A UFLC-MS/MS method with a switching ionization mode for simultaneous quantitation of polygalaxanthone III, four ginsenosides and tumulosic acid in rat plasma: Application to a comparative pharmacokinetic study in normal and Alzheimer's disease rats

Journal of Mass Spectrometry

Volumn 48, Issue 8, 2013, Pages 904-913

  Lv, Chunxiao ^a   Li, Qing ^a   Zhang, Yaowen ^a   Sui, Zhenyu ^a   He, Bosai ^a   Xu, Huarong ^a   Yin, Yidi ^a   Chen, Xiaohui ^a   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

ginsenosides; Kai Xin San; polygalaxanthone III; tumulosic acid; UFLC MS MS

Indexed keywords

CHROMATOGRAPHIC SEPARATIONS; GINSENOSIDES; KAI-XIN-SAN; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MULTIPLE-REACTION MONITORING MODES; POLYGALAXANTHONE III; TANDEM MASS SPECTROMETRIC DETECTION; UFLC-MS/MS;

DRUG PRODUCTS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEURODEGENERATIVE DISEASES; PHARMACOKINETICS; UTILITY TRUCKS;

BODY FLUIDS;

AMYLOID BETA PROTEIN[25-35]; CHINESE DRUG; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; HERBACEOUS AGENT; KAI XIN SAN; POLYGALAXANTHONE III; TUMULOSIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMNESIA; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CHINESE MEDICINE; COMPARATIVE STUDY; CONTROLLED STUDY; DEMENTIA; DRUG ABSORPTION; GINSENG; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; PLASMA; POLYGALA; PORIA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTITATIVE ANALYSIS; RAT; TANDEM MASS SPECTROMETRY; ULTRA FAST LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

GINSENOSIDES; KAI-XIN-SAN; POLYGALAXANTHONE III; TUMULOSIC ACID; UFLC-MS/MS;

ADMINISTRATION, ORAL; ALZHEIMER DISEASE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUGS, CHINESE HERBAL; GINSENOSIDES; GLYCOSIDES; LEAST-SQUARES ANALYSIS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; XANTHONES;

EID: 84881095428     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3230     Document Type: Article

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