Inhibition of Proliferation and Induction of Autophagy by Atorvastatin in PC3 Prostate Cancer Cells Correlate with Downregulation of Bcl2 and Upregulation of miR-182 and p21

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Peng, Xinjian ^a   Li, Wenping ^a   Yuan, Liang ^a   Mehta, Rajendra G ^a   Kopelovich, Levy ^b   McCormick, David L ^a  

^a IIT RESEARCH INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; GERANYLGERANIOL; MICRORNA 182; PEPTIDES AND PROTEINS; PROTEIN BCL 2; PROTEIN LC3 II; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MICROARRAY ANALYSIS; PROSTATE CANCER; PROTEIN EXPRESSION; PROTO ONCOGENE; UPREGULATION;

AUTOPHAGY; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DITERPENES; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPTANOIC ACIDS; HUMANS; MALE; MICRORNAS; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; UP-REGULATION;

EID: 84881011767     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070442     Document Type: Article

References (45)

1. Roth EM, McKenney JM, Hanotin C, Asset G, Stein EA, (2012) Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med 367: 1891-900.
2. Reboulleau A, Robert V, Vedie B, Doublet A, Grynberg A, et al. (2012) Involvement of cholesterol efflux pathway in the control of cardiomyocytes cholesterol homeostasis. J Mol Cell Cardiol 53: 196-205.
3. Roy M, Kung HJ, Ghosh P, (2011) Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. Am J Cancer Res 1: 542-561.
4. Zheng X, Cui XX, Gao Z, Zhao Y, Shi Y, et al. (2011) Inhibitory effect of dietary atorvastatin and celecoxib together with voluntary running wheel exercise on the progression of androgen-dependent LNCaP prostate tumors to androgen independence. Exp Ther Med 2: 221-228.
5. Zhang Y, Zang T, (2012) Association between statin usage and prostate cancer prevention: a refined meta-analysis based on literature from the years 2005-2010. Urol Int 90: 259-262.
6. Bansal D, Undela K, D'Cruz S, Schifano F, (2012) Statin use and risk of prostate cancer: a meta-analysis of observational studies. PLoS One 7: e46691.
7. Platz EA, Leitzmann MF, Visvanathan K, Rimm EB, Stampfer MJ, et al. (2006) Statin drugs and risk of advanced prostate cancer. J Natl Cancer Inst 98: 1819-1825.
8. Zheng X, Cui XX, Gao Z, Zhao Y, Lin Y, et al. (2010) Atorvastatin and celecoxib in combination inhibits the progression of androgen-dependent LNCaP xenograft prostate tumors to androgen independence. Cancer Prev Res 3: 114-124.
9. Toepfer N, Childress C, Parikh A, Rukstalis D, Yang W, (2011) Atorvastatin induces autophagy in prostate cancer PC3 cells through activation of LC3 transcription. Cancer Biol Ther 12: 691-699.
10. Sassano A, Platanias LC, (2008) Statins in tumor suppression. Cancer Lett 260: 11-19.
11. Garcia-Ruiz C, Morales A, Fernandez-Checa JC, (2012) Statins and protein prenylation in cancer cell biology and therapy. Anticancer Agents Med Chem 12: 303-315.
12. Li X, Li X, Wang J, Ye Z, Li JC, (2012) Oridonin up-regulates expression of p21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci 8: 901-912.
13. Lages E, Ipas H, Guttin A, Nesr H, Berger F, et al. (2012) MicroRNAs: molecular features and role in cancer. Front Biosci 17: 2508-2540.
14. Zhu S, Si ML, Wu H, Mo YY, (2007) MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). J Biol Chem 282: 14328-14336.
15. Filipowicz W, Bhattacharyya SN, Sonenberg N, (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet 9: 102-114.
16. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, et al. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070.
17. Nguyen HC, Xie W, Yang M, Hsieh CL, Drouin S, et al. (2012) Expression differences of circulating microRNAs in metastatic castration resistant prostate cancer and low-risk, localized prostate cancer. Prostate 73: 346-354.
18. Davis C, Ross SA, (2008) Evidence for dietary regulation of microRNA in cancer cells. Nutrition Rev 66: 477-482.
19. Schoof CR, Botelho EL, Izzotti A, Vasques Ldos R, (2012) MicroRNAs in cancer treatment and prognosis. Am J Cancer Res 2: 414-433.
20. Yan D, Dong XD, Chen X, Yao S, Wang L, et al. (2012) Role of MicroRNA-182 in Posterior Uveal Melanoma: Regulation of Tumor Development through MITF, BCL2 and Cyclin D2. PLoS One 7: e40967.
21. Le XF, Almeida MI, Mao W, Spizzo R, Rossi S, et al. (2012) Modulation of MicroRNA-194 and Cell Migration by HER2-Targeting Trastuzumab in Breast Cancer. PLoS One 7: e41170.
22. Ware JH, Zhou Z, Guan J, Kennedy AR, Kopelovich L, (2007) Establishment of human cancer cell clones with different characteristics: a model for screening chemopreventive agents. Anticancer Res 27: 1-16.
23. Peng X, Tiwari N, Roy S, Yuan L, Murillo G, et al. (2012) Regulation of CYP24 splicing by 1,25-dihydroxyvitamin D3 in human colon cancer cells. J Endocrinol 212: 207-215.
24. Peng X, Mehta R, Wang S, Chellappan S, Mehta RG, (2006) Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells. Cancer Res 66: 7361-7369.
25. Peng X, Vaishnav A, Murillo G, Alimirah F, Torres KE, et al. (2010) Protection against cellular stress by 25-hydroxyvitamin D3 in breast epithelial cells. J Cell Biochem 110: 1324-1333.
26. Ichimura Y, Imamura Y, Emoto K, Umeda M, Noda T, et al. (2004) In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagy. J Biol Chem 279: 40584-40592.
27. Tanida I, Ueno T, Kominami E, (2004) LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 36: 2503-2518.
28. Zhang M, Jiang M, Bi Y, Zhu H, Zhou Z, et al. (2012) Autophagy and apoptosis act as partners to induce germ cell death after heat stress in mice. PLoS One 7: e41412.
29. Marino ML, Pellegrini P, Di Lernia G, Djavaheri-Mergny M, Brnjic S, et al. (2012) Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem 287: 30664-30676.
30. Hu W, Feng Z, Levine AJ, (2012) The Regulation of Multiple p53 Stress Responses is Mediated through MDM2. Genes Cancer 3: 199-208.
31. Neilsen CT, Goodall GJ, Bracken CP, (2012) IsomiRs- the overlooked repertoire in the dynamic microRNAome. Trends Genet 28: 544-549.
32. Mihelich BL, Khramtsova EA, Arva N, Vaishnav A, Johnson DN, et al. (2011) miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells. J Biol Chem 286: 44503-44511.
33. Schaefer A, Jung M, Mollenkopf HJ, Wagner I, Stephan C, et al. (2010) Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int J Cancer 126: 1166-1176.
34. Guttilla IK, White BA, (2009) Coordinate regulation of FOXO1 by miR-27a, miR-96, and miR-182 in breast cancer cells. J Biol Chem 284: 23204-23216.
35. Kong WQ, Bai R, Liu T, Cai CL, Liu M, et al. (2012) MicroRNA-182 targets cAMP-responsive element-binding protein 1 and suppresses cell growth in human gastric adenocarcinoma. FEBS J 279: 1252-1260.
36. Sun Y, Fang R, Li C, Li L, Li F, et al. (2010) Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro. Biochem Biophys Res Commun 396: 501-507.
37. Zhang L, Liu T, Huang Y, Liu J, (2011) microRNA-182 inhibits the proliferation and invasion of human lung adenocarcinoma cells through its effect on human cortical actin-associated protein. Int J Mol Med 28: 381-388.
38. Rasheed SA, Teo CR, Beillard EJ, Voorhoeve M, Casey PJ, (2013) MicroRNA-182 and microRNA-200a control G-protein subunit alpha-13 (GNA13) expression and cell invasion synergistically in prostate cancer cells. J Biol Chem 288: 7986-7995.
39. Li G, Luna C, Qiu J, Epstein DL, Gonzalez P, (2009) Alterations in microRNA expression in stress-induced cellular senescence. Mech Ageing Dev 130: 731-741.
40. Wang M, Tan W, Zhou J, Leow J, Go M, et al. (2008) A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. J Biol Chem 283: 18678-18684.
41. Kim KM, Park SJ, Jung SH, Kim EJ, Jogeswar G, et al. (2012) miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Miner Res 27: 1669-1679.
42. Alvarez-Díaz S, Valle N, Ferrer-Mayorga G, Lombardía L, Herrera M, et al. (2012) MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells. Hum Mol Genet 21: 2157-2165.
43. Shi Z, Ruvkun G, (2012) The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A 109: 4568-4573.
44. Li M, Liu Y, Shi H, Zhang Y, Wang G, et al. (2012) Statins inhibit pulmonary artery smooth muscle cell proliferation by upregulation of HO-1 and p21(WAF1). Naunyn Schmiedebergs Arch Pharmacol 385: 961-968.
45. Lin YC, Lin JH, Chou CW, Chang YF, Yeh SH, et al. (2008) Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res 68: 2375-2383.