Grand challenges in bioengineered nanorobotics for cancer therapy

IEEE Transactions on Biomedical Engineering

Volumn 60, Issue 3, 2013, Pages 667-673

  Lenaghan, Scott C ^a   Wang, Yongzhong ^a   Xi, Ning ^b,c   Fukuda, Toshio ^d   Tarn, Tzyhjong ^e,f   Hamel, William R ^a   Zhang, Mingjun ^a  

^a University of Tennessee   (United States)

^b Michigan State University   (United States)

^c CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^d NAGOYA UNIVERSITY   (Japan)

^e WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

^f TSINGHUA UNIVERSITY   (China)

Author keywords

Bioengineered robots; Cancer therapy; Medical robotics; Micro nano robotics; Nanobiotechnology; Nanoparticles

Indexed keywords

CANCER THERAPY; GRAND CHALLENGE; LIFE-SCIENCES; MEDICAL ROBOTICS; MICRO/NANO-ROBOTICS; SITE-SPECIFIC DRUG DELIVERIES; SYSTEM INTEGRATION; TISSUE REPAIR;

DECISION MAKING; DRUG DELIVERY; FACINGS; NANOBIOTECHNOLOGY; NANOPARTICLES; NANOROBOTS; ONCOLOGY;

NANOROBOTICS;

CYCLOPEPTIDE; SINGLE STRANDED DNA;

ARTICLE; BIOCOMPATIBILITY; BIOENGINEERING; CANCER DIAGNOSIS; CANCER THERAPY; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CROSS LINKING; DECISION MAKING; DRUG DELIVERY SYSTEM; GENETIC ENGINEERING AND GENE TECHNOLOGY; HUMAN; IMMUNE RESPONSE; KIDNEY CLEARANCE; MAGNETIC FIELD; MEMBRANE FORMATION; MICROMANIPULATION; MOLECULARLY TARGETED THERAPY; NANOROBOTICS; PLASMA HALF LIFE; POWER SUPPLY; ROBOTICS;

BIOMEDICAL ENGINEERING; CONGRESSES AS TOPIC; DISTRICT OF COLUMBIA; HUMANS; NANOMEDICINE; NEOPLASMS; ROBOTICS;

EID: 84880840937     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2013.2244599     Document Type: Article

References (41)

1. K. E. Drexler, "Molecular engineering: An approach to the development of general capabilities for molecular manipulation," Proc. Nat. Acad. Sci., vol. 78, pp. 5275-5278, Sep. 1, 1981.
2. K. E. Drexler, D. Forrest, R. A. Freitas, J. Storrs Hall, N. Jcobstein, T. Mckendree, and R. Merkle, "On physics, fundamentals, and nanorobots: A Rebuttal to Smalley's assertion that self-replicating mechanical nanorobots are simply not possible," Inst. Mol. Manuf., 2001.
3. R. E. Smalley, "Of chemistry, love and nanobots," Sci. Am., vol. 285, pp. 76-77, 2001.
4. R. Baum, "Nanotechnology: Drexler and Smalley make the case for and against 'molecular assemblers'," Chem. Eng. News, vol. 81, pp. 37-42, 2003.
5. M. Sitti and R. S. Fearing, "Synthetic gecko foot-hair micro/nanostructures as dry adhesives," J. Adhes. Sci. Technol., vol. 17, pp. 1055-1073, Jan. 01, 2003.
6. M. E. Davis, Z. G. Chen, and D. M. Shin, "Nanoparticle therapeutics: An emerging treatment modality for cancer," Nature Rev. Drug Discovery, vol. 7, pp. 771-782, 2008.
7. E. Marshall, "Gene therapy death prompts review of adenovirus vector," Science, vol. 286, pp. 2244-2245, Dec. 17, 1999.
8. M. L. Flenniken, D. A. Willits, S. Brumfield, M. J. Young, and T. Douglas, "The small heat shock protein cage from methanococcus jannaschii is a versatile nanoscale platform for genetic and chemical modification," Nano Lett., vol. 3, pp. 1573-1576, Nov. 01, 2003.
9. S. C. Lenaghan and M. Zhang, "Real-time observation of the secretion of a nanocomposite adhesive from English ivy (Hedera helix)," Plant Sci., vol. 183, pp. 206-211, 2012.
10. M. Zhang, M. Liu, H. Prest, and S. Fischer, "Nanoparticles secreted from ivy rootlets for surface climbing," Nano Lett., vol. 8, pp. 1277-1280, May 2008.
11. C. M. Soto, A. S. Blum, G. J. Vora, N. Lebedev, C. E. Meador, A. P. Won, A. Chatterji, J. E. Johnson, and B. R. Ratna, "Fluorescent signal amplification of carbocyanine dyes using engineered viral nanoparticles," J. Amer. Chem. Soc., vol. 128, pp. 5184-5189, Apr. 01, 2006.
12. M. Everts, V. Saini, J. L. Leddon, R. J. Kok, M. Stoff-Khalili, M. A. Preuss, C. L. Millican, G. Perkins, J. M. Brown, H. Bagaria, D. E. Nikles, D. T. Johnson, V. P. Zharov, and D. T. Curiel, "Covalently linked Au nanoparticles to a viral vector: Potential for combined photothermal and gene cancer therapy," Nano Lett., vol. 6, pp. 587-591, Apr. 01, 2006.
13. K. Cho, X. Wang, S. Nie, Z. Chen, and D. M. Shin, "Therapeutic nanoparticles for drug delivery in cancer," Clin. Cancer Res., vol. 14, pp. 1310-1316, Mar. 1, 2008.
14. H. Bar, I. Yacoby, and I. Benhar, "Killing cancer cells by targeted drug-carrying phage nanomedicines," BMC Biotechnol., vol. 8, pp. 37-51, 2008.
15. M. Hirabayashi, K. Oiwa, A. Nishikawa, F. Tanaka, and M. Hagiya, "Toward self-assembly of phage-like nanorobot," in Proc. 9th IEEE Conf. Nanotechnol., 2009, pp. 530-535.
16. S. G. Tarasov, V. Gaponenko, O. M. Z. Howard, Y. Chen, J. J. Oppenheim, M. A. Dyba, S. Subramaniam, Y. Lee, C. Michejda, and N. I. Tarasova, "Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles," Proc. Nat. Acad. Sci., vol. 108, pp. 9798-9803, Jun. 14, 2011.
17. S. M. Douglas, A. H. Marblestone, S. Teerapittayanon, A. Vazquez, G. M. Church, and W. M. Shih, "Rapid prototyping of 3D DNA-origami shapes with caDNAno," Nucleic Acids Res., vol. 37, pp. 5001-5006, Aug. 1, 2009.
18. S. M. Douglas, I. Bachelet, and G. M. Church, "A logic-gated nanorobot for targeted transport of molecular payloads," Science, vol. 335, pp. 831-834, Feb. 17, 2012.
19. K. Nagpal, S. K. Singh, and D. N. Mishra, "Chitosan nanoparticles: A promising system in novel drug delivery," Chem. Pharm. Bull., vol. 58, pp. 1423-1430, 2010.
20. S. Mitra, U. Gaur, P. C. Ghosh, and A. N. Maitra, "Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier," J. Controlled Release, vol. 74, pp. 317-323, 2001. (Pubitemid 32727639)
21. E. M. Purcell, "Life at low Reynolds number," Amer. J. Phys., vol. 45, pp. 3-11, 1977.
22. S. A. Berger and L.-D. Jou, "Flows in Stenotic vessels," Annu. Rev. Fluid Mech., vol. 32, pp. 347-382, 2000.
23. J. M. Paulsson, A. Moshfegh, E. Dadfar, C. Held, S. H. Jacobson, and J. Lundahl, "In vivo extravasation induces the expression of interleukin 1 receptor type 1 in human neutrophils," Clin. Exp. Immunol., vol. 168, pp. 105-112, 2012.
24. B. J. Toley and N. S. Forbes, "Motility is critical for effective distribution and accumulation of bacteria in tumor tissue," Integrative Biol., vol. 4, pp. 165-176, 2012.
25. S. C. Lenaghan, C. A. Davis, W. R. Henson, Z. Zhang, and M. Zhang, "High-speed microscopic imaging of flagella motility and swimming in Giardia lamblia trophozoites," Proc. Nat. Acad. Sci., vol. 108, pp. E550-E558, Aug. 23, 2011.
26. L. Zhang, J. J. Abbott, L. Dong, K. E. Peyer, B. E. Kratochvil, H. Zhang, C. Bergeles, and B. J. Nelson, "Characterizing the swimming properties of artificial bacterial Flagella," Nano Lett., vol. 9, pp. 3663-3667, 2009.
27. A. Ghanbari and M. Bahrami, "A novel swimming microrobot based on artificial cilia for biomedical applications," J. Intell. Robot. Syst., vol. 63, pp. 399-416, 2011.
28. S. Martel and M. Mohammadi, "Using a swarm of self-propelled natural microrobots in the form of flagellated bacteria to perform complex micro-assembly tasks," in Proc. IEEE Int. Conf. Robot. Autom., 2010, pp. 500-505.
29. D. H. Kim, U. K. Cheang, L. hidai, D. Byun, and M. J. Kim, "Artificial magnetotactic motion control of Tetrahymena pyriformis using ferromagnetic nanoparticles: A tool for fabrication of microbiorobots," Appl. Phys. Lett., vol. 97, pp. 173702-173703, 2010.
30. M. Sitti, "Microscale and nanoscale robotics systems [grand challenges of robotics]," IEEE Robot. Autom. Mag., vol. 14, no. 1, pp. 53-60, Mar. 2007. (Pubitemid 46566618)
31. S. Park, K. Cha, and J. Park, "Development of biomedical microrobot for intravascular therapy," Int. J. Adv. Robot. Syst., vol. 7, 2010, pp. 91-98.
32. M. Guanying and Y. Guozheng, "Wireless powered microrobot for gastrointestinal detection," in Proc. Int. Conf. Mechatronics Autom., 2007, pp. 1085-1089.
33. W. J. Heetderks, "RF powering of millimeter- and submillimeter-sized neural prosthetic implants," IEEE Trans. Biomed. Eng., vol. 35, no. 5, pp. 323-327, May 1988.
34. D. J. Bell, S. Leutenegger, K. M. Hammar, L. X. Dong, and B. J. Nelson, "Flagella-like propulsion for microrobots using a nanocoil and a rotating electromagnetic field," in Proc. IEEE Int. Conf. Robot. Autom., 2007, pp. 1128-1133.
35. S. Floyd, C. Pawashe, and M. Sitti, "Two-dimensional contact and noncontact micromanipulation in liquid using an untethered mobile magnetic microrobot," IEEE Trans. Robot., vol. 25, no. 6, pp. 1332-1342, Dec. 2009.
36. +-dependent electrical control of flagellar activity in Euglena," J. Cell Sci., vol. 23, pp. 211-225, 1977.
37. R. L. Camp, V. Neumeister, and D. L. Rimm, "A decade of tissue microarrays: Progress in the discovery and validation of cancer biomarkers," J. Clin. Oncol., vol. 26, pp. 5630-5637, Dec. 1, 2008.
38. J. Elbaz and I. Willner, "DNA origami: Nanorobots grab cellular control," Nature Mater., vol. 11, pp. 276-277, 2012.
39. P. Hong, W. L. Li, and J. M. Li, "Applications of aptasensors in clinical diagnostics," Sensors, vol. 12, pp. 1181-1193, Feb. 2012.
40. L. Wei, C. Cai, J. Lin, and T. Chen, "Dual-drug delivery system based on hydrogel/micelle composites," Biomaterials, vol. 30, pp. 2606-2613, 2009.
41. L. Arcese, M. Fruchard, and A. Ferreira, "Endovascular magnetically guided robots: Navigation modeling and optimization," IEEE Trans. Biomed. Eng., vol. 59, no. 4, pp. 977-987, Apr. 2012.