Effect of ginsenoside re on depression- and anxiety-like behaviors and cognition memory deficit induced by repeated immobilization in rats

Journal of Microbiology and Biotechnology

Volumn 22, Issue 5, 2012, Pages 708-720

  Lee, Bombi ^a   Shim, Insop ^a   Lee, Hyejung ^a   Hahm, Dae Hyun ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Anxiety; Cognition; Depression; Ginsenoside Re; Immobilization stress

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; FLUOXETINE; GINSENOSIDE RE; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ANXIETY DISORDER; ARTICLE; AVOIDANCE BEHAVIOR; BEHAVIOR DISORDER; BODY WEIGHT; COGNITIVE DEFECT; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DRUG EFFECT; DRUG MECHANISM; ELEVATED PLUS MAZE TEST; ESCAPE BEHAVIOR; FORCED SWIMMING TEST; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMOBILIZATION STRESS; IMMUNOREACTIVITY; LOCUS CERULEUS; MALE; MAZE TEST; MEMORY DISORDER; NONHUMAN; PROTEIN EXPRESSION; RAT; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; CORTICOTROPIN-RELEASING HORMONE; DEPRESSION; DISEASE MODELS, ANIMAL; GINSENOSIDES; HUMANS; IMMOBILIZATION; MALE; MEMORY DISORDERS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 84862107978     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.1112.12046     Document Type: Article

References (53)

1. Bhatnagar, S., J. B. Mitchell, K. Betito, P. Boksa, and M. J. Meaney. 1995. Effects of chronic intermittent cold stress on pituitary adrenocortical and sympathetic adrenomedullary functioning. Physiol. Behav. 57: 633-639.
2. Bignante, E. A., P. A. Rodriguez Manzanares, E. C. Mlewski, M. E. Bertotto, D. F. Bussolino, G. Paglini, and V. A. Molina. 2008. Involvement of septal Cdk5 in the emergence of excessive anxiety induced by stress. Eur. Neuropsychopharmacol. 18: 578-588.
3. Bondi, C. O., J. D. Jett, and D. A. Morilak. 2010. Beneficial effects of desipramine on cognitive function of chronically stressed rats are mediated by alphal-adrenergic receptors in medial prefrontal cortex. Prog. Neuropsychopharmacol. Biol. Psychiatry 34: 913-923.
4. Carvalho, M. C., S. Masson, M. L. Brandão, and M. A. de Souza Silva. 2008. Anxiolytic-like effects of substance P administration into the dorsal, but not ventral, hippocampus and its influence on serotonin. Peptides 29: 1191-1200.
5. Choi, J. H., S. Y. Yoon, E. J. Choi, Y. S. Ryu, H. S. Ko, D. S. Yim, et al. 2007. Anxiolytic and antidepressant activities of ginsenoside Rbl. Biomol. Ther. (Seoul) 15: 27-32.
6. Chotiwat, C. and R. B. Harris. 2008. Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 295: R1762-R1773.
7. Cryan, J. F. and A. Holmes. 2005. The ascent of mouse: Advances in modelling human depression and anxiety. Nat. Rev. Drug Discov. 4: 775-790.
8. Dal-Zotto, S., O. Marti, and A. Armario. 2000. Influence of single or repeated experience of rats with forced swimming on behavioural and physiological responses to the stressor. Behav. Brain Res. 114: 175-181.
9. Daniels, W. M., L. Richter, and D. J. Stein. 2004. The effects of repeated intra-amygdala CRF injections on rat behavior and HPA axis function after stress. Metab. Brain Dis. 19: 15-23.
10. Elizalde, N., F. J. Gil-Bea, M. J. Ramirez, B. Aisa, B. Lasheras, J. Del Rio, and R. M. Tordera. 2008. Long-lasting behavioral effects and recognition memory deficit induced by chronic mild stress in mice: Effect of antidepressant treatment. Psychopharmacology (Berl) 199: 1-14.
11. Fan, J. M., X. O. Chen, H. Jin, and J. Z. Du. 2009. Gestational hypoxia alone or combined with restraint sensitizes the hypothalamiC pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring. Neuroscience 159: 1363-1373.
12. Fiebich, B. L., R. Knörle, K. Appel, T. Kammler, and G. Weiss. 2011. Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passi,flora in antidepressant pharmacological models. Fitoterapia 82: 474-480.
13. Getachew, B., S. R. Hauser, R. E. Taylor, and Y. Tizabi. 2008. Desipramine blocks alcohol-induced anxiety- and depressivelike behaviors in two rat strains. Pharmacol. Biochem. Behav. 91: 97-103.
14. Grauer, S. M., V. L. Pulito, R. L. Navarra, M. P. Kelly, C. Kelley, R. Graf, et al. 2009. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J. Pharmacol. Exp. Ther. 331: 574-590.
15. Gregus, A., A. J. Wintink, A. C. Davis, and L. E. Kalynchuk. 2005. Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats. Behav. Brain Res. 156: 105-114.
16. Herrera-Guzmán, I., J. E. Herrera-Abarca, E. Gudayol-Ferré, D. Herrera-Guzmán, L. Gómez-Carbajal, M. Peña-Olvira, et al. 2010. Effects of selective serotonin reuptake and dual serotonergicnoradrenergic reuptake treatments on attention and executive functions in patients with major depressive disorder. Psychiatry Res. 177: 323-329.
17. Jin, S. H., J. K. Park, K. Y. Nam, S. N. Park, and N. P. Jung. 1999. Korean red ginseng saponins with low ratios of protopanaxadiol and protopanaxatriol saponin improve scopolamineinduced learning disability and spatial working memory in mice. J. Ethnopharmacol. 66: 123-129.
18. Johnson, S. A., N. M. Fournier, and L. E. Kalynchuk. 2006. Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor. Behav. Brain Res. 168: 280-288.
19. Jovanovski, E., A. Jenkins, A. G. Dias, V. Peeva, J. Sievenpiper, J. T. Amason, et al. 2010. Effects of Korean red ginseng (Panax ginseng C. A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individuals. Am. J. Hypertens. 23: 469-472.
20. Kim, N. H., K. Y. Kim, H. J. Jeong, and H. M. Kim. 2011. Antidepressant-like effect of altered Korean red ginseng in mice. Behav. Med. 37: 42-46.
21. Kim, J. H., S. A. Kang, S. M. Han, and I. Shim. 2009. Comparison of the antiobesity effects of the protopanaxadioland protopanaxatriol-type saponins of red ginseng. Phytother. Res. 23: 78-85.
22. Klenerova, V., I. Krejci, P. Sida, Z. Hlinak, and S. Hynie. 2010. Oxytocin and carbetocin ameliorating effects on restraint stressinduced short- and long-term behavioral changes in rats. Neuro. Endocrinol. Lett. 31: 622-630.
23. Maccari, S. and S. Morley-Fletcher. 2007. Effects of prenatal restraint stress on the hypothalamus-pituitary-adrenal axis and related behavioural and neurobiological alterations [Review]. Psychoneuroendocrinology 32: S10-S15.
24. Magariños, A. M., C. J. Li, J. Gal Toth, K. G. Bath, D. Jing, F. S. Lee, and B. S. McEwen. 2011. Effect of brain-derived neurotrophic factor haploinsufficiency on stress-induced remodeling of hippocampal neurons. Hippocampus 21: 253-264.
25. Marks, W., N. M. Fournier, and L. E. Kalynchuk. 2009. Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength. Physiol. Rehav 98: 67-72
26. Mineka, S. and R. Zinbarg. 2006. A contemporary learning theory perspective on the etiology of anxiety disorders: It's not what you thought it was. Am. Psychol. 61: 10-26.
27. Mochizuki, D., R. Tsujita, S. Yamada, K. Kawasaki, Y. Otsuka, S. Hashimoto, et al. 2002. Neurochemical and behavioural characterization of milnacipran, a serotonin and noradrenaline reuptake inhibitor in rats. Psychopharmacology (Berl) 162: 323-332.
28. Naert, G., G. Ixart, T. Maurice, L. Tapia-Arancibia, and L. Givalois. 2011. Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol. Cell Neurosci. 46: 55-66.
29. Nestler, E. J., M. Barrot, R. J. DiLeone, A. J. Eisch, S. J. Gold, and L. M. Monteggia. 2002. Neurobiology of depression. Neuron 34: 13-25.
30. Osterhout, C. A., C. R. Sterling, D. M. Chikaraishi, and A. W. Tank. 2005. Induction of tyrosine hydroxylase in the locus coeruleus of transgenic mice in response to stress or nicotine treatment: Lack of activation of tyrosine hydroxylase promoter activity. J. Neurochem. 94: 731-741.
31. Padovan, C. M. and F. S. Guimarães. 2000. Restraint-induced hypoactivity in an elevated plus-maze. Braz. J. Med. Biol. Res. 33: 79-83.
32. Park, H. J., H. S. Shim, H. Kim, K. S. Kim, H. Lee, D. H. Hahm, and I. Shim. 2010. Effects of Glycyrrhizae Radix on repeated restraint stress-induced neurochemical and behavioral responses. Korean J. Physiol. Pharmacol. 14: 371-376.
33. Patel, S., C. T. Roelke, D. J. Rademacher, W. E. Cullinan, and C. J. Hillard. 2004. Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 145: 5431-5438.
34. Paxinos, G. and C. Watson. 1986. The Rat Brain in Stereotaxic Coordinates, pp. 54-85. Academic Press, NY.
35. Sandi, C., J. J. Merino, M. I. Cordero, K. Touyarot, and C. Venero. 2001. Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, ITS polysialylation and Ll. Neuroscience 102: 329-339.
36. Sandstrom, N. J. and S. R. Hart. 2005. Isolation stress during the third postnatal week alters radial arm maze performance and corticosterone levels in adulthood. Behavior. Brain Res. 156: 289-296.
37. Savaskan, E., S. E. Muller, A. Bohringer, A. Schulz, and H. Schachinger. 2008. Antidepressive therapy with escitalopram improves mood, cognitive symptoms, and identity memory for angry faces in elderly depressed patients. Int. J. Neuropsychopharmacol. 11: 381-388.
38. Sevgi, S., M. Ozek, and L. Eroglu. 2003. L-NAME prevents anxiety-like and depression-like behavior in rats exposed to restraint stress. Methods Find. Exp. Clin. Pharmacol. 28: 95-99.
39. Siuciak, J. A., D. R. Lewis, S. J. Wiegand, and R. M. Lindsay. 1997. Antidepressant-like effect of brain-derived neurotrophic factor (BDNF). Pharmacol. Biochem. Behav. 56: 131-137.
40. Tanaka, M. and G. Telegdy. 2008. Involvement of adrenergic and serotonergic receptors in antidepressant-like effect of urocortin 3 in a modified forced swimming test in mice. Brain Res. Bull. 77: 301-305.
41. Tanke, M. A., D. S. Fokkema, B. Doombos, F. Postema, and J. Korf. 2008. Sustained release of corticosterone in rats affects reactivity, but does not affect habituation to immobilization and acoustic stimuli. Life Sci. 83: 135-141.
42. Tode, T., Y. Kikuchi, J. Hirata, T. Kita, H. Nakata, and I. Nagata. 1999. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int. J. Gynaecol. Obstet. 67: 169-174.
43. Tsigos, C. and G. P. Chrousos. 2002. Hypothalamic-pituitaryadrenal axis, neuroendocrine factors and stress. J. Psychosom. Res. 53: 865-871.
44. Ulrich-Lai, Y. M., W. Xie, J. T. Meij, C. M. Dolgas, L. Yu, and J. P. Herman. 2006. Limbic and HPA axis function in an animal model of chronic neuropathic pain. Physiol. Behav. 88: 67-76.
45. Vieira, C., T. C. De Lima, P. Carobrez Ade, and C. Lino-de-Oliveira. 2008. Frequency of climbing behavior as a predictor of altered motor activity in rat forced swimming test. Neurosci. Lett. 445: 170-173.
46. Vyas, A., R. Mitra, B. S. Rao, and S. Chattarji. 2002. Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J. Neurosci. 2: 6810-6818.
47. Walesiuk, A. and J. J. Braszko. 2009. Preventive action of Ginkgo biloba in stress- and corticosterone-induced impairment of spatial memory in rats. Phytomedicine 16: 40-46.
48. Walf, A. A. and C. A. Frye. 2007. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat. Protoc. 2: 322-328.
49. Wang, Y. Z., J. Chen, S. F. Chu, Y. S. Wang, X. Y. Wang, N. H. Chen, and J. T. Zhang. 2009. Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rgl's metabolites ginsenoside Rhl and protopanaxatriol. J. Pharmacol. Sci. 109: 504-510.
50. Wong, M. L. and J. Licinio. 2001. Research and treatment approaches to depression. Nat. Rev. Neurosci. 2: 343-351.
51. Xing, B., Y. Zhao, H. Zhang, Y. Dang, T. Chen, J. Huang, and Q. Luo. 2011. Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antidepressant-like effect in the rat forced swim test. Brain Res. Bull. 85: 153-157.
52. Yamada, N., H. Araki, and H. Yoshimura. 2011. Identification of antidepressant-like ingredients in ginseng root (Panax ginseng C. A. Meyer) using a menopausal depressive-like state in female mice: Participation of 5-HT2A receptors. Psychopharmacology (Berl) 216: 589-599.
53. Yan, B., J. He, H. Xu, Y. Zhang, X. Bi, S. Thakur, et al. 2007. Quetiapine attenuates the depressive and anxiolytic-like behavioural changes induced by global cerebral ischemia in mice. Behav Brain Res. 182: 36-41.