A UFLC-MS/MS method for simultaneous quantitation of spinosin, mangiferin and ferulic acid in rat plasma: Application to a comparative pharmacokinetic study in normal and insomnic rats

Journal of Mass Spectrometry

Volumn 47, Issue 10, 2012, Pages 1333-1340

  He, Bosai ^a   Li, Qing ^a   Jia, Ying ^a   Zhao, Longshan ^a   Xiao, Feng ^a   Lv, Chunxiao ^a   Xu, Huarong ^a   Chen, Xiaohui ^a   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

insomnia; mangiferin; pharmacokinetics; spinosin; UFLC MS MS

Indexed keywords

ACCEPTANCE CRITERIA; ACTIVE INGREDIENTS; ANALYTES; EXTRACTION RECOVERY; FERULIC ACIDS; GRADIENT ELUTION; INSOMNIA; LOWER LIMITS; MANGIFERIN; MOBILE PHASE; PHARMACOKINETIC PARAMETERS; PHARMACOKINETIC PROFILES; PHARMACOKINETIC STUDIES; RAT PLASMA; SPINOSIN; TRADITIONAL CHINESE MEDICINE; TURBO ION SPRAY; UFLC-MS/MS; VALIDATED METHODS;

FORMIC ACID; METHANOL; PHARMACOKINETICS; RATS;

BODY FLUIDS;

CHINESE DRUG; FERULIC ACID; FORMIC ACID; MANGIFERIN; METHANOL; SPINOSIN; SUAN ZAO REN; UNCLASSIFIED DRUG; WATER;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; FLOW RATE; INSOMNIA; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRA FAST LIQUID CHROMATOGRAPHY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARIC ACIDS; DRUG STABILITY; DRUGS, CHINESE HERBAL; FLAVONOIDS; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SLEEP INITIATION AND MAINTENANCE DISORDERS; TANDEM MASS SPECTROMETRY; XANTHONES;

PORIA; RATTUS;

EID: 84867018187     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3072     Document Type: Article

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