Prohibitin is a novel target gene of vitamin D involved in its antiproliferative action in breast cancer cells

Cancer Research

Volumn 66, Issue 14, 2006, Pages 7361-7369

  Peng, Xinjian ^a   Mehta, Rajeshwari ^b   Wang, Sheng ^c   Chellappan, Srikumar ^d   Mehta, Rajendra G ^a  

^a ILLINOIS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1ALPHA HYDROXYVITAMIN D5; BROXURIDINE; CYTOCHROME P450; RETINOID X RECEPTOR; TETRACYCLINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VITAMIN D DERIVATIVE; VITAMIN D RECEPTOR;

ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STRAIN MCF 7; CELLULAR DISTRIBUTION; COMPUTER MODEL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG INHIBITION; GENE; GENE LOCATION; GENE OVEREXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROHIBITIN GENE; PROMOTER REGION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA TRANSLATION; TRANSACTIVATION; UPREGULATION; WESTERN BLOTTING;

BASE SEQUENCE; BREAST NEOPLASMS; BROMODEOXYURIDINE; CELL LINE, TUMOR; CELL NUCLEUS; HUMANS; HYDROXYCHOLECALCIFEROLS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; RNA INTERFERENCE; S PHASE; STEROID HYDROXYLASES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 33746913034     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1004     Document Type: Article

References (42)

1. 5. J Natl Cancer Inst 1997;89:212-8.
2. Mehta RG. Stage-specific inhibition of mammary carcinogenesis by 1α-hydroxyvitamin D5. Eur J Cancer 2004;40:2331-7.
3. 5) in breast cancer prevention and therapy. Recent Results Cancer Res 2003;164:393-411.
4. 5. J Natl Cancer Inst 2000;92:1836-40.
5. Hussain EA, Peng X, Mehta RR, Mehta RG. Growth inhibition of carcinogen-transformed MCF-12F breast epithelial cells and hormone-sensitive BT-474 breast cancer cells by 1α-hydroxyvitamin D5. Carcinogenesis 2006;27:551-9.
6. Sato T, Saito H, Swensen J, et al. The human prohibitin gene located on chromosome 17q21 is mutated in sporadic breast cancer. Cancer Res 1992;52:1643-6.
7. Coates PJ, Nenutil R, McGregor A, et al. Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. Exp Cell Res 2000;265:262-73.
8. Nijtmans LG, Artal SM, Grivell LA, Coates PJ. The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing, and degenerative disease. Cell Mol Life Sci 2002;59:143-55.
9. Nijtmans LG, de Jong L, Artal Sanz M, et al. Prohibitins act as a membrane-bound chaperone for the stabilization of mitochondrial proteins. EMBO J 2000;19:2444-51.
10. Mishra S, Murphy LC, Nyomba BL, Murphy LJ. Prohibitin: a potential target for new therapeutics. Trends Mol Med 2005;11:192-7.
11. Nuell MJ, Stewart DA, Walker L, et al. Prohibitin, an evolutionarily conserved intracellular protein that blocks DNA synthesis in normal fibroblasts and HeLa cells. Mol Cell Biol 1991;11:1372-81.
12. Fusaro G, Dasgupta P, Rastogi S, Joshi B, Chellappan S. Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling. J Biol Chem 2003;278:47853-61.
13. Gamble SC, Odontiadis M, Waxman J, et al. Androgens target prohibitin to regulate proliferation of prostate cancer cells. Oncogene 2004;23:2996-3004.
14. Thompson WE, Asselin E, Branch A, et al. Regulation of prohibitin expression during follicular development and atresia in the mammalian ovary. Biol Reprod 2004;71:282-90.
15. Wang S, Nath N, Fusaro G, Chellappan S. Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals. Mol Cell Biol 1999;19:7447-60.
16. Wang S, Nath N, Adlam M, Chellappan S. Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function. Oncogene 1999;18:3501-10.
17. Wang S, Fusaro G, Padmanabhan J, Chellappan S. Prohibitin co-localizes with Rb in the nucleus and recruits N-CoR and HDAC1 for transcriptional repression. Oncogene 2002;21:8388-96.
18. Wang KJ, Wang RT, Zhang JZ. Identification of tumor markers using two-dimensional electrophoresis in gastric carcinoma. World J Gastroenterol 2004;10:2179-83.
19. Asamoto M, Cohen SM. Prohibitin gene is overexpressed but not mutated in rat bladder carcinomas and cell lines. Cancer Lett 1994;83:201-7.
20. Shan L. cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo 4,5-β-pyridine and 7,12-dimethylbenz-α-anthracene. Carcinogenesis 2002;23:1561-8.
21. Menssen A, Hermeking H. Characterization of the c-MYC-regulated transcriptome by SAGE: identification and analysis of c-MYC target genes. Proc Natl Acad Sci USA 2002;99:6274-9.
22. Haggerty TJ, Zeller KI, Osthus RC, Wonsey DR, Dang CV. A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites. Proc Natl Acad Sci U S A 2003;100:5313-8.
23. Rajalingam K, Wunder C, Brinkmann V, et al. Prohibitin is required for Ras-induced Raf-MEK-ERK activation and epithelial cell migration. Nat Cell Biol 2005;7:837-43.
24. Peng X, Maruo T, Cao Y, et al. A novel RARβ isoform directed by a distinct promoter P3 and mediated by retinoic acid in breast cancer cells. Cancer Res 2004;64:8911-8.
25. Peng X, Wood S, Bratescu L, Shilkaitis A, Christov K. Retinoids suppress premalignant MCF10AT but not malignant MCF10CA1a breast epithelial cells in vivo. Role of retinoic acid receptor β2 expression. Cancer Lett 2005;222:153-63.
26. Quandt K, Frech K, Karas H, Wingender E, Werner T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res 1995;23:4878-84.
27. Messeguer X, Escudero R, Farré D, Nuñez O. PROMO: detection of known transcription regulatory elements using species-tailored searches. Bioinformatics 2002;18:333-4.
28. 3 activates Raf kinase and Raf perinuclear translocation via a protein kinase C-dependent pathway. J Biol Chem 1993;268:25132-8.
29. 3-stimulated Egr induction. J Biol Chem 1995;270:3642-7.
30. Sinkkonen L, Malinen M, Saavalainen K, Vaisanen S, Carlberg C. Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter. Nucleic Acids Res 2005;33:2440-51.
31. 3 responding gene. J Cell Biochem 2000;77:75-81.
32. 0-arrested cells. Mech Ageing Dev 2002;123:287-95.
33. Thompson WE, Ramalho-Santos J, Sutovsky P. Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control. Biol Reprod 2003;69:254-60.
34. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med 2004;10:625-32.
35. Wang S, Zhang B, Faller DV. Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. EMBO J 2002;21:3019-28.
36. Bacher S, Achatz G, Schmitz ML, Lamers MC. Prohibitin and prohibitone are contained in high-molecular weight complexes and interact with α-actinin and annexin A2. Biochimie 2002;84:1207-20.
37. Chou PY, Fasman GD. Empirical predictions of protein conformation. Annu Rev Biochem 1978;47:251-76.
38. Garnier J, Osguthorpe DJ, Robson B. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J Mol Biol 1978;120:97-120.
39. Wang S, Zhang B, Faller DV. BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists. EMBO J 2004;23:2293-303.
40. 3 suppresses the androgen-stimulated growth of mouse mammary carcinoma SC-3 cells by transcriptional repression of fibroblast growth factor 8. J Cell Physiol 2006;207:793-9.
41. Crescioli C, Ferruzzi P, Caporali A, et al. Inhibition of spontaneous and androgen-induced prostate growth by a nonhypercalcemic calcitriol analog. Endocrinology 2003;144:3046-57.
42. 3. J Biol Chem 2005;280:37319-30.