Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 24, 2011, Pages 9798-9803

  Tarasov, Sergey G ^a   Gaponenko, Vadim ^b   Howard, O M Zack ^a   Chen, Yuhong ^a   Oppenheim, Joost J ^a   Dyba, Marzena A ^a,c   Subramaniam, Sriram ^d   Lee, Youngshim ^b   Michejda, Christopher ^a   Tarasova, Nadya I ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c SAIC FREDERICK INC   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer; CXCL12; Undruggable target; Virus like particles

Indexed keywords

ACRIDONE DERIVATIVE; CHEMOKINE RECEPTOR CXCR4; HKH 40A; MACROGOL; NANOPARTICLE; NAPHTHALIMIDE DERIVATIVE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; WMC 77; X4 2 6 PEPTIDE NANOPARTICLE;

ALPHA HELIX; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENCAPSULATION; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; STRUCTURE ANALYSIS; VIRUS LIKE AGENT;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; CELL SURVIVAL; CIRCULAR DICHROISM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; MICE, NUDE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR SEQUENCE DATA; NANOPARTICLES; PARTICLE SIZE; PEPTIDES; PROTEIN BINDING; RECEPTORS, CXCR4;

EID: 79959951981     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1014598108     Document Type: Article

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