Acute toxicity of some synthetic cyanogens in rats: Time-dependent cyanide generation and cytochrome oxidase inhibition in soft tissues after sub-lethal oral intoxication

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 595-609

  Rao, Pooja ^a   Singh, Poonam ^a   Yadav, Shiv Kumar ^a   Gujar, Niranjan L ^a   Bhattacharya, Rahul ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Cyanogenesis; Cyanogens; Cytochrome oxidase inhibition; Thiocyanate

Indexed keywords

ACETONITRILE; ACRYLONITRILE; CHEMICAL COMPOUND; CYANIDE; CYANOGEN; CYTOCHROME C OXIDASE; MALONONITRILE; NITROPRUSSIDE SODIUM; PROPIONITRILE; SUCCINONITRILE; THIOCYANATE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; LETHAL DOSE; NONHUMAN; RAT; SOFT TISSUE; SURVIVAL TIME; TOXICITY TESTING; URINE LEVEL;

ACETONITRILE; ACN; ACRYLONITRILE; ATCN; CENTRAL NERVOUS SYSTEM; CNS; CYANOGENESIS; CYANOGENS; CYP; CYTOCHROME OXIDASE; CYTOCHROME OXIDASE INHIBITION; CYTOCHROME P450; CYTOX; MALONONITRILE; MCN; PCN; PROPIONITRILE; SCN; SNP; SODIUM NITROPRUSSIDE; SUCCINONITRILE; THIOCYANATE;

ADMINISTRATION, ORAL; ANIMALS; BIOTRANSFORMATION; CYANIDES; ELECTRON TRANSPORT COMPLEX IV; ENZYME INHIBITORS; FEMALE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; KAPLAN-MEIER ESTIMATE; LETHAL DOSE 50; NITRILES; NITROPRUSSIDE; RANDOM ALLOCATION; RATS; RATS, WISTAR; THIOCYANATES; TISSUE DISTRIBUTION; TOXICITY TESTS, ACUTE; VASODILATOR AGENTS;

EID: 84880976553     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.06.035     Document Type: Article

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