메뉴 건너뛰기




Volumn 104, Issue 8, 2013, Pages 1052-1061

Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CELL MARKER; CELL PROTEIN; DCR2 PROTEIN; DEC1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; KI 67 ANTIGEN; PROTEIN P53; RAF PROTEIN; SUNITINIB; UNCLASSIFIED DRUG;

EID: 84881093688     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12176     Document Type: Article
Times cited : (58)

References (49)
  • 3
    • 42649145828 scopus 로고    scopus 로고
    • Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review
    • Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 2008; 34: 193-205.
    • (2008) Cancer Treat Rev , vol.34 , pp. 193-205
    • Gupta, K.1    Miller, J.D.2    Li, J.Z.3    Russell, M.W.4    Charbonneau, C.5
  • 5
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-11.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 7
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, Russo P, Mazumdar M. Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002; 20: 289-96.
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 8
    • 76749116183 scopus 로고    scopus 로고
    • Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial
    • Gore ME, Griffin CL, Hancock B et al. Interferon alfa-2a versus combination therapy with interferon alfa-2a, interleukin-2, and fluorouracil in patients with untreated metastatic renal cell carcinoma (MRC RE04/EORTC GU 30012): an open-label randomised trial. Lancet 2010; 375: 641-8.
    • (2010) Lancet , vol.375 , pp. 641-648
    • Gore, M.E.1    Griffin, C.L.2    Hancock, B.3
  • 9
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, Raymond E. Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007; 6: 734-45.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 10
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H. Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res 2009; 69: 2506-13.
    • (2009) Cancer Res , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 11
    • 76249126867 scopus 로고    scopus 로고
    • Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma
    • Huang D, Ding Y, Li Y et al. Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma. Cancer Res 2010; 70: 1053-62.
    • (2010) Cancer Res , vol.70 , pp. 1053-1062
    • Huang, D.1    Ding, Y.2    Li, Y.3
  • 12
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-24.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 13
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol 2009; 27: 3584-90.
    • (2009) J Clin Oncol , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 14
    • 76249133170 scopus 로고    scopus 로고
    • Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma
    • Huang D, Ding Y, Zhou M et al. Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. Cancer Res 2010; 70: 1063-71.
    • (2010) Cancer Res , vol.70 , pp. 1063-1071
    • Huang, D.1    Ding, Y.2    Zhou, M.3
  • 15
    • 77953467629 scopus 로고    scopus 로고
    • Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study
    • Hammers HJ, Verheul HM, Salumbides B et al. Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study. Mol Cancer Ther 2010; 9: 1525-35.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1525-1535
    • Hammers, H.J.1    Verheul, H.M.2    Salumbides, B.3
  • 16
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8: 592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 17
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature 2004; 432: 307-15.
    • (2004) Nature , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 19
    • 52949152429 scopus 로고    scopus 로고
    • Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation
    • Gewirtz DA, Holt SE, Elmore LW. Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 2008; 76: 947-57.
    • (2008) Biochem Pharmacol , vol.76 , pp. 947-957
    • Gewirtz, D.A.1    Holt, S.E.2    Elmore, L.W.3
  • 21
    • 77949737971 scopus 로고    scopus 로고
    • A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
    • Alimonti A, Nardella C, Chen Z et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest 2010; 120: 681-93.
    • (2010) J Clin Invest , vol.120 , pp. 681-693
    • Alimonti, A.1    Nardella, C.2    Chen, Z.3
  • 22
    • 80052273035 scopus 로고    scopus 로고
    • Inhibition of VEGF induces cellular senescence in colorectal cancer cells
    • Hasan MR, Ho SH, Owen DA, Tai IT. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. Int J Cancer 2011; 129: 2115-23.
    • (2011) Int J Cancer , vol.129 , pp. 2115-2123
    • Hasan, M.R.1    Ho, S.H.2    Owen, D.A.3    Tai, I.T.4
  • 23
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • Schmitt CA, Fridman JS, Yang M et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002; 109: 335-46.
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3
  • 24
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri GP, Lee X, Basile G et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995; 92: 9363-7.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 25
    • 58849154235 scopus 로고    scopus 로고
    • Senescence-messaging secretome: SMS-ing cellular stress
    • Kuilman T, Peeper DS. Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer 2009; 9: 81-94.
    • (2009) Nat Rev Cancer , vol.9 , pp. 81-94
    • Kuilman, T.1    Peeper, D.S.2
  • 26
    • 77952105389 scopus 로고    scopus 로고
    • Inflammatory networks during cellular senescence: causes and consequences
    • Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med 2010; 16: 238-46.
    • (2010) Trends Mol Med , vol.16 , pp. 238-246
    • Freund, A.1    Orjalo, A.V.2    Desprez, P.Y.3    Campisi, J.4
  • 27
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: the dark side of tumor suppression
    • Coppe JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010; 5: 99-118.
    • (2010) Annu Rev Pathol , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 28
    • 79551683487 scopus 로고    scopus 로고
    • Cellular senescence: putting the paradoxes in perspective
    • Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev 2010; 21: 107-12.
    • (2010) Curr Opin Genet Dev , vol.21 , pp. 107-112
    • Campisi, J.1
  • 29
    • 0030613551 scopus 로고    scopus 로고
    • The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
    • Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997; 91: 243-52.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 30
    • 28444472744 scopus 로고    scopus 로고
    • Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors
    • Gurova KV, Hill JE, Guo C et al. Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors. Proc Natl Acad Sci USA 2005; 102: 17448-53.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17448-17453
    • Gurova, K.V.1    Hill, J.E.2    Guo, C.3
  • 31
    • 78751697353 scopus 로고    scopus 로고
    • Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation
    • Moniz LS, Stambolic V. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Mol Cell Biol 2010; 31: 30-42.
    • (2010) Mol Cell Biol , vol.31 , pp. 30-42
    • Moniz, L.S.1    Stambolic, V.2
  • 32
    • 77953474634 scopus 로고    scopus 로고
    • Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization
    • Zhang W, Xu W, Xiong S. Blockade of Notch1 signaling alleviates murine lupus via blunting macrophage activation and M2b polarization. J Immunol 2010; 184: 6465-78.
    • (2010) J Immunol , vol.184 , pp. 6465-6478
    • Zhang, W.1    Xu, W.2    Xiong, S.3
  • 33
    • 80051921285 scopus 로고    scopus 로고
    • Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component
    • Zhang W, Xu W, Xiong S. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol 2011; 187: 1764-77.
    • (2011) J Immunol , vol.187 , pp. 1764-1777
    • Zhang, W.1    Xu, W.2    Xiong, S.3
  • 34
    • 84255200363 scopus 로고    scopus 로고
    • Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway
    • Liu H, Xu J, Zhou L et al. Hepatitis B virus large surface antigen promotes liver carcinogenesis by activating the Src/PI3K/Akt pathway. Cancer Res 2011; 71: 7547-57.
    • (2011) Cancer Res , vol.71 , pp. 7547-7557
    • Liu, H.1    Xu, J.2    Zhou, L.3
  • 35
    • 77954230484 scopus 로고    scopus 로고
    • Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage
    • Xu J, Yun X, Jiang J et al. Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage. Hepatology 2010; 52: 142-54.
    • (2010) Hepatology , vol.52 , pp. 142-154
    • Xu, J.1    Yun, X.2    Jiang, J.3
  • 36
    • 84862742319 scopus 로고    scopus 로고
    • Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1
    • Xu J, Liu H, Chen L et al. Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1. Gastroenterology 2012; 143: 199-212.e4.
    • (2012) Gastroenterology , vol.143
    • Xu, J.1    Liu, H.2    Chen, L.3
  • 37
    • 41449091585 scopus 로고    scopus 로고
    • DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence
    • Qian Y, Zhang J, Yan B, Chen X. DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 2008; 283: 2896-905.
    • (2008) J Biol Chem , vol.283 , pp. 2896-2905
    • Qian, Y.1    Zhang, J.2    Yan, B.3    Chen, X.4
  • 38
    • 0035846652 scopus 로고    scopus 로고
    • 8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts
    • Tsutsui H, Ide T, Shiomi T et al. 8-oxo-dGTPase, which prevents oxidative stress-induced DNA damage, increases in the mitochondria from failing hearts. Circulation 2001; 104: 2883-5.
    • (2001) Circulation , vol.104 , pp. 2883-2885
    • Tsutsui, H.1    Ide, T.2    Shiomi, T.3
  • 39
    • 0033543728 scopus 로고    scopus 로고
    • A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
    • Komarov PG, Komarova EA, Kondratov RV et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999; 285: 1733-7.
    • (1999) Science , vol.285 , pp. 1733-1737
    • Komarov, P.G.1    Komarova, E.A.2    Kondratov, R.V.3
  • 40
    • 33747620737 scopus 로고    scopus 로고
    • Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
    • Strom E, Sathe S, Komarov PG et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol 2006; 2: 474-9.
    • (2006) Nat Chem Biol , vol.2 , pp. 474-479
    • Strom, E.1    Sathe, S.2    Komarov, P.G.3
  • 42
    • 0027482547 scopus 로고
    • Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex
    • Li S, Sedivy JM. Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex. Proc Natl Acad Sci USA 1993; 90: 9247-51.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9247-9251
    • Li, S.1    Sedivy, J.M.2
  • 43
    • 0037457987 scopus 로고    scopus 로고
    • Evidence that exposure of the telomere 3′ overhang sequence induces senescence
    • Li GZ, Eller MS, Firoozabadi R, Gilchrest BA. Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci USA 2003; 100: 527-31.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 527-531
    • Li, G.Z.1    Eller, M.S.2    Firoozabadi, R.3    Gilchrest, B.A.4
  • 44
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006; 295: 2516-24.
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 45
    • 82555189379 scopus 로고    scopus 로고
    • Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance
    • Gotink KJ, Broxterman HJ, Labots M et al. Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance. Clin Cancer Res 2011; 17: 7337-46.
    • (2011) Clin Cancer Res , vol.17 , pp. 7337-7346
    • Gotink, K.J.1    Broxterman, H.J.2    Labots, M.3
  • 47
    • 80054789761 scopus 로고    scopus 로고
    • Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity
    • Chien Y, Scuoppo C, Wang X et al. Control of the senescence-associated secretory phenotype by NF-kappaB promotes senescence and enhances chemosensitivity. Genes Dev 2011; 25: 2125-36.
    • (2011) Genes Dev , vol.25 , pp. 2125-2136
    • Chien, Y.1    Scuoppo, C.2    Wang, X.3
  • 49
    • 80054784360 scopus 로고    scopus 로고
    • Opposing roles of NF-kappaB in anti-cancer treatment outcome unveiled by cross-species investigations
    • Jing H, Kase J, Dorr JR et al. Opposing roles of NF-kappaB in anti-cancer treatment outcome unveiled by cross-species investigations. Genes Dev 2011; 25: 2137-46.
    • (2011) Genes Dev , vol.25 , pp. 2137-2146
    • Jing, H.1    Kase, J.2    Dorr, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.