J., Parker, M. W., Tramontano, A., Federici, G. and Ricci, G. (1998) Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione. J. Mol. Biol. 284, 1717-1725
14. Ricci, G., Del Boccio, G., Pennelli, A., Aceto, A., Whitehead, E. P. and Federici, G. (1989) Nonequivalence of the two subunits of horse erythrocyte glutathione transferase in their reaction with sulfhydryl reagents. J. Biol. Chem. 264, 5462-5467
15. Lo Bello, M., Nuccetelli, M., Caccuri, A. M., Stella, L., Parker, M. W., Rossjohn, J., McKinstry, W. J., Mozzi, A. F., Federici, G., Polizio, F. et al. (2001) Human glutathione transferase P1-1 and nitric oxide carriers; a new role for an old enzyme. J. Biol. Chem. 276, 42138-42145
16. Stella, L., Nicotra, M., Ricci, G., Rosato, N. and Di Iorio, E. E. (1999) Molecular dynamics simulations of glutathione transferase P1-1: analysis of the induced-fit mechanism by GSH binding. Proteins 37, 1-9
17. van Gunsteren, W. F., Billeter, S. R., Eising, A. A., Hünenberger, P. H., Krüger, P., Mark, A. E., Scott, A. E. and Tironi, I. G. (1996) Biomolecular Simulation: The GROMOS96 Manual and User Guide. VDF Hochschulverlag AG an der ETH Zürich, Zürich
18. Koradi, R., Billeter, M. and Wuthrich, K. (1996) MOLMOL: a program for display and analysis of macromolecular structures. J. Mol. Graph. 14, 51-55
19. Ueno, T. and Yoshimura, T. (2000) The physiological activity and in vivo distribution of dinitrosyl dithiolato iron complex. Jpn. J. Pharmacol. 82, 95-101
20. Caccuri, A. M., Antonini, G., Ascenzi, P., Nicotra, M., Nuccetelli, M., Mazzetti, A. P., Federici, G., Lo Bello, M. and Ricci, G. (1999) Temperature adaptation of glutathione S-transferase P1-1. J. Biol. Chem. 274, 19276-19280
21. Shimizu, K., Toriyama, F. and Yoshida, H. (1995) The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous squamous cell carcinoma and normal human skin. Virchows Arch. 425, 589-592
22. Adams, P. A. and Sikakana, C. N. T. (1990) Factors affecting the inactivalion of human placental glutathione S-transferase. The kinetic mechanism and pH-dependence of solvational and 1-chloro-2,4-dinitrobenzene- mediated inactivation of the enzyme. Biochem. Pharmacol. 39, 1883-1889
23. Stella, L., Di Iorio, E. E., Nicotra, M. and Ricci, G. (1999) Molecular dynamics simulations of glutathione transferase P1-1: conformational fluctuations of the apo structure. Proteins 37, 10-19
24. Stella, L., Caccuri, A. M., Rosato, N., Nicotra, M., Lo Bello, M., De Matteis, F., Mazzetti, A. P., Federici, G. and Ricci, G. (1998) Flexibility of helix 2 in the human glutathione transferase P1-1. J. Biol. Chem. 273, 23267-23273
25. Hitchens, T. K., Mannervik, B. and Rule, G. S. (2001) Disorder-to-order transition of the active site of human class Pi glutathione transferase, GST P1-1. Biochemistry 40, 11660-11669
26. Degani, Y. and Degani, C. (1979) Subunit-selective chemical modifications of creatine kinase. Evidence for asymmetrical association of the subunits. Biochemistry 18, 5917-5923
27. Lee, M. H., Gautam-Basak, M., Wooley, C. and Sander, E. G. (1988) Deoxycytidylate hydroxymethylase: purification, properties and the role of a thiol group in catalysis. Biochemistry 27, 1367-1373
28. Kovina, M. V., Selivanov, V. A., Kochevova, N. V. and Kochetov, G. A. (1997) Kinetic mechanism of active site non-equivalence in transketolase. FEBS Lett. 418, 11-14
29. Wolodko, W. T., Brownie, E. R., O'Connor, M. D. and Bridger W. A. (1983) Thiophosphorylation as a probe for subunit interactions in Escherichia coli succinyl coenzyme A synthetase. Further evidence for catalytic cooperativity and substrate synergism. J. Biol. Chem. 258, 14116-14119
30. Laidler, K. J. and Meiser, J. H. (1999) Physical Chemistry, pp. 169, Houghton Mifflin Company, Boston, U.S.A.