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Volumn 1293, Issue 1, 2013, Pages 18-24

Functional genomics lead to new therapies in follicular lymphoma

Author keywords

Genomic data; Mouse model; Therapies

Indexed keywords

EPHRIN RECEPTOR A7;

EID: 84880930644     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12120     Document Type: Article
Times cited : (4)

References (70)
  • 1
    • 80155148301 scopus 로고    scopus 로고
    • The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma
    • Oricchio, E. et al. 2011. The Eph-receptor A7 is a soluble tumor suppressor for follicular lymphoma. Cell 147: 554-564.
    • (2011) Cell , vol.147 , pp. 554-564
    • Oricchio, E.1
  • 2
    • 77249119762 scopus 로고    scopus 로고
    • The landscape of somatic copy-number alteration across human cancers
    • Beroukhim, R. et al. 2010. The landscape of somatic copy-number alteration across human cancers. Nature 463: 899-905.
    • (2010) Nature , vol.463 , pp. 899-905
    • Beroukhim, R.1
  • 3
    • 6944244084 scopus 로고    scopus 로고
    • A module map showing conditional activity of expression modules in cancer
    • Segal, E., N. Friedman, D. Koller & A. Regev. 2004. A module map showing conditional activity of expression modules in cancer. Nat. Genet. 36: 1090-1098.
    • (2004) Nat. Genet. , vol.36 , pp. 1090-1098
    • Segal, E.1    Friedman, N.2    Koller, D.3    Regev, A.4
  • 4
    • 83255165727 scopus 로고    scopus 로고
    • High order chromatin architecture shapes the landscape of chromosomal alterations in cancer
    • Fudenberg, G., G. Getz, M. Meyerson & L.A. Mirny. 2011. High order chromatin architecture shapes the landscape of chromosomal alterations in cancer. Nat. Biotechnol. 29: 1109-1113.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 1109-1113
    • Fudenberg, G.1    Getz, G.2    Meyerson, M.3    Mirny, L.A.4
  • 5
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D. & R.A. Weinberg. 2011. Hallmarks of cancer: the next generation. Cell 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch, J.S. et al. 2012. The origin and evolution of mutations in acute myeloid leukemia. Cell 150: 264-278.
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1
  • 7
    • 70349454058 scopus 로고    scopus 로고
    • Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
    • Bric, A. et al. 2009. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell 16: 324-335.
    • (2009) Cancer Cell , vol.16 , pp. 324-335
    • Bric, A.1
  • 8
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • Ngo, V.N. et al. 2006. A loss-of-function RNA interference screen for molecular targets in cancer. Nature 441: 106-110.
    • (2006) Nature , vol.441 , pp. 106-110
    • Ngo, V.N.1
  • 9
    • 77950518606 scopus 로고    scopus 로고
    • Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia
    • Mavrakis, K.J. et al. 2010. Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia. Nat. Cell Biol. 12: 372-379.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 372-379
    • Mavrakis, K.J.1
  • 10
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber, J. et al. 2011. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature 478: 524-528.
    • (2011) Nature , vol.478 , pp. 524-528
    • Zuber, J.1
  • 11
    • 56349121125 scopus 로고    scopus 로고
    • An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
    • Zender, L. et al. 2008. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell 135: 852-864.
    • (2008) Cell , vol.135 , pp. 852-864
    • Zender, L.1
  • 12
    • 1542283724 scopus 로고    scopus 로고
    • VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia
    • Egle, A., A.W. Harris, M.L. Bath, et al. 2004. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood 103: 2276-2283.
    • (2004) Blood , vol.103 , pp. 2276-2283
    • Egle, A.1    Harris, A.W.2    Bath, M.L.3
  • 13
    • 1642586272 scopus 로고    scopus 로고
    • Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
    • Wendel, H.G. et al. 2004. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428: 332-337.
    • (2004) Nature , vol.428 , pp. 332-337
    • Wendel, H.G.1
  • 14
    • 80054845323 scopus 로고    scopus 로고
    • Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma
    • Schatz, J.H. et al. 2011. Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma. J. Exp. Med. 208: 1799-1807.
    • (2011) J. Exp. Med. , vol.208 , pp. 1799-1807
    • Schatz, J.H.1
  • 15
    • 0023854161 scopus 로고
    • The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells
    • Harris, A.W. et al. 1988. The E mu-myc transgenic mouse. A model for high-incidence spontaneous lymphoma and leukemia of early B cells. J. Exp. Med. 167: 353-371.
    • (1988) J. Exp. Med. , vol.167 , pp. 353-371
    • Harris, A.W.1
  • 16
    • 19344368745 scopus 로고    scopus 로고
    • Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice
    • Cattoretti, G. et al. 2005. Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice. Cancer Cell 7: 445-455.
    • (2005) Cancer Cell , vol.7 , pp. 445-455
    • Cattoretti, G.1
  • 17
    • 33244481730 scopus 로고    scopus 로고
    • Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma
    • Gladden, A.B., R. Woolery, P. Aggarwal, et al. 2006. Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphoma. Oncogene 25: 998-1007.
    • (2006) Oncogene , vol.25 , pp. 998-1007
    • Gladden, A.B.1    Woolery, R.2    Aggarwal, P.3
  • 18
    • 0021821903 scopus 로고
    • Involvement of the bcl-2 gene in human follicular lymphoma
    • Tsujimoto, Y., J. Cossman, E. Jaffe & C.M. Croce. 1985. Involvement of the bcl-2 gene in human follicular lymphoma. Science 228: 1440-1443.
    • (1985) Science , vol.228 , pp. 1440-1443
    • Tsujimoto, Y.1    Cossman, J.2    Jaffe, E.3    Croce, C.M.4
  • 20
    • 8644252736 scopus 로고    scopus 로고
    • Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells
    • Dave, S.S. et al. 2004. Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N. Engl. J. Med. 351, 2159-2169.
    • (2004) N. Engl. J. Med. , vol.351 , pp. 2159-2169
    • Dave, S.S.1
  • 21
    • 0038724269 scopus 로고    scopus 로고
    • Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations
    • Martinez-Climent, J.A. et al. 2003. Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations. Blood 101: 3109-3117.
    • (2003) Blood , vol.101 , pp. 3109-3117
    • Martinez-Climent, J.A.1
  • 22
    • 0027422990 scopus 로고
    • p53 mutations are associated with histologic transformation of follicular lymphoma
    • Lo Coco, F. et al. 1993. p53 mutations are associated with histologic transformation of follicular lymphoma. Blood 82: 2289-2295.
    • (1993) Blood , vol.82 , pp. 2289-2295
    • Lo Coco, F.1
  • 23
    • 36249017414 scopus 로고    scopus 로고
    • Molecular cytogenetic analysis of follicular lymphoma (FL) provides detailed characterization of chromosomal instability associated with the t(14;18)(q32;q21) positive and negative subsets and histologic progression
    • Nanjangud, G. et al. 2007. Molecular cytogenetic analysis of follicular lymphoma (FL) provides detailed characterization of chromosomal instability associated with the t(14;18)(q32;q21) positive and negative subsets and histologic progression. Cytogenet. Genome Res. 118: 337-344.
    • (2007) Cytogenet. Genome Res. , vol.118 , pp. 337-344
    • Nanjangud, G.1
  • 24
    • 59449095253 scopus 로고    scopus 로고
    • Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances
    • Cheung, K.J. et al. 2009. Genome-wide profiling of follicular lymphoma by array comparative genomic hybridization reveals prognostically significant DNA copy number imbalances. Blood 113: 137-148.
    • (2009) Blood , vol.113 , pp. 137-148
    • Cheung, K.J.1
  • 25
    • 0035169514 scopus 로고    scopus 로고
    • Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patients with follicular lymphoma with a low tumor burden: clinical and molecular evaluation
    • Colombat, P. et al. 2001. Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patients with follicular lymphoma with a low tumor burden: clinical and molecular evaluation. Blood 97: 101-106.
    • (2001) Blood , vol.97 , pp. 101-106
    • Colombat, P.1
  • 26
    • 84861409254 scopus 로고    scopus 로고
    • Anti-CD20 antibody therapy for B-cell lymphomas
    • Maloney, D.G. 2012. Anti-CD20 antibody therapy for B-cell lymphomas. N. Engl. J. Med. 366: 2008-2016.
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2008-2016
    • Maloney, D.G.1
  • 27
    • 33745877121 scopus 로고    scopus 로고
    • Follicular lymphoma international prognostic index
    • Solal-Celigny, P. 2006. Follicular lymphoma international prognostic index. Curr. Treat. Options Oncol. 7: 270-275.
    • (2006) Curr. Treat. Options Oncol. , vol.7 , pp. 270-275
    • Solal-Celigny, P.1
  • 28
    • 70349745593 scopus 로고    scopus 로고
    • Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project
    • Federico, M. et al. 2009. Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project. J. Clin. Oncol. 27: 4555-4562.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4555-4562
    • Federico, M.1
  • 29
    • 80052029516 scopus 로고    scopus 로고
    • Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
    • Morin, R.D. et al. 2011. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature 476: 298-303.
    • (2011) Nature , vol.476 , pp. 298-303
    • Morin, R.D.1
  • 30
    • 79952167230 scopus 로고    scopus 로고
    • Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
    • Yap, D.B. et al. 2011. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 117: 2451-2459.
    • (2011) Blood , vol.117 , pp. 2451-2459
    • Yap, D.B.1
  • 31
    • 83555173561 scopus 로고    scopus 로고
    • Combined genetic inactivation of beta2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma
    • Challa-Malladi, M. et al. 2011. Combined genetic inactivation of beta2-Microglobulin and CD58 reveals frequent escape from immune recognition in diffuse large B cell lymphoma. Cancer Cell 20: 728-740.
    • (2011) Cancer Cell , vol.20 , pp. 728-740
    • Challa-Malladi, M.1
  • 32
    • 73849145729 scopus 로고    scopus 로고
    • Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
    • Davis, R.E. et al. 2010. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature 463: 88-92.
    • (2010) Nature , vol.463 , pp. 88-92
    • Davis, R.E.1
  • 33
    • 0023105238 scopus 로고
    • Multiple recurrent genomic defects in follicular lymphoma: a possible model for cancer
    • Yunis, J.J. et al. 1987.Multiple recurrent genomic defects in follicular lymphoma: a possible model for cancer. N. Engl. J. Med. 316: 79-84.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 79-84
    • Yunis, J.J.1
  • 34
    • 66649127621 scopus 로고    scopus 로고
    • Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    • Compagno, M. et al. 2009. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature 459: 717-721.
    • (2009) Nature , vol.459 , pp. 717-721
    • Compagno, M.1
  • 35
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B-cell lymphomas
    • Kato, M. et al. 2009. Frequent inactivation of A20 in B-cell lymphomas. Nature 459: 712-716.
    • (2009) Nature , vol.459 , pp. 712-716
    • Kato, M.1
  • 36
    • 78650004237 scopus 로고    scopus 로고
    • BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma
    • Mandelbaum, J. et al. 2010. BLIMP1 is a tumor suppressor gene frequently disrupted in activated B cell-like diffuse large B cell lymphoma. Cancer Cell 18: 568-579.
    • (2010) Cancer Cell , vol.18 , pp. 568-579
    • Mandelbaum, J.1
  • 37
    • 34250813682 scopus 로고    scopus 로고
    • Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas
    • Dawson, D.W. et al. 2007. Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas. Oncogene 26: 4243-4252.
    • (2007) Oncogene , vol.26 , pp. 4243-4252
    • Dawson, D.W.1
  • 38
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: bidirectional signalling and beyond
    • Pasquale, E.B. 2010. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat. Rev. Cancer 10: 165-180.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 165-180
    • Pasquale, E.B.1
  • 39
    • 41149084179 scopus 로고    scopus 로고
    • Eph-ephrin bidirectional signaling in physiology and disease
    • Pasquale, E.B. 2008. Eph-ephrin bidirectional signaling in physiology and disease. Cell 133: 38-52.
    • (2008) Cell , vol.133 , pp. 38-52
    • Pasquale, E.B.1
  • 40
    • 21744443473 scopus 로고    scopus 로고
    • Ephrin signalling controls brain size by regulating apoptosis of neural progenitors
    • Depaepe, V. et al. 2005. Ephrin signalling controls brain size by regulating apoptosis of neural progenitors. Nature 435: 1244-1250.
    • (2005) Nature , vol.435 , pp. 1244-1250
    • Depaepe, V.1
  • 41
    • 21544467294 scopus 로고    scopus 로고
    • Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system
    • Rashid, T. et al. 2005. Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system. Neuron 47: 57-69.
    • (2005) Neuron , vol.47 , pp. 57-69
    • Rashid, T.1
  • 42
    • 0034626791 scopus 로고    scopus 로고
    • Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
    • Holmberg, J., D.L. Clarke & J. Frisen. 2000. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature 408: 203-206.
    • (2000) Nature , vol.408 , pp. 203-206
    • Holmberg, J.1    Clarke, D.L.2    Frisen, J.3
  • 43
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein, I.B. 2002. Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297: 63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 44
    • 33846899456 scopus 로고    scopus 로고
    • Restoration of p53 function leads to tumour regression in vivo
    • Ventura, A. et al. 2007. Restoration of p53 function leads to tumour regression in vivo. Nature 445: 661-665.
    • (2007) Nature , vol.445 , pp. 661-665
    • Ventura, A.1
  • 45
    • 61449182121 scopus 로고    scopus 로고
    • Principles of cancer therapy: oncogene and non-oncogene addiction
    • Luo, J., N.L. Solimini & S.J. Elledge. 2009. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136: 823-837.
    • (2009) Cell , vol.136 , pp. 823-837
    • Luo, J.1    Solimini, N.L.2    Elledge, S.J.3
  • 46
    • 24644498612 scopus 로고    scopus 로고
    • Downregulation of EphA7 by hypermethylation in colorectal cancer
    • Wang, J. et al. 2005. Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene 24: 5637-5647.
    • (2005) Oncogene , vol.24 , pp. 5637-5647
    • Wang, J.1
  • 47
    • 77950591484 scopus 로고    scopus 로고
    • Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia
    • Kuang, S.Q. et al. 2010. Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia. Blood 115: 2412-2419.
    • (2010) Blood , vol.115 , pp. 2412-2419
    • Kuang, S.Q.1
  • 48
    • 58149402919 scopus 로고    scopus 로고
    • Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features
    • Guan, M., C. Xu, F. Zhang & C. Ye. 2009. Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. Int. J. Cancer 124: 88-94.
    • (2009) Int. J. Cancer , vol.124 , pp. 88-94
    • Guan, M.1    Xu, C.2    Zhang, F.3    Ye, C.4
  • 49
    • 77955090106 scopus 로고    scopus 로고
    • Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy
    • Barretina, J. et al. 2010. Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat. Genet. 42: 715-721.
    • (2010) Nat. Genet. , vol.42 , pp. 715-721
    • Barretina, J.1
  • 50
    • 84866851740 scopus 로고    scopus 로고
    • Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
    • Peifer, M. et al. 2012. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat. Genet. 44: 1104-1110.
    • (2012) Nat. Genet. , vol.44 , pp. 1104-1110
    • Peifer, M.1
  • 51
    • 80052158097 scopus 로고    scopus 로고
    • The mutational landscape of head and neck squamous cell carcinoma
    • Stransky, N. et al. 2011. The mutational landscape of head and neck squamous cell carcinoma. Science 333: 1157-1160.
    • (2011) Science , vol.333 , pp. 1157-1160
    • Stransky, N.1
  • 52
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • Hodis, E. et al. 2012. A landscape of driver mutations in melanoma. Cell 150: 251-263.
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, E.1
  • 53
    • 84866410479 scopus 로고    scopus 로고
    • Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing
    • Imielinski, M. et al. 2012. Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell 150: 1107-1120.
    • (2012) Cell , vol.150 , pp. 1107-1120
    • Imielinski, M.1
  • 54
    • 84863723010 scopus 로고    scopus 로고
    • The mutational landscape of lethal castration-resistant prostate cancer
    • Grasso, C.S. et al. 2012. The mutational landscape of lethal castration-resistant prostate cancer. Nature 487: 239-243.
    • (2012) Nature , vol.487 , pp. 239-243
    • Grasso, C.S.1
  • 55
    • 84866849548 scopus 로고    scopus 로고
    • Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
    • Rudin, C.M. et al. 2012. Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat. Genet. 44: 1111-1116.
    • (2012) Nat. Genet. , vol.44 , pp. 1111-1116
    • Rudin, C.M.1
  • 56
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker, B.J. et al. 2001. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344: 1031-1037.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1031-1037
    • Druker, B.J.1
  • 57
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • Poulikakos, P.I., C. Zhang, G. Bollag, et al. 2010. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 464: 427-430.
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3
  • 58
    • 33845444046 scopus 로고    scopus 로고
    • Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia
    • Druker, B.J. et al. 2006. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355: 2408-2417.
    • (2006) N. Engl. J. Med. , vol.355 , pp. 2408-2417
    • Druker, B.J.1
  • 59
    • 84863651163 scopus 로고    scopus 로고
    • Combinatorial drug therapy for cancer in the post-genomic era
    • Al-Lazikani, B., U. Banerji & P. Workman. 2012. Combinatorial drug therapy for cancer in the post-genomic era. Nat. Biotechnol. 30: 679-692.
    • (2012) Nat. Biotechnol. , vol.30 , pp. 679-692
    • Al-Lazikani, B.1    Banerji, U.2    Workman, P.3
  • 60
    • 84863720872 scopus 로고    scopus 로고
    • A tumour suppressor network relying on the polyamine-hypusine axis
    • Scuoppo, C. et al. 2012. A tumour suppressor network relying on the polyamine-hypusine axis. Nature 487: 244-248.
    • (2012) Nature , vol.487 , pp. 244-248
    • Scuoppo, C.1
  • 61
    • 84863541457 scopus 로고    scopus 로고
    • Recurrent hemizygous deletions in cancers may optimize proliferative potential
    • Solimini, N.L. et al. 2012. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science 337: 104-109.
    • (2012) Science , vol.337 , pp. 104-109
    • Solimini, N.L.1
  • 62
    • 84865227709 scopus 로고    scopus 로고
    • Cancer vulnerabilities unveiled by genomic loss
    • Nijhawan, D. et al. 2012. Cancer vulnerabilities unveiled by genomic loss. Cell 150: 842-854.
    • (2012) Cell , vol.150 , pp. 842-854
    • Nijhawan, D.1
  • 63
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding, L., G. Getz, D.A. Wheeler, et al. 2008. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3
  • 64
    • 84865459654 scopus 로고    scopus 로고
    • Recurrent R-spondin fusions in colon cancer
    • Seshagiri, S., E.W. Stawiski, S. Durinck, et al. 2012. Recurrent R-spondin fusions in colon cancer. Nature 488: 660-664.
    • (2012) Nature , vol.488 , pp. 660-664
    • Seshagiri, S.1    Stawiski, E.W.2    Durinck, S.3
  • 65
    • 84864444165 scopus 로고    scopus 로고
    • Novel mutations target distinct subgroups of medulloblastoma
    • Robinson, G., M. Parker, T.A. Kranenburg, et al. 2012. Novel mutations target distinct subgroups of medulloblastoma. Nature 488: 43-48.
    • (2012) Nature , vol.488 , pp. 43-48
    • Robinson, G.1    Parker, M.2    Kranenburg, T.A.3
  • 66
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens, P.J., P.S. Tarpey, H. Davies, et al. 2012. The landscape of cancer genes and mutational processes in breast cancer. Nature 486: 400-404.
    • (2012) Nature , vol.486 , pp. 400-404
    • Stephens, P.J.1    Tarpey, P.S.2    Davies, H.3
  • 67
    • 84655176646 scopus 로고    scopus 로고
    • Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
    • Guo, G., Y. Gui, S. Gao, et al. 2011. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat. Genet. 44: 17-19.
    • (2011) Nat. Genet , vol.44 , pp. 17-19
    • Guo, G.1    Gui, Y.2    Gao, S.3
  • 68
    • 84862523863 scopus 로고    scopus 로고
    • Sequence analysis of mutations and translocations across breast cancer subtypes
    • Banerji, S., K. Cibulskis, C. Rangel-Escareno, et al. 2012. Sequence analysis of mutations and translocations across breast cancer subtypes. Nature 486: 405-409.
    • (2012) Nature , vol.486 , pp. 405-409
    • Banerji, S.1    Cibulskis, K.2    Rangel-Escareno, C.3
  • 69
    • 84861581164 scopus 로고    scopus 로고
    • Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
    • Barbieri, C.E., S.C. Baca, M.S. Lawrence, et al. 2012. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer. Nat. Genet. 44: 685-689.
    • (2012) Nat. Genet , vol.44 , pp. 685-689
    • Barbieri, C.E.1    Baca, S.C.2    Lawrence, M.S.3
  • 70
    • 84864419974 scopus 로고    scopus 로고
    • Dissecting the genomic complexity underlying medulloblastoma
    • Jones, D.T., N. Jäger, M. Kool, et al. 2012. Dissecting the genomic complexity underlying medulloblastoma. Nature 488: 100-105.
    • (2012) Nature , vol.488 , pp. 100-105
    • Jones, D.T.1    Jäger, N.2    Kool, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.