The influence of study design and sex-differences on results from developmental neurotoxicity studies of bisphenol A, implications for toxicity testing

Toxicology

Volumn 311, Issue 1-2, 2013, Pages 13-26

  Beronius, Anna ^a   Johansson, Niklas ^a   Rudén, Christina ^b   Hanberg, Annika ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Bisphenol A; Developmental neurotoxicity; Regulatory testing; Risk assessment; Sex differences

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL;

AGGRESSION; ANXIETY; ARTICLE; DEPRESSION; DEVELOPMENTAL TOXICITY; EXPLORATORY BEHAVIOR; EXPOSURE; LEARNING; MATERNAL BEHAVIOR; MEMORY; MOTOR ACTIVITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROGENY; SEX DIFFERENCE; SEXUAL BEHAVIOR; SOCIAL BEHAVIOR; STRESS; STUDY DESIGN; TOXICITY TESTING;

BISPHENOL A; BPA; DEVELOPMENTAL NEUROTOXICITY; DNT; EDC; ELEVATED PLUS MAZE; ENDOCRINE DISRUPTING COMPOUND; EPM; LOAEL; LOWEST OBSERVED ADVERSE EFFECT LEVEL; NMDR; NO OBSERVED ADVERSE EFFECT LEVEL; NOAEL; NON-MONOTONIC DOSE-RESPONSE; OF; OPEN FIELD; PARTIAL LEAST SQUARES PROJECTION TO LATENT STRUCTURES MODELING; PCA; PLS; PRINCIPAL COMPONENTS ANALYSIS; REFERENCE DOSE; REGULATORY TESTING; RFD; RISK ASSESSMENT; SEX-DIFFERENCES; TDI; TEST GUIDELINE; TG; TOLERABLE DAILY INTAKE;

ANIMALS; BENZHYDRYL COMPOUNDS; ENDPOINT DETERMINATION; FEMALE; HUMANS; MALE; NEUROTOXICITY SYNDROMES; PHENOLS; RESEARCH DESIGN; SEX CHARACTERISTICS; TOXICITY TESTS;

EID: 84880823601     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.02.012     Document Type: Article

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