메뉴 건너뛰기




Volumn 13, Issue 4, 2013, Pages 233-250

Antiplatelet and anticoagulant therapy for atherothrombotic disease: The role of current and emerging agents

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; APIXABAN; ARGATROBAN; ATECEGATRAN METOXIL; ATOPAXAR; BLOOD CLOTTING FACTOR 10A INHIBITOR; CANGRELOR; CLOPIDOGREL; DABIGATRAN; DALTEPARIN; ELINOGREL; ENOXAPARIN; FIBRINOGEN RECEPTOR ANTAGONIST; HIRULOG; LOW MOLECULAR WEIGHT HEPARIN; OTAMIXABAN; PEGNIVACOGIN; PLACEBO; PRASUGREL; RIVAROXABAN; TERUTROBAN; THIENOPYRIDINE DERIVATIVE; THROMBIN INHIBITOR; THROMBOXANE A2; TICAGRELOR; UNINDEXED DRUG; VORAPAXAR; WARFARIN; XIMELAGATRAN;

EID: 84880857957     PISSN: 11753277     EISSN: 1179187X     Source Type: Journal    
DOI: 10.1007/s40256-013-0022-7     Document Type: Review
Times cited : (38)

References (134)
  • 1
    • 79751531393 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2011 update: A report from the American Heart Association
    • 21160056 10.1161/CIR.0b013e3182009701
    • Roger VL, Go AS, Lloyd-Jones DM, et al. Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation. 2011;123(4):e18-209.
    • (2011) Circulation , vol.123 , Issue.4
    • Roger, V.L.1    Go, A.S.2    Lloyd-Jones, D.M.3
  • 2
    • 0034954596 scopus 로고    scopus 로고
    • The P2Y12 receptor as a therapeutic target in cardiovascular disease
    • 11454254 1:CAS:528:DC%2BD3MXkvFWhu7Y%3D 10.1080/09537100120058739
    • Storey RF. The P2Y12 receptor as a therapeutic target in cardiovascular disease. Platelets. 2001;12(4):197-209.
    • (2001) Platelets , vol.12 , Issue.4 , pp. 197-209
    • Storey, R.F.1
  • 3
    • 32044443180 scopus 로고    scopus 로고
    • Atherothrombosis in acute coronary syndromes: Mechanisms, markers, and mediators of vulnerability
    • 16470323
    • Wasserman EJ, Shipley NM. Atherothrombosis in acute coronary syndromes: mechanisms, markers, and mediators of vulnerability. Mt Sinai J Med. 2006;73(1):431-9.
    • (2006) Mt Sinai J Med , vol.73 , Issue.1 , pp. 431-439
    • Wasserman, E.J.1    Shipley, N.M.2
  • 4
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • 18077812 1:CAS:528:DC%2BD2sXhsVemurrL 10.1056/NEJMra071014
    • Davi G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357(24):2482-94.
    • (2007) N Engl J Med , vol.357 , Issue.24 , pp. 2482-2494
    • Davi, G.1    Patrono, C.2
  • 5
    • 85047693299 scopus 로고    scopus 로고
    • Central role of the P2Y12 receptor in platelet activation
    • 14755328 1:CAS:528:DC%2BD2cXhtFSlsrs%3D
    • Dorsam RT, Kunapuli SP. Central role of the P2Y12 receptor in platelet activation. J Clin Investig. 2004;113(3):340-5.
    • (2004) J Clin Investig , vol.113 , Issue.3 , pp. 340-345
    • Dorsam, R.T.1    Kunapuli, S.P.2
  • 6
    • 0035128439 scopus 로고    scopus 로고
    • New anticoagulant drugs
    • 11157644 1:CAS:528:DC%2BD3MXhtlamsrk%3D 10.1378/chest.119.1-suppl.95S
    • Weitz JI, Hirsh J. New anticoagulant drugs. Chest. 2001;119(1 Suppl):95S-107S.
    • (2001) Chest , vol.119 , Issue.1 SUPPL.
    • Weitz, J.I.1    Hirsh, J.2
  • 7
    • 40749118934 scopus 로고    scopus 로고
    • Cell adhesion mechanisms in platelets
    • 18174460 1:CAS:528:DC%2BD1cXit1OlsL4%3D 10.1161/ATVBAHA.107.150474
    • Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol. 2008;28(3):403-12.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , Issue.3 , pp. 403-412
    • Varga-Szabo, D.1    Pleines, I.2    Nieswandt, B.3
  • 8
    • 66049107647 scopus 로고    scopus 로고
    • Platelet receptors and signaling in the dynamics of thrombus formation
    • 19286885 1:CAS:528:DC%2BD1MXntVGqsr8%3D 10.3324/haematol.2008.003178
    • Rivera J, Lozano ML, Navarro-Nunez L, et al. Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica. 2009;94(5):700-11.
    • (2009) Haematologica , vol.94 , Issue.5 , pp. 700-711
    • Rivera, J.1    Lozano, M.L.2    Navarro-Nunez, L.3
  • 9
    • 0030837662 scopus 로고    scopus 로고
    • Randomised double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction. Coumadin Aspirin Reinfarction Study (CARS) Investigators
    • Randomised double-blind trial of fixed low-dose warfarin with aspirin after myocardial infarction. Coumadin Aspirin Reinfarction Study (CARS) Investigators. Lancet. 1997;350(9075):389-96.
    • (1997) Lancet , vol.350 , Issue.9075 , pp. 389-396
  • 10
    • 0037022204 scopus 로고    scopus 로고
    • Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: Primary results of the CHAMP study
    • 11827919 1:CAS:528:DC%2BD38XhslGiurc%3D 10.1161/hc0502.103329
    • Fiore LD, Ezekowitz MD, Brophy MT, et al. Department of Veterans Affairs Cooperative Studies Program Clinical Trial comparing combined warfarin and aspirin with aspirin alone in survivors of acute myocardial infarction: primary results of the CHAMP study. Circulation. 2002;105(5):557-63.
    • (2002) Circulation , vol.105 , Issue.5 , pp. 557-563
    • Fiore, L.D.1    Ezekowitz, M.D.2    Brophy, M.T.3
  • 11
    • 23644443663 scopus 로고    scopus 로고
    • Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: Meta-analysis with estimates of risk and benefit
    • 16103468 1:CAS:528:DC%2BD2MXpvFCisbo%3D 10.7326/0003-4819-143-4- 200508160-00005
    • Rothberg MB, Celestin C, Fiore LD, et al. Warfarin plus aspirin after myocardial infarction or the acute coronary syndrome: meta-analysis with estimates of risk and benefit. Ann Intern Med. 2005;143(4):241-50.
    • (2005) Ann Intern Med , vol.143 , Issue.4 , pp. 241-250
    • Rothberg, M.B.1    Celestin, C.2    Fiore, L.D.3
  • 12
    • 33845606632 scopus 로고    scopus 로고
    • Activation of platelet function through G protein-coupled receptors
    • 17158345 1:CAS:528:DC%2BD28Xht1Ohu77F 10.1161/01.RES.0000251742.71301.16
    • Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res. 2006;99(12):1293-304.
    • (2006) Circ Res , vol.99 , Issue.12 , pp. 1293-1304
    • Offermanns, S.1
  • 13
    • 84867738043 scopus 로고    scopus 로고
    • The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: From aspirin to the present day
    • 23083110 1:CAS:528:DC%2BC38XhvVynt7bF 10.2165/11640880-000000000-00000
    • Angiolillo DJ. The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day. Drugs. 2012;72(16):2087-116.
    • (2012) Drugs , vol.72 , Issue.16 , pp. 2087-2116
    • Angiolillo, D.J.1
  • 14
    • 84864583013 scopus 로고    scopus 로고
    • New directions in antiplatelet therapy
    • 22715450 10.1161/CIRCINTERVENTIONS.111.966176
    • Ferreiro JL, Angiolillo DJ. New directions in antiplatelet therapy. Circ Cardiovasc Interv. 2012;5(3):433-45.
    • (2012) Circ Cardiovasc Interv , vol.5 , Issue.3 , pp. 433-445
    • Ferreiro, J.L.1    Angiolillo, D.J.2
  • 15
    • 0141484537 scopus 로고    scopus 로고
    • Thrombin and platelet activation
    • 12970120 1:CAS:528:DC%2BD3sXotVensLs%3D 10.1378/chest.124.3-suppl.18S
    • Brass LF. Thrombin and platelet activation. Chest. 2003;124(3 Suppl):18S-25S.
    • (2003) Chest , vol.124 , Issue.3 SUPPL.
    • Brass, L.F.1
  • 16
    • 78650034786 scopus 로고    scopus 로고
    • Novel anticoagulants for stroke prevention in atrial fibrillation: Current clinical evidence and future developments
    • 21144965 1:CAS:528:DC%2BC3MXnvV2lsQ%3D%3D 10.1016/j.jacc.2010.09.017
    • Schirmer SH, Baumhakel M, Neuberger HR, et al. Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments. J Am Coll Cardiol. 2010;56(25):2067-76.
    • (2010) J Am Coll Cardiol , vol.56 , Issue.25 , pp. 2067-2076
    • Schirmer, S.H.1    Baumhakel, M.2    Neuberger, H.R.3
  • 17
    • 65349153111 scopus 로고    scopus 로고
    • Blood coagulation: Hemostasis and thrombin regulation
    • 19372317 1:CAS:528:DC%2BD1MXlvV2gt70%3D 10.1213/ane.0b013e31819bcc9c
    • Tanaka KA, Key NS, Levy JH. Blood coagulation: hemostasis and thrombin regulation. Anesth Analg. 2009;108(5):1433-46.
    • (2009) Anesth Analg , vol.108 , Issue.5 , pp. 1433-1446
    • Tanaka, K.A.1    Key, N.S.2    Levy, J.H.3
  • 18
    • 67651171598 scopus 로고    scopus 로고
    • New antithrombotic agents: Are they needed and what can they offer to patients with a non-ST-elevation acute coronary syndrome?
    • 19491132 10.1093/eurheartj/ehp230 1:CAS:528:DC%2BD1MXptVCjtL0%3D
    • Van de Werf F. New antithrombotic agents: are they needed and what can they offer to patients with a non-ST-elevation acute coronary syndrome? Eur Heart J. 2009;30(14):1695-702.
    • (2009) Eur Heart J , vol.30 , Issue.14 , pp. 1695-1702
    • Van De Werf, F.1
  • 19
    • 0036660207 scopus 로고    scopus 로고
    • Thrombin functions during tissue factor-induced blood coagulation
    • 12070020 1:CAS:528:DC%2BD38XltF2rsLk%3D 10.1182/blood.V100.1.148
    • Brummel KE, Paradis SG, Butenas S, et al. Thrombin functions during tissue factor-induced blood coagulation. Blood. 2002;100(1):148-52.
    • (2002) Blood , vol.100 , Issue.1 , pp. 148-152
    • Brummel, K.E.1    Paradis, S.G.2    Butenas, S.3
  • 20
    • 28344436780 scopus 로고    scopus 로고
    • Protease-activated receptors in hemostasis, thrombosis and vascular biology
    • 16102047 1:CAS:528:DC%2BD2MXpsFKjs7w%3D 10.1111/j.1538-7836.2005.01377.x
    • Coughlin SR. Protease-activated receptors in hemostasis, thrombosis and vascular biology. J Thromb Haemost. 2005;3(8):1800-14.
    • (2005) J Thromb Haemost , vol.3 , Issue.8 , pp. 1800-1814
    • Coughlin, S.R.1
  • 21
    • 60249101860 scopus 로고    scopus 로고
    • Emergence of new oral antithrombotics: A critical appraisal of their clinical potential
    • 19337550 1:CAS:528:DC%2BD1MXjtlWgt7s%3D
    • Lassen MR, Laux V. Emergence of new oral antithrombotics: a critical appraisal of their clinical potential. Vasc Health Risk Manag. 2008;4(6):1373-86.
    • (2008) Vasc Health Risk Manag , vol.4 , Issue.6 , pp. 1373-1386
    • Lassen, M.R.1    Laux, V.2
  • 22
    • 0141707881 scopus 로고    scopus 로고
    • Thrombin formation
    • 12970118 1:CAS:528:DC%2BD3sXotVensL0%3D 10.1378/chest.124.3-suppl.4S
    • Mann KG. Thrombin formation. Chest. 2003;124(3 Suppl):4S-10S.
    • (2003) Chest , vol.124 , Issue.3 SUPPL.
    • Mann, K.G.1
  • 23
    • 0037065502 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
    • Antithrombotic Trialists' Collaboration 10.1136/bmj.324.7329.71
    • Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324(7329):71-86.
    • (2002) BMJ , vol.324 , Issue.7329 , pp. 71-86
  • 24
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • 19717846 1:CAS:528:DC%2BD1MXhtFaltL%2FJ 10.1056/NEJMoa0904327
    • Wallentin L, Becker RC, Budaj A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045-57.
    • (2009) N Engl J Med , vol.361 , Issue.11 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3
  • 25
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • 17982182 1:CAS:528:DC%2BD2sXhtlWis7rN 10.1056/NEJMoa0706482
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001-15.
    • (2007) N Engl J Med , vol.357 , Issue.20 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 26
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • 11519503 1:CAS:528:DC%2BD3MXms1arsrY%3D 10.1056/NEJMoa010746
    • Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7):494-502.
    • (2001) N Engl J Med , vol.345 , Issue.7 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3
  • 27
    • 78649857680 scopus 로고    scopus 로고
    • Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis
    • 20930120 1:CAS:528:DC%2BC3cXhtl2ktrjP 10.1073/pnas.1013309107
    • Cornelissen I, Palmer D, David T, et al. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis. Proc Natl Acad Sci USA. 2010;107(43):18605-10.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.43 , pp. 18605-18610
    • Cornelissen, I.1    Palmer, D.2    David, T.3
  • 28
    • 8144222110 scopus 로고    scopus 로고
    • Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy
    • 15505105 10.1161/01.CIR.0000146341.63677.3C 1:CAS:528: DC%2BD2cXptVejsro%3D
    • Gruner S, Prostredna M, Aktas B, et al. Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy. Circulation. 2004;110(18):2946-51.
    • (2004) Circulation , vol.110 , Issue.18 , pp. 2946-2951
    • Gruner, S.1    Prostredna, M.2    Aktas, B.3
  • 29
    • 77649207179 scopus 로고    scopus 로고
    • A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques
    • 20223370 1:CAS:528:DC%2BC3cXkvVeiu78%3D 10.1016/j.jacc.2009.11.051
    • Reininger AJ, Bernlochner I, Penz SM, et al. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol. 2010;55(11):1147-58.
    • (2010) J Am Coll Cardiol , vol.55 , Issue.11 , pp. 1147-1158
    • Reininger, A.J.1    Bernlochner, I.2    Penz, S.M.3
  • 30
    • 79955108369 scopus 로고    scopus 로고
    • Optimizing platelet inhibition in clopidogrel poor metabolizers: Therapeutic options and practical considerations
    • 21511220 10.1016/j.jcin.2011.03.001
    • Angiolillo DJ, Ueno M. Optimizing platelet inhibition in clopidogrel poor metabolizers: therapeutic options and practical considerations. JACC Cardiovasc Interv. 2011;4(4):411-4.
    • (2011) JACC Cardiovasc Interv , vol.4 , Issue.4 , pp. 411-414
    • Angiolillo, D.J.1    Ueno, M.2
  • 31
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials
    • 19482214 10.1016/S0140-6736(09)60503-1 1:CAS:528:DC%2BD1MXmsFyhsro%3D
    • Baigent C, Blackwell L, Collins R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373(9678):1849- 60.
    • (2009) Lancet , vol.373 , Issue.9678 , pp. 1849-1860
    • Baigent, C.1    Blackwell, L.2    Collins, R.3
  • 32
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • 16908769 10.1161/CIRCULATIONAHA.106.612812
    • Eikelboom JW, Mehta SR, Anand SS, et al. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation. 2006;114(8):774-82.
    • (2006) Circulation , vol.114 , Issue.8 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3
  • 33
    • 34547801673 scopus 로고    scopus 로고
    • Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes
    • 17456480 10.1093/eurheartj/ehm019
    • Rao SV, Eikelboom JA, Granger CB, et al. Bleeding and blood transfusion issues in patients with non-ST-segment elevation acute coronary syndromes. Eur Heart J. 2007;28(10):1193-204.
    • (2007) Eur Heart J , vol.28 , Issue.10 , pp. 1193-1204
    • Rao, S.V.1    Eikelboom, J.A.2    Granger, C.B.3
  • 34
    • 0035895332 scopus 로고    scopus 로고
    • Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: A meta-analysis of phase III multicenter randomized trials
    • 11208677 1:CAS:528:DC%2BD3MXhtFajsb8%3D 10.1161/01.CIR.103.2.201
    • Chew DP, Bhatt DL, Sapp S, et al. Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a meta-analysis of phase III multicenter randomized trials. Circulation. 2001;103(2):201-6.
    • (2001) Circulation , vol.103 , Issue.2 , pp. 201-206
    • Chew, D.P.1    Bhatt, D.L.2    Sapp, S.3
  • 35
    • 0037132843 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A meta-analysis of all major randomised clinical trials
    • 11812552 1:CAS:528:DC%2BD38XmsV2lsA%3D%3D 10.1016/S0140-6736(02)07442-1
    • Boersma E, Harrington RA, Moliterno DJ, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet. 2002;359(9302):189-98.
    • (2002) Lancet , vol.359 , Issue.9302 , pp. 189-198
    • Boersma, E.1    Harrington, R.A.2    Moliterno, D.J.3
  • 36
    • 0037221185 scopus 로고    scopus 로고
    • Intravenous glycoprotein IIb/IIIa receptor antagonists reduce mortality after percutaneous coronary interventions
    • 12570940 1:CAS:528:DC%2BD3sXpsVKjsw%3D%3D 10.1016/S0735-1097(02)02666-9
    • Karvouni E, Katritsis DG, Ioannidis JP. Intravenous glycoprotein IIb/IIIa receptor antagonists reduce mortality after percutaneous coronary interventions. J Am Coll Cardiol. 2003;41(1):26-32.
    • (2003) J Am Coll Cardiol , vol.41 , Issue.1 , pp. 26-32
    • Karvouni, E.1    Katritsis, D.G.2    Ioannidis, J.P.3
  • 37
    • 33645507439 scopus 로고    scopus 로고
    • Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: The ISAR-REACT 2 randomized trial
    • 16533938 1:CAS:528:DC%2BD28Xjt12isbc%3D 10.1001/jama.295.13.joc60034
    • Kastrati A, Mehilli J, Neumann FJ, et al. Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA. 2006;295(13):1531-8.
    • (2006) JAMA , vol.295 , Issue.13 , pp. 1531-1538
    • Kastrati, A.1    Mehilli, J.2    Neumann, F.J.3
  • 38
    • 77950635286 scopus 로고    scopus 로고
    • Basic principles of platelet biology and clinical implications
    • 20197627 1:CAS:528:DC%2BC3cXls1Sksb0%3D 10.1253/circj.CJ-09-0982
    • Angiolillo DJ, Ueno M, Goto S. Basic principles of platelet biology and clinical implications. Circ J. 2010;74(4):597-607.
    • (2010) Circ J , vol.74 , Issue.4 , pp. 597-607
    • Angiolillo, D.J.1    Ueno, M.2    Goto, S.3
  • 39
    • 58249143713 scopus 로고    scopus 로고
    • Advances in antiplatelet therapy: Agents in clinical development
    • 19166712 1:CAS:528:DC%2BD1MXhtVegsrk%3D 10.1016/j.amjcard.2008.11.023
    • Angiolillo DJ, Bhatt DL, Gurbel PA, et al. Advances in antiplatelet therapy: agents in clinical development. Am J Cardiol. 2009;103(3 Suppl):40A-51A.
    • (2009) Am J Cardiol , vol.103 , Issue.3 SUPPL.
    • Angiolillo, D.J.1    Bhatt, D.L.2    Gurbel, P.A.3
  • 40
    • 77956290748 scopus 로고    scopus 로고
    • Dose comparisons of clopidogrel and aspirin in acute coronary syndromes
    • 20818903 10.1056/NEJMoa0909475
    • Mehta SR, Bassand JP, Chrolavicius S, et al. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010;363(10):930-42.
    • (2010) N Engl J Med , vol.363 , Issue.10 , pp. 930-942
    • Mehta, S.R.1    Bassand, J.P.2    Chrolavicius, S.3
  • 41
    • 57049165937 scopus 로고    scopus 로고
    • Platelet ADP-receptor antagonists for cardiovascular disease: Past, present and future
    • 18957959 1:CAS:528:DC%2BD1cXhtl2qtbzF 10.1038/ncpcardio1372
    • Raju NC, Eikelboom JW, Hirsh J. Platelet ADP-receptor antagonists for cardiovascular disease: past, present and future. Nat Clin Pract Cardiovasc Med. 2008;5(12):766-80.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , Issue.12 , pp. 766-780
    • Raju, N.C.1    Eikelboom, J.W.2    Hirsh, J.3
  • 42
    • 34047096264 scopus 로고    scopus 로고
    • Variability in individual responsiveness to clopidogrel: Clinical implications, management, and future perspectives
    • 17418288 1:CAS:528:DC%2BD2sXjvFGgt7s%3D 10.1016/j.jacc.2006.11.044
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol. 2007;49(14):1505-16.
    • (2007) J Am Coll Cardiol , vol.49 , Issue.14 , pp. 1505-1516
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 43
    • 77449149717 scopus 로고    scopus 로고
    • Platelet adenosine diphosphate P2Y12 receptor antagonism: Benefits and limitations of current treatment strategies and future directions
    • 20089227 10.1016/S0300-8932(10)70010-5
    • Angiolillo DJ, Ferreiro JL. Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions. Rev Esp Cardiol. 2010;63(1):60-76.
    • (2010) Rev Esp Cardiol , vol.63 , Issue.1 , pp. 60-76
    • Angiolillo, D.J.1    Ferreiro, J.L.2
  • 44
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • 20801494 1:CAS:528:DC%2BC3cXht12ks7jF 10.1016/S0140-6736(10)61273-1
    • Mega JL, Close SL, Wiviott SD, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis. Lancet. 2010;376(9749):1312-9.
    • (2010) Lancet , vol.376 , Issue.9749 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 45
    • 58749090547 scopus 로고    scopus 로고
    • Genetic determinants of response to clopidogrel and cardiovascular events
    • 19106083 1:CAS:528:DC%2BD1MXhtVSlsbY%3D 10.1056/NEJMoa0808227
    • Simon T, Verstuyft C, Mary-Krause M, et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med. 2009;360(4):363-75.
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 363-375
    • Simon, T.1    Verstuyft, C.2    Mary-Krause, M.3
  • 46
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to clopidogrel
    • 19106084 1:CAS:528:DC%2BD1MXhtVSlsbs%3D 10.1056/NEJMoa0809171
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med. 2009;360(4):354-62.
    • (2009) N Engl J Med , vol.360 , Issue.4 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 47
    • 84874550138 scopus 로고    scopus 로고
    • Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms (CYP2C19, ABCB1, PON1), noncompliance, diet, smoking, co-medications (including proton pump inhibitors), and pre-existent variability in platelet function
    • 23333143 1:CAS:528:DC%2BC3sXht1Gmsrg%3D 10.1016/j.jacc.2012.11.040
    • Frelinger AL III, Bhatt DL, Lee RD, et al. Clopidogrel pharmacokinetics and pharmacodynamics vary widely despite exclusion or control of polymorphisms (CYP2C19, ABCB1, PON1), noncompliance, diet, smoking, co-medications (including proton pump inhibitors), and pre-existent variability in platelet function. J Am Coll Cardiol. 2013;61(8):872-9.
    • (2013) J Am Coll Cardiol , vol.61 , Issue.8 , pp. 872-879
    • Frelinger III, A.L.1    Bhatt, D.L.2    Lee, R.D.3
  • 48
    • 61549124132 scopus 로고    scopus 로고
    • Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome
    • 19258584 1:CAS:528:DC%2BD1MXivFejt7g%3D 10.1001/jama.2009.261
    • Ho PM, Maddox TM, Wang L, et al. Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome. JAMA. 2009;301(9):937-44.
    • (2009) JAMA , vol.301 , Issue.9 , pp. 937-944
    • Ho, P.M.1    Maddox, T.M.2    Wang, L.3
  • 49
    • 78650517232 scopus 로고    scopus 로고
    • Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: Randomized, placebo-controlled, crossover comparison studies
    • 20844485 1:CAS:528:DC%2BC3cXhsFylt7zP 10.1038/clpt.2010.219
    • Angiolillo DJ, Gibson CM, Cheng S, et al. Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clin Pharmacol Ther. 2011;89(1):65-74.
    • (2011) Clin Pharmacol Ther , vol.89 , Issue.1 , pp. 65-74
    • Angiolillo, D.J.1    Gibson, C.M.2    Cheng, S.3
  • 50
    • 84859138447 scopus 로고    scopus 로고
    • A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers
    • 22464259 1:CAS:528:DC%2BC38XltVKiu7w%3D 10.1016/j.jacc.2011.12.024
    • Frelinger AL III, Lee RD, Mulford DJ, et al. A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers. J Am Coll Cardiol. 2012;59(14):1304-11.
    • (2012) J Am Coll Cardiol , vol.59 , Issue.14 , pp. 1304-1311
    • Frelinger III, A.L.1    Lee, R.D.2    Mulford, D.J.3
  • 51
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • 20925534 1:CAS:528:DC%2BC3cXhsVCht7rN 10.1056/NEJMoa1007964
    • Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med. 2010;363(20):1909-17.
    • (2010) N Engl J Med , vol.363 , Issue.20 , pp. 1909-1917
    • Bhatt, D.L.1    Cryer, B.L.2    Contant, C.F.3
  • 52
    • 79951677465 scopus 로고    scopus 로고
    • Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: Results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry
    • 21262992 1:CAS:528:DC%2BC3MXhs1Sgs7Y%3D 10.1161/CIRCULATIONAHA.110.965640
    • Simon T, Steg PG, Gilard M, et al. Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial infarction: results from the French Registry of Acute ST-Elevation and Non-ST-Elevation Myocardial Infarction (FAST-MI) registry. Circulation. 2011;123(5):474-82.
    • (2011) Circulation , vol.123 , Issue.5 , pp. 474-482
    • Simon, T.1    Steg, P.G.2    Gilard, M.3
  • 53
  • 54
    • 84870032410 scopus 로고    scopus 로고
    • Bedside monitoring to adjust antiplatelet therapy for coronary stenting
    • 23121439 1:CAS:528:DC%2BC38XhslyltrvL 10.1056/NEJMoa1209979
    • Collet JP, Cuisset T, Range G, et al. Bedside monitoring to adjust antiplatelet therapy for coronary stenting. N Engl J Med. 2012;367(22):2100-9.
    • (2012) N Engl J Med , vol.367 , Issue.22 , pp. 2100-2109
    • Collet, J.P.1    Cuisset, T.2    Range, G.3
  • 55
    • 84865271531 scopus 로고    scopus 로고
    • 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/Non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines
    • 22800849 10.1161/CIR.0b013e318256f1e0
    • Jneid H, Anderson JL, Wright RS, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/Non-ST- elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2012;126(7):875-910.
    • (2012) Circulation , vol.126 , Issue.7 , pp. 875-910
    • Jneid, H.1    Anderson, J.L.2    Wright, R.S.3
  • 56
    • 84855992555 scopus 로고    scopus 로고
    • 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions
    • 22070834 10.1016/j.jacc.2011.08.007
    • Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol. 2011;58(24):e44-122.
    • (2011) J Am Coll Cardiol , vol.58 , Issue.24
    • Levine, G.N.1    Bates, E.R.2    Blankenship, J.C.3
  • 57
    • 79952598836 scopus 로고    scopus 로고
    • Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVITAS randomized trial
    • 21406646 1:CAS:528:DC%2BC3MXjsFKgsb8%3D 10.1001/jama.2011.290
    • Price MJ, Berger PB, Teirstein PS, et al. Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA. 2011;305(11):1097-105.
    • (2011) JAMA , vol.305 , Issue.11 , pp. 1097-1105
    • Price, M.J.1    Berger, P.B.2    Teirstein, P.S.3
  • 58
    • 84861857758 scopus 로고    scopus 로고
    • A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: Results of the TRIGGER-PCI (Testing Platelet Reactivity in Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy with Prasugrel) study
    • 22520250 1:CAS:528:DC%2BC38XosVGrtbw%3D 10.1016/j.jacc.2012.02.026
    • Trenk D, Stone GW, Gawaz M, et al. A randomized trial of prasugrel versus clopidogrel in patients with high platelet reactivity on clopidogrel after elective percutaneous coronary intervention with implantation of drug-eluting stents: results of the TRIGGER-PCI (Testing Platelet Reactivity In Patients Undergoing Elective Stent Placement on Clopidogrel to Guide Alternative Therapy With Prasugrel) study. J Am Coll Cardiol. 2012;59(24):2159-64.
    • (2012) J Am Coll Cardiol , vol.59 , Issue.24 , pp. 2159-2164
    • Trenk, D.1    Stone, G.W.2    Gawaz, M.3
  • 59
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee
    • CAPRIE Steering Committee 10.1016/S0140-6736(96)09457-3
    • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet. 1996;348(9038):1329-39.
    • (1996) Lancet , vol.348 , Issue.9038 , pp. 1329-1339
  • 60
    • 0037145863 scopus 로고    scopus 로고
    • Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial
    • 12435254 1:CAS:528:DC%2BD38XoslOksL0%3D 10.1001/jama.288.19.2411
    • Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002;288(19):2411-20.
    • (2002) JAMA , vol.288 , Issue.19 , pp. 2411-2420
    • Steinhubl, S.R.1    Berger, P.B.2    Mann III, J.T.3
  • 61
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • 11520521 1:CAS:528:DC%2BD3MXmtV2ht7g%3D 10.1016/S0140-6736(01)05701-4
    • Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001;358(9281):527-33.
    • (2001) Lancet , vol.358 , Issue.9281 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3
  • 62
    • 20144373281 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation
    • 15758000 1:CAS:528:DC%2BD2MXisFShsbY%3D 10.1056/NEJMoa050522
    • Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352(12):1179-89.
    • (2005) N Engl J Med , vol.352 , Issue.12 , pp. 1179-1189
    • Sabatine, M.S.1    Cannon, C.P.2    Gibson, C.M.3
  • 63
    • 24644495673 scopus 로고    scopus 로고
    • Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: The PCI-CLARITY study
    • 16143698 1:CAS:528:DC%2BD2MXpvFKht74%3D 10.1001/jama.294.10.1224
    • Sabatine MS, Cannon CP, Gibson CM, et al. Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY study. JAMA. 2005;294(10):1224-32.
    • (2005) JAMA , vol.294 , Issue.10 , pp. 1224-1232
    • Sabatine, M.S.1    Cannon, C.P.2    Gibson, C.M.3
  • 64
    • 27644548513 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: Randomised placebo-controlled trial
    • 16271642 1:CAS:528:DC%2BD2MXhtFOhu77K 10.1016/S0140-6736(05)67660-X
    • Chen ZM, Jiang LX, Chen YP, et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366(9497):1607-21.
    • (2005) Lancet , vol.366 , Issue.9497 , pp. 1607-1621
    • Chen, Z.M.1    Jiang, L.X.2    Chen, Y.P.3
  • 65
    • 33645861080 scopus 로고    scopus 로고
    • Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • 16531616 1:CAS:528:DC%2BD28Xjs12gsLk%3D 10.1056/NEJMoa060989
    • Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354(16):1706-17.
    • (2006) N Engl J Med , vol.354 , Issue.16 , pp. 1706-1717
    • Bhatt, D.L.1    Fox, K.A.2    Hacke, W.3
  • 66
    • 34247869852 scopus 로고    scopus 로고
    • Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial
    • 17498584 10.1016/j.jacc.2007.03.025
    • Bhatt DL, Flather MD, Hacke W, et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol. 2007;49(19):1982-8.
    • (2007) J Am Coll Cardiol , vol.49 , Issue.19 , pp. 1982-1988
    • Bhatt, D.L.1    Flather, M.D.2    Hacke, W.3
  • 67
    • 77958005516 scopus 로고    scopus 로고
    • Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial
    • 20817281 1:CAS:528:DC%2BC3cXht1KrsbbE 10.1016/S0140-6736(10)61088-4
    • Mehta SR, Tanguay JF, Eikelboom JW, et al. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010;376(9748):1233-43.
    • (2010) Lancet , vol.376 , Issue.9748 , pp. 1233-1243
    • Mehta, S.R.1    Tanguay, J.F.2    Eikelboom, J.W.3
  • 68
    • 33646732608 scopus 로고    scopus 로고
    • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
    • 16621870 1:CAS:528:DC%2BD28Xls1Crt7g%3D 10.1093/eurheartj/ehi877
    • Jernberg T, Payne CD, Winters KJ, et al. Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J. 2006;27(10):1166-73.
    • (2006) Eur Heart J , vol.27 , Issue.10 , pp. 1166-1173
    • Jernberg, T.1    Payne, C.D.2    Winters, K.J.3
  • 69
    • 36849074168 scopus 로고    scopus 로고
    • Prasugrel: A novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile
    • 18078435 1:CAS:528:DC%2BD1cXnvFelsg%3D%3D 10.1111/j.1527-3466.2007.00027. x
    • Jakubowski JA, Winters KJ, Naganuma H, et al. Prasugrel: a novel thienopyridine antiplatelet agent. A review of preclinical and clinical studies and the mechanistic basis for its distinct antiplatelet profile. Cardiovasc Drug Rev. 2007;25(4):357-74.
    • (2007) Cardiovasc Drug Rev , vol.25 , Issue.4 , pp. 357-374
    • Jakubowski, J.A.1    Winters, K.J.2    Naganuma, H.3
  • 70
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • 18055486 1:CAS:528:DC%2BD1cXis1Sqtr8%3D 10.1093/eurheartj/ehm545
    • Wallentin L, Varenhorst C, James S, et al. Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur Heart J. 2008;29(1):21-30.
    • (2008) Eur Heart J , vol.29 , Issue.1 , pp. 21-30
    • Wallentin, L.1    Varenhorst, C.2    James, S.3
  • 71
    • 37349111065 scopus 로고    scopus 로고
    • Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: The Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial
    • 18056526 1:CAS:528:DC%2BD2sXhsVWjsr7N 10.1161/CIRCULATIONAHA.107.740324
    • Wiviott SD, Trenk D, Frelinger AL, et al. Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 trial. Circulation. 2007;116(25):2923-32.
    • (2007) Circulation , vol.116 , Issue.25 , pp. 2923-2932
    • Wiviott, S.D.1    Trenk, D.2    Frelinger, A.L.3
  • 73
    • 77955690680 scopus 로고    scopus 로고
    • Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: The TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial
    • 20598967 1:CAS:528:DC%2BC3cXosVWgu7c%3D 10.1016/j.ahj.2010.04.022
    • Chin CT, Roe MT, Fox KA, et al. Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial. Am Heart J. 2010;160(1):16-22.
    • (2010) Am Heart J , vol.160 , Issue.1 , pp. 16-22
    • Chin, C.T.1    Roe, M.T.2    Fox, K.A.3
  • 74
    • 84867177857 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel for acute coronary syndromes without revascularization
    • doi: 10.1056/NEJMoa1205512
    • Roe MT, Armstrong PW, Fox KA, et al. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med. 2012. doi: 10.1056/NEJMoa1205512.
    • (2012) N Engl J Med
    • Roe, M.T.1    Armstrong, P.W.2    Fox, K.A.3
  • 75
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • 16476694 1:CAS:528:DC%2BD28XlsFGqtLs%3D 10.1093/eurheartj/ehi754
    • Husted S, Emanuelsson H, Heptinstall S, et al. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J. 2006;27(9):1038-47.
    • (2006) Eur Heart J , vol.27 , Issue.9 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3
  • 76
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: The ONSET/OFFSET study
    • 19923168 1:CAS:528:DC%2BD1MXhsFGgtb3N 10.1161/CIRCULATIONAHA.109.912550
    • Gurbel PA, Bliden KP, Butler K, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation. 2009;120(25):2577-85.
    • (2009) Circulation , vol.120 , Issue.25 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3
  • 78
    • 80051550924 scopus 로고    scopus 로고
    • Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial
    • 21709065 1:CAS:528:DC%2BC3MXpslGisrc%3D 10.1161/CIRCULATIONAHA.111.047498
    • Mahaffey KW, Wojdyla DM, Carroll K, et al. Ticagrelor compared with clopidogrel by geographic region in the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation. 2011;124(5):544-54.
    • (2011) Circulation , vol.124 , Issue.5 , pp. 544-554
    • Mahaffey, K.W.1    Wojdyla, D.M.2    Carroll, K.3
  • 79
    • 84880889982 scopus 로고    scopus 로고
    • Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS) Accessed 10 May 2011
    • Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS). http://clinicaltrials.gov/ct2/show/NCT01225562?term=ticagrelor&rank=6 (2011). Accessed 10 May 2011.
    • (2011)
  • 80
    • 84880912788 scopus 로고    scopus 로고
    • A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID) NCT01732822. Accessed 15 Mar 2013
    • A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease (EUCLID). http://www.clinicaltrials. gov/ct2/show/NCT01732822?term=ticagrelor&rank=11 (2013). NCT01732822. Accessed 15 Mar 2013.
    • (2013)
  • 81
    • 77954510334 scopus 로고    scopus 로고
    • Elinogrel: Pharmacological principles, preclinical and early phase clinical testing
    • 20608816 1:CAS:528:DC%2BC3cXosFClt7g%3D 10.2217/fca.10.67
    • Ueno M, Rao SV, Angiolillo DJ. Elinogrel: pharmacological principles, preclinical and early phase clinical testing. Future Cardiol. 2010;6(4):445-53.
    • (2010) Future Cardiol , vol.6 , Issue.4 , pp. 445-453
    • Ueno, M.1    Rao, S.V.2    Angiolillo, D.J.3
  • 82
    • 77955677366 scopus 로고    scopus 로고
    • Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)
    • 20598974 1:CAS:528:DC%2BC3cXosVWnsr8%3D 10.1016/j.ahj.2010.04.008
    • Leonardi S, Rao SV, Harrington RA, et al. Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y(12)-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI). Am Heart J. 2010;160(1):65-72.
    • (2010) Am Heart J , vol.160 , Issue.1 , pp. 65-72
    • Leonardi, S.1    Rao, S.V.2    Harrington, R.A.3
  • 83
    • 84864617340 scopus 로고    scopus 로고
    • A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: The INNOVATE-PCI trial
    • 22647518 1:CAS:528:DC%2BC38XptVyjsb4%3D 10.1161/CIRCINTERVENTIONS.111. 964197
    • Welsh RC, Rao SV, Zeymer U, et al. A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVATE-PCI trial. Circ Cardiovasc Interv. 2012;5(3):336-46.
    • (2012) Circ Cardiovasc Interv , vol.5 , Issue.3 , pp. 336-346
    • Welsh, R.C.1    Rao, S.V.2    Zeymer, U.3
  • 84
    • 84864620660 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic effects of elinogrel: Results of the platelet function substudy from the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (INNOVATE-PCI) trial
    • 22619259 1:CAS:528:DC%2BC38XptVyjsb8%3D 10.1161/CIRCINTERVENTIONS.111. 965608
    • Angiolillo DJ, Welsh RC, Trenk D, et al. Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudy from the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patients (INNOVATE-PCI) trial. Circ Cardiovasc Interv. 2012;5(3):347-56.
    • (2012) Circ Cardiovasc Interv , vol.5 , Issue.3 , pp. 347-356
    • Angiolillo, D.J.1    Welsh, R.C.2    Trenk, D.3
  • 85
    • 77955226780 scopus 로고    scopus 로고
    • Update on the clinical development of cangrelor
    • 20670184 1:CAS:528:DC%2BC3cXpsVChurg%3D 10.1586/erc.10.90
    • Ueno M, Ferreiro JL, Angiolillo DJ. Update on the clinical development of cangrelor. Expert Rev Cardiovasc Ther. 2010;8(8):1069-77.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , Issue.8 , pp. 1069-1077
    • Ueno, M.1    Ferreiro, J.L.2    Angiolillo, D.J.3
  • 86
    • 84856023997 scopus 로고    scopus 로고
    • Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: A randomized controlled trial
    • 22253393 1:CAS:528:DC%2BC38Xht1equrw%3D 10.1001/jama.2011.2002
    • Angiolillo DJ, Firstenberg MS, Price MJ, et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. JAMA. 2012;307(3):265-74.
    • (2012) JAMA , vol.307 , Issue.3 , pp. 265-274
    • Angiolillo, D.J.1    Firstenberg, M.S.2    Price, M.J.3
  • 87
    • 71849087338 scopus 로고    scopus 로고
    • Platelet inhibition with cangrelor in patients undergoing PCI
    • 19915221 1:CAS:528:DC%2BD1MXhsFGlsbfF 10.1056/NEJMoa0908628
    • Harrington RA, Stone GW, McNulty S, et al. Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med. 2009;361(24):2318-29.
    • (2009) N Engl J Med , vol.361 , Issue.24 , pp. 2318-2329
    • Harrington, R.A.1    Stone, G.W.2    McNulty, S.3
  • 88
    • 71849119604 scopus 로고    scopus 로고
    • Intravenous platelet blockade with cangrelor during PCI
    • 19915222 1:CAS:528:DC%2BD1MXhsFGltr7P 10.1056/NEJMoa0908629
    • Bhatt DL, Lincoff AM, Gibson CM, et al. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med. 2009;361(24):2330-41.
    • (2009) N Engl J Med , vol.361 , Issue.24 , pp. 2330-2341
    • Bhatt, D.L.1    Lincoff, A.M.2    Gibson, C.M.3
  • 89
    • 84861316695 scopus 로고    scopus 로고
    • Rationale and design of the Cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON PHOENIX trial
    • 22607853 10.1016/j.ahj.2012.02.018
    • Leonardi S, Mahaffey KW, White HD, et al. Rationale and design of the Cangrelor versus standard therapy to acHieve optimal Management of Platelet InhibitiON PHOENIX trial. Am Heart J. 2012;163(5):768-76.
    • (2012) Am Heart J , vol.163 , Issue.5 , pp. 768-776
    • Leonardi, S.1    Mahaffey, K.W.2    White, H.D.3
  • 90
    • 84875779761 scopus 로고    scopus 로고
    • Effect of platelet inhibition with cangrelor during PCI on ischemic events
    • 10.1056/NEJMoa1300815
    • Bhatt DL, Stone GW, Mahaffey KW, et al. Effect of platelet inhibition with cangrelor during PCI on ischemic events. N Engl J Med. 2013. doi: 10.1056/NEJMoa1300815.
    • (2013) N Engl J Med
    • Bhatt, D.L.1    Stone, G.W.2    Mahaffey, K.W.3
  • 91
    • 0029057398 scopus 로고
    • An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey
    • 7796507 1:CAS:528:DyaK2MXmvFKqsLc%3D 10.1161/01.CIR.91.12.2961
    • Cook JJ, Sitko GR, Bednar B, et al. An antibody against the exosite of the cloned thrombin receptor inhibits experimental arterial thrombosis in the African green monkey. Circulation. 1995;91(12):2961-71.
    • (1995) Circulation , vol.91 , Issue.12 , pp. 2961-2971
    • Cook, J.J.1    Sitko, G.R.2    Bednar, B.3
  • 92
    • 0037310962 scopus 로고    scopus 로고
    • Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates
    • 12538843 1:CAS:528:DC%2BD3sXpvVCluw%3D%3D 10.1124/jpet.102.042663
    • Derian CK, Damiano BP, Addo MF, et al. Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther. 2003;304(2):855-61.
    • (2003) J Pharmacol Exp Ther , vol.304 , Issue.2 , pp. 855-861
    • Derian, C.K.1    Damiano, B.P.2    Addo, M.F.3
  • 93
    • 12444304462 scopus 로고    scopus 로고
    • Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig
    • 12892834 1:CAS:528:DC%2BD3sXlvVWgurg%3D 10.1016/S0014-2999(03)01973-3
    • Kato Y, Kita Y, Hirasawa-Taniyama Y, et al. Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur J Pharmacol. 2003;473(2-3):163-9.
    • (2003) Eur J Pharmacol , vol.473 , Issue.2-3 , pp. 163-169
    • Kato, Y.1    Kita, Y.2    Hirasawa-Taniyama, Y.3
  • 94
    • 33846095378 scopus 로고    scopus 로고
    • Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis
    • 17190826 1:CAS:528:DC%2BD2sXjt12ksQ%3D%3D 10.1073/pnas.0610188104
    • Vandendries ER, Hamilton JR, Coughlin SR, et al. Par4 is required for platelet thrombus propagation but not fibrin generation in a mouse model of thrombosis. Proc Natl Acad Sci USA. 2007;104(1):288-92.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.1 , pp. 288-292
    • Vandendries, E.R.1    Hamilton, J.R.2    Coughlin, S.R.3
  • 95
    • 73949157474 scopus 로고    scopus 로고
    • Platelet thrombin receptor antagonism and atherothrombosis
    • 19948715 1:CAS:528:DC%2BC3cXhtFOmsQ%3D%3D 10.1093/eurheartj/ehp504
    • Angiolillo DJ, Capodanno D, Goto S. Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J. 2010;31(1):17-28.
    • (2010) Eur Heart J , vol.31 , Issue.1 , pp. 17-28
    • Angiolillo, D.J.1    Capodanno, D.2    Goto, S.3
  • 96
    • 84870937888 scopus 로고    scopus 로고
    • Risk of intracranial hemorrhage with protease-activated receptor-1 antagonists
    • 23160882 1:CAS:528:DC%2BC38XhslKhsbzF 10.1161/STROKEAHA.112.670604
    • Lee M, Saver JL, Hong KS, et al. Risk of intracranial hemorrhage with protease-activated receptor-1 antagonists. Stroke. 2012;43(12):3189-95.
    • (2012) Stroke , vol.43 , Issue.12 , pp. 3189-3195
    • Lee, M.1    Saver, J.L.2    Hong, K.S.3
  • 97
    • 84866844938 scopus 로고    scopus 로고
    • Safety and efficacy of protease-activated receptor-1 antagonists in patients with coronary artery disease: A meta-analysis of randomized clinical trials
    • 22845871 1:CAS:528:DC%2BC38XhslSkurfN 10.1111/j.1538-7836.2012.04869.x
    • Capodanno D, Bhatt DL, Goto S, et al. Safety and efficacy of protease-activated receptor-1 antagonists in patients with coronary artery disease: a meta-analysis of randomized clinical trials. J Thromb Haemost. 2012;10(10):2006-15.
    • (2012) J Thromb Haemost , vol.10 , Issue.10 , pp. 2006-2015
    • Capodanno, D.1    Bhatt, D.L.2    Goto, S.3
  • 98
    • 44949114152 scopus 로고    scopus 로고
    • Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
    • 18447380 1:CAS:528:DC%2BD1cXlt1Ghu70%3D 10.1021/jm800180e
    • Chackalamannil S, Wang Y, Greenlee WJ, et al. Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J Med Chem. 2008;51(11):3061-4.
    • (2008) J Med Chem , vol.51 , Issue.11 , pp. 3061-3064
    • Chackalamannil, S.1    Wang, Y.2    Greenlee, W.J.3
  • 99
    • 68949156886 scopus 로고    scopus 로고
    • Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial
    • 19699854 1:CAS:528:DC%2BD1MXhtVegs7bL 10.1016/j.ahj.2009.06.027
    • Morrow DA, Scirica BM, Fox KA, et al. Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: design and rationale for the Thrombin-Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 degrees P)-TIMI 50 trial. Am Heart J. 2009;158(3):335-41.
    • (2009) Am Heart J , vol.158 , Issue.3 , pp. 335-341
    • Morrow, D.A.1    Scirica, B.M.2    Fox, K.A.3
  • 100
    • 85058720552 scopus 로고    scopus 로고
    • The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA CER) trial: Study design and rationale
    • The TRA*CER Executive and Steering Committees 10.1016/j.ahj.2009. 07.001 1:CAS:528:DC%2BD1MXhtVegs7bK
    • The TRA*CER Executive and Steering Committees. The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale. Am Heart J. 2009;158(3):327-34.
    • (2009) Am Heart J , vol.158 , Issue.3 , pp. 327-334
  • 101
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
    • 19286091 1:CAS:528:DC%2BD1MXjtFKqtrs%3D 10.1016/S0140-6736(09)60230-0
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet. 2009;373(9667):919-28.
    • (2009) Lancet , vol.373 , Issue.9667 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 102
    • 77649207578 scopus 로고    scopus 로고
    • Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
    • 20124733 1:CAS:528:DC%2BC3MXhvVeru7w%3D 10.5551/jat.3038
    • Goto S, Yamaguchi T, Ikeda Y, et al. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb. 2010;17(2):156-64.
    • (2010) J Atheroscler Thromb , vol.17 , Issue.2 , pp. 156-164
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3
  • 103
    • 83655177669 scopus 로고    scopus 로고
    • Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
    • 22077816 1:CAS:528:DC%2BC38XhtVKit7c%3D 10.1056/NEJMoa1109719
    • Tricoci P, Huang Z, Held C, et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med. 2012;366(1):20-33.
    • (2012) N Engl J Med , vol.366 , Issue.1 , pp. 20-33
    • Tricoci, P.1    Huang, Z.2    Held, C.3
  • 104
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • 22443427 1:CAS:528:DC%2BC38XlslOrsLk%3D 10.1056/NEJMoa1200933
    • Morrow DA, Braunwald E, Bonaca MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med. 2012;366(15):1404-13.
    • (2012) N Engl J Med , vol.366 , Issue.15 , pp. 1404-1413
    • Morrow, D.A.1    Braunwald, E.2    Bonaca, M.P.3
  • 105
    • 79955618078 scopus 로고    scopus 로고
    • Inhibitors of the platelet thrombin receptor will they live up to their promises?
    • 21502575 10.1161/CIRCULATIONAHA.111.021733
    • Van de Werf F. Inhibitors of the platelet thrombin receptor will they live up to their promises? Circulation. 2011;123(17):1833-5.
    • (2011) Circulation , vol.123 , Issue.17 , pp. 1833-1835
    • Van De Werf, F.1
  • 106
    • 36448931550 scopus 로고    scopus 로고
    • Anti-thrombotic and bleeding time effects of e555, an orally active protease-activated receptor-1 antagonist, in guinea pigs (abstract)
    • Kogushi M, Kobayashi H, Matsuoka T, et al. Anti-thrombotic and bleeding time effects of e555, an orally active protease-activated receptor-1 antagonist, in guinea pigs (abstract). Circulation. 2003;108:280.
    • (2003) Circulation , vol.108 , pp. 280
    • Kogushi, M.1    Kobayashi, H.2    Matsuoka, T.3
  • 107
    • 84864862425 scopus 로고    scopus 로고
    • Atopaxar: A review of its mechanism of action and role in patients with coronary artery disease
    • 22871190 1:CAS:528:DC%2BC38XhtFKisrjJ 10.2217/fca.12.35
    • Rollini F, Tello-Montoliu A, Angiolillo DJ. Atopaxar: a review of its mechanism of action and role in patients with coronary artery disease. Future Cardiol. 2012;8(4):503-11.
    • (2012) Future Cardiol , vol.8 , Issue.4 , pp. 503-511
    • Rollini, F.1    Tello-Montoliu, A.2    Angiolillo, D.J.3
  • 108
    • 67749086022 scopus 로고    scopus 로고
    • The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease
    • 19572075 1:CAS:528:DC%2BD1MXptlemurg%3D
    • Serebruany VL, Kogushi M, Dastros-Pitei D, et al. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb Haemost. 2009;102(1):111-9.
    • (2009) Thromb Haemost , vol.102 , Issue.1 , pp. 111-119
    • Serebruany, V.L.1    Kogushi, M.2    Dastros-Pitei, D.3
  • 109
    • 78149355554 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease
    • 20805115 1:CAS:528:DC%2BC3cXhsVSlt7nP 10.1093/eurheartj/ehq320
    • Goto S, Ogawa H, Takeuchi M, et al. Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease. Eur Heart J. 2010;31(21):2601-13.
    • (2010) Eur Heart J , vol.31 , Issue.21 , pp. 2601-2613
    • Goto, S.1    Ogawa, H.2    Takeuchi, M.3
  • 110
    • 85027946204 scopus 로고    scopus 로고
    • Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: The lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial
    • 21502577 10.1161/CIRCULATIONAHA.110.000786 1:CAS:528:DC%2BC3MXlsVynsb8%3D
    • O'Donoghue ML, Bhatt DL, Wiviott SD, et al. Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial. Circulation. 2011;123(17):1843-53.
    • (2011) Circulation , vol.123 , Issue.17 , pp. 1843-1853
    • O'Donoghue, M.L.1    Bhatt, D.L.2    Wiviott, S.D.3
  • 111
    • 85027951718 scopus 로고    scopus 로고
    • Randomized trial of atopaxar in the treatment of patients with coronary artery disease: The lessons from antagonizing the cellular effect of Thrombin-Coronary Artery Disease Trial
    • 21502571 1:CAS:528:DC%2BC3MXlsVynsbw%3D 10.1161/CIRCULATIONAHA.110.001404
    • Wiviott SD, Flather MD, O'Donoghue ML, et al. Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin-Coronary Artery Disease Trial. Circulation. 2011;123(17):1854-63.
    • (2011) Circulation , vol.123 , Issue.17 , pp. 1854-1863
    • Wiviott, S.D.1    Flather, M.D.2    O'Donoghue, M.L.3
  • 112
    • 76549094772 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases
    • 20050853 1:CAS:528:DC%2BC3cXitlCiurs%3D 10.1111/j.1476-5381.2009.00555.x
    • Siller-Matula JM, Krumphuber J, Jilma B. Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases. Br J Pharmacol. 2010;159(3):502-17.
    • (2010) Br J Pharmacol , vol.159 , Issue.3 , pp. 502-517
    • Siller-Matula, J.M.1    Krumphuber, J.2    Jilma, B.3
  • 113
    • 76449090664 scopus 로고    scopus 로고
    • Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events
    • 20170841 1:CAS:528:DC%2BC3cXjs12lurs%3D 10.1016/S1474-4422(10)70038-7
    • Hankey GJ, Eikelboom JW. Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events. Lancet Neurol. 2010;9(3):273-84.
    • (2010) Lancet Neurol , vol.9 , Issue.3 , pp. 273-284
    • Hankey, G.J.1    Eikelboom, J.W.2
  • 114
    • 34248664839 scopus 로고    scopus 로고
    • ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation
    • 16908781 10.1161/CIRCULATIONAHA.106.177292 A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation): Developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society
    • Fuster V, Ryden LE, Cannom DS, et al. ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients With Atrial Fibrillation): developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Circulation. 2006;114(7):e257-354.
    • (2006) Circulation , vol.114 , Issue.7
    • Fuster, V.1    Ryden, L.E.2    Cannom, D.S.3
  • 115
    • 0024316072 scopus 로고
    • Major bleeding in outpatients treated with warfarin: Incidence and prediction by factors known at the start of outpatient therapy
    • 2787958 1:STN:280:DyaL1MzjtlOktg%3D%3D 10.1016/S0002-9343(89)80689-8
    • Landefeld CS, Goldman L. Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy. Am J Med. 1989;87(2):144-52.
    • (1989) Am J Med , vol.87 , Issue.2 , pp. 144-152
    • Landefeld, C.S.1    Goldman, L.2
  • 116
    • 33947533514 scopus 로고    scopus 로고
    • One-year cardiovascular event rates in outpatients with atherothrombosis
    • 17374814 1:CAS:528:DC%2BD2sXlvVWmt74%3D 10.1001/jama.297.11.1197
    • Steg PG, Bhatt DL, Wilson PW, et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007;297(11):1197-206.
    • (2007) JAMA , vol.297 , Issue.11 , pp. 1197-1206
    • Steg, P.G.1    Bhatt, D.L.2    Wilson, P.W.3
  • 117
    • 84880872013 scopus 로고    scopus 로고
    • Phase III Acute Coronary Syndrome (APPRAISE-2) Accessed 9 May 2011
    • Phase III Acute Coronary Syndrome (APPRAISE-2). http://clinicaltrials. gov/ct2/show/NCT00831441?term=apixaban&rank=15 (2010). Accessed 9 May 2011.
    • (2010)
  • 119
    • 79955887785 scopus 로고    scopus 로고
    • Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS-ACS 2 TIMI 51) trial: A randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome
    • 21570509 1:CAS:528:DC%2BC3MXmtFansLY%3D 10.1016/j.ahj.2011.01.026
    • Gibson CM, Mega JL, Burton P, et al. Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS-ACS 2 TIMI 51) trial: a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome. Am Heart J. 2011;161(5):815-21.
    • (2011) Am Heart J , vol.161 , Issue.5 , pp. 815-821
    • Gibson, C.M.1    Mega, J.L.2    Burton, P.3
  • 120
    • 80052232522 scopus 로고    scopus 로고
    • Dabigatran vs. Placebo in patients with acute coronary syndromes on dual antiplatelet therapy: A randomized, double-blind, phase II trial
    • 21551462 1:CAS:528:DC%2BC3MXhsFamt77I 10.1093/eurheartj/ehr113
    • Oldgren J, Budaj A, Granger CB, et al. Dabigatran vs. placebo in patients with acute coronary syndromes on dual antiplatelet therapy: a randomized, double-blind, phase II trial. Eur Heart J. 2011;32(22):2781-9.
    • (2011) Eur Heart J , vol.32 , Issue.22 , pp. 2781-2789
    • Oldgren, J.1    Budaj, A.2    Granger, C.B.3
  • 121
    • 74249107395 scopus 로고    scopus 로고
    • The clinical implications of new oral anticoagulants: Will the potential advantages be achieved?
    • 20062925 1:CAS:528:DC%2BC3cXhs1Cqu74%3D 10.1160/TH09-06-0361
    • Phillips KW, Ansell J. The clinical implications of new oral anticoagulants: will the potential advantages be achieved? Thromb Haemost. 2010;103(1):34-9.
    • (2010) Thromb Haemost , vol.103 , Issue.1 , pp. 34-39
    • Phillips, K.W.1    Ansell, J.2
  • 122
    • 79851499067 scopus 로고    scopus 로고
    • A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: Design and rationale of the RADAR Phase IIb trial
    • 21315207 1:CAS:528:DC%2BC3MXhvVyrurc%3D 10.1016/j.ahj.2010.10.022
    • Povsic TJ, Cohen MG, Mehran R, et al. A randomized, partially blinded, multicenter, active-controlled, dose-ranging study assessing the safety, efficacy, and pharmacodynamics of the REG1 anticoagulation system in patients with acute coronary syndromes: design and rationale of the RADAR Phase IIb trial. Am Heart J. 2011;161(2):261-8.
    • (2011) Am Heart J , vol.161 , Issue.2 , pp. 261-268
    • Povsic, T.J.1    Cohen, M.G.2    Mehran, R.3
  • 123
    • 67649563209 scopus 로고    scopus 로고
    • Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: Results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial
    • 19470889 10.1161/CIRCULATIONAHA.108.832139 1:CAS:528:DC%2BD1MXms1alsbw%3D
    • Alexander JH, Becker RC, Bhatt DL, et al. Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial. Circulation. 2009;119(22):2877-85.
    • (2009) Circulation , vol.119 , Issue.22 , pp. 2877-2885
    • Alexander, J.H.1    Becker, R.C.2    Bhatt, D.L.3
  • 124
    • 67649562905 scopus 로고    scopus 로고
    • Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): A randomised, double-blind, phase II trial
    • 19539361 1:CAS:528:DC%2BD1MXotFCgtLc%3D 10.1016/S0140-6736(09)60738-8
    • Mega JL, Braunwald E, Mohanavelu S, et al. Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet. 2009;374(9683):29-38.
    • (2009) Lancet , vol.374 , Issue.9683 , pp. 29-38
    • Mega, J.L.1    Braunwald, E.2    Mohanavelu, S.3
  • 125
    • 80051834654 scopus 로고    scopus 로고
    • CNovel oral anticoagulants: Focus on stroke prevention and treatment of venous thrombo-embolism
    • 1976a
    • Steffel J, Braunwald E. Novel oral anticoagulants: focus on stroke prevention and treatment of venous thrombo-embolism. Eur Heart J. 2011;32(16):1968-76, 1976a.
    • (2011) Eur Heart J , vol.32 , Issue.16 , pp. 1968-1976
    • Steffel, J.1    Braunwald, E.2
  • 126
    • 69949096467 scopus 로고    scopus 로고
    • Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): A randomised, double-blind, active-controlled, phase 2 trial
    • 19717184 1:CAS:528:DC%2BD1MXhtV2ksLnK 10.1016/S0140-6736(09)61454-9
    • Sabatine MS, Antman EM, Widimsky P, et al. Otamixaban for the treatment of patients with non-ST-elevation acute coronary syndromes (SEPIA-ACS1 TIMI 42): a randomised, double-blind, active-controlled, phase 2 trial. Lancet. 2009;374(9692):787-95.
    • (2009) Lancet , vol.374 , Issue.9692 , pp. 787-795
    • Sabatine, M.S.1    Antman, E.M.2    Widimsky, P.3
  • 127
    • 0041829444 scopus 로고    scopus 로고
    • Oral ximelagatran for secondary prophylaxis after myocardial infarction: The ESTEEM randomised controlled trial
    • 13678873 1:CAS:528:DC%2BD3sXntVGktLY%3D 10.1016/S0140-6736(03)14287-0
    • Wallentin L, Wilcox RG, Weaver WD, et al. Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomised controlled trial. Lancet. 2003;362(9386):789-97.
    • (2003) Lancet , vol.362 , Issue.9386 , pp. 789-797
    • Wallentin, L.1    Wilcox, R.G.2    Weaver, W.D.3
  • 128
    • 80052162121 scopus 로고    scopus 로고
    • Apixaban with antiplatelet therapy after acute coronary syndrome
    • 21780946 1:CAS:528:DC%2BC3MXhtV2lu73I 10.1056/NEJMoa1105819
    • Alexander JH, Lopes RD, James S, et al. Apixaban with antiplatelet therapy after acute coronary syndrome. N Engl J Med. 2011;365(8):699-708.
    • (2011) N Engl J Med , vol.365 , Issue.8 , pp. 699-708
    • Alexander, J.H.1    Lopes, R.D.2    James, S.3
  • 129
    • 84862907587 scopus 로고    scopus 로고
    • Rivaroxaban in patients with a recent acute coronary syndrome
    • 22077192 1:CAS:528:DC%2BC38XhtVKit7Y%3D 10.1056/NEJMoa1112277
    • Mega JL, Braunwald E, Wiviott SD, et al. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012;366(1):9-19.
    • (2012) N Engl J Med , vol.366 , Issue.1 , pp. 9-19
    • Mega, J.L.1    Braunwald, E.2    Wiviott, S.D.3
  • 130
    • 33645497961 scopus 로고    scopus 로고
    • Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: The OASIS-6 randomized trial
    • 16537725 1:CAS:528:DC%2BD28Xjt12isbs%3D 10.1001/jama.295.13.joc60038
    • Yusuf S, Mehta SR, Chrolavicius S, et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction: the OASIS-6 randomized trial. JAMA. 2006;295(13):1519-30.
    • (2006) JAMA , vol.295 , Issue.13 , pp. 1519-1530
    • Yusuf, S.1    Mehta, S.R.2    Chrolavicius, S.3
  • 131
    • 33645498094 scopus 로고    scopus 로고
    • Comparison of fondaparinux and enoxaparin in acute coronary syndromes
    • 16537663 1:CAS:528:DC%2BD28XjtFWhuro%3D 10.1056/NEJMoa055443
    • Yusuf S, Mehta SR, Chrolavicius S, et al. Comparison of fondaparinux and enoxaparin in acute coronary syndromes. N Engl J Med. 2006;354(14):1464-76.
    • (2006) N Engl J Med , vol.354 , Issue.14 , pp. 1464-1476
    • Yusuf, S.1    Mehta, S.R.2    Chrolavicius, S.3
  • 132
    • 84870298498 scopus 로고    scopus 로고
    • Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: A double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy
    • 23194481 1:CAS:528:DC%2BC38Xhs1Cjtr7O 10.1016/j.ahj.2012.10.001
    • Steg PG, Mehta SR, Pollack CV Jr, et al. Design and rationale of the treatment of acute coronary syndromes with otamixaban trial: a double-blind triple-dummy 2-stage randomized trial comparing otamixaban to unfractionated heparin and eptifibatide in non-ST-segment elevation acute coronary syndromes with a planned early invasive strategy. Am Heart J. 2012;164(6):817-24.
    • (2012) Am Heart J , vol.164 , Issue.6 , pp. 817-824
    • Steg, P.G.1    Mehta, S.R.2    Pollack, Jr.C.V.3
  • 133
    • 84880858441 scopus 로고    scopus 로고
    • A phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the
    • Epub ahead of print
    • Povsic TJ, Vavalle JP, Aberle LH, et al. A phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial. Eur Heart J. 2012; Epub ahead of print.
    • (2012) Eur Heart J
    • Povsic, T.J.1    Vavalle, J.P.2    Aberle, L.H.3
  • 134
    • 84880887975 scopus 로고    scopus 로고
    • Accessed 18 Mar 2013
    • Regado Biosciences. http://www.regadobio.com/index.php/2012/12/regado- biosciences-inc-secures-51-million-series-e-financing/ (2013). Accessed 18 Mar 2013.
    • (2013) Regado Biosciences


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.