Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology

Neurobiology of Aging

Volumn 25, Issue 6, 2004, Pages 697-711

  Schönheit, Bärbel ^a   Zarski, Rosemarie ^a   Ohm, Thomas G ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Alzheimer's disease; Amyloid cascade hypothesis; Amyloid plaques; Anterograde neurodegeneration; Braak staging; Entorhinal cortex; Hippocampal formation; Hippocampus; Neurofibrillary tangles; Spatial pattern; Time course; A4 peptide

Indexed keywords

ADULT; AGED; ALZHEIMER DISEASE; AUTOPSY; BRAIN NERVE CELL; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DENTATE GYRUS; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; MICROSCOPY; PATHOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW; SUBICULUM; TEMPORAL LOBE;

EID: 2542558147     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2003.09.009     Document Type: Note

References (45)

1. Ackermann H. BIAS - a programme package for biometrical analysis of samples. Comp. Stat. 11:1991;223-224
2. Armstrong R.A. The relationship between senile plaques, neurofibrillary tangles and amyloid (A4) deposits in Alzheimer's disease - a principal components analysis. Neurosci. Res. Commun. 9:1991;91-97
3. Armstrong R.A., Myers D., Smith C.U.M. The distribution of senile plaques, neurofibrillary tangles and beta/A4 deposits in the hippocampus in Alzheimer's disease. Neurosci. Res. Commun. 10:1992;87-94
4. Armstrong R.A., Myers D., Smith C.U.M., Cairns N., Luthert P.J. Alzheimer's disease - the relationship between the density of senile plaques, neurofibrillary tangles and A4 protein in human patients. Neurosci. Lett. 123:1991;141-143
5. Bancher C., Braak H., Fischer P., Jellinger K.A. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neurosci. Lett. 162(1/2):1993;179-182
6. Braak H, Duyckaerts C, Braak E, Piette F. Neuropathological staging of Alzheimer-related changes correlates with psychometricaly assessed intellectual status. In: Alzheimer's disease: advances in clinical and basic research; 1993.
7. Braak H., Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. (Berl.). 82(4):1991;239-259
8. Braak H., Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging. 18(4):1997;351-357
9. Braak H., Braak E., Bohl J., Reintjes R. Age, neurofibrillary changes, A beta-amyloid and the onset of Alzheimer's disease. Neurosci. Lett. 210(2):1996;87-90
10. Braak H., Braak E., Ohm T.G., Bohl J. Alzheimer's disease: mismatch between amyloid plaques and neuritic plaques. Neurosci. Lett. 103:1989;24-28
11. Braak H., Braak E. Author's response to commentaries. Neurobiol. Aging. 18(4):1997;389-392
12. Braak H, Braak E. Temporal sequence of Alzheimer's disease-related pathology. In: Peters, Morrison, editors. Cerebral cortex. New York: Kluwer Academic/Plenum Publishers; 1999. p. 475-512.
13. Busch C., Bohl J., Ohm T.G. Spatial, temporal and numeric analysis of Alzheimer changes in the nucleus coeruleus. Neurobiol. Aging. 18(4):1997;401-406
14. Cras P., Smith M.A., Richey P.L., Siedlak S.L., Mulvihill P., Perry G. Extracellular neurofibrillary tangles reflect neuronal loss and provide further evidence of extensive protein cross-linking in Alzheimer disease. Acta Neuropathol. (Berl.). 89(4):1995;291-295
15. Cummings B.J. Plaques and tangles: searching for primary events in a forest of data. Neurobiol. Aging. 18(4):1997;358-362
16. Duvernoy HM. The human hippocampus. An atlas of applied anatomy. München: J.F. Bergmann; 1998.
17. Giaccone G., Pedrotti B., Migheli A., Verga L., Perez J., Racagni G., et al. Beta PP and Tau interaction. A possible link between amyloid and neurofibrillary tangles in Alzheimer's disease. Am. J. Pathol. 148(1):1996;79-87
18. Gold G., Bouras C., Kovari E., Canuto A., Glaria B.G., Malky A., et al. Clinical validity of Braak neuropathological staging in the oldest-old. Acta Neuropathol. (Berl.). 99(5):2000;579-582
19. Gotz J., Chen F., Van Dorpe J., Nitsch R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 293(5534):2001;1491-1495
20. Gotz J., Nitsch R.M. Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice. NeuroReport. 12(9):2001;2007-2016
21. Grober E., Dickson D., Sliwinski M.J., Buschke H., Katz M., Crystal H., et al. Memory and mental status correlates of modified Braak staging. Neurobiol. Aging. 20(6):1999;573-579
22. Hardy J.A. An anatomical cascade hypothesis for Alzheimer's disease. Trends Neurosci. 15:1992;200-201
23. Hardy J.A., Higgins G.A. Alzheimer's disease: the amyloid cascade hypothesis. Science. 256(5054):1992;184-185
24. He Y., Duyckaerts C., Delaere P., Piette F., Hauw J.J. Alzheimer's lesions labelled by anti-ubiquitin antibodies: comparison with other staining techniques. A study of 15 cases with graded intellectual status in ageing and Alzheimer's disease. Neuropathol. Appl. Neurobiol. 19(4):1993;364-371
25. Lamy C., Duyckaerts C., Delaere P., Payan C., Fermanian J., Poulain V., et al. Comparison of 7 staining methods for senile plaques and neurofibrillary tangles in a prospective series of 15 elderly patients. Neuropathol. Appl. Neurobiol. 15:1989;563-578
26. Magistretti P.J., Morrison J.H. Noradrenaline- and vasoactive intestinal peptide-containing neuronal systems in neocortex: functional convergence with contrasting morphology. Neuroscience. 24:1988;367-378
27. Masliah E., Terry R. The role of synaptic proteins in the pathogenesis of disorders of the central nervous system. Brain Pathol. 3(1):1993;77-85
28. Morris J.C. The challenge of characterizing normal brain aging in relation to Alzheimer's disease. Neurobiol. Aging. 18(4):1997;388-389
29. Morris J.C., Mckeel D.W., Storandt M., Rubin E.H., Price J.L., Grant E.A., et al. Very mild Alzheimer's disease - informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology. 41:1991;469-478
30. Morris J.C., Storandt M., Mckeel D.W., Rubin E.H., Price J.L., Grant E.A., et al. Cerebral amyloid deposition and diffuse plaques in "normal" aging: evidence for presymptomatic and very mild Alzheimer's disease. Neurology. 46(3):1996;707-719
31. Ohm T.G., Braak E., Braak H. A competition between silver-stain and immunocytochemistry. Neural Transm (P-D Sect). 1:1989;111
32. Ohm T.G., Muller H., Braak H., Bohl J. Close-meshed prevalence rates of different stages as a tool to uncover the rate of Alzheimer's disease-related neurofibrillary changes. Neuroscience. 64(1):1995;209-217
33. Pigino G., Pelsman A., Mori H., Busciglio J. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J. Neurosci. 21(3):2001;834-842
34. Price JL. Tangles and plaques in healthy aging and Alzheimer's disease: independence or interaction. Semin Neurosci 1994;(395-402):402.
35. Price J.L., Davis P.B., Morris J.C., White D.L. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol. Aging. 12(4):1991;295-312
36. Price J.L., Morris J.C. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann. Neurol. 45(3):1999;358-368
37. Rosenwald A., Reusche E., Ogomori K., Teichert H.M. Comparison of silver-stainings and immunohistology for the detection of neurofibrillary tangles and extracellular cerebral amyloid in paraffin sections. Acta Neuropathol. (Berl). 86(2):1993;182-186
38. Rub U., Del Tredici K., Schultz C., Thal D.R., Braak E., Braak H. The evolution of Alzheimer's disease-related cytoskeletal pathology in the human raphe nuclei. Neuropathol. Appl. Neurobiol. 26(6):2000;553-567
39. Sassin I., Schultz C., Thal D.R., Rub U., Arai K., Braak E., et al. Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert. Acta Neuropathol. (Berl). 100(3):2000;259-269
40. Seress L. Interspecies comparison of the hippocampal formation shows increased emphasis on the regio superior in the Ammon's horn of the human brain. J. Hirnforsch. 29(3):1988;335-340
41. Smith M.A., Siedlak S.L., Richey P.L., Mulvihill P., Ghiso J., Frangione B., et al. Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease. Nat. Med. 1(4):1995;365-369
42. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., et al. Physical basis of cognitive alterations in Alzheimer's disease - synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30:1991;572-580
43. Uboga N.V., Price J.L. Formation of diffuse and fibrillar tangles in aging and early Alzheimer's disease. Neurobiol. Aging. 21(1):2000;1-10
44. van Hoesen G.W., Hyman B.T. Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease. Prog. Brain Res. 83:1990;445-457
45. Wegiel J., Bobinski M., Tarnawski M., Dziewiatkowski J., Popovitch E., Miller D.C., et al. Fibrillar amyloid-beta affects neurofibrillary changes but only in neurons already involved in neurofibrillary degeneration. Acta Neuropathol. (Berl). 101(6):2001;585-590