ADME characterization in rats revealed immediate secretion of AZD7903 into the stomach after IV dosing

Xenobiotica

Volumn 43, Issue 9, 2013, Pages 823-835

  Haglund, J ^a   Borg, N ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Active transport; ADME; Disposition; Excretion; Metabolism; Sex differences

Indexed keywords

(4) 1 [(2) 3 (3,4 DICHLOROPHENYL)PROP 2 EN 1 YL] 2H,5H SPIRO[IMIDAZOLIDINE 4,3' INDOLE] 2,2',5 (1'H) TRIONE; AZD 7903; UNCLASSIFIED DRUG; VANILLOID RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; BILE DUCT; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG HALF LIFE; DRUG METABOLISM; FEMALE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; QUANTITATIVE ANALYSIS; RADIOACTIVITY; RAT; STEADY STATE; STOMACH SECRETION; WHOLE BODY AUTORADIOGRAPHY;

ABSORPTION; ADMINISTRATION, INTRAVENOUS; ANIMALS; FEMALE; HYDANTOINS; INDOLES; KINETICS; MALE; RATS; SEX FACTORS; STOMACH; TRPV CATION CHANNELS;

EID: 84881006142     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.767951     Document Type: Article

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