-
3
-
-
42649145828
-
Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review
-
Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 2008; 34: 193-205.
-
(2008)
Cancer Treat Rev
, vol.34
, pp. 193-205
-
-
Gupta, K.1
Miller, J.D.2
Li, J.Z.3
Russell, M.W.4
Charbonneau, C.5
-
4
-
-
79955802498
-
What can molecular pathology contribute to the management of renal cell carcinoma?
-
Stewart GD, O'Mahony FC, Powles T, Riddick AC, Harrison DJ, Faratian D. What can molecular pathology contribute to the management of renal cell carcinoma? Nat Rev Urol 2011; 8: 255-65.
-
(2011)
Nat Rev Urol
, vol.8
, pp. 255-265
-
-
Stewart, G.D.1
O'Mahony, F.C.2
Powles, T.3
Riddick, A.C.4
Harrison, D.J.5
Faratian, D.6
-
5
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-11.
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
7
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96.
-
(2002)
J Clin Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
Russo, P.4
Mazumdar, M.5
-
8
-
-
76749116183
-
Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial
-
Gore ME, Griffin CL, Hancock B et al. Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial. Lancet 2010; 375: 641-8.
-
(2010)
Lancet
, vol.375
, pp. 641-648
-
-
Gore, M.E.1
Griffin, C.L.2
Hancock, B.3
-
9
-
-
34548316976
-
Molecular basis for sunitinib efficacy and future clinical development
-
Faivre S, Demetri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007; 6: 734-45.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 734-745
-
-
Faivre, S.1
Demetri, G.2
Sargent, W.3
Raymond, E.4
-
10
-
-
65549129226
-
Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
-
Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res 2009; 69: 2506-13.
-
(2009)
Cancer Res
, vol.69
, pp. 2506-2513
-
-
Xin, H.1
Zhang, C.2
Herrmann, A.3
Du, Y.4
Figlin, R.5
Yu, H.6
-
11
-
-
76249126867
-
Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
-
Huang D, Ding Y, Li Y et al. Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 2010; 70: 1053-62.
-
(2010)
Cancer Res
, vol.70
, pp. 1053-1062
-
-
Huang, D.1
Ding, Y.2
Li, Y.3
-
12
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
13
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-90.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
14
-
-
76249133170
-
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
-
Huang D, Ding Y, Zhou M et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 2010; 70: 1063-71.
-
(2010)
Cancer Res
, vol.70
, pp. 1063-1071
-
-
Huang, D.1
Ding, Y.2
Zhou, M.3
-
15
-
-
77953467629
-
Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study
-
Hammers HJ, Verheul HM, Salumbides B et al. Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study. Mol Cancer Ther 2010; 9: 1525-35.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1525-1535
-
-
Hammers, H.J.1
Verheul, H.M.2
Salumbides, B.3
-
16
-
-
47949099628
-
Modes of resistance to anti-angiogenic therapy
-
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8: 592-603.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 592-603
-
-
Bergers, G.1
Hanahan, D.2
-
17
-
-
9244224723
-
Intrinsic tumour suppression
-
Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004; 432: 307-15.
-
(2004)
Nature
, vol.432
, pp. 307-315
-
-
Lowe, S.W.1
Cepero, E.2
Evan, G.3
-
19
-
-
52949152429
-
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation
-
Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 2008; 76: 947-57.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 947-957
-
-
Gewirtz, D.A.1
Holt, S.E.2
Elmore, L.W.3
-
20
-
-
78751513758
-
The BH3 mimetic ABT-737 induces cancer cell senescence
-
Song JH, Kandasamy K, Zemskova M, Lin YW, Kraft AS. The BH3 mimetic ABT-737 induces cancer cell senescence. Cancer Res 2010; 71: 506-15.
-
(2010)
Cancer Res
, vol.71
, pp. 506-515
-
-
Song, J.H.1
Kandasamy, K.2
Zemskova, M.3
Lin, Y.W.4
Kraft, A.S.5
-
21
-
-
77949737971
-
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
-
Alimonti A, Nardella C, Chen Z et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest 2010; 120: 681-93.
-
(2010)
J Clin Invest
, vol.120
, pp. 681-693
-
-
Alimonti, A.1
Nardella, C.2
Chen, Z.3
-
22
-
-
80052273035
-
Inhibition of VEGF induces cellular senescence in colorectal cancer cells
-
Hasan MR, Ho SH, Owen DA, Tai IT. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. Int J Cancer 2011; 129: 2115-23.
-
(2011)
Int J Cancer
, vol.129
, pp. 2115-2123
-
-
Hasan, M.R.1
Ho, S.H.2
Owen, D.A.3
Tai, I.T.4
-
23
-
-
0037013154
-
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
-
Schmitt CA, Fridman JS, Yang M et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109: 335-46.
-
(2002)
Cell
, vol.109
, pp. 335-346
-
-
Schmitt, C.A.1
Fridman, J.S.2
Yang, M.3
-
24
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-7.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
-
25
-
-
58849154235
-
Senescence-messaging secretome: SMS-ing cellular stress
-
Kuilman T, Peeper DS. Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 2009; 9: 81-94.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 81-94
-
-
Kuilman, T.1
Peeper, D.S.2
-
26
-
-
77952105389
-
Inflammatory networks during cellular senescence: causes and consequences
-
Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16: 238-46.
-
(2010)
Trends Mol Med
, vol.16
, pp. 238-246
-
-
Freund, A.1
Orjalo, A.V.2
Desprez, P.Y.3
Campisi, J.4
-
27
-
-
77949881221
-
The senescence-associated secretory phenotype: the dark side of tumor suppression
-
Coppe JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5: 99-118.
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 99-118
-
-
Coppe, J.P.1
Desprez, P.Y.2
Krtolica, A.3
Campisi, J.4
-
28
-
-
79551683487
-
Cellular senescence: putting the paradoxes in perspective
-
Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 2010; 21: 107-12.
-
(2010)
Curr Opin Genet Dev
, vol.21
, pp. 107-112
-
-
Campisi, J.1
-
29
-
-
0030613551
-
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
-
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997; 91: 243-52.
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
30
-
-
28444472744
-
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors
-
Gurova KV, Hill JE, Guo C et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA 2005; 102: 17448-53.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17448-17453
-
-
Gurova, K.V.1
Hill, J.E.2
Guo, C.3
-
31
-
-
78751697353
-
Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation
-
Moniz LS, Stambolic V. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Mol Cell Biol 2010; 31: 30-42.
-
(2010)
Mol Cell Biol
, vol.31
, pp. 30-42
-
-
Moniz, L.S.1
Stambolic, V.2
-
32
-
-
77953474634
-
Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization
-
Zhang W, Xu W, Xiong S. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol 2010; 184: 6465-78.
-
(2010)
J Immunol
, vol.184
, pp. 6465-6478
-
-
Zhang, W.1
Xu, W.2
Xiong, S.3
-
33
-
-
80051921285
-
Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component
-
Zhang W, Xu W, Xiong S. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol 2011; 187: 1764-77.
-
(2011)
J Immunol
, vol.187
, pp. 1764-1777
-
-
Zhang, W.1
Xu, W.2
Xiong, S.3
-
34
-
-
84255200363
-
Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway
-
Liu H, Xu J, Zhou L et al. Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. Cancer Res 2011; 71: 7547-57.
-
(2011)
Cancer Res
, vol.71
, pp. 7547-7557
-
-
Liu, H.1
Xu, J.2
Zhou, L.3
-
35
-
-
77954230484
-
Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
-
Xu J, Yun X, Jiang J et al. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology 2010; 52: 142-54.
-
(2010)
Hepatology
, vol.52
, pp. 142-154
-
-
Xu, J.1
Yun, X.2
Jiang, J.3
-
36
-
-
84862742319
-
Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1
-
Xu J, Liu H, Chen L et al. Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1. Gastroenterology 2012; 143: 199-212.e4.
-
(2012)
Gastroenterology
, vol.143
-
-
Xu, J.1
Liu, H.2
Chen, L.3
-
37
-
-
41449091585
-
DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
-
Qian Y, Zhang J, Yan B, Chen X. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 2008; 283: 2896-905.
-
(2008)
J Biol Chem
, vol.283
, pp. 2896-2905
-
-
Qian, Y.1
Zhang, J.2
Yan, B.3
Chen, X.4
-
38
-
-
0035846652
-
8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts
-
Tsutsui H, Ide T, Shiomi T et al. 8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts. Circulation 2001; 104: 2883-5.
-
(2001)
Circulation
, vol.104
, pp. 2883-2885
-
-
Tsutsui, H.1
Ide, T.2
Shiomi, T.3
-
39
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov PG, Komarova EA, Kondratov RV et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999; 285: 1733-7.
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
Komarova, E.A.2
Kondratov, R.V.3
-
40
-
-
33747620737
-
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
-
Strom E, Sathe S, Komarov PG et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol 2006; 2: 474-9.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 474-479
-
-
Strom, E.1
Sathe, S.2
Komarov, P.G.3
-
42
-
-
0027482547
-
Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex
-
Li S, Sedivy JM. Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex. Proc Natl Acad Sci USA 1993; 90: 9247-51.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 9247-9251
-
-
Li, S.1
Sedivy, J.M.2
-
44
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006; 295: 2516-24.
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
-
45
-
-
82555189379
-
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance
-
Gotink KJ, Broxterman HJ, Labots M et al. Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance. Clin Cancer Res 2011; 17: 7337-46.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7337-7346
-
-
Gotink, K.J.1
Broxterman, H.J.2
Labots, M.3
-
46
-
-
1542615083
-
p53 pathway in renal cell carcinoma is repressed by a dominant mechanism
-
Gurova KV, Hill JE, Razorenova OV, Chumakov PM, Gudkov AV. p53 pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res 2004; 64: 1951-8.
-
(2004)
Cancer Res
, vol.64
, pp. 1951-1958
-
-
Gurova, K.V.1
Hill, J.E.2
Razorenova, O.V.3
Chumakov, P.M.4
Gudkov, A.V.5
-
47
-
-
80054789761
-
Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity
-
Chien Y, Scuoppo C, Wang X et al. Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity. Genes Dev 2011; 25: 2125-36.
-
(2011)
Genes Dev
, vol.25
, pp. 2125-2136
-
-
Chien, Y.1
Scuoppo, C.2
Wang, X.3
-
49
-
-
80054784360
-
Opposing roles of NF-kappaB in anti-cancer treatment outcome unveiled by cross-species investigations
-
Jing H, Kase J, Dorr JR et al. Opposing roles of NF-kappaB in anti-cancer treatment outcome unveiled by cross-species investigations. Genes Dev 2011; 25: 2137-46.
-
(2011)
Genes Dev
, vol.25
, pp. 2137-2146
-
-
Jing, H.1
Kase, J.2
Dorr, J.R.3
|