-
1
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008, 112(13):4808-17.
-
(2008)
Blood
, vol.112
, Issue.13
, pp. 4808-4817
-
-
Druker, B.J.1
-
2
-
-
9244222261
-
Targeted cancer therapy
-
Sawyers C. Targeted cancer therapy. Nature 2004, 432:294-297.
-
(2004)
Nature
, vol.432
, pp. 294-297
-
-
Sawyers, C.1
-
3
-
-
2442517439
-
Targeting targeted therapy
-
Green MR. Targeting targeted therapy. New England J Med 2004, 350:2191-2193.
-
(2004)
New England J Med
, vol.350
, pp. 2191-2193
-
-
Green, M.R.1
-
4
-
-
3543037572
-
Molecularly targeted therapy: have the floodgates opened?
-
Druker BJ. Molecularly targeted therapy: have the floodgates opened?. Oncologist 2004, 9:357-360.
-
(2004)
Oncologist
, vol.9
, pp. 357-360
-
-
Druker, B.J.1
-
6
-
-
24944497371
-
Features of selective kinase inhibitors
-
Knight ZA, Shokat KM. Features of selective kinase inhibitors. Chem Biol 2005, 12(6):621-637.
-
(2005)
Chem Biol
, vol.12
, Issue.6
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
-
7
-
-
67651006061
-
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions
-
Sos ML, et al. Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest 2009, 119(6):1727-1740.
-
(2009)
J Clin Invest
, vol.119
, Issue.6
, pp. 1727-1740
-
-
Sos, M.L.1
-
8
-
-
79960435101
-
Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer
-
Molinari F, Felicioni L, Buscarino M, De Dosso S, Buttitta F, Malatesta S, Movilia A, Luoni M, Boldorini R, Alabiso O, Girlando S, Soini B, Spitale A, Di Nicolantonio F, Saletti P, Crippa S, Mazzucchelli L, Marchetti A, Bardelli A, Frattini M. Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer. Clin Cancer Res 2011, 17(14):4901-4914.
-
(2011)
Clin Cancer Res
, vol.17
, Issue.14
, pp. 4901-4914
-
-
Molinari, F.1
Felicioni, L.2
Buscarino, M.3
De Dosso, S.4
Buttitta, F.5
Malatesta, S.6
Movilia, A.7
Luoni, M.8
Boldorini, R.9
Alabiso, O.10
Girlando, S.11
Soini, B.12
Spitale, A.13
Di Nicolantonio, F.14
Saletti, P.15
Crippa, S.16
Mazzucchelli, L.17
Marchetti, A.18
Bardelli, A.19
Frattini, M.20
more..
-
9
-
-
0035845531
-
Chemosensitivity prediction by transcriptional profiling
-
Staunton JE, et al. Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci 2001, 98:10787-10792.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 10787-10792
-
-
Staunton, J.E.1
-
10
-
-
34548799629
-
A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
-
Lee JK, Havaleshko DM, Cho H, Weinstein JN, Kaldjian EP, Karpovich J, Grimshaw A, Theodorescu D. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci 2007, 104(32):13086-13091.
-
(2007)
Proc Natl Acad Sci
, vol.104
, Issue.32
, pp. 13086-13091
-
-
Lee, J.K.1
Havaleshko, D.M.2
Cho, H.3
Weinstein, J.N.4
Kaldjian, E.P.5
Karpovich, J.6
Grimshaw, A.7
Theodorescu, D.8
-
11
-
-
78651445374
-
Predicting in vitro drug sensitivity using random forests
-
Riddick G, Song H, Ahn S, Walling J, Borges-Rivera D, Zhang W, Fine HA. Predicting in vitro drug sensitivity using random forests. Bioinformatics 2011, 27(2):220-224.
-
(2011)
Bioinformatics
, vol.27
, Issue.2
, pp. 220-224
-
-
Riddick, G.1
Song, H.2
Ahn, S.3
Walling, J.4
Borges-Rivera, D.5
Zhang, W.6
Fine, H.A.7
-
12
-
-
84881548007
-
Prediction of drug response using genomic signatures from the Cancer Cell Line Encyclopedia
-
Venkatesan K, Stransky N, Margolin A, Reddy A, Raman P, Sonkin D, Jones M, Wilson C, Kim S, Warmuth M, Sellers W, Lehar J, Barretina J, Caponigro G, Garraway L, Morrissey M. Prediction of drug response using genomic signatures from the Cancer Cell Line Encyclopedia. AACR Meet Abstr 2010, 2010:PR2. http://www.aacrmeetingabstracts.org.
-
(2010)
AACR Meet Abstr
, vol.2010
-
-
Venkatesan, K.1
Stransky, N.2
Margolin, A.3
Reddy, A.4
Raman, P.5
Sonkin, D.6
Jones, M.7
Wilson, C.8
Kim, S.9
Warmuth, M.10
Sellers, W.11
Lehar, J.12
Barretina, J.13
Caponigro, G.14
Garraway, L.15
Morrissey, M.16
-
13
-
-
74549168922
-
Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data
-
Mitsos A, Melas IN, Siminelakis P, Chairakaki AD, Saez-Rodriguez J, Alexopoulos LG. Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data. PLoS Comput Biol 2009, 5(12):e1000591+. http://dx.doi.org/10.1371/journal.pcbi.1000591.
-
(2009)
PLoS Comput Biol
, vol.5
, Issue.12
-
-
Mitsos, A.1
Melas, I.N.2
Siminelakis, P.3
Chairakaki, A.D.4
Saez-Rodriguez, J.5
Alexopoulos, L.G.6
-
14
-
-
79954517618
-
Molecular tumor profiling for prediction of response to anticancer therapies
-
Walther Z, Sklar J. Molecular tumor profiling for prediction of response to anticancer therapies. Cancer J 2011, 17(2):71-9.
-
(2011)
Cancer J
, vol.17
, Issue.2
, pp. 71-79
-
-
Walther, Z.1
Sklar, J.2
-
15
-
-
84859169877
-
The cancer cell line encyclopedia enables Predictive modelling of anticancer drug sensitivity
-
Barretina J, et al. The cancer cell line encyclopedia enables Predictive modelling of anticancer drug sensitivity. Nature 2012, 483(7391):603-607. [http://dx.doi.org/10.1038/nature11003].
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 603-607
-
-
Barretina, J.1
-
16
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, Faraoni R, Floyd M, Hunt JP, Lockhart DJ, Milanov ZV, Morrison MJ, Pallares G, Patel HK, Pritchard S, Wodicka LM, Zarrinkar PP. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008, 26:127-132.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
Gallant, P.4
Atteridge, C.E.5
Campbell, B.T.6
Chan, K.W.7
Ciceri, P.8
Davis, M.I.9
Edeen, P.T.10
Faraoni, R.11
Floyd, M.12
Hunt, J.P.13
Lockhart, D.J.14
Milanov, Z.V.15
Morrison, M.J.16
Pallares, G.17
Patel, H.K.18
Pritchard, S.19
Wodicka, L.M.20
Zarrinkar, P.P.21
more..
-
18
-
-
66649137944
-
RNAi screen for rapid therapeutic target identification in leukemia patients
-
Tyner JW, Deininger MW, Loriaux MM, Chang BH, Gotlib JR, Willis SG, Erickson H, Kovacsovics T, O'Hare T, Heinrich MC, Druker BJ. RNAi screen for rapid therapeutic target identification in leukemia patients. Proc Natl Acad Sci U S A 2009, 106(21):8695-8700.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.21
, pp. 8695-8700
-
-
Tyner, J.W.1
Deininger, M.W.2
Loriaux, M.M.3
Chang, B.H.4
Gotlib, J.R.5
Willis, S.G.6
Erickson, H.7
Kovacsovics, T.8
O'Hare, T.9
Heinrich, M.C.10
Druker, B.J.11
-
19
-
-
64249106832
-
Mouse xenograft models vs GEM models for human cancer therapeutics
-
Richmond A, Su Y. Mouse xenograft models vs GEM models for human cancer therapeutics. Dis Model Mech 2008, 1(2-3):78-82.
-
(2008)
Dis Model Mech
, vol.1
, Issue.2-3
, pp. 78-82
-
-
Richmond, A.1
Su, Y.2
-
20
-
-
70449475105
-
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
-
Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B, Karaman MW, Pratz KW, Pallares G, Chao Q, Sprankle KG, Patel HK, Levis M, Armstrong RC, James J, Bhagwat SS. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009, 114(14):2984-2992.
-
(2009)
Blood
, vol.114
, Issue.14
, pp. 2984-2992
-
-
Zarrinkar, P.P.1
Gunawardane, R.N.2
Cramer, M.D.3
Gardner, M.F.4
Brigham, D.5
Belli, B.6
Karaman, M.W.7
Pratz, K.W.8
Pallares, G.9
Chao, Q.10
Sprankle, K.G.11
Patel, H.K.12
Levis, M.13
Armstrong, R.C.14
James, J.15
Bhagwat, S.S.16
-
21
-
-
0027464950
-
P53 abnormalities in different subtypes of human sarcomas
-
Andreassen A, Oyjord T, Hovig E, Holm R, Florenes V, et al. p53 abnormalities in different subtypes of human sarcomas. Cancer Res 1993, 53(3):468-471.
-
(1993)
Cancer Res
, vol.53
, Issue.3
, pp. 468-471
-
-
Andreassen, A.1
Oyjord, T.2
Hovig, E.3
Holm, R.4
Florenes, V.5
-
22
-
-
33846882630
-
Molecular pathogenesis of osteosarcoma
-
Kansara M, Thomas DM. Molecular pathogenesis of osteosarcoma. DNA Cell Biol 2007, 26:1-18.
-
(2007)
DNA Cell Biol
, vol.26
, pp. 1-18
-
-
Kansara, M.1
Thomas, D.M.2
-
23
-
-
0141705379
-
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
-
Overholtzer M, Rao PH, Favis R, Lu XY, Elowitz MB, Barany F, Ladanyi M, Gorlick R, Levine AJ. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proc Natl Acad Sci 2003, 100(20):11547-11552.
-
(2003)
Proc Natl Acad Sci
, vol.100
, Issue.20
, pp. 11547-11552
-
-
Overholtzer, M.1
Rao, P.H.2
Favis, R.3
Lu, X.Y.4
Elowitz, M.B.5
Barany, F.6
Ladanyi, M.7
Gorlick, R.8
Levine, A.J.9
-
24
-
-
0033595635
-
Alteration of pRb/p16/cdk4 regulation in human osteosarcoma
-
Benassi MS, Molendini L, Gamberi G, Ragazzini P, Sollazzo MR, Merli M, Asp J, Magagnoli G, Balladelli A, Bertoni F, Picci P. Alteration of pRb/p16/cdk4 regulation in human osteosarcoma. Int J Cancer 1999, 84(5):489-493.
-
(1999)
Int J Cancer
, vol.84
, Issue.5
, pp. 489-493
-
-
Benassi, M.S.1
Molendini, L.2
Gamberi, G.3
Ragazzini, P.4
Sollazzo, M.R.5
Merli, M.6
Asp, J.7
Magagnoli, G.8
Balladelli, A.9
Bertoni, F.10
Picci, P.11
-
25
-
-
0034045930
-
Involvement of p21Waf1 Cip1 in protein kinase C alpha induced cell cycle progression
-
Besson A, Yong VW. Involvement of p21Waf1 Cip1 in protein kinase C alpha induced cell cycle progression. Mol Cell Biol 2000, 20(13):4580-90.
-
(2000)
Mol Cell Biol
, vol.20
, Issue.13
, pp. 4580-4590
-
-
Besson, A.1
Yong, V.W.2
-
26
-
-
77953364958
-
Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma
-
Shapovalov Y, Benavidez D, Zuch D, Eliseev RA. Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. Int J Cancer 2010, 127:67-76.
-
(2010)
Int J Cancer
, vol.127
, pp. 67-76
-
-
Shapovalov, Y.1
Benavidez, D.2
Zuch, D.3
Eliseev, R.A.4
-
27
-
-
0031780665
-
Ubiquitin, E6-AP, and their role in p53 inactivation
-
Scheffner M. Ubiquitin, E6-AP, and their role in p53 inactivation. Pharmacol Ther 1998, 78(3):129-139.
-
(1998)
Pharmacol Ther
, vol.78
, Issue.3
, pp. 129-139
-
-
Scheffner, M.1
-
28
-
-
0033035897
-
ERK pathway mediates the activation of Cdk2 in IGF1 induced proliferation of human osteosarcoma MG63 cells
-
Zhang W, Lee JC, Kumar S, Gowen M. ERK pathway mediates the activation of Cdk2 in IGF1 induced proliferation of human osteosarcoma MG63 cells. J Bone Miner Res 1999, 14(4):528-535.
-
(1999)
J Bone Miner Res
, vol.14
, Issue.4
, pp. 528-535
-
-
Zhang, W.1
Lee, J.C.2
Kumar, S.3
Gowen, M.4
-
29
-
-
84861333261
-
High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes
-
Choy E, Hornicek F, MacConaill L, Harmon D, Tariq Z, Garraway L, Duan Z. High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes. Cancer 2012, 118(11):2905-2914.
-
(2012)
Cancer
, vol.118
, Issue.11
, pp. 2905-2914
-
-
Choy, E.1
Hornicek, F.2
MacConaill, L.3
Harmon, D.4
Tariq, Z.5
Garraway, L.6
Duan, Z.7
-
30
-
-
24044551995
-
PI3K/Akt/mTOR pathway as a target for cancer therapy
-
Morgensztern D, McLeod H. PI3K/Akt/mTOR pathway as a target for cancer therapy. Anticancer Drugs 2005, 16(8):797-803.
-
(2005)
Anticancer Drugs
, vol.16
, Issue.8
, pp. 797-803
-
-
Morgensztern, D.1
McLeod, H.2
-
31
-
-
0036082913
-
ET1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells
-
Robin P, Boulven I, Desmyter C, Harbon S, Leiber D. ET1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells. Am J Physiol - Cell Physiol 2002, 283:C251-C260.
-
(2002)
Am J Physiol - Cell Physiol
, vol.283
-
-
Robin, P.1
Boulven, I.2
Desmyter, C.3
Harbon, S.4
Leiber, D.5
-
32
-
-
0033982936
-
KEGG: Kyoto Encycolpedia of Genes and Genomes
-
Kanehisa M, Goto S. KEGG: Kyoto Encycolpedia of Genes and Genomes. Nucleic Acids Res 2000, 28:27-30.
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 27-30
-
-
Kanehisa, M.1
Goto, S.2
-
33
-
-
84881549066
-
-
[Library containing dissociation constants of Drugs]., Pubchem
-
Pubchem [Library containing dissociation constants of Drugs]. http://pubchem.ncbi.nlm.nih.gov/, Pubchem.
-
-
-
-
34
-
-
84891424303
-
A Kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs
-
Pal R, Berlow N. A Kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs. Pacific Symposium on Biocomputing 2012, 351-62. http://psb.stanford.edu/psb-online/proceedings/psb12/pal.pdf.
-
(2012)
Pacific Symposium on Biocomputing
, pp. 351-362
-
-
Pal, R.1
Berlow, N.2
-
38
-
-
69349084710
-
Bayesian robustness in the control of gene regulatory networks
-
Pal R, Datta A, Dougherty ER. Bayesian robustness in the control of gene regulatory networks. IEEE Trans Signal Process 2009, 57:3667-3678.
-
(2009)
IEEE Trans Signal Process
, vol.57
, pp. 3667-3678
-
-
Pal, R.1
Datta, A.2
Dougherty, E.R.3
|