Anticancer drug sensitivity analysis: An integrated approach applied to Erlotinib sensitivity prediction in the CCLE database

Proceedings - IEEE International Workshop on Genomic Signal Processing and Statistics

Volumn , Issue , 2012, Pages 9-12

  Pal, Ranadip ^a   Berlow, Noah ^a   Haider, Saad ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNCTIONAL BEHAVIORS; GENERATING FUNCTIONS; INDUSTRY COLLABORATION; INHIBITION PROFILE; INTEGRATED APPROACH; PREDICTION ACCURACY; PREDICTIVE MODELING; SENSITIVITY PREDICTION;

CELL CULTURE; GENE EXPRESSION; SIGNAL PROCESSING;

FORECASTING;

EID: 84877823775     PISSN: 21503001     EISSN: 2150301X     Source Type: Conference Proceeding    
DOI: 10.1109/GENSIPS.2012.6507714     Document Type: Conference Paper

References (7)

1. Jordi Barretina and et al., "The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.," Nature, vol. 483, no. 7391, pp. 603-607, Mar. 2012.
2. Martin L. Sos and et al., "Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.," The Journal of clinical investigation, vol. 119, no. 6, pp. 1727-1740, 2009.
3. Jane E. Staunton and et al., "Chemosensitivity prediction by transcriptional profiling," Proceedings of The National Academy of Sciences, vol. 98, pp. 10787-10792, 2001.
4. R. Pal and N. Berlow, "A kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs," in Pacific Symposium on Biocomputing http://psb.stanford.edu/psbonline/ proceedings/psb12/pal.pdf, 2012, pp. 351-62.
5. Mazen W. Karaman and et al., "A quantitative analysis of kinase inhibitor selectivity.," Nature biotechnology, vol. 26, no. 1, pp. 127-132, January 2008.
6. Patrick P. Zarrinkar and et al., "AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)," Blood, vol. 114, no. 14, pp. 2984-2992, 2009.
7. Broad-Novartis Cancer Cell Line Encyclopedia, "http://www. broadinstitute.org/ccle/home," Genetic and pharmacologic characterization of a large panel of human cancer cell lines.