Acute and chronic 1-Methyl-4-Phenyl-1,2,3,6-tetrahydropyridine administrations elicit similar microglial activation in the substantia nigra of monkeys

Journal of Neuropathology and Experimental Neurology

Volumn 68, Issue 9, 2009, Pages 977-984

  Vázquez Claverie, Marianne ^a   Garrido Gil, Pablo ^a   San Sebastián, Waldy ^a   Izal Azcárate, Amaya ^a   Belzunegui, Silvia ^a   Marcilla, Irene ^a   López, Berta ^a   Luquin, María Rosario ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

1 Methyl 4 phenyl 1, 2, 3, 6 tetrahydropyridine; Activated microglia; Dopaminergic cells; Monkeys; Parkinson disease

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL ACTIVATION; CELL COUNT; CELL DEGENERATION; CELL LOSS; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; HISTOPATHOLOGY; IMMUNOCYTOCHEMISTRY; LONG TERM EXPOSURE; MALE; MICROGLIA; MONKEY; NERVE CELL; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; STEREOLOGY; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACACA FASCICULARIS; MALE; MICROGLIA; MPTP POISONING; NERVE DEGENERATION; NEURONS; NEUROTOXINS; SUBSTANTIA NIGRA;

EID: 70349218447     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181b35e41     Document Type: Article

References (42)

1. Rodnitzky RL. Parkinson's disease. In: Conn PM, ed. Neuroscience in Medicine. Philadelphia, PA: J. B. Lippincott Co., 1995:427-29
2. McGeer PL, Itagaki S, Boyes BE, et al. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988;38:1285-91
3. Langston JW, Forno LS, Tetrud J, et al. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine exposure. Ann Neurol 1999;46: 598-605
4. Sherer TB, Betarbet R, Kim JH, et al. Selective microglial activation in the rat rotenone model of Parkinson's disease. Neurosci Lett 2003;341: 87-90 (Pubitemid 36398476)
5. Cicchetti F, Brownell AL, Williams K, et al. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci 2002;15:991-98
6. McGeer PL, Schwab C, Parent A, et al. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine administration. Ann Neurol 2003;54:599-604
7. Barcia C, Sanchez Bahillo A, Fernandez-Villalba E, et al. Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia 2004;46:402-9
8. Gao HM, Jiang J, Wilson B, et al. Microglial activationYmediated delayed and progressive degeneration of rat nigral dopaminergic neurons: Relevance to Parkinson's disease. J Neurochem 2002;81:1285-97
9. Nagatsu T, Sawada M. Inflammatory process in Parkinson's disease: Role for cytokines. Curr Pharm Des 2005;11:999-1016
10. Teismann P, Schulz JB. Cellular pathology of Parkinson's disease: Astrocytes, microglia and inflammation. Cell Tissue Res 2004;318: 149-61
11. Hunot S, Hirsch EC. Neuroinflammatory processes in Parkinson's disease. Ann Neurol 2003;53(suppl 3):S49-S58; [discussion S-60]
12. Babior BM. Phagocytes and oxidative stress. Am J Med 2000;109:33-44
13. Liu B, Gao HM, Wang JY, et al. Role of nitric oxide in inflammation-mediated neurodegeneration. Ann N Y Acad Sci 2002;962:318-31
14. Czlonkowska A, Kurkowska-Jastrzebska I, Czlonkowski A, et al. Immune processes in the pathogenesis of Parkinson's diseaseVa potential role for microglia and nitric oxide. Med Sci Monit 2002;8:RA165-RA177
15. Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 2004;63:901-10
16. Knott C, Stern G, Wilkin GP. Inflammatory regulators in Parkinson's disease: iNOS, lipocortin-1, and cyclooxygenases-1 and-2. Mol Cell Neurosci 2000;16:724-39
17. Teismann P, Ferger B. Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease. Synapse 2001;39:167-74
18. Sanchez-Pernaute R, Ferree A, Cooper O, et al. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease. J Neuroinflammation 2004;1:6
19. Feng Z, Li D, Fung PC, et al. COX-2Ydeficient mice are less prone to MPTP-neurotoxicity than wild-type mice. Neuroreport 2003;14: 1927-29
20. Klivenyi P, Gardian G, Calingasan NY, et al. Additive neuroprotec-tive effects of creatine and a cyclooxygenase 2 inhibitor against dopa-mine depletion in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. J Mol Neurosci 2003; 21:191-98
21. Orr CF, Rowe DB, Halliday GM. An inflammatory review of Parkinson's disease. Prog Neurobiol 2002;68:325-40
22. Polazzi E, Contestabile A. Reciprocal interactions between microglia and neurons: From survival to neuropathology. Rev Neurosci 2002;13: 221-42
23. Wang T, Pei Z, Zhang W, Liu B, Langenbach R, Lee C, et al. MPP+-inducd COX-2 activation and subsequent dopaminergic neuro-degenerarion. Faseb J 2005;19(9):1134-36
24. Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, et al. Cyclooxygenase-2 is instrumental in Parkinson's disease neurodegener-ation. Proc Natl Acad Sci U S A 2003;100(9):5473-78
25. Vijitruth R, Liu M, Choy DY, Nguyen XV, Hunter RL, Bing G. Cyclooxygenase-2 mediates microglial activation and secondary dop-aminergic cell death in the mouse MPTP model of Parkinson's disease. J Neuroinflammation 2006;3:6
26. Zucca FA, Giaveri G, Gallorini M, et al. The neuromelanin of human substantia nigra: Physiological and pathogenic aspects. Pigment Cell Res 2004;17:610-17
27. Zhang W, Wang T, Pei Z, et al. Aggregated alpha-synuclein activates microglia: A process leading to disease progression in Parkinson's disease. FASEB J 2005;19:533-42
28. Luquin MR, Montoro RJ, Guillen J, et al. Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Neuron 1999;22:743-50
29. Gundersen HJ, Bagger P, Bendtsen TF, et al. The new stereological tools: Dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988;96: 857-81
30. Vazquez-Claverie M, Garrido-Gil P, San Sebastian W, et al. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) does not elicit long-lasting increases in cyclooxygenase-2 expression in dopaminergic neurons of monkeys. J Neuropathol Exp Neurol 2009;68:26-36
31. Dorph-Petersen KA, Nyengaard JR, Gundersen HJ. Tissue shrinkage and unbiased stereological estimation of particle number and size. J Microsc 2001;204:232-46
32. West MJ. New stereological methods for counting neurons. Neurobiol Aging 1993;14(4):275-85
33. Hurley SD, O'Banion MK, Song DD, et al. Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys. Exp Neurol 2003;184:659-68
34. Cho BP, Song DY, Sugama S, et al. Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia 2006;53: 92-102
35. Rock RB, Gekker G, Hu S, et al. Role of microglia in central nervous system infections. Clin Microbiol Rev 2004;17:942-64
36. Streit WJ, Walter SA, Pennell NA. Reactive microgliosis. Prog Neuro-biol 1999;57:563-81
37. Kim YS, Joh TH. Microglia, major player in the brain inflammation: Their roles in the pathogenesis of Parkinson's disease. Exp Mol Med 2006 31;38:333-47
38. Hartmann A, Hunot S, Hirsch EC. Inflammation and dopaminergic neuronal loss in Parkinson's disease: A complex matter. Exp Neurol 2003;184:561-64
39. Hirsch EC, Hunot S, Hartmann A. Neuroinflammatory processes in Parkinson's disease. Parkinsonism Relat Disord 2005;11(suppl 1): S9-S15
40. Garrido-Gil P, Belzunegui S, San Sebastian W, Izal-Azcarate A, Lopez B, Marcilla I, et al. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure fails to produce delayed degeneration of substantia nigra neurons in monkeys. J Neurosci Res 2009;87:586-97
41. Draheim HJ, Prinz M, Weber JR, Weiser T, Kettenmann H, Hanisch UK. Induction of potassium channels in mouse brain microglia: Cells aquire responsiveness to pneumococcal cell wall components during late development. Neuroscience 1999;89:1379-90
42. Vila M, Jackson-Lewis V, Guegan C, Wu DC, Teismann P, Choi DK, et al. The role of glial cells in Parkinson's disease. Curr Opin Neurol 2001;14:483-89