Aucubin prevents loss of hippocampal neurons and regulates antioxidative activity in diabetic encephalopathy rats

Phytotherapy Research

Volumn 23, Issue 7, 2009, Pages 980-986

  Xue, Hong Yu ^a   Jin, Lei ^a   Jin, Li Ji ^a   Li, Xiao Yu ^a   Zhang, Peng ^a   Ma, Yong Sheng ^a   Lu, Ya Nan ^a   Xia, Yan Qiu ^a   Xu, Yong Ping ^a,b  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b Dalian SEM Bioengineer and Biotech Ltd   (China)

Author keywords

Antioxidative effect; Aucubin; Diabetic encephalopathy; Hippocampus; Neuroprotection; Nitric oxide synthase

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; AUCUBIN; CATALASE; CATALPOL; GLUCOSE; GLUTATHIONE PEROXIDASE; LIPID PEROXIDE; MALONALDEHYDE; NITRIC OXIDE SYNTHASE; SUPEROXIDE DISMUTASE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN DISEASE; BRAIN NERVE CELL; COGNITION; CONTROLLED STUDY; DIABETIC ENCEPHALOPATHY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; MALE; MAZE TEST; NEUROPROTECTION; NICK END LABELING; NONHUMAN; RAT; STREPTOZOCIN DIABETES;

ANIMALS; ANTIOXIDANTS; BRAIN DISEASES; COGNITION DISORDERS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSIDES; HIPPOCAMPUS; IRIDOIDS; LIPID PEROXIDES; MALE; MALONDIALDEHYDE; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR;

RATTUS;

EID: 67650152193     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2734     Document Type: Article

References (32)

1. An SJ, Pae HO, Oh GS et al. 2002. Inhibition of TNF-a, IL-1 h, and IL-6 productions and NF-κB activation in lipopolysaccharide- activated RAW 264.7 macrophages by catalposide, an iridoid glycoside isolated from Catalpa ovata G. Don (Bignoniaceae). Int Immunopharmacol 2: 1173-1181. (Pubitemid 34899400)
2. Ben-Zvi I, Green Y, Nakhoul F, Kanter Y, Nagler RM. 2007. Effects of diabetes mellitus, chronic renal failure and hemodialysis on serum and salivary antioxidant status. Nephron Clin Pract 105: c114-c120. (Pubitemid 46215204)
3. Bernini R, Iavarone C, Trogolo C. 1984. 1-O-β-D- glucopyranosyleucommiol, an iridoid glucoside from Aucuba japonica. Phytochemistry 23: 1431-1433.
4. Bestetti G, Rossi GL. 1982. Hypothalamic changes in diabetic Chinese hamsters. A semiquantitative, light and electron microscopic study. Lab Invest 47: 516-522.
5. Bianco A, Iavarone C, Trogolo C. 1974. Structure of eucommiol, a new cyclopentenoid-tetraol from Eucommia ulmoides. Tetrahedron 130: 4117-4121.
6. Biessels GJ, Kamal A, Urban IJ, Spruijt BM, Erkelens DW, Gispen WH. 1998. Water maze learning and hippocampal synaptic plasticity in streptozotocin- diabetic rats: effects of insulin treatment. Brain Res 800: 125-135. (Pubitemid 28361929)
7. Biessels GJ, Kappelle AC, Bravenboer B, Erkelens DW, Gispen WH. 1994. Cerebral function in diabetes mellitus. Diabetologia 37: 634-650.
8. Canabal DD, Potian JG, Duran RG, McArdle JJ, Routh VH. 2007. Hyperglycemia impairs glucose and insulin regulation of nitric oxide production in glucose-inhibited neurons in the ventromedial hypothalamus. Am J Physiol Regul Integr Comp Physiol 293: 592-600. (Pubitemid 47205039)
9. Chang HK, Jang MH, Lim BV et al. 2004. Administration of Ginseng radix decreases nitric oxide synthase expression in the hippocampus of streptozotocin-induced diabetic rats. Am J Chin Med 32: 497-507. (Pubitemid 39302668)
10. Gispen WH, Biessels GJ. 2000. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci 23: 542-549. (Pubitemid 30802191)
11. Gold AE, Deary IJ, Jones RW, O'Hare JP, Reckless JP, Frier BM. 1994. Severe deterioration in cognitive function and personality in five patients with long-standing diabetes: a complication of diabetes or a consequence of treatment? Diabet Med 11: 499-505.
12. Harput US, Saracoglu I, Inoue M, Ogihara Y. 2002. Phenylethanoid and iridoid glycosides from Veronica persica. Chem Pharm Bull 50(6): 869-871. (Pubitemid 41694916)
13. Hink U, Li H, Mollnau H et al. 2001. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88: E14-E22.
14. Ho J, Lee YH, Lee YD, Jun WJ, Kim HK, Hong BS, Shin DH, Cho HY. 2005. Inhibitory effect of Aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts. Biosci Biotechnol Biochem 43: 500-506.
15. Jiang B, Liu JH, Bao YM, An LJ. 2004. Catalpol inhibits apoptosis in hydrogen peroxide-induced PC12 cells by preventing cytochrome c release and inactivating of caspase cascade. Toxicon 43: 53-59.
16. Jin L, Xue HY, Jin LJ, Li SY, Xu YP. 2008. Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocininduced diabetes. Eur J Pharmacol 582: 162-167.
17. Lazzarino G, Tavazzi B, Pierro DD, Vagnozzi R, Penco M, Giardina B. 1995. The relevance of malondialdehyde as a biochemical index of lipid peroxidation of postischemic tissues in the rat and human beings. Biol Trace Elem Res 47: 165-170.
18. Li DQ, Duan YL, Bao YM, Liu CP, Liu Y, An LJ. 2004. Neuroprotection of catalpol in transient global ischemia in gerbils. Neurosci Res 50: 169-177.
19. Li DQ, Li Y, Liu YX, Bao YM, Hu B, An LJ. 2005a. Catalpol prevents the loss of CA1 hippocampal neurons and reduces working errors in gerbils after ischemia-reperfusion injury. Toxicon 46: 845-851.
20. Li ZG, Zhang W, Sima AA. 2005b. The role of impaired insulin/IGF action in primary diabetic encephalopathy. Brain Res 1037: 12-24. (Pubitemid 40362377)
21. Mao Y, Ootaka T, Saito T, Sato H, Sato T, Ito S. 2003. The involvement of advanced glycation endproducts (AGEs) in renal injury of diabetic glomerulosclerosis: association with phenotypic change in renal cells and infiltration of immune cells. Clin Exp Nephrol 7: 201-209. (Pubitemid 37229252)
22. Nishikawa T, Kukidome D, Sonoda K et al. 2007. Impact of mitochondrial ROS production on diabetic vascular complications. Diabetes Res Clin Pract 77: S41-S45. (Pubitemid 47212551)
23. Pailer M, Haschke-Hofmeister E. 1969. Inhaltsttoffe aus Plantago major. Planta Med 17: 139-145.
24. Paxinos G, Watson C. 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press: Sydney.
25. Saravia FE, Beauquis J, Revsin Y, Homo-Delarche F, De Kloet ER, De Nicola AF. 2006. Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment. Cell Mol Neurobiol 26: 943-957.
26. Shrilatha B, Muralidhara. 2007. Occurrence of oxidative impairments, response of antioxidant defences and associated biochemical perturbations in male reproductive milieu in the streptozotocin-diabetic rat. Int J Androl 30: 508-518.
27. Sima AAF, Kamiya H, Li ZG. 2004. C-peptide, hyperglycemia, and central nervous system complications in diabetes. Eur J Pharmacol 490: 187-197. (Pubitemid 38482172)
28. Suomi J, Sirén H, Wiedmer SK, Riekkola ML. 2001. Isolation of aucubin and catalpol from Melitaea cinxia larvae and quantification by micellar electrokinetic capillary chromatography. Anal Chim Acta 429: 91-99. (Pubitemid 32332907)
29. Tamura Y, Nishibe S. 2002. Changes in the concentrations of bioactive compounds in plantain leaves. J Agric Food Chem 50(9): 2514-2518. (Pubitemid 34437360)
30. Thornalley PJ, Langborg A, Minhas HS. 1999. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem J 344: 109-116.
31. Van Dam PS, Bravenboer B. 1997. Oxidative stress and antioxidant treatment in diabetic neuropathy. Neurosci Res Commun 21: 41-48. (Pubitemid 27336351)
32. Xue H, Jin L, Jin L et al. 2008. Neuroprotection of aucubin in primary diabetic encephalopathy. Sci China C Life Sci 51: 495-502. (Pubitemid 351713026)