ENU-induced Mutation in the DNA-binding Domain of KLF3 Reveals Important Roles for KLF3 in Cardiovascular Development and Function in Mice

PLoS Genetics

Volumn 9, Issue 7, 2013, Pages

  Kelsey, Lois ^a,b   Flenniken, Ann M ^a,b   Qu, Dawei ^a,b   Funnell, Alister P W ^c   Pearson, Richard ^c   Zhou, Yu Qing ^b,d   Voronina, Irina ^a,b   Berberovic, Zorana ^a,b   Wood, Geoffrey ^b,d   Newbigging, Susan ^b,d   Weiss, Edward S ^b   Wong, Michael ^b,d,e   Quach, Ivan ^a   Yeh, S Y Sandy ^a   Deshwar, Ashish R ^d,e   Scott, Ian C ^d,e,f   McKerlie, Colin ^b,d   Henkelman, Mark ^b,d,e   Backx, Peter ^e,f   Simpson, Jeremy ^e,f   Osborne, Lucy ^b,e   Rossant, Janet ^b,d   Crossley, Merlin ^c   Bruneau, Benoit ^g   Adamson, S Lee ^a,b,e,f   more..

^a MOUNT SINAI HOSPITAL   (Canada)

^b Toronto Centre for Phenogenomics   (Canada)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f HEART AND STROKE FOUNDATION OF CANADA   (Canada)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ETHYLNITROSOUREA; HISTIDINE; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 3; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA VALVE STENOSIS; ARTICLE; BINDING SITE; CARDIOVASCULAR FUNCTION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE MUTATION; HEART DEVELOPMENT; HEART VENTRICLE HYPERTROPHY; HETEROZYGOTE; HOMOZYGOTE; HYPOTENSION; KLF3 GENE; MALE; MISSENSE MUTATION; MOUSE; MUTANT; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL DEATH; PHENOTYPE; POINT MUTATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ZEBRA FISH;

ANIMALS; AORTIC VALVE STENOSIS; CARDIOVASCULAR DISEASES; DNA-BINDING PROTEINS; ETHYLNITROSOUREA; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MUTATION, MISSENSE; NUCLEOTIDE MOTIFS;

EID: 84880842004     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003612     Document Type: Article

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