메뉴 건너뛰기




Volumn 72, Issue 16, 2012, Pages 2087-2116

The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: From aspirin to the present day

Author keywords

Abciximab; Acute coronary syndromes; Antiplatelets; Aspirin; Atopaxar; Cangrelor; Cilostazol; Clopidogrel; Egaptivon pegol; Elinogrel; Eptifibatide; Ifetroban; Omeprazole; ONO 3708; Pantoprazole; Pharmacokinetics; Pharmacology; Picotamide; Prasugrel; Ramatroban; Sarpogrelate; Sulotroban; Terutroban sodium; Thienopyridines; Ticagrelor; Ticlopidine; Tirofiban; Vapiprost; Vorapaxar; Z 335.

Indexed keywords

ABCIXIMAB; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ATOPAXAR; CANGRELOR; CILOSTAZOL; CLOPIDOGREL; ELINOGREL; ENZYME INHIBITOR; EPTIFIBATIDE; ESOMEPRAZOLE; FIBRINOGEN RECEPTOR ANTAGONIST; METOPROLOL; OMEPRAZOLE; PICOTAMIDE; PLACEBO; PRASUGREL; PROTEINASE ACTIVATED RECEPTOR 1 INHIBITOR; PROTON PUMP INHIBITOR; PURINERGIC P2Y12 RECEPTOR; STREPTOKINASE; TERUTROBAN; THIENOPYRIDINE DERIVATIVE; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; TICAGRELOR; TICLOPIDINE; TIROFIBAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORAPAXAR;

EID: 84867738043     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11640880-000000000-00000     Document Type: Review
Times cited : (110)

References (203)
  • 1
    • 84856158305 scopus 로고    scopus 로고
    • ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
    • Hamm CW, Bassand J-P, Agewall S, et al. ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J 2011; 32: 2999-3054
    • (2011) Eur Heart J , vol.32 , pp. 2999-3054
    • Hamm, C.W.1    Bassand, J.-P.2    Agewall, S.3
  • 2
    • 70349675844 scopus 로고    scopus 로고
    • Acute coronary syndromes: Morbidity, mortality, and pharmacoeconomic burden
    • Kolansky DM. Acute coronary syndromes: morbidity, mortality, and pharmacoeconomic burden. Am J Manag Care 2009; 15: S36-41
    • (2009) Am J Manag Care , vol.15
    • Kolansky, D.M.1
  • 3
    • 35448971466 scopus 로고    scopus 로고
    • Universal definition of myocardial infarction
    • on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
    • Thygesen K, Alpert JS, White HD, on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525-38
    • (2007) Eur Heart J , vol.28 , pp. 2525-2538
    • Thygesen, K.1    Alpert, J.S.2    White, H.D.3
  • 4
    • 79955764408 scopus 로고    scopus 로고
    • ACCFAHA focused update of the guidelines for the management of patients with unstable anginanon-stelevation myocardial infarction (updating the 2007 guideline): A report of the American college of cardiology foundation/American heart association task force on practice guidelines
    • Wright RS, Anderson JL, Adams CD, et al. 2011 ACCF/AHA focused update of the guidelines for the management of patients with unstable angina/non- STelevation myocardial infarction (updating the 2007 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2011; 123: 2022-60
    • (2011) Circulation 2011 , vol.123 , pp. 2022-2060
    • Wright, R.S.1    Anderson, J.L.2    Adams, C.D.3
  • 5
    • 84855992555 scopus 로고    scopus 로고
    • ACCF/AHA/SCAI guideline for percutaneous coronary intervention: A report of the American college of cardiology foundation/American heart association task force on practice guidelines and the society for cardiovascular angiography and interventions
    • 122
    • Levine GN, Bates ER, Blankenship JC, et al. 2011 ACCF/AHA/SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol 2011; 58: e44-122
    • (2011) J Am Coll Cardiol 2011 , vol.58
    • Levine, G.N.1    Bates, E.R.2    Blankenship, J.C.3
  • 6
    • 57349189353 scopus 로고    scopus 로고
    • Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: The task force on the management of st-segment elevation acute myocardial infarction of the European society of cardiology
    • ESC Committee for Practice Guidelines (CPG)
    • Van de Werf F, Bax J, Betriu A, et al., ESC Committee for Practice Guidelines (CPG). Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 2008; 29: 2909-45
    • (2008) Eur Heart J , vol.29 , pp. 2909-2945
    • Van De Werf, F.1    Bax, J.2    Betriu, A.3
  • 7
    • 79955760903 scopus 로고    scopus 로고
    • ACCFAHA focused update incorporated into the ACCAHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: A report of the American college of cardiology foundation/American heart association task force on practice guidelines
    • Anderson JL, Adams CD, Antman EM, et al. 2011 ACCF/AHA focused update incorporated into the ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 2011; 123: e426-579
    • (2011) Circulation , vol.123
    • Anderson, J.L.1    Adams, C.D.2    Antman, E.M.3
  • 8
    • 37249068049 scopus 로고    scopus 로고
    • Platelet activation and atherothrombosis
    • Dav̀ G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007; 357: 2482-94
    • (2007) N Engl J Med , vol.357 , pp. 2482-2494
    • Dav̀, G.1    Patrono, C.2
  • 9
    • 34248371253 scopus 로고    scopus 로고
    • Clinical aspects of platelet inhibitors and thrombus formation
    • Meadows TA, BhattDL.Clinical aspects of platelet inhibitors and thrombus formation. Circ Res 2007; 100: 1261-75
    • (2007) Circ Res , vol.100 , pp. 1261-1275
    • Meadows, T.A.1    Bhatt, D.L.2
  • 11
    • 85047693299 scopus 로고    scopus 로고
    • Central role of the P2Y12 receptor in platelet activation
    • Dorsam RT, Kunapuli SP. Central role of the P2Y12 receptor in platelet activation. J Clin Invest 2004; 113: 340-5
    • (2004) J Clin Invest , vol.113 , pp. 340-345
    • Dorsam, R.T.1    Kunapuli, S.P.2
  • 12
    • 33845606632 scopus 로고    scopus 로고
    • Activation of platelet function through G protein-coupled receptors
    • Offermanns S. Activation of platelet function through G protein-coupled receptors. Circ Res 2006; 99: 1293-304
    • (2006) Circ Res , vol.99 , pp. 1293-1304
    • Offermanns, S.1
  • 13
    • 33748495552 scopus 로고    scopus 로고
    • Protease-activated receptors in cardiovascular diseases
    • Leger AJ, Covic L, Kuliopulos A. Protease-activated receptors in cardiovascular diseases. Circulation 2006; 114: 1070-7
    • (2006) Circulation , vol.114 , pp. 1070-1077
    • Leger, A.J.1    Covic, L.2    Kuliopulos, A.3
  • 14
    • 77950635286 scopus 로고    scopus 로고
    • Basic principles of platelet biology and clinical implications
    • Angiolillo DJ, Ueno M, Goto S. Basic principles of platelet biology and clinical implications. Circ J 2010; 74: 597-607
    • (2010) Circ J , vol.74 , pp. 597-607
    • Angiolillo, D.J.1    Ueno, M.2    Goto, S.3
  • 15
    • 0014190795 scopus 로고
    • Impaired platelet-connective-tissue reaction in man after aspirin ingestion
    • Weiss HJ, Aledort LM. Impaired platelet-connective-tissue reaction in man after aspirin ingestion. Lancet 1967; 290: 495-7
    • (1967) Lancet , vol.290 , pp. 495-497
    • Weiss, H.J.1    Aledort, L.M.2
  • 16
    • 0035924765 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors and the antiplatelet effects of aspirin
    • Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 2001; 345: 1809-17
    • (2001) N Engl J Med , vol.345 , pp. 1809-1817
    • Catella-Lawson, F.1    Reilly, M.P.2    Kapoor, S.C.3
  • 17
    • 0016805004 scopus 로고
    • The mechanism of the effect of aspirin on human platelets:I. Acetylation of a particulate fraction protein
    • Roth GJ, Majerus PW. The mechanism of the effect of aspirin on human platelets: I. Acetylation of a particulate fraction protein. J Clin Invest 1975; 56: 624-32
    • (1975) J Clin Invest , vol.56 , pp. 624-632
    • Roth, G.J.1    Majerus, P.W.2
  • 18
    • 0017151909 scopus 로고
    • Dose-dependent influence of acetylsalicyclic acid on platelet functions and plasmatic coagulation factors
    • Loew D, Vinazzer H. Dose-dependent influence of acetylsalicyclic acid on platelet functions and plasmatic coagulation factors. Haemostasis 1976; 5: 239-49
    • (1976) Haemostasis , vol.5 , pp. 239-249
    • Loew, D.1    Vinazzer, H.2
  • 19
    • 0017598164 scopus 로고
    • Increased blood fibrinolytic activity after aspirin ingestion
    • Moroz LA. Increased blood fibrinolytic activity after aspirin ingestion. N Engl J Med 1977; 296: 525-9
    • (1977) N Engl J Med , vol.296 , pp. 525-529
    • Moroz, L.A.1
  • 20
    • 0023805341 scopus 로고
    • Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2
    • ISIS-2 Trial Investigators ISIS-2 (Second International Study of Infarct Survival) Collaborative Group
    • ISIS-2 Trial Investigators. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Lancet 1988; 2: 349-60
    • (1988) Lancet , vol.2 , pp. 349-360
  • 21
    • 0003177415 scopus 로고    scopus 로고
    • Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death myocardial infarction and stroke in high risk patients [published Erratum Appears in BMJ 2002 Jan 19; 324 (7330): 141]
    • Antithrombotic Trialists' Collaboration Jan 12;
    • Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients [published erratum appears in BMJ 2002 Jan 19; 324 (7330): 141]. BMJ 2002 Jan 12; 324 (7329): 71-86
    • (2002) BMJ , vol.324 , Issue.7329 , pp. 71-86
  • 22
    • 77956290748 scopus 로고    scopus 로고
    • Dose comparisons of clopidogrel and aspirin in acute coronary syndromes
    • CURRENT-OASIS 7 Investigators
    • CURRENT-OASIS 7 Investigators. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med 2010; 363: 930-42
    • (2010) N Engl J Med , vol.363 , pp. 930-942
  • 23
    • 60749114799 scopus 로고    scopus 로고
    • Interindividual variability in the response to oral antiplatelet drugs: A position paper of the working group on antiplatelet drugs resistance appointed by the section of cardiovascular interventions of the polish cardiac society, endorsed by the working group on thrombosis of the European Society of cardiology
    • Kuliczkowski W, Witkowski A, Polonski L, et al. Interindividual variability in the response to oral antiplatelet drugs: a position paper of the Working Group on antiplatelet drugs resistance appointed by the Section of Cardiovascular Interventions of the Polish Cardiac Society, endorsed by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J 2009; 30: 426-35
    • (2009) Eur Heart J , vol.30 , pp. 426-435
    • Kuliczkowski, W.1    Witkowski, A.2    Polonski, L.3
  • 24
    • 79958727320 scopus 로고    scopus 로고
    • Clinical importance of aspirin and clopidogrel resistance
    • Feher G, Feher A, Pusch G, et al. Clinical importance of aspirin and clopidogrel resistance. World J Cardiol 2010; 2: 171-86
    • (2010) World J Cardiol , vol.2 , pp. 171-186
    • Feher, G.1    Feher, A.2    Pusch, G.3
  • 25
    • 34447503098 scopus 로고    scopus 로고
    • Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: A systematic review and meta-analysis
    • Snoep JD, Hovens MM, Eikenboom JC, et al. Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: a systematic review and meta-analysis. Arch Intern Med 2007; 167: 1593-9
    • (2007) Arch Intern Med , vol.167 , pp. 1593-1599
    • Snoep, J.D.1    Hovens, M.M.2    Eikenboom, J.C.3
  • 26
    • 27444434164 scopus 로고    scopus 로고
    • Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation
    • Tantry US, Bliden KP, Gurbel PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. J Am Coll Cardiol 2005; 46: 1705-9
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1705-1709
    • Tantry, U.S.1    Bliden, K.P.2    Gurbel, P.A.3
  • 27
    • 58249142825 scopus 로고    scopus 로고
    • Variability in responsiveness to oral antiplatelet therapy
    • Angiolillo D. Variability in responsiveness to oral antiplatelet therapy. Am J Cardiol 2009; 103: 27A-34A
    • (2009) Am J Cardiol , vol.103
    • Angiolillo, D.1
  • 28
    • 6444220783 scopus 로고    scopus 로고
    • Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndromes
    • Collet J-P, Montalescot G, Blanchet B. Impact of prior use or recent withdrawal of oral antiplatelet agents on acute coronary syndromes. Circulation 2004; 110: 2361-7
    • (2004) Circulation , vol.110 , pp. 2361-2367
    • Collet, J.-P.1    Montalescot, G.2    Blanchet, B.3
  • 29
    • 33749003498 scopus 로고    scopus 로고
    • Impact of medication therapy discontinuation on mortality after myocardial infarction
    • Ho PM, Spertus JA, Masoudi FA, et al. Impact of medication therapy discontinuation on mortality after myocardial infarction. Arch Intern Med 2006; 166: 1842-7
    • (2006) Arch Intern Med , vol.166 , pp. 1842-1847
    • Ho, P.M.1    Spertus, J.A.2    Masoudi, F.A.3
  • 30
    • 79960676489 scopus 로고    scopus 로고
    • Discontinuation of low dose aspirin and risk of myocardial infarction: Case-control study in UK primary care
    • García Rodríguez LA, Cea-Soriano L, Martín-Merino E, et al. Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care. Br Med J 2011; 343: d4094
    • (2011) Br Med J , vol.343
    • García Rodríguez, L.A.1    Cea-Soriano, L.2    Martín-Merino, E.3
  • 31
    • 49349102463 scopus 로고    scopus 로고
    • Aspirin resistance: An underestimated risk in patients with drug-eluting stents?
    • Trenk D, Neumann F-J. Aspirin resistance: an underestimated risk in patients with drug-eluting stents? J Am Coll Cardiol 2008; 52: 740-2
    • (2008) J Am Coll Cardiol , vol.52 , pp. 740-742
    • Trenk, D.1    Neumann, F.-J.2
  • 32
    • 77950796980 scopus 로고    scopus 로고
    • Aspirin and clopidogrel resistance: Methodological challenges and opportunities
    • Gasparyan AY. Aspirin and clopidogrel resistance: methodological challenges and opportunities. Vasc Health Risk Manag 2010; 6: 109-12
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 109-112
    • Gasparyan, A.Y.1
  • 33
    • 80053165917 scopus 로고    scopus 로고
    • Aspirin resistance and compliance with therapy
    • Dawson J, Quinn T, Rafferty M, et al. Aspirin resistance and compliance with therapy. Cardiovasc Ther 2011; 29: 301-7
    • (2011) Cardiovasc Ther , vol.29 , pp. 301-307
    • Dawson, J.1    Quinn, T.2    Rafferty, M.3
  • 34
    • 79959318812 scopus 로고    scopus 로고
    • Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease
    • Capodanno D, Patel A, Dharmashankar K, et al. Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease. Circ Cardiovasc Interv 2011; 4: 180-7
    • (2011) Circ Cardiovasc Interv , vol.4 , pp. 180-187
    • Capodanno, D.1    Patel, A.2    Dharmashankar, K.3
  • 35
    • 84875376664 scopus 로고    scopus 로고
    • Critical appraisal of a fixed combination of esomeprazole and low dose aspirin in risk reduction
    • Vachhani R, Bouhaidar D, Zfass A, et al. Critical appraisal of a fixed combination of esomeprazole and low dose aspirin in risk reduction. Ther Clin Risk Manag 2010; 6: 287-92
    • (2010) Ther Clin Risk Manag , vol.6 , pp. 287-292
    • Vachhani, R.1    Bouhaidar, D.2    Zfass, A.3
  • 36
    • 34248352504 scopus 로고    scopus 로고
    • Aspirin dose for the prevention of cardiovascular disease: A systematic review
    • Campbell CL, Smyth S, Montalescot G, et al. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA 2007; 297: 2018-24
    • (2007) JAMA , vol.297 , pp. 2018-2024
    • Campbell, C.L.1    Smyth, S.2    Montalescot, G.3
  • 37
    • 33744999455 scopus 로고    scopus 로고
    • Biology and pharmacology of the platelet P2Y12 receptor
    • Storey RF. Biology and pharmacology of the platelet P2Y12 receptor. Curr Pharmaceut Design 2006; 12: 1255-9
    • (2006) Curr Pharmaceut Design , vol.12 , pp. 1255-1259
    • Storey, R.F.1
  • 38
    • 0037005777 scopus 로고    scopus 로고
    • Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting
    • Bhatt DL, Bertrand ME, Berger PB, et al. Meta-analysis of randomized and registry comparisons of ticlopidine with clopidogrel after stenting. J Am Coll Cardiol 2002; 39: 9-14
    • (2002) J Am Coll Cardiol , vol.39 , pp. 9-14
    • Bhatt, D.L.1    Bertrand, M.E.2    Berger, P.B.3
  • 39
    • 3042744028 scopus 로고    scopus 로고
    • Identification of the active metabolite of ticlopidine from rat in vitro metabolites
    • Yoneda K, Iwamura R, Kishi H, et al. Identification of the active metabolite of ticlopidine from rat in vitro metabolites. Br J Pharmacol 2004; 142: 551-7
    • (2004) Br J Pharmacol , vol.142 , pp. 551-557
    • Yoneda, K.1    Iwamura, R.2    Kishi, H.3
  • 40
    • 18044378766 scopus 로고    scopus 로고
    • Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate receptor antagonists for the prevention of atherothrombosis
    • Savi P, Herbert JM. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate receptor antagonists for the prevention of atherothrombosis. Semin Thromb Hemost 2005; 31: 174-83
    • (2005) Semin Thromb Hemost , vol.31 , pp. 174-183
    • Savi, P.1    Herbert, J.M.2
  • 41
    • 75749102996 scopus 로고    scopus 로고
    • Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans
    • Farid NA, Kurihara A, Wrighton SA. Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans. J Clin Pharmacol 2010; 50: 126-42
    • (2010) J Clin Pharmacol , vol.50 , pp. 126-142
    • Farid, N.A.1    Kurihara, A.2    Wrighton, S.A.3
  • 42
    • 0029782279 scopus 로고    scopus 로고
    • Pharmacodynamics of ticlopidine: Relation between dose and time of administration to platelet inhibition
    • Kuzniar J, Splawinska B, Malinga K, et al. Pharmacodynamics of ticlopidine: relation between dose and time of administration to platelet inhibition. Int J Clin Pharmacol Ther 1996; 34: 357-61
    • (1996) Int J Clin Pharmacol Ther , vol.34 , pp. 357-361
    • Kuzniar, J.1    Splawinska, B.2    Malinga, K.3
  • 43
    • 9244251971 scopus 로고    scopus 로고
    • A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents
    • Schomig A, Neumann FJ, Kastrati A, et al. A randomized comparison of antiplatelet and anticoagulant therapy after the placement of coronary-artery stents. N Engl J Med 1996; 334: 1084-9
    • (1996) N Engl J Med , vol.334 , pp. 1084-1089
    • Schomig, A.1    Neumann, F.J.2    Kastrati, A.3
  • 44
    • 7844220998 scopus 로고    scopus 로고
    • Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting the full anticoagulation versus aspirin and ticlopidine (fantastic) study
    • Bertrand ME, Legrand V, Boland J, et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study. Circulation 1998; 98 (16): 1597-603
    • (1998) Circulation , vol.98 , Issue.16 , pp. 1597-1603
    • Bertrand, M.E.1    Legrand, V.2    Boland, J.3
  • 45
    • 0032481092 scopus 로고    scopus 로고
    • A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators
    • Leon MB, Baim DS, Popma JJ, et al. A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. Stent Anticoagulation Restenosis Study Investigators. N Engl J Med 1998; 339: 1665-71
    • (1998) N Engl J Med , vol.339 , pp. 1665-1671
    • Leon, M.B.1    Baim, D.S.2    Popma, J.J.3
  • 46
    • 0032542028 scopus 로고    scopus 로고
    • Randomized evaluation of anticoagulation versus antiplatelet therapy after coronary stent implantation in high-risk patients: The multicenter aspirin and ticlopidine trial after intracoronary stenting (MATTIS)
    • Urban P, Macaya C, Rupprecht HJ, et al. Randomized evaluation of anticoagulation versus antiplatelet therapy after coronary stent implantation in high-risk patients: the multicenter aspirin and ticlopidine trial after intracoronary stenting (MATTIS). Circulation 1998; 98: 2126-32
    • (1998) Circulation , vol.98 , pp. 2126-2132
    • Urban, P.1    MacAya, C.2    Rupprecht, H.J.3
  • 47
    • 78951495116 scopus 로고    scopus 로고
    • Differential impacts of CYP2C19 gene polymorphisms on the antiplatelet effects of clopidogrel and ticlopidine
    • Maeda A, Ando H, Asai T, et al. Differential impacts of CYP2C19 gene polymorphisms on the antiplatelet effects of clopidogrel and ticlopidine. Clin Pharmacol Ther 2011; 89: 229-33
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 229-233
    • Maeda, A.1    Ando, H.2    Asai, T.3
  • 48
    • 34548497430 scopus 로고    scopus 로고
    • Poor responsiveness to clopidogrel: Drug-specific or class-effect mechanism? Evidence from a clopidogrel-to-ticlopidine crossover study
    • Campo G, Valgimigli M, Gemmati D, et al. Poor responsiveness to clopidogrel: drug-specific or class-effect mechanism? Evidence from a clopidogrel-to-ticlopidine crossover study. J Am Coll Cardiol 2007; 50: 1132-7
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1132-1137
    • Campo, G.1    Valgimigli, M.2    Gemmati, D.3
  • 49
    • 63049106291 scopus 로고    scopus 로고
    • Ticlopidine-and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): Review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008)
    • Zakarija A, Kwaan HC, Moake JL, et al. Ticlopidine-and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008). Kidney Int Suppl 2009; 112: S20-4
    • Kidney Int Suppl , vol.2009
    • Zakarija, A.1    Kwaan, H.C.2    Moake, J.L.3
  • 50
    • 0033518847 scopus 로고    scopus 로고
    • Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting
    • Steinhubl SR, Tan WA, Foody JM, et al. Incidence and clinical course of thrombotic thrombocytopenic purpura due to ticlopidine following coronary stenting. EPISTENT Investigators. Evaluation of Platelet IIb/IIIa Inhibitor for Stenting. JAMA 1999; 281: 806-10
    • (1999) JAMA , vol.281 , pp. 806-810
    • Steinhubl, S.R.1    Tan, W.A.2    Foody, J.M.3
  • 51
  • 52
    • 0034622539 scopus 로고    scopus 로고
    • Doubleblind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting the Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS)
    • Bertrand ME, Rupprecht H-J, Urban P, et al. Doubleblind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting. The Clopidogrel Aspirin Stent International Cooperative Study (CLASSICS). Circulation 2000; 102: 624-9
    • (2000) Circulation , vol.102 , pp. 624-629
    • Bertrand, M.E.1    Rupprecht, H.-J.2    Urban, P.3
  • 53
    • 0032813891 scopus 로고    scopus 로고
    • Pharmacokinetic profile of 14C-labeled clopidogrel
    • Lins R, Broekhuysen J, Necciari J, et al. Pharmacokinetic profile of 14C-labeled clopidogrel. Semin Thromb Hemost 1999; 25 Suppl. 2: 29-33
    • (1999) Semin Thromb Hemost , vol.25 , Issue.SUPPL. 2 , pp. 29-33
    • Lins, R.1    Broekhuysen, J.2    Necciari, J.3
  • 55
    • 78651239845 scopus 로고    scopus 로고
    • Paraoxonase-1 is a major determinant of clopidogrel efficacy
    • Bouman HJ, Schö mig E, van Werkum JW, et al. Paraoxonase-1 is a major determinant of clopidogrel efficacy. Nat Med 2011; 17: 110-6
    • (2011) Nat Med , vol.17 , pp. 110-116
    • Bouman, H.J.1    Schö Mig, E.2    Van Werkum, J.W.3
  • 56
    • 84863500468 scopus 로고    scopus 로고
    • For the PON1 Meta-Analysis Group. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: A systematic review and meta-analysis
    • Reny J-L, Combescure C, Daali Y, et al., for the PON1 Meta-Analysis Group. Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis. J Thromb Haemost 2012; 10: 1242-51
    • (2012) J Thromb Haemost , vol.10 , pp. 1242-1251
    • Reny, J.-L.1    Combescure, C.2    Daali, Y.3
  • 57
    • 0032814002 scopus 로고    scopus 로고
    • Clopidogrel loading dose regimens: Kinetic profile of pharmacodynamic response in healthy subjects
    • Savcic M, Hauert J, Bachmann F, et al. Clopidogrel loading dose regimens: kinetic profile of pharmacodynamic response in healthy subjects. Semin Thromb Hemost 1999; 25: 15-9
    • (1999) Semin Thromb Hemost , vol.25 , pp. 15-19
    • Savcic, M.1    Hauert, J.2    Bachmann, F.3
  • 58
    • 73949112820 scopus 로고    scopus 로고
    • Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease the ONSET/OFFSET study
    • Gurbel PA, Bliden KP, Butler K, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease. The ONSET/OFFSET study. Circulation 2009; 120: 2577-85
    • (2009) Circulation , vol.120 , pp. 2577-2585
    • Gurbel, P.A.1    Bliden, K.P.2    Butler, K.3
  • 59
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee.
    • CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329-39
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 60
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S, Zhao F, Mehta SR, et al. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345: 494-502
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3
  • 61
    • 20144373281 scopus 로고    scopus 로고
    • CLARITY-TIMI 28 Investigators, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with STsegment elevation
    • Sabatine MS, Cannon CP, CLARITY-TIMI 28 Investigators, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with STsegment elevation. N Engl J Med 2005; 352: 1179-89
    • (2005) N Engl J Med , vol.352 , pp. 1179-1189
    • Sabatine, M.S.1    Cannon, C.P.2
  • 62
    • 27644548513 scopus 로고    scopus 로고
    • Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: Randomised placebo-controlled trial
    • Chen ZM, Jiang LX, Chen YP, et al. Addition of clopidogrel to aspirin in 45 852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet 2005; 366: 1607-21
    • (2005) Lancet , vol.366 , pp. 1607-1621
    • Chen, Z.M.1    Jiang, L.X.2    Chen, Y.P.3
  • 64
    • 33645861080 scopus 로고    scopus 로고
    • CHARISMA Investigators: Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events
    • Bhatt DL, Fox KA, Hacke W, et al. CHARISMA Investigators: clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006; 354: 1706-17
    • (2006) N Engl J Med , vol.354 , pp. 1706-1717
    • Bhatt, D.L.1    Fox, K.A.2    Hacke, W.3
  • 65
    • 77958005516 scopus 로고    scopus 로고
    • Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): A randomised factorial trial
    • Mehta SR, Tanguay JF, Eikelboom JW, et al. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet 2010; 376: 1233-43
    • (2010) Lancet , vol.376 , pp. 1233-1243
    • Mehta, S.R.1    Tanguay, J.F.2    Eikelboom, J.W.3
  • 66
    • 70349443275 scopus 로고    scopus 로고
    • Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: Results from the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial
    • Dangas G, Mehran R, Guagliumi G, et al. Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty: results from the HORIZONS-AMI (harmonizing outcomes with revascularization and stents in acute myocardial infarction) trial. J Am Coll Cardiol 2009; 54: 1438-46
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1438-1446
    • Dangas, G.1    Mehran, R.2    Guagliumi, G.3
  • 67
    • 34247869852 scopus 로고    scopus 로고
    • Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial
    • Bhatt DL, Flather MD, Hacke W, et al. Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol 2007; 49: 1982-8
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1982-1988
    • Bhatt, D.L.1    Flather, M.D.2    Hacke, W.3
  • 68
    • 77953191080 scopus 로고    scopus 로고
    • Platelet function testing and risk of bleeding complications
    • Ferreiro JL, Sibbing D, Angiolillo DJ. Platelet function testing and risk of bleeding complications. Thromb Haemost 2010; 103: 1128-35
    • (2010) Thromb Haemost , vol.103 , pp. 1128-1135
    • Ferreiro, J.L.1    Sibbing, D.2    Angiolillo, D.J.3
  • 69
    • 84866976698 scopus 로고    scopus 로고
    • Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease
    • Epub Jul 19
    • Rollini F, Tello-Montoliu A, Angiolillo DJ. Advances in platelet function testing assessing bleeding complications in patients with coronary artery disease. Platelets. Epub 2012 Jul 19
    • (2012) Platelets.
    • Rollini, F.1    Tello-Montoliu, A.2    Angiolillo, D.J.3
  • 70
    • 77449149717 scopus 로고    scopus 로고
    • Platelet adenosine diphosphate P2Y12 receptor antagonism: Benefits and limitations of current treatment strategies and future directions
    • Angiolillo DJ, Ferreiro JL. Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directions. Rev Esp Cardiol 2010; 63: 60-76
    • (2010) Rev Esp Cardiol , vol.63 , pp. 60-76
    • Angiolillo, D.J.1    Ferreiro, J.L.2
  • 71
    • 34047096264 scopus 로고    scopus 로고
    • Variability to individual responsiveness to clopidogrel; Clinical implication, management, and future perspectives
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E, et al. Variability to individual responsiveness to clopidogrel; clinical implication, management, and future perspectives. J Am Coll Cardiol 2007; 49: 1505-16
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1505-1516
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 72
    • 77953911457 scopus 로고    scopus 로고
    • Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate
    • Bonello L, Tantry US, Marcucci R, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. J Am Coll Cardiol 2010; 56: 919-33
    • (2010) J Am Coll Cardiol , vol.56 , pp. 919-933
    • Bonello, L.1    Tantry, U.S.2    Marcucci, R.3
  • 73
    • 77958573028 scopus 로고    scopus 로고
    • Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism
    • Bonello L, Armero S, Ait Mokhtar O, et al. Clopidogrel loading dose adjustment according to platelet reactivity monitoring in patients carrying the 2C19*2 loss of function polymorphism. J Am Coll Cardiol 2010; 56: 1630-6
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1630-1636
    • Bonello, L.A.R.1    Armero, S.2    Ait Mokhtar, O.3
  • 74
    • 84868205680 scopus 로고    scopus 로고
    • Angiographic and platelet reactivity outcomes with prasugrel 60 mg pretreatment and clopidogrel 600mg pretreatment in primary percutaneous coronary intervention
    • Epub Aug 2
    • Li Y, Tai BC, Sia W, et al. Angiographic and platelet reactivity outcomes with prasugrel 60 mg pretreatment and clopidogrel 600mg pretreatment in primary percutaneous coronary intervention. J Thromb Thrombolysis. Epub 2012 Aug 2
    • (2012) J Thromb Thrombolysis.
    • Li, Y.1    Tai, B.C.2    Sia, W.3
  • 75
    • 77955603691 scopus 로고    scopus 로고
    • Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: Initial evidence of a therapeutic window
    • Sibbing D, Steinhubl SR, Schulz S, et al. Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: initial evidence of a therapeutic window. J Am Coll Cardiol 2010; 56: 317-8
    • (2010) J Am Coll Cardiol , vol.56 , pp. 317-318
    • Sibbing, D.1    Steinhubl, S.R.2    Schulz, S.3
  • 76
    • 79958110089 scopus 로고    scopus 로고
    • Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome
    • Campo G, Parrinello G, Ferraresi P, et al. Prospective evaluation of on-clopidogrel platelet reactivity over time in patients treated with percutaneous coronary intervention relationship with gene polymorphisms and clinical outcome. J Am Coll Cardiol 2011; 57: 2474-83
    • (2011) J Am Coll Cardiol , vol.57 , pp. 2474-2483
    • Campo, G.1    Parrinello, G.2    Ferraresi, P.3
  • 77
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel PA, Bliden KP, Hiatt BL, et al. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 2003; 107: 2908-13
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3
  • 78
    • 61349172986 scopus 로고    scopus 로고
    • Unmet needs in oral antiplatelet therapy with ADP receptor blocking agents
    • Husted S. Unmet needs in oral antiplatelet therapy with ADP receptor blocking agents. Fundam Clin Pharmacol 2008; 23: 1-9
    • (2008) Fundam Clin Pharmacol , vol.23 , pp. 1-9
    • Husted, S.1
  • 79
    • 77953896604 scopus 로고    scopus 로고
    • Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration
    • Hulot J-S, Collet J-P, Silvain J, et al. Cardiovascular risk in clopidogrel-treated patients according to cytochrome P450 2C19*2 loss-of-function allele or proton pump inhibitor coadministration. J Am Coll Cardiol 2010; 56: 134-43
    • (2010) J Am Coll Cardiol , vol.56 , pp. 134-143
    • Hulot, J.-S.1    Collet, J.-P.2    Silvain, J.3
  • 80
    • 78049326068 scopus 로고    scopus 로고
    • Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A meta-analysis
    • Mega JL, Simon T, Collet JP, et al. Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis. JAMA 2010; 304: 1821-30
    • (2010) JAMA , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J.P.3
  • 81
    • 77952591958 scopus 로고    scopus 로고
    • Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement
    • Hochholzer W, Trenk D, Fromm M, et al. Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placement. J Am Coll Cardiol 2010; 55: 2427-34
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2427-2434
    • Hochholzer, W.1    Trenk, D.2    Fromm, M.3
  • 82
    • 16244395149 scopus 로고    scopus 로고
    • Clopidogrel administration prior to coronary artery bypass grafting surgery: The cardiologist's panacea or the surgeon's headache?
    • Kapetanakis EI, Medlam DA, Boyce SW, et al. Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache? Eur Heart J 2005; 26: 576-83
    • (2005) Eur Heart J , vol.26 , pp. 576-583
    • Kapetanakis, E.I.1    Medlam, D.A.2    Boyce, S.W.3
  • 83
    • 0036079135 scopus 로고    scopus 로고
    • The CURE trial: Using clopidogrel in acute coronary syndromes without ST-segment elevation
    • Gerschutz GP, Bhatt DL. The CURE trial: using clopidogrel in acute coronary syndromes without ST-segment elevation. Cleve Clin J Med 2002; 69: 377-8
    • (2002) Cleve Clin J Med , vol.69 , pp. 377-378
    • Gerschutz, G.P.1    Bhatt, D.L.2
  • 85
    • 79955108369 scopus 로고    scopus 로고
    • Optimizing platelet inhibition in clopidogrel poor metabolizers: Therapeutic options and practical considerations
    • Angiolillo DJ, Ueno M. Optimizing platelet inhibition in clopidogrel poor metabolizers: therapeutic options and practical considerations. JACC Cardiovasc Interv 2011; 4 (4): 411-4
    • (2011) JACC Cardiovasc Interv , vol.4 , Issue.4 , pp. 411-414
    • Angiolillo, D.J.1    Ueno, M.2
  • 86
    • 33847130538 scopus 로고    scopus 로고
    • Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study
    • Angiolillo DJ, Shoemaker SB, Desai B, et al. Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study. Circulation 2007; 115: 708-16
    • (2007) Circulation , vol.115 , pp. 708-716
    • Angiolillo, D.J.1    Shoemaker, S.B.2    Desai, B.3
  • 87
    • 79952598836 scopus 로고    scopus 로고
    • Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: The GRAVITAS randomized trial
    • GRAVITAS Investigators et al
    • Price MJ, Berger PB, Teirstein PS, et al. GRAVITAS Investigators et al. Standard-vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA 2011; 305: 1097-105
    • (2011) JAMA , vol.305 , pp. 1097-1105
    • Price, M.J.1    Berger, P.B.2    Teirstein, P.S.3
  • 88
    • 81855211733 scopus 로고    scopus 로고
    • Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease
    • Mega JL, Hochholzer W, Frelinger 3rd AL, et al. Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular disease. JAMA 2011; 306: 2221-8
    • (2011) JAMA , vol.306 , pp. 2221-2228
    • Mega, J.L.1    Hochholzer, W.2    Frelinger Iii., A.L.3
  • 89
    • 67650745975 scopus 로고    scopus 로고
    • Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: Results from the double-blind, prospective, randomized Tailoring Treatment with Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Study
    • Valgimigli M, Campo G, de Cesare N, et al. Intensifying platelet inhibition with tirofiban in poor responders to aspirin, clopidogrel, or both agents undergoing elective coronary intervention: results from the double-blind, prospective, randomized Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Study. Circulation 2009; 119: 3215-22
    • (2009) Circulation , vol.119 , pp. 3215-3222
    • Valgimigli, M.1    Campo, G.2    De Cesare, N.3
  • 90
    • 57549099501 scopus 로고    scopus 로고
    • Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: A prospective, randomized study
    • Cuisset T, Frere C, Quilici J, et al. Glycoprotein IIb/IIIa inhibitors improve outcome after coronary stenting in clopidogrel nonresponders: a prospective, randomized study. JACC Cardiovasc Interv 2008; 1: 649-53
    • (2008) JACC Cardiovasc Interv , vol.1 , pp. 649-653
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 91
    • 14844328650 scopus 로고    scopus 로고
    • Effects of cilostazol on platelet activation in coronary stenting patients who already treated with aspirin and clopidogrel
    • Ahn JC, Song WH, Kwon JA, et al. Effects of cilostazol on platelet activation in coronary stenting patients who already treated with aspirin and clopidogrel. Korean J Intern Med 2004; 19: 230-6
    • (2004) Korean J Intern Med , vol.19 , pp. 230-236
    • Ahn, J.C.1    Song, W.H.2    Kwon, J.A.3
  • 92
    • 52449085759 scopus 로고    scopus 로고
    • A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: Results of the OPTIMUS-2 study
    • Angiolillo DJ, Capranzano P, Goto S, et al. A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study. Eur Heart J 2008; 29: 2202-11
    • (2008) Eur Heart J , vol.29 , pp. 2202-2211
    • Angiolillo, D.J.1    Capranzano, P.2    Goto, S.3
  • 93
    • 79961056489 scopus 로고    scopus 로고
    • Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy
    • Angiolillo DJ, Capranzano P, Ferreiro JL, et al. Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapy. Thromb Haemost 2011; 106: 253-62
    • (2011) Thromb Haemost , vol.106 , pp. 253-262
    • Angiolillo, D.J.1    Capranzano, P.2    Ferreiro, J.L.3
  • 94
    • 77953661111 scopus 로고    scopus 로고
    • Adding cilostazol to dual antiplatelet therapy achieves greater platelet inhibition than high maintenance dose clopidogrel in patients with acute myocardial infarction: Results of the Adjunctive Cilostazol versus high maintenance dose clopidogrel in patients with AMI (ACCEL-AMI) study
    • Jeong YH, Hwang JY, Kim IS, et al. Adding cilostazol to dual antiplatelet therapy achieves greater platelet inhibition than high maintenance dose clopidogrel in patients with acute myocardial infarction: results of the Adjunctive Cilostazol versus high maintenance dose clopidogrel in patients with AMI (ACCEL-AMI) study. Circ Cardiovasc Interv 2010; 3: 17-26
    • (2010) Circ Cardiovasc Interv , vol.3 , pp. 17-26
    • Jeong, Y.H.1    Hwang, J.Y.2    Kim, I.S.3
  • 95
    • 79955093619 scopus 로고    scopus 로고
    • Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype
    • Kim IS, Jeong YH, Park Y, et al. Platelet inhibition by adjunctive cilostazol versus high maintenance-dose clopidogrel in patients with acute myocardial infarction according to cytochrome P450 2C19 genotype. JACC Cardiovasc Interv 2011; 4: 381-91
    • (2011) JACC Cardiovasc Interv , vol.4 , pp. 381-391
    • Kim, I.S.1    Jeong, Y.H.2    Park, Y.3
  • 96
    • 62949165644 scopus 로고    scopus 로고
    • Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: A randomized, controlled study
    • Han Y, Li Y, Wang S, et al. Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: a randomized, controlled study. Am Heart J 2009; 157: 733-9
    • (2009) Am Heart J , vol.157 , pp. 733-739
    • Han, Y.1    Li, Y.2    Wang, S.3
  • 98
    • 80053232385 scopus 로고    scopus 로고
    • The pharmacogenetics of antiplatelet agents: Towards personalized therapy?
    • Ahmad T, Voora D, Becker RC. The pharmacogenetics of antiplatelet agents: towards personalized therapy? Nat Rev Cardiol 2001; 8: 560-71
    • (2001) Nat Rev Cardiol , vol.8 , pp. 560-571
    • Ahmad, T.1    Voora, D.2    Becker, R.C.3
  • 99
    • 84867708851 scopus 로고    scopus 로고
    • Individualised antiplatelet therapy: Is there a role for platelet function testing in routine clinical practice?
    • Collet J-P, van Werkum JW. Individualised antiplatelet therapy: is there a role for platelet function testing in routine clinical practice? Eur Cardiol 2010; 6: 41-9
    • (2010) Eur Cardiol , vol.6 , pp. 41-49
    • Collet, J.-P.1    Van Werkum, J.W.2
  • 100
    • 77955638355 scopus 로고    scopus 로고
    • ACCFAHA clopidogrel clinical alert: Approaches to the fda 'boxed warning'. A report of the american college of cardiology foundation task force on clinical expert consensus documents and the american heart association
    • Holmes DR, Dehmer GJ, Kaul S, et al. ACCF/AHA clopidogrel clinical alert: approaches to the FDA 'Boxed Warning'. A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association. J Am Coll Cardiol 2010; 56 (4): 321-41
    • (2010) J Am Coll Cardiol , vol.56 , Issue.4 , pp. 321-341
    • Holmes, D.R.1    Dehmer, G.J.2    Kaul, S.3
  • 101
    • 79551549640 scopus 로고    scopus 로고
    • Allergic reactions to clopidogrel and cross-reactivity to other agents
    • Lokhandwala J, Best PJ, Henry Y, et al. Allergic reactions to clopidogrel and cross-reactivity to other agents. Curr Allergy Asthma Rep 2011; 11: 52-7
    • (2011) Curr Allergy Asthma Rep , vol.11 , pp. 52-57
    • Lokhandwala, J.1    Best, P.J.2    Henry, Y.3
  • 102
    • 78650517232 scopus 로고    scopus 로고
    • Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: Randomized, placebo-controlled, crossover comparison studies
    • Angiolillo DJ, Gibson CM, Cheng S, et al. Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clin Pharmacol Ther 2011; 89: 65-74
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 65-74
    • Angiolillo, D.J.1    Gibson, C.M.2    Cheng, S.3
  • 103
    • 78650113666 scopus 로고    scopus 로고
    • Effects of concomitant versus staggered clopidogrel and omeprazole intake results of a prospective randomized crossover study
    • Ferreiro JL, Ueno M, Capodanno D, et al. Effects of concomitant versus staggered clopidogrel and omeprazole intake results of a prospective randomized crossover study. Circ Cardiovasc Interv 2010; 3: 436-41
    • (2010) Circ Cardiovasc Interv , vol.3 , pp. 436-441
    • Ferreiro, J.L.1    Ueno, M.2    Capodanno, D.3
  • 104
    • 84860390152 scopus 로고    scopus 로고
    • Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: Results of a prospective, randomized, crossover study
    • Ferreiro JL, Ueno M, Tomasello SD, et al. Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study. Circ Cardiovasc Interv 2011; 4: 273-9
    • (2011) Circ Cardiovasc Interv , vol.4 , pp. 273-279
    • Ferreiro, J.L.1    Ueno, M.2    Tomasello, S.D.3
  • 105
    • 78149487926 scopus 로고    scopus 로고
    • Clopidogrel with or without omeprazole in coronary artery disease
    • Bhatt DL, Cryer BL, Contant CF, et al. Clopidogrel with or without omeprazole in coronary artery disease. N Engl J Med 2010; 363: 1909-17
    • (2010) N Engl J Med , vol.363 , pp. 1909-1917
    • Bhatt, D.L.1    Cryer, B.L.2    Contant, C.F.3
  • 107
    • 33845451677 scopus 로고    scopus 로고
    • A comparison of prasugrel and clopidogrel loading doses on platelet function: Magnitude of platelet inhibition is related to active metabolite formation
    • Brandt JT, Payne CD, Wiviott SD, et al. A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J 2007; 153: 66.e9-e16
    • (2007) Am Heart J , vol.153
    • Brandt, J.T.1    Payne, C.D.2    Wiviott, S.D.3
  • 108
    • 36348977461 scopus 로고    scopus 로고
    • Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel
    • Payne CD, Li YG, Small DS, et al. Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel. J Cardiovasc Pharmacol 2007; 50: 555-62
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 555-562
    • Payne, C.D.1    Li, Y.G.2    Small, D.S.3
  • 109
    • 37849002889 scopus 로고    scopus 로고
    • Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
    • Wallentin L, Varenhorst C, James S, et al. Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur Heart J 2008; 29: 21-30
    • (2008) Eur Heart J , vol.29 , pp. 21-30
    • Wallentin, L.1    Varenhorst, C.2    James, S.3
  • 110
    • 68649097104 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation with prasugrel and clopidogrel: An integrated analysis in 846 subjects
    • Li YG, Ni L, Brandt JT, et al. Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects. Platelets 2009; 20: 316-27
    • (2009) Platelets , vol.20 , pp. 316-327
    • Li, Y.G.1    Ni, L.2    Brandt, J.T.3
  • 111
    • 37349111065 scopus 로고    scopus 로고
    • Prasugrel compared with high loading-and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: The Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 Trial
    • Wiviott SD, Trenk D, Frelinger AL, et al. Prasugrel compared with high loading-and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in Myocardial Infarction 44 Trial. Circulation 2007; 116: 2923-32
    • (2007) Circulation , vol.116 , pp. 2923-2932
    • Wiviott, S.D.1    Trenk, D.2    Frelinger, A.L.3
  • 112
    • 79952149001 scopus 로고    scopus 로고
    • A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: Results of the Optimizing anti-Platelet Therapy in diabetes MellitUS (OPTIMUS)-3 Trial
    • Angiolillo DJ, Badimon JJ, Saucedo JF, et al. A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 Trial. Eur Heart J 2011; 32: 838-46
    • (2011) Eur Heart J , vol.32 , pp. 838-846
    • Angiolillo, D.J.1    Badimon, J.J.2    Saucedo, J.F.3
  • 113
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-15
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 114
    • 43749117048 scopus 로고    scopus 로고
    • Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: A TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel-Thrombolysis in Myocardial Infarction) analysis
    • Antman EM, Wiviott SD, Murphy SA, et al. Early and late benefits of prasugrel in patients with acute coronary syndromes undergoing percutaneous coronary intervention: a TRITON-TIMI 38 (TRial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet InhibitioN with Prasugrel- Thrombolysis In Myocardial Infarction) analysis. J Am Coll Cardiol 2008; 51: 2028-33
    • (2008) J Am Coll Cardiol , vol.51 , pp. 2028-2033
    • Antman, E.M.1    Wiviott, S.D.2    Murphy, S.A.3
  • 115
    • 42149119040 scopus 로고    scopus 로고
    • Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: A subanalysis of a randomised trial
    • Wiviott SD, Braunwald E, McCabe CH, et al. Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: a subanalysis of a randomised trial. Lancet 2008; 371: 1353-63
    • (2008) Lancet , vol.371 , pp. 1353-1363
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 116
    • 55949103494 scopus 로고    scopus 로고
    • Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38
    • Wiviott SD, Braunwald E, Angiolillo DJ, et al. Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. Circulation 2008; 118: 1626-36
    • (2008) Circulation , vol.118 , pp. 1626-1636
    • Wiviott, S.D.1    Braunwald, E.2    Angiolillo, D.J.3
  • 117
    • 60649112469 scopus 로고    scopus 로고
    • Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): Double-blind, randomised controlled trial
    • Montalescot G, Wiviott SD, Braunwald E, et al. Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial. Lancet 2009; 373: 723-31
    • (2009) Lancet , vol.373 , pp. 723-731
    • Montalescot, G.1    Wiviott, S.D.2    Braunwald, E.3
  • 118
    • 66349133650 scopus 로고    scopus 로고
    • Cytochrome p-450 polymorphisms and response to prasugrel: Relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome p-450 polymorphisms and response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation 2009; 119: 2553-60
    • (2009) Circulation , vol.119 , pp. 2553-2560
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 119
    • 79959694977 scopus 로고    scopus 로고
    • Mortality benefit with prasugrel in TRITON-TIMI 38 coronary artery bypass grafting (CABG) cohort: Risk adjusted retrospective data analysis [abstract]
    • Smith PK, Despotis GJ, Goodnough LT, et al. Mortality benefit with prasugrel in TRITON-TIMI 38 coronary artery bypass grafting (CABG) cohort: risk adjusted retrospective data analysis [abstract]. Circulation 2010; 122: A10881
    • (2010) Circulation , vol.122
    • Smith, P.K.1    Despotis, G.J.2    Goodnough, L.T.3
  • 120
    • 54149097794 scopus 로고    scopus 로고
    • Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial
    • Murphy SA, Antman EM, Wiviott SD, et al. Reduction in recurrent cardiovascular events with prasugrel compared with clopidogrel in patients with acute coronary syndromes from the TRITON-TIMI 38 trial. Eur Heart J 2008; 29: 2473-9
    • (2008) Eur Heart J , vol.29 , pp. 2473-2479
    • Murphy, S.A.1    Antman, E.M.2    Wiviott, S.D.3
  • 121
    • 84867177857 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel for acute coronary syndromes without revascularizatoin
    • Epub Aug 25
    • Roe MT, Armstrong PW, Fox KA, et al. Prasugrel versus clopidogrel for acute coronary syndromes without revascularizatoin. N Engl J Med. Epub 2012 Aug 25
    • (2012) N Engl J Med.
    • Roe, M.T.1    Armstrong, P.W.2    Fox, K.A.3
  • 122
    • 77956681628 scopus 로고    scopus 로고
    • Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: Results of the SWAP (SWitching Anti Platelet) study
    • Angiolillo DJ, Saucedo JF, Deraad R, et al. Increased platelet inhibition after switching from maintenance clopidogrel to prasugrel in patients with acute coronary syndromes: results of the SWAP (SWitching Anti Platelet) study. J Am Coll Cardiol 2010; 56: 1017-23
    • (2010) J Am Coll Cardiol , vol.56 , pp. 1017-1023
    • Angiolillo, D.J.1    Saucedo, J.F.2    Deraad, R.3
  • 123
    • 74249088972 scopus 로고    scopus 로고
    • Prasugrel compared with high-dose clopidogrel in acute coronary syndrome: The randomised, double-blind ACAPULCO study
    • Montalescot G, Sideris G, Cohen R, et al. Prasugrel compared with high-dose clopidogrel in acute coronary syndrome: the randomised, double-blind ACAPULCO study. Thromb Haemost 2010; 103: 213-23
    • (2010) Thromb Haemost , vol.103 , pp. 213-223
    • Montalescot, G.1    Sideris, G.2    Cohen, R.3
  • 124
    • 79960603731 scopus 로고    scopus 로고
    • High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in acute coronary syndromes
    • Bonello L, Pansieri M, Mancini J, et al. High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in acute coronary syndromes. J Am Coll Cardiol 2011; 58: 467-73
    • (2011) J Am Coll Cardiol , vol.58 , pp. 467-473
    • Bonello, L.1    Pansieri, M.2    Mancini, J.3
  • 125
    • 67651173161 scopus 로고    scopus 로고
    • Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial
    • Michelson AD, Frelinger 3rd AL, Braunwald E, et al. Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. Eur Heart J 2009; 30: 1753-63
    • (2009) Eur Heart J , vol.30 , pp. 1753-1763
    • Michelson, A.D.1    Frelinger Iii., A.L.2    Braunwald, E.3
  • 126
    • 84875381213 scopus 로고    scopus 로고
    • Effient (prasugrel) [package insert] Indianapolis (IN): Eli Lilly, 2011
    • Effient (prasugrel) [package insert]. Indianapolis (IN): Eli Lilly, 2011
  • 127
    • 84867177305 scopus 로고    scopus 로고
    • Recovery of platelet function following discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated subjects with stable coronary disease: The RECOVERY trial [abstract]
    • Price MJ, Logan DK, Walder JS, et al. Recovery of platelet function following discontinuation of prasugrel or clopidogrel maintenance dosing in aspirin-treated subjects with stable coronary disease: the RECOVERY trial [abstract]. J Am Coll Cardiol 2011; 57: e1636
    • (2011) J Am Coll Cardiol , vol.57
    • Price, M.J.1    Logan, D.K.2    Walder, J.S.3
  • 129
    • 84875374540 scopus 로고    scopus 로고
    • US FDA NDA 22-307 Risk Evaluation and Mitigation Strategy. Trade name: EFFIENT (prasugrel) [online]. Available from URL: [Accessed 2012 Jun 26]
    • US FDA. NDA 22-307 Risk Evaluation and Mitigation Strategy. Trade name: EFFIENT (prasugrel) [online]. Available from URL: http://www.fda.gov/downloads/ Drugs/DrugSafety/PostmarketDrugSafetyInformationfor PatientsandProviders/ UCM187493.pdf [Accessed 2012 Jun 26]
  • 130
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITONTIMI 38 trial: A pharmacogenetic analysis
    • Mega JL, Close SL, Wiviott SD, et al. Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITONTIMI 38 trial: a pharmacogenetic analysis. Lancet 2010; 376: 1312-9
    • (2010) Lancet , vol.376 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 131
    • 82255169699 scopus 로고    scopus 로고
    • Evaluating the risk-benefit profile of the directacting P2Y12 inhibitor ticagrelor in acute coronary syndromes
    • Husted S. Evaluating the risk-benefit profile of the directacting P2Y12 inhibitor ticagrelor in acute coronary syndromes. Postgrad Med 2011; 123: 79-90
    • (2011) Postgrad Med , vol.123 , pp. 79-90
    • Husted, S.1
  • 132
    • 70449484408 scopus 로고    scopus 로고
    • Ticagrelor: The first reversibly binding oral P2Y12 receptor antagonist
    • Husted S, van Giezen JJ. Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist. Cardiovasc Ther 2009; 27: 259-74
    • (2009) Cardiovasc Ther , vol.27 , pp. 259-274
    • Husted, S.1    Van Giezen, J.J.2
  • 133
    • 69249213604 scopus 로고    scopus 로고
    • Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signalling and platelet aggregation
    • van Giezen JJ, Nilsson L, Berntsson P, et al. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signalling and platelet aggregation. J Thromb Haemostat 2009; 7: 1556-65
    • (2009) J Thromb Haemostat , Issue.7 , pp. 1556-1565
    • Van Giezen, J.J.1    Nilsson, L.2    Berntsson, P.3
  • 134
    • 77953498801 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers
    • Butler K, Teng R. Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers. Br J Clin Pharmacol 2010; 70: 65-77
    • (2010) Br J Clin Pharmacol , vol.70 , pp. 65-77
    • Butler, K.1    Teng, R.2
  • 135
    • 77955992168 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects
    • Teng R, Oliver S, Hayes MA, et al. Absorption, distribution, metabolism, and excretion of ticagrelor in healthy subjects. Drug Metab Dispos 2010; 38: 1514-21
    • (2010) Drug Metab Dispos , vol.38 , pp. 1514-1521
    • Teng, R.1    Oliver, S.2    Hayes, M.A.3
  • 136
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, et al. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J 2006; 27: 1038-47
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3
  • 137
    • 77958003916 scopus 로고    scopus 로고
    • Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes
    • Storey RF, Angiolillo DJ, Patil SB, et al. Inhibitory effects of ticagrelor compared with clopidogrel on platelet function in patients with acute coronary syndromes. J AmColl Cardiol 2010; 56: 1456-62
    • (2010) J AmColl Cardiol , vol.56 , pp. 1456-1462
    • Storey, R.F.1    Angiolillo, D.J.2    Patil, S.B.3
  • 138
    • 79960189314 scopus 로고    scopus 로고
    • The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: Combined analysis of the ONSET/OFFSET and RESPOND studies
    • Bliden KP, Tantry US, Storey RF, et al. The effect of ticagrelor versus clopidogrel on high on-treatment platelet reactivity: combined analysis of the ONSET/OFFSET and RESPOND studies. Am Heart J 2011; 162: 160-5
    • (2011) Am Heart J , vol.162 , pp. 160-165
    • Bliden, K.P.1    Tantry, U.S.2    Storey, R.F.3
  • 139
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • Wallentin L, Becker RC, Budai A, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2009; 361: 1045-57
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budai, A.3
  • 140
    • 80051550924 scopus 로고    scopus 로고
    • Ticagrelor compared with clopidogrel by geographic region in the platelet inhibition and patient outcomes (PLATO) trial
    • Mahaffey KW, Wojdyla DM, Carroll K, et al. Ticagrelor compared with clopidogrel by geographic region in the platelet inhibition and patient outcomes (PLATO) trial. Circulation 2011; 124: 544-54
    • (2011) Circulation , vol.124 , pp. 544-554
    • Mahaffey, K.W.1    Wojdyla, D.M.2    Carroll, K.3
  • 141
    • 0020692577 scopus 로고
    • Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man
    • FitzGerald GA, Oates JA, Hawiger J, et al. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. J Clin Invest 1983; 71: 676-88
    • (1983) J Clin Invest , vol.71 , pp. 676-688
    • Fitzgerald, G.A.1    Oates, J.A.2    Hawiger, J.3
  • 142
    • 80052611377 scopus 로고    scopus 로고
    • Anti-platelet therapy: Cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy
    • Warner TD, Nylander S, Whatling C. Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. Br J Clin Pharmacol 2011; 72: 619-33
    • (2011) Br J Clin Pharmacol , vol.72 , pp. 619-633
    • Warner, T.D.1    Nylander, S.2    Whatling, C.3
  • 143
    • 79952045828 scopus 로고    scopus 로고
    • In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation
    • Armstrong PCJ, Leadbeater PD, Chan MV, et al. In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation. J Thromb Haemost 2011; 9: 552-61
    • (2011) J Thromb Haemost , vol.9 , pp. 552-561
    • Pcj, A.1    Leadbeater, P.D.2    Chan, M.V.3
  • 144
    • 80053399937 scopus 로고    scopus 로고
    • Antiplatelet effects of aspirin vary with level of P2Y12 receptor blockade supplied by either ticagrelor or prasugrel
    • Kirkby NS, Leadbeater PDM, Chan MV, et al. Antiplatelet effects of aspirin vary with level of P2Y12 receptor blockade supplied by either ticagrelor or prasugrel. J Thromb Haem 2011; 9: 2103-5
    • (2011) J Thromb Haem , vol.9 , pp. 2103-2105
    • Kirkby, N.S.1    Pdm, L.2    Chan, M.V.3
  • 145
    • 74649085430 scopus 로고    scopus 로고
    • Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): A randomised double-blind study
    • Cannon CP, Harrington RA, James S, et al. Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet 2010; 375: 283-93
    • (2010) Lancet , vol.375 , pp. 283-293
    • Cannon, C.P.1    Harrington, R.A.2    James, S.3
  • 146
    • 82255188048 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: Substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial
    • Jun 17
    • James SK, Roe MT, Cannon CP, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes intended for non-invasive management: substudy from prospective randomised PLATelet inhibition and patient Outcomes (PLATO) trial. BMJ 2011 Jun 17; 342: d3527
    • (2011) BMJ , vol.342
    • James, S.K.1    Roe, M.T.2    Cannon, C.P.3
  • 147
    • 79551563636 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: Results from the PLATO (Platelet
    • Held C, Asenblad N, Bassand JP, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial. J Am Coll Cardiol 2011; 57: 672-84
    • (2011) J Am Coll Cardiol , vol.57 , pp. 672-684
    • Held, C.1    Asenblad, N.2    Bassand, J.P.3
  • 148
    • 78650174722 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: A Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis
    • Steg PG, James S, Harrington RA, et al. Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation 2010; 122: 2131-41
    • (2010) Circulation , vol.122 , pp. 2131-2141
    • Steg, P.G.1    James, S.2    Harrington, R.A.3
  • 149
    • 84862146372 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes with prior history of stroke or transient ischemic attack
    • James SK, Storey RF, Khurmi N, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes with prior history of stroke or transient ischemic attack. Circulation 2012; 125: 2914-21
    • (2012) Circulation , vol.125 , pp. 2914-2921
    • James, S.K.1    Storey, R.F.2    Khurmi, N.3
  • 150
    • 77957270303 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: Results from the Platelet Inhibition and Patient Outcomes (PLATO) trial
    • James S, Budaj A, Aylward P, et al. Ticagrelor versus clopidogrel in acute coronary syndromes in relation to renal function: results from the Platelet Inhibition and Patient Outcomes (PLATO) trial. Circulation 2010; 122: 1056-67
    • (2010) Circulation , vol.122 , pp. 1056-1067
    • James, S.1    Budaj, A.2    Aylward, P.3
  • 151
    • 78650368771 scopus 로고    scopus 로고
    • Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: A substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial
    • James S, Angiolillo DJ, Cornel JH, et al. Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trial. Eur Heart J 2010; 31: 3006-16
    • (2010) Eur Heart J , vol.31 , pp. 3006-3016
    • James, S.1    Angiolillo, D.J.2    Cornel, J.H.3
  • 152
    • 77958100874 scopus 로고    scopus 로고
    • Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
    • Wallentin L, James S, Storey RF, et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial. Lancet 2010; 376: 1320-8
    • (2010) Lancet , vol.376 , pp. 1320-1328
    • Wallentin, L.1    James, S.2    Storey, R.F.3
  • 153
    • 79951785678 scopus 로고    scopus 로고
    • First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: The ONSET/OFFSET and RESPOND genotype studies
    • Tantry US, Bliden KP, Wei C, et al. First analysis of the relation between CYP2C19 genotype and pharmacodynamics in patients treated with ticagrelor versus clopidogrel: the ONSET/OFFSET and RESPOND genotype studies. Circ Cardiovasc Genet 2010; 3: 556-66
    • (2010) Circ Cardiovasc Genet , vol.3 , pp. 556-566
    • Tantry, U.S.1    Bliden, K.P.2    Wei, C.3
  • 154
    • 84860880262 scopus 로고    scopus 로고
    • [online] Wilmington (DE): AstraZeneca, [online] [Accessed 2012 Jun 26]
    • Brilinta-(ticagrelor) tablets: full prescribing information [online]. Wilmington (DE): AstraZeneca, 2011 [online]. Available from URL: http://www1.astrazeneca-us.com/pi/brilinta.pdf [Accessed 2012 Jun 26]
    • (2011) Brilinta-(ticagrelor) Tablets: Full Prescribing Information
  • 156
    • 82955201646 scopus 로고    scopus 로고
    • Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes
    • Storey RF, Becker RC, Harrington RA, et al. Characterization of dyspnoea in PLATO study patients treated with ticagrelor or clopidogrel and its association with clinical outcomes. Eur Heart J 2011; 32: 2945-53
    • (2011) Eur Heart J , vol.32 , pp. 2945-2953
    • Storey, R.F.1    Becker, R.C.2    Harrington, R.A.3
  • 157
    • 80955144190 scopus 로고    scopus 로고
    • Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patient Outcomes [PLATO] pulmonary function substudy)
    • Storey RF, Becker RC, Harrington RA, et al. Pulmonary function in patients with acute coronary syndrome treated with ticagrelor or clopidogrel (from the Platelet Inhibition and Patient Outcomes [PLATO] pulmonary function substudy). Am J Cardiol 2011; 108: 1542-6
    • (2011) Am J Cardiol , vol.108 , pp. 1542-1546
    • Storey, R.F.1    Becker, R.C.2    Harrington, R.A.3
  • 158
    • 0035895332 scopus 로고    scopus 로고
    • Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: A metaanalysis of phase III multicenter randomized trials
    • Chew DP, Bhatt DL, Sapp S, et al. Increased mortality with oral platelet glycoprotein IIb/IIIa antagonists: a metaanalysis of phase III multicenter randomized trials. Circulation 2001; 103: 201-6
    • (2001) Circulation , vol.103 , pp. 201-206
    • Chew, D.P.1    Bhatt, D.L.2    Sapp, S.3
  • 159
    • 0037132843 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: A meta-analysis of all major randomised clinical trials
    • Boersma E, Harrington RA, Moliterno DJ, et al. Platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes: a meta-analysis of all major randomised clinical trials. Lancet 2002; 359: 189-98
    • (2002) Lancet , vol.359 , pp. 189-198
    • Boersma, E.1    Harrington, R.A.2    Moliterno, D.J.3
  • 160
    • 33645507439 scopus 로고    scopus 로고
    • Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: The ISAR-REACT 2 randomized trial
    • Kastrati A, Mehilli J, Neumann FJ, et al. Abciximab in patients with acute coronary syndromes undergoing percutaneous coronary intervention after clopidogrel pretreatment: the ISAR-REACT 2 randomized trial. JAMA 2006; 295: 1531-8
    • (2006) JAMA , vol.295 , pp. 1531-1538
    • Kastrati, A.1    Mehilli, J.2    Neumann, F.J.3
  • 161
    • 34548359246 scopus 로고    scopus 로고
    • Abciximab in primary coronary stenting of ST-elevation myocardial infarction: A European meta-analysis on individual patients' data with long-term follow-up
    • Montalescot G, Antoniucci D, Kastrati A. Abciximab in primary coronary stenting of ST-elevation myocardial infarction: a European meta-analysis on individual patients' data with long-term follow-up. Eur Heart J 2007; 28: 443-9
    • (2007) Eur Heart J , vol.28 , pp. 443-449
    • Montalescot, G.1    Antoniucci, D.2    Kastrati, A.3
  • 163
    • 73949101141 scopus 로고    scopus 로고
    • Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: A meta-analysis of randomized trials
    • Valgimigli M, Biondi-Zoccai G, Tebaldi M, et al. Tirofiban as adjunctive therapy for acute coronary syndromes and percutaneous coronary intervention: a meta-analysis of randomized trials. Eur Heart J 2010; 31: 35-49
    • (2010) Eur Heart J , vol.31 , pp. 35-49
    • Valgimigli, M.1    Biondi-Zoccai, G.2    Tebaldi, M.3
  • 164
    • 79959354932 scopus 로고    scopus 로고
    • Eptifibatide: The evidence for its role in the management of acute coronary syndromes
    • Shah I, Khan SO, Malhotra S, et al. Eptifibatide: the evidence for its role in the management of acute coronary syndromes. Core Evid 2010; 4: 49-65
    • (2010) Core Evid , vol.4 , pp. 49-65
    • Shah, I.1    Khan, S.O.2    Malhotra, S.3
  • 165
    • 0030919511 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II Integrilin to Minimise Platelet Aggregation and Coronary Thrombosis-II
    • IMPACT-II Investigators
    • IMPACT-II Investigators. Randomised placebo-controlled trial of effect of eptifibatide on complications of percutaneous coronary intervention: IMPACT-II. Integrilin to Minimise Platelet Aggregation and Coronary Thrombosis-II. Lancet 1997; 349: 1422-8
    • (1997) Lancet , vol.349 , pp. 1422-1428
  • 166
    • 0034676781 scopus 로고    scopus 로고
    • Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): A randomised, placebo-controlled trial
    • ESPRIT Investigators.
    • ESPRIT Investigators. Novel dosing regimen of eptifibatide in planned coronary stent implantation (ESPRIT): a randomised, placebo-controlled trial. Lancet 2000; 356: 2037-44
    • (2000) Lancet , vol.356 , pp. 2037-2044
  • 167
    • 66149124479 scopus 로고    scopus 로고
    • Early versus delayed, provisional eptifibatide in acute coronary syndromes
    • Giugliano RP, White JA, Bode C, et al. Early versus delayed, provisional eptifibatide in acute coronary syndromes. N Engl J Med 2009; 360: 2176-90
    • (2009) N Engl J Med , vol.360 , pp. 2176-2190
    • Giugliano, R.P.1    White, J.A.2    Bode, C.3
  • 168
    • 70450187946 scopus 로고    scopus 로고
    • Cangrelor: A review on its mechanism of action and clinical development
    • Ferreiro JL, Ueno M, Angiolillo DJ. Cangrelor: a review on its mechanism of action and clinical development. Expert Rev Cardiovasc Ther 2009; 7: 1195-201
    • (2009) Expert Rev Cardiovasc Ther , vol.7 , pp. 1195-1201
    • Ferreiro, J.L.1    Ueno, M.2    Angiolillo, D.J.3
  • 169
    • 18044388905 scopus 로고    scopus 로고
    • Preclinical and clinical studies with selective reversible direct P2Y12 antagonists
    • van Giezen JJ, Humphries RG. Preclinical and clinical studies with selective reversible direct P2Y12 antagonists. Semin Thromb Hemost 2005; 31: 195-204
    • (2005) Semin Thromb Hemost , vol.31 , pp. 195-204
    • Van Giezen, J.J.1    Humphries, R.G.2
  • 170
    • 0035085132 scopus 로고    scopus 로고
    • Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes
    • Storey RF, Oldroyd KG, Wilcox RG. Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Thromb Haemost 2001; 85: 401-7
    • (2001) Thromb Haemost , vol.85 , pp. 401-407
    • Storey, R.F.1    Oldroyd, K.G.2    Wilcox, R.G.3
  • 171
    • 71849119604 scopus 로고    scopus 로고
    • Intravenous platelet blockade with cangrelor during PCI
    • Bhatt DL, Lincoff AM, Gibson CM, et al. Intravenous platelet blockade with cangrelor during PCI. N Engl J Med 2009; 361: 2330-41
    • (2009) N Engl J Med , vol.361 , pp. 2330-2341
    • Bhatt, D.L.1    Lincoff, A.M.2    Gibson, C.M.3
  • 172
    • 71849087338 scopus 로고    scopus 로고
    • Platelet inhibition with cangrelor in patients undergoing PCI
    • Harrington RA, Stone GW, McNulty S, et al. Platelet inhibition with cangrelor in patients undergoing PCI. N Engl J Med 2009; 361: 2318-29
    • (2009) N Engl J Med , vol.361 , pp. 2318-2329
    • Harrington, R.A.1    Stone, G.W.2    McNulty, S.3
  • 173
    • 84856509788 scopus 로고    scopus 로고
    • Reduced immediate ischemic events with cangrelor in PCI: A pooled analysis of the CHAMPION trials using the universal definition of myocardial infarction
    • White HD, Chew DP, Dauerman HL, et al. Reduced immediate ischemic events with cangrelor in PCI: a pooled analysis of the CHAMPION trials using the universal definition of myocardial infarction.AmHeart J 2012; 163: 182-90
    • (2012) AmHeart J , vol.163 , pp. 182-190
    • White, H.D.1    Chew, D.P.2    Dauerman, H.L.3
  • 174
    • 84856023997 scopus 로고    scopus 로고
    • Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: A randomized controlled trial
    • Angiolillo DJ, Firstenberg MS, Price MJ, et al. Bridging antiplatelet therapy with cangrelor in patients undergoing cardiac surgery: a randomized controlled trial. JAMA 2012; 307: 265-74
    • (2012) JAMA , vol.307 , pp. 265-274
    • Angiolillo, D.J.1    Firstenberg, M.S.2    Price, M.J.3
  • 175
    • 77954510334 scopus 로고    scopus 로고
    • Elinogrel: Pharmacological principles, preclinical and early phase clinical testing
    • Ueno M, Rao SV, Angiolillo DJ. Elinogrel: pharmacological principles, preclinical and early phase clinical testing. Future Cardiol 2010; 6: 445-53
    • (2010) Future Cardiol , vol.6 , pp. 445-453
    • Ueno, M.1    Rao, S.V.2    Angiolillo, D.J.3
  • 176
    • 84875376069 scopus 로고    scopus 로고
    • Initial intravenous experience with PRT060128 (PRT128), an orallyavailable, direct-acting, and reversible P2Y12 inhibitor [abstract no. P-T-292]
    • Lieu HD, Conley PB, Andre P, et al. Initial intravenous experience with PRT060128 (PRT128), an orallyavailable, direct-acting, and reversible P2Y12 inhibitor [abstract no. P-T-292]. J Thromb Haemost 2007; 5 Suppl. 2
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2
    • Lieu, H.D.1    Conley, P.B.2    Andre, P.3
  • 177
    • 73149118496 scopus 로고    scopus 로고
    • The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP 2C19*2 genotype: First experience in patients
    • Gurbel PA, Bliden KP, Antonino MJ, et al. The effect of elinogrel on high platelet reactivity during dual antiplatelet therapy and the relation to CYP 2C19*2 genotype: first experience in patients. J Thromb Haemost 2010; 8: 43-53
    • (2010) J Thromb Haemost , vol.8 , pp. 43-53
    • Gurbel, P.A.1    Bliden, K.P.2    Antonino, M.J.3
  • 178
    • 70649090353 scopus 로고    scopus 로고
    • Note
    • Berger JS, Roe MT, Gibson CM, et al. Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADPreceptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the Early Rapid ReversAl of platelet thrombosis with intravenous Elinogrel before PCI to optimize reperfusion in acute Myocardial Infarction (ERASE MI) pilot trial. Am Heart J 2009; 158: 998-1004 e1
    • (2009) Am Heart J , vol.158
    • Berger, J.S.1    Roe, M.T.2    Gibson, C.M.3
  • 179
    • 76549100069 scopus 로고    scopus 로고
    • Oral Dosing of PRT060128 a novel direct-acting reversible p2y12 antagonist overcomes high platelet reactivity in patients non-responsive to clopidogrel therapy [abstract no.5603]
    • Gurbel PA, Conley PB, Andre P, et al. Oral dosing of PRT060128, a novel direct-acting, reversible P2Y12 antagonist overcomes high platelet reactivity in patients non-responsive to clopidogrel therapy [abstract no. 5603]. Circulation 2008; 118: S972
    • (2008) Circulation , vol.118
    • Gurbel, P.A.1    Conley, P.B.2    Andre, P.3
  • 180
    • 84875381505 scopus 로고    scopus 로고
    • Pharmacodynamic substudy from the intravenous and oral administration of elinogrel to evaluate the tolerability and efficacy in nonurgent PCI patients (INOVATE-PCI) trial [abstract no. P2437]
    • abstract suppl 416
    • Angiolillo DJ, Rao S, Trenk D, et al. Pharmacodynamic substudy from the intravenous and oral administration of elinogrel to evaluate the tolerability and efficacy in nonurgent PCI patients (INOVATE-PCI) trial [abstract no. P2437]. Eur Heart J 2011; 32 (abstract suppl.): 416
    • (2011) Eur Heart J , vol.32
    • Angiolillo, D.J.1    Rao, S.2    Trenk, D.3
  • 181
    • 84856293074 scopus 로고    scopus 로고
    • INNOVATE PCI: A Phase II Safety and Efficacy Study of PRT060128 (elinogrel) A Novel Intravenous and Oral P2Y12 Inhibitor in Non-urgent PCI [session no 707001-707002]
    • 2010 Aug 28-Sep 1; Stockholm [online]. Available from URL: [Accessed 2012 Jun 26]
    • Rao S, Kristensen SD. INNOVATE PCI: a phase II safety and efficacy study of PRT060128 (elinogrel), a novel intravenous and oral P2Y12 inhibitor, in non-urgent PCI [session no. 707001-707002]. ESC Congress 2010; 2010 Aug 28-Sep 1; Stockholm [online]. Available from URL: http://www.escardio.org/congresses/ esc-2010/congressreports/Pages/707-1-INNOVATE.aspx [Accessed 2012 Jun 26]
    • (2010) ESC Congress
    • Rao, S.1    Kristensen, S.D.2
  • 182
    • 73949157474 scopus 로고    scopus 로고
    • Platelet thrombin receptor antagonism and atherothrombosis
    • Angiolillo DJ, Capodanno D, Goto S. Platelet thrombin receptor antagonism and atherothrombosis. Eur Hear J 2010; 31: 17-28
    • (2010) Eur Hear J , vol.31 , pp. 17-28
    • Angiolillo, D.J.1    Capodanno, D.2    Goto, S.3
  • 183
    • 24944580749 scopus 로고    scopus 로고
    • Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
    • Chackalamannil S, Xia Y, Greenlee WJ, et al. Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents. J Med Chem 2005; 48: 5884-7
    • (2005) J Med Chem , vol.48 , pp. 5884-5887
    • Chackalamannil, S.1    Xia, Y.2    Greenlee, W.J.3
  • 184
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing nonurgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
    • Becker RC, Moliterno DJ, Jennings LK, et al. Safety and tolerability of SCH 530348 in patients undergoing nonurgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study. Lancet 2009; 373: 919-28
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3
  • 185
    • 77649207578 scopus 로고    scopus 로고
    • Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome
    • Goto S, Yamaguchi T, Ikeda Y, et al. Safety and exploratory efficacy of the novel thrombin receptor (PAR-1) antagonist SCH530348 for non-ST-segment elevation acute coronary syndrome. J Atheroscler Thromb 2010; 17: 156-64
    • (2010) J Atheroscler Thromb , vol.17 , pp. 156-164
    • Goto, S.1    Yamaguchi, T.2    Ikeda, Y.3
  • 186
    • 83655177669 scopus 로고    scopus 로고
    • Thrombin-receptor antagonist vorapaxar in acute coronary syndromes
    • Tricoci P, Huang Z, Held C, et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes. N Engl J Med 2012; 366: 20-33
    • (2012) N Engl J Med , vol.366 , pp. 20-33
    • Tricoci, P.1    Huang, Z.2    Held, C.3
  • 187
    • 84875377993 scopus 로고    scopus 로고
    • Merck Suffers Late-stage Blow To Vorapaxar. InPharm 2011 Jan 18 [online]. Available From URL: [Accessed 2012 Jun 26]
    • Merck suffers late-stage blow to vorapaxar. InPharm 2011 Jan 18 [online]. Available from URL: http://www.in pharm.com/news/110118/merck-vorapaxar-trials [Accessed 2012 Jun 26]
  • 188
    • 84875377205 scopus 로고    scopus 로고
    • Merck Sharp & Dohme Corp. Merck statement on changes to clinical studies of vorapaxar. 2011 [online] [Accessed 2012 Oct 9]
    • Merck Sharp & Dohme Corp. Merck statement on changes to clinical studies of vorapaxar. 2011 [online]. Available from URL: http://www.google.com/ url?sa=t&rct=j&q= &esrc=s&source=web&cd=3&ved= 0CDQQFjAC&url =http%3A%2F%2Fphx.corporate-ir.net%2FExternal. File%3Fitem%3DUGFyZW50SUQ9Nzc1NTZ8 Q2hpb GRJRD0tMXxUeXBlPTM%3D%26t%3D1&ei=Dm N0UPKzKcSW0QGA-YCQDw&usg=AFQjCNFKeDz HWSka4ShXThfMgBZOTAIFoA [Accessed 2012 Oct 9]
  • 189
    • 84859555815 scopus 로고    scopus 로고
    • Vorapaxar in the secondary prevention of atherothrombotic events
    • Morrow DA, Braunwald E, Bonaca MP, et al. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012; 366: 1404-13
    • (2012) N Engl J Med , vol.366 , pp. 1404-1413
    • Morrow, D.A.1    Braunwald, E.2    Bonaca, M.P.3
  • 190
    • 78149355554 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease
    • Goto S, Ogawa H, Takeuchi M, et al. Double-blind, placebo-controlled phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease. Eur Heart J 2010; 31: 2601-13
    • (2010) Eur Heart J , vol.31 , pp. 2601-2613
    • Goto, S.1    Ogawa, H.2    Takeuchi, M.3
  • 191
    • 85027946204 scopus 로고    scopus 로고
    • Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: The lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial
    • O'Donoghue ML, Bhatt DL, Wiviott SD, et al. Safety and tolerability of atopaxar in the treatment of patients with acute coronary syndromes: the lessons from antagonizing the cellular effects of Thrombin-Acute Coronary Syndromes Trial. Circulation 2011; 123: 1843-53
    • (2011) Circulation , vol.123 , pp. 1843-1853
    • O'Donoghue, M.L.1    Bhatt, D.L.2    Wiviott, S.D.3
  • 192
    • 85027951718 scopus 로고    scopus 로고
    • Randomized trial of atopaxar in the treatment of patients with coronary artery disease: The lessons from antagonizing the cellular effect of Thrombin-Coronary Artery Disease Trial
    • Wiviott SD, Flather MD, O'Donoghue ML, et al. Randomized trial of atopaxar in the treatment of patients with coronary artery disease: the lessons from antagonizing the cellular effect of Thrombin-Coronary Artery Disease Trial. Circulation 2011; 123: 1854-63
    • (2011) Circulation , vol.123 , pp. 1854-1863
    • Wiviott, S.D.1    Flather, M.D.2    O'Donoghue, M.L.3
  • 193
    • 0032941161 scopus 로고    scopus 로고
    • Effects of aspirin or picotamide, an antithromboxane agent, in combination with low-intensity oral anticoagulation in patients with acute myocardial infarction: A controlled randomized pilot trial
    • Vetrano A, Milani M, Corsini G. Effects of aspirin or picotamide, an antithromboxane agent, in combination with low-intensity oral anticoagulation in patients with acute myocardial infarction: a controlled randomized pilot trial. G Ital Cardiol 1999; 29: 524-8
    • (1999) G Ital Cardiol , vol.29 , pp. 524-528
    • Vetrano, A.1    Milani, M.2    Corsini, G.3
  • 194
    • 79955871263 scopus 로고    scopus 로고
    • Daily administration of the TP receptor antagonist terutroban improved endothelial function in high-cardiovascular-risk patients with atherosclerosis
    • Lesault PF, Boyer L, Pelle G, et al. Daily administration of the TP receptor antagonist terutroban improved endothelial function in high-cardiovascular-risk patients with atherosclerosis. Br J Clin Pharmacol 2011; 71: 844-51
    • (2011) Br J Clin Pharmacol , vol.71 , pp. 844-851
    • Lesault, P.F.1    Boyer, L.2    Pelle, G.3
  • 195
    • 79958770159 scopus 로고    scopus 로고
    • Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): A randomized, double-blind, parallelgroup trial
    • Bousser MG, Amarenco P, Chamorro A, et al. Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomized, double-blind, parallelgroup trial. Lancet 2011; 377: 2013-22
    • (2011) Lancet , vol.377 , pp. 2013-2022
    • Bousser, M.G.1    Amarenco, P.2    Chamorro, A.3
  • 197
    • 37349040378 scopus 로고    scopus 로고
    • Firstin-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers
    • Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, et al. Firstin-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation 2007; 116: 2678-86
    • (2007) Circulation , vol.116 , pp. 2678-2686
    • Gilbert, J.C.1    Defeo-Fraulini, T.2    Hutabarat, R.M.3
  • 198
    • 84858690837 scopus 로고    scopus 로고
    • ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion
    • Siller-Matula JM, Merhi Y, Tanguay JF, et al. ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion. Arterioscler Thromb Vasc Biol 2012; 32: 902-9
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 902-909
    • Siller-Matula, J.M.1    Merhi, Y.2    Tanguay, J.F.3
  • 199
    • 1642357645 scopus 로고    scopus 로고
    • Therapeutic potentials of sarpogrelate in cardiovascular disease
    • Saini HK, Takeda N, Goyal RK, et al. Therapeutic potentials of sarpogrelate in cardiovascular disease. Cardiovasc Drug Rev 2004; 22: 27-54
    • (2004) Cardiovasc Drug Rev , vol.22 , pp. 27-54
    • Saini, H.K.1    Takeda, N.2    Goyal, R.K.3
  • 200
    • 33144482404 scopus 로고    scopus 로고
    • Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding
    • Goto S. Cilostazol: potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding. Atheroscler Suppl 2005; 6: 3-11
    • (2005) Atheroscler Suppl , vol.6 , pp. 3-11
    • Goto, S.1
  • 201
    • 77956884231 scopus 로고    scopus 로고
    • Cilostazol for prevention of secondary stroke (CSPS 2): An aspirincontrolled, double-blind, randomised non-inferiority trial
    • Shinohara Y, Katayama Y, Uchiyama S, et al. Cilostazol for prevention of secondary stroke (CSPS 2): an aspirincontrolled, double-blind, randomised non-inferiority trial. Lancet Neurol 2010; 9: 959-68
    • (2010) Lancet Neurol , vol.9 , pp. 959-968
    • Shinohara, Y.1    Katayama, Y.2    Uchiyama, S.3
  • 202
    • 27644555633 scopus 로고    scopus 로고
    • Triple versus dual antiplatelet therapy after coronary stenting: Impact on stent thrombosis
    • Lee SW, Park SW, Hong MK, et al. Triple versus dual antiplatelet therapy after coronary stenting: impact on stent thrombosis. J Am Coll Cardiol 2005; 46: 1833-7
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1833-1837
    • Lee, S.W.1    Park, S.W.2    Hong, M.K.3
  • 203
    • 84883270071 scopus 로고    scopus 로고
    • Cilostazol added to aspirin and clopidogrel reduces revascularization without increases in major adverse events in patients with drugeluting stents: A meta-analysis of randomized controlled trials
    • Epub Jun 22
    • Sakurai R, Koo BK, Kaneda H, et al. Cilostazol added to aspirin and clopidogrel reduces revascularization without increases in major adverse events in patients with drugeluting stents: a meta-analysis of randomized controlled trials. Int J Cardiol. Epub 2012 Jun 22
    • (2012) Int J Cardiol.
    • Sakurai, R.1    Koo, B.K.2    Kaneda, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.