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Volumn 149, Issue 1, 2013, Pages 86-96

Pam3CSK4 enhanced beta cell loss and diabetogenesis: The roles of IFN-gamma and IL-17

Author keywords

Apoptosis; Autoimmunity; Proinflammatory cytokines; Subdiabetogenic dose

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; PAM 3CSK 4; STREPTOZOCIN; TOLL LIKE RECEPTOR AGONIST; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84880956826     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2013.06.001     Document Type: Article
Times cited : (5)

References (46)
  • 1
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
    • Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., Akira S. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 1999, 11:443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 2
    • 33750803442 scopus 로고    scopus 로고
    • Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production
    • Fujimoto C., Yu C.R., Shi G., Vistica B.P., Wawrousek E.F., Klinman D.M., Chan C.C., Egwuagu C.E., Gery I. Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production. J. Immunol. 2006, 177:6896-6903.
    • (2006) J. Immunol. , vol.177 , pp. 6896-6903
    • Fujimoto, C.1    Yu, C.R.2    Shi, G.3    Vistica, B.P.4    Wawrousek, E.F.5    Klinman, D.M.6    Chan, C.C.7    Egwuagu, C.E.8    Gery, I.9
  • 3
    • 0036839577 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors, Implications for regulating inflammatory and immune responses
    • Ber A.A. Endogenous ligands of Toll-like receptors, Implications for regulating inflammatory and immune responses. Trends Immunol. 2002, 23:509-512.
    • (2002) Trends Immunol. , vol.23 , pp. 509-512
    • Ber, A.A.1
  • 4
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • Akira S. Mammalian Toll-like receptors. Curr. Opin. Immunol. 2003, 15:5-11.
    • (2003) Curr. Opin. Immunol. , vol.15 , pp. 5-11
    • Akira, S.1
  • 5
    • 4444249701 scopus 로고    scopus 로고
    • Toll-like receptors and their role in the development of autoimmune diseases
    • Toubi E., Shoenfeld Y. Toll-like receptors and their role in the development of autoimmune diseases. Autoimmunity 2004, 37:183-186.
    • (2004) Autoimmunity , vol.37 , pp. 183-186
    • Toubi, E.1    Shoenfeld, Y.2
  • 6
    • 20444393509 scopus 로고    scopus 로고
    • TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells
    • Patel M., Xu D., Kewin P., Choo-Kang B., McSharry C., Thomson N.C., Liew F.Y. TLR2 agonist ameliorates established allergic airway inflammation by promoting Th1 response and not via regulatory T cells. J. Immunol. 2005, 1742:7558-7563.
    • (2005) J. Immunol. , vol.1742 , pp. 7558-7563
    • Patel, M.1    Xu, D.2    Kewin, P.3    Choo-Kang, B.4    McSharry, C.5    Thomson, N.C.6    Liew, F.Y.7
  • 11
    • 2442680510 scopus 로고    scopus 로고
    • Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin
    • Friesen N.T.E., Buchau A.S., Schott-Ohly P., Lgssiar A., Gleichmann H. Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. Diabetologia 2004, 47:676-685.
    • (2004) Diabetologia , vol.47 , pp. 676-685
    • Friesen, N.T.E.1    Buchau, A.S.2    Schott-Ohly, P.3    Lgssiar, A.4    Gleichmann, H.5
  • 12
    • 0036700969 scopus 로고    scopus 로고
    • Streptozotocin upregulates GAD67 expression in MIN6N8a mouse beta cells
    • Chol S.E., Noh H.L., Kim H.M., Yoon J.W., Kang Y. Streptozotocin upregulates GAD67 expression in MIN6N8a mouse beta cells. J. Autoimmun. 2002, 19:1-8.
    • (2002) J. Autoimmun. , vol.19 , pp. 1-8
    • Chol, S.E.1    Noh, H.L.2    Kim, H.M.3    Yoon, J.W.4    Kang, Y.5
  • 13
    • 30944455075 scopus 로고    scopus 로고
    • IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin
    • Mensah-Brown E.P.K., Shahin A., Al-Shamisi M., Wei X., Lukic M.L. IL-23 leads to diabetes induction after subdiabetogenic treatment with multiple low doses of streptozotocin. Eur. J. Immunol. 2006, 36:216-223.
    • (2006) Eur. J. Immunol. , vol.36 , pp. 216-223
    • Mensah-Brown, E.P.K.1    Shahin, A.2    Al-Shamisi, M.3    Wei, X.4    Lukic, M.L.5
  • 14
    • 0242492516 scopus 로고    scopus 로고
    • Lack of the mediators of innate immunity attenuates the development of autoimmune diabetes in mice
    • Lukic M.L., Mensah-Brown E., Wei X., Shahin A., Liew F.Y. Lack of the mediators of innate immunity attenuates the development of autoimmune diabetes in mice. J. Autoimmun. 2003, 21:239-246.
    • (2003) J. Autoimmun. , vol.21 , pp. 239-246
    • Lukic, M.L.1    Mensah-Brown, E.2    Wei, X.3    Shahin, A.4    Liew, F.Y.5
  • 15
    • 0041820127 scopus 로고    scopus 로고
    • Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes
    • Lamhamedi-Cherradi S.E., Zheng S., Tisch R.M., Chen Y.H. Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes. Diabetes 2003, 52:2274-2278.
    • (2003) Diabetes , vol.52 , pp. 2274-2278
    • Lamhamedi-Cherradi, S.E.1    Zheng, S.2    Tisch, R.M.3    Chen, Y.H.4
  • 16
    • 0042977338 scopus 로고    scopus 로고
    • Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin, prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct
    • Nicoletti F., Di Marco R., Papaccio G., Conget I., Gomis R., Bernadini R., Sims J.E., Shoenfeld Y., Bendtzen K. Essential pathogenic role of endogenous IL-18 in murine diabetes induced by multiple low doses of streptozotocin, prevention of hyperglycemia and insulitis by a recombinant IL-18-binding protein: Fc construct. Eur. J. Immunol. 2003, 33:2278-2286.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2278-2286
    • Nicoletti, F.1    Di Marco, R.2    Papaccio, G.3    Conget, I.4    Gomis, R.5    Bernadini, R.6    Sims, J.E.7    Shoenfeld, Y.8    Bendtzen, K.9
  • 17
    • 0035865053 scopus 로고    scopus 로고
    • Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent
    • Pechhold K., Patterson N.B., Blum C., Fleischacker C.L., Boehm B.O., Harlan D.M. Low dose streptozotocin-induced diabetes in rat insulin promoter-mCD80-transgenic mice is T cell autoantigen-specific and CD28 dependent. J. Immunol. 2001, 166:2531-2539.
    • (2001) J. Immunol. , vol.166 , pp. 2531-2539
    • Pechhold, K.1    Patterson, N.B.2    Blum, C.3    Fleischacker, C.L.4    Boehm, B.O.5    Harlan, D.M.6
  • 18
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae S., Komiyama Y., Nambu A., Sudo K., Iwase M., Homma I., Sekikawa K., Asano M., Iwakura Y. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 2002, 17:375-387.
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1    Komiyama, Y.2    Nambu, A.3    Sudo, K.4    Iwase, M.5    Homma, I.6    Sekikawa, K.7    Asano, M.8    Iwakura, Y.9
  • 19
    • 0014042613 scopus 로고
    • Method of isolation of intact islets of Langerhans from the rat pancreas
    • Lacy P.E., Kostianovsky M. Method of isolation of intact islets of Langerhans from the rat pancreas. Diabetes 1967, 16:35-39.
    • (1967) Diabetes , vol.16 , pp. 35-39
    • Lacy, P.E.1    Kostianovsky, M.2
  • 20
    • 0016209124 scopus 로고
    • The preparation of, and studies on, free cell suspensions from mouse pancreatic islets
    • Lernmark A. The preparation of, and studies on, free cell suspensions from mouse pancreatic islets. Diabetologia 1974, 10:431-438.
    • (1974) Diabetologia , vol.10 , pp. 431-438
    • Lernmark, A.1
  • 25
    • 0031686176 scopus 로고    scopus 로고
    • Effector mechanisms in low-dose streptozotocin-induced diabetes
    • Lukic M., Stosic-Grujicic S., Shahin A. Effector mechanisms in low-dose streptozotocin-induced diabetes. Dev. Immunol. 1998, 6:119-128.
    • (1998) Dev. Immunol. , vol.6 , pp. 119-128
    • Lukic, M.1    Stosic-Grujicic, S.2    Shahin, A.3
  • 27
    • 0345358584 scopus 로고    scopus 로고
    • The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
    • Trinchieri G., Pflanz S., Kastelein R.A. The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses. Immunity 2003, 19:641-644.
    • (2003) Immunity , vol.19 , pp. 641-644
    • Trinchieri, G.1    Pflanz, S.2    Kastelein, R.A.3
  • 28
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 2003, 3:133-146.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133-146
    • Trinchieri, G.1
  • 29
    • 10244260369 scopus 로고    scopus 로고
    • Immune cells, pancreas development, regeneration and type 1diabetes
    • Homo-Delarche F., Drexhage H.A. Immune cells, pancreas development, regeneration and type 1diabetes. Trends Immunol. 2004, 25:222-229.
    • (2004) Trends Immunol. , vol.25 , pp. 222-229
    • Homo-Delarche, F.1    Drexhage, H.A.2
  • 31
    • 4644287379 scopus 로고    scopus 로고
    • Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expression of? CD154 on the pancreatic β-cells
    • Haase C., Skak K., Michelsen B.K., Markholst H. Local activation of dendritic cells leads to insulitis and development of insulin-dependent diabetes in transgenic mice expression of? CD154 on the pancreatic β-cells. Diabetes 2004, 53:2588-2595.
    • (2004) Diabetes , vol.53 , pp. 2588-2595
    • Haase, C.1    Skak, K.2    Michelsen, B.K.3    Markholst, H.4
  • 32
    • 2942692039 scopus 로고    scopus 로고
    • +T cells, expanded with dendritic cells presenting a single autoantigen peptide, suppress autoimmune diabetes
    • +T cells, expanded with dendritic cells presenting a single autoantigen peptide, suppress autoimmune diabetes. J. Exp. Med. 2004, 199:1467-1477.
    • (2004) J. Exp. Med. , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 33
    • 8444245925 scopus 로고    scopus 로고
    • Toll-dependent control mechanisms of CD4 T cell activation
    • Pasare C., Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004, 21:733-741.
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medzhitov, R.2
  • 34
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 2005, 6:345-352.
    • (2005) Nat. Immunol. , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 35
    • 33746189406 scopus 로고    scopus 로고
    • FOXP3 and NFAT: partners in tolerance
    • Rudensky A.Y., Gavin M., Zheng Y. FOXP3 and NFAT: partners in tolerance. Cell 2006, 126:253-256.
    • (2006) Cell , vol.126 , pp. 253-256
    • Rudensky, A.Y.1    Gavin, M.2    Zheng, Y.3
  • 36
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 37
    • 10844252294 scopus 로고    scopus 로고
    • + regulatory cell activation and function by dendritic cells
    • + regulatory cell activation and function by dendritic cells. Int. Immunol. 2004, 16:1769-1780.
    • (2004) Int. Immunol. , vol.16 , pp. 1769-1780
    • Fehervari, Z.1    Sakaguchi, S.2
  • 38
    • 32844469349 scopus 로고    scopus 로고
    • + T regulatory cells: crosstalk between two professionals in immunity versus tolerance
    • + T regulatory cells: crosstalk between two professionals in immunity versus tolerance. Front. Biosci. 2006, 11:1360-1370.
    • (2006) Front. Biosci. , vol.11 , pp. 1360-1370
    • Chen, W.1
  • 39
    • 0036888372 scopus 로고    scopus 로고
    • Cytokines: promoters and dampeners of autoimmunity
    • Hill N., Sarvetnick N. Cytokines: promoters and dampeners of autoimmunity. Curr. Opin. Immunol. 2002, 14:791-797.
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 791-797
    • Hill, N.1    Sarvetnick, N.2
  • 40
    • 0035004613 scopus 로고    scopus 로고
    • Dual role of interferon-gamma signaling pathway in sensitivity of pancreatic beta cells to immune destruction
    • Gysemans C.A., Pavlovic D., Bouillon R., Eizirik D.L., Mathieu C. Dual role of interferon-gamma signaling pathway in sensitivity of pancreatic beta cells to immune destruction. Diabetologia 2001, 44:567-574.
    • (2001) Diabetologia , vol.44 , pp. 567-574
    • Gysemans, C.A.1    Pavlovic, D.2    Bouillon, R.3    Eizirik, D.L.4    Mathieu, C.5
  • 42
    • 23644437526 scopus 로고    scopus 로고
    • Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β cells
    • Gysemans C.A., Ladriere L., Callewaert H., Rasschaert J., Flamez D., Levy D.E., Matthys P., Eizirik D.L., Mathieu C. Disruption of the γ-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of β cells. Diabetes 2005, 54:2396-2403.
    • (2005) Diabetes , vol.54 , pp. 2396-2403
    • Gysemans, C.A.1    Ladriere, L.2    Callewaert, H.3    Rasschaert, J.4    Flamez, D.5    Levy, D.E.6    Matthys, P.7    Eizirik, D.L.8    Mathieu, C.9
  • 44
    • 23044454798 scopus 로고    scopus 로고
    • Expression and function of toll-like receptor on T cells
    • Xu D., Komai-Koma M., Liew F.Y. Expression and function of toll-like receptor on T cells. Cell. Immunol. 2005, 233:85-89.
    • (2005) Cell. Immunol. , vol.233 , pp. 85-89
    • Xu, D.1    Komai-Koma, M.2    Liew, F.Y.3
  • 45
    • 56149125346 scopus 로고    scopus 로고
    • Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis
    • O'Connor R.A., Prendergast C.T., Sabatos C.A., Lau C.W., Leech M.D., Wraith D.C., Anderton S.M. Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis. J. Immunol. 2008, 181:3750-3754.
    • (2008) J. Immunol. , vol.181 , pp. 3750-3754
    • O'Connor, R.A.1    Prendergast, C.T.2    Sabatos, C.A.3    Lau, C.W.4    Leech, M.D.5    Wraith, D.C.6    Anderton, S.M.7
  • 46
    • 57149129697 scopus 로고    scopus 로고
    • Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice
    • Mensah-Brown E.P.K., Al Rabesi Z., Shahin A., Al Shamsi M., Arsenijevic N., Hsu D.K., Liu F.T., Lukic M.L. Targeted disruption of the galectin-3 gene results in decreased susceptibility to multiple low dose streptozotocin-induced diabetes in mice. Clin. Immunol. 2009, 130:83-88.
    • (2009) Clin. Immunol. , vol.130 , pp. 83-88
    • Mensah-Brown, E.P.K.1    Al Rabesi, Z.2    Shahin, A.3    Al Shamsi, M.4    Arsenijevic, N.5    Hsu, D.K.6    Liu, F.T.7    Lukic, M.L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.