A kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs

Pacific Symposium on Biocomputing

Volumn , Issue , 2012, Pages 351-362

  Pal, Ranadip ^a   Berlow, Noah ^a  

^a Department of Electrical and Computer Engineering   (United States)

Author keywords

Drug sensitivity prediction; Targeted therapy design

Indexed keywords

CELL CULTURE; DISEASES; DRUG INTERACTIONS; ENZYME INHIBITION; FORECASTING; ONCOLOGY; STATISTICAL TESTS; STOCHASTIC SYSTEMS; TUMORS;

COMBINATION THERAPY; DRUG COMBINATIONS; DRUG SENSITIVITY; KINASE INHIBITORS; OSTEOSARCOMA CELLS; SENSITIVITY PREDICTION; TARGETED CANCER THERAPY; THERAPY DESIGN;

DRUG THERAPY;

ANTINEOPLASTIC AGENT; PROTEIN KINASE INHIBITOR;

ALGORITHM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOLOGY; DOG; DRUG RESISTANCE; HUMAN; MATHEMATICAL PHENOMENA; METABOLISM; MOLECULARLY TARGETED THERAPY; NEOPLASM; OSTEOSARCOMA; STATISTICS; TUMOR CELL LINE;

ALGORITHMS; ANIMALS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; COMPUTATIONAL BIOLOGY; DOGS; DRUG RESISTANCE, NEOPLASM; HUMANS; MATHEMATICAL CONCEPTS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NEOPLASMS; OSTEOSARCOMA; PROTEIN KINASE INHIBITORS; STOCHASTIC PROCESSES;

EID: 84891424303     PISSN: 23356928     EISSN: 23356936     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (14)

1. C. Sawyers, Nature 432, 294 (2004).
2. M. R. Green, New England Journal of Medicine 350:21, 2191 (2004).
3. B. J. Druker, Oncologist 9, 357 (2004).
4. A. Hopkins, J. Mason and J. Overington, Current Opinion in Structural Biology 16, 127 (2006).
5. Z. A. Knight and K. M. Shokat, Chemistry & Biology 12, 621 (2005).
6. G. Manning, D. B. Whyte, R. Martinez, T. Hunter and S. Sudarsanam, Science 298, 1912 (2002).
7. M. W. Karaman, S. Herrgard, D. K. Treiber, P. Gallant, C. E. Atteridge, B. T. Campbell, K. W. Chan, P. Ciceri, M. I. Davis, P. T. Edeen, R. Faraoni, M. Floyd, J. P. Hunt, D. J. Lockhart, Z. V. Milanov, M. J. Morrison, G. Pallares, H. K. Patel, S. Pritchard, L. M. Wodicka and P. P. Zarrinkar, Nature biotechnology 26, 127 (January 2008).
8. Chen, Jianping, Zhang and Xi, Bioinformatics 23, 563 (2007).
9. D. Goldstein and et al., Nat. Rev. Drug Discov. 7, 391 (2008).
10. J. E. Staunton, D. K. Slonim, H. A. Coller, P. Tamayo, M. J. Angelo, J. Park, U. Scherf, J. K. Lee, W. O. Reinhold, J. N. Weinstein, J. P. Mesirov, E. S. Lander and T. R. Golub, Proceedings of The National Academy of Sciences 98, 10787 (2001).
11. J. K. Lee, D. M. Havaleshko, H. Cho, J. N. Weinstein, E. P. Kaldjian, J. Karpovich, A. Grimshaw and D. Theodorescu, Proceedings of the National Academy of Sciences 104, 13086 (August 2007).
12. Z. Szallasi, J. Stelling and V. Periwal, System Modeling in Cell Biology from Concepts to Nuts and Bolts (MIT Press, Cambridge, MA, 2006).
13. M. Karnaugh, Trans. AIEE. pt. I 72, 593 (1953).
14. P. P. Zarrinkar, R. N. Gunawardane, M. D. Cramer, M. F. Gardner, D. Brigham, B. Belli, M. W. Karaman, K. W. Pratz, G. Pallares, Q. Chao, K. G. Sprankle, H. K. Patel, M. Levis, R. C. Armstrong, J. James and S. S. Bhagwat, Blood 114, 2984 (2009).