Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats

Toxicological Sciences

Volumn 115, Issue 1, 2010, Pages 167-182

  Stump, Donald G ^a   Beck, Melissa J ^a   Radovsky, Ann ^a   Garman, Robert H ^b   Freshwater, Lester L ^c   Sheets, Larry P ^d   Marty, M Sue ^e   Waechter Jr , John M ^e   Dimond, Stephen S ^f   van Miller, John P ^g   Shiotsuka, Ronald N ^h   Beyer, Dieter ⁱ   Chappelle, Anne H ^j   Hentges, Steven G ^k  

^a WIL RESEARCH LABORATORIES   (United States)

^b Consultants in Veterinary Pathology Inc ^*  (United States)

^c BioSTAT Consultants   (United States)

^d BAYER CROPSCIENCE   (United States)

^e DOW CHEMICAL COMPANY   (United States)

^f Environmental Health and Safety   (United States)

^g Toxicology/Regulatory Services Inc   (United States)

^h Formerly Baver Material Science AG   (United States)

ⁱ BAYER PHARMA AG   (Germany)

^j Sunoco   (United States)

^k AMERICAN CHEMISTRY COUNCIL   (United States)

more..

Author keywords

Bisphenol A; CAS No. 80 05 7; Developmental neurotoxicity; Learning and memory; Morphometry; Neurobehavior; Neuropathology; OECD 426

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; PHENOL DERIVATIVE;

ACOUSTIC REFLEX; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN WEIGHT; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; DIETARY INTAKE; FEMALE; FOOD INTAKE; LACTATION; LEARNING; MALE; MAZE TEST; MEMORY; MOTOR ACTIVITY; NERVOUS SYSTEM DEVELOPMENT; NEUROPATHOLOGY; NEUROTOXICITY; NEWBORN; NONHUMAN; PRENATAL EXPOSURE; PROGENY; RAT; STARTLE REFLEX; WEIGHT REDUCTION; AIR POLLUTANT; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; CONGENITAL MALFORMATION; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; GROWTH, DEVELOPMENT AND AGING; LONGEVITY; NERVOUS SYSTEM; NEUROLOGIC DISEASE; PATHOLOGY; PREGNANCY; PRENATAL DEVELOPMENT; SPRAGUE DAWLEY RAT;

RATTUS;

ABNORMALITIES, DRUG-INDUCED; AIR POLLUTANTS, OCCUPATIONAL; ANIMALS; ANIMALS, NEWBORN; BRAIN; FEMALE; LACTATION; LONGEVITY; MALE; MATERNAL EXPOSURE; MAZE LEARNING; MOTOR ACTIVITY; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; PHENOLS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77953124996     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq025     Document Type: Article

References (43)

1. Adams, J., Buelke-Sam, J., Kimmel, C. A., Nelson, C. J., Reiter, L. W., Sobotka, T. J., Tilson, H. A., and Nelson, B. K. (1985). Collaborative behavioral teratology study: protocol design and testing procedure. Neurobehav. Toxicol. Teratol. 7, 579-586.
2. Balls, M., Blaauboer, B. J., Fentem, J. H., Bruner, L., Combes, R. D., Ekwall, B., Fielder, R. J., Guillouzo, A., Lewis, R. W., Lovell, D. P., et al. (1994). Practical aspects of the validation of toxicity test procedures. Altern. Lab. Anim. 23, 129-147.
3. Biegel, L. B., Flaws, J. A., Hirshfield, A. N., O'Connor, J. C., Elliott, G. S., Ladics, G. S., Silbergeld, E. K., Van Pelt, C. S., Hurtt, M. E., Cook, J. C., et al. (1998). Ninety-day feeding and one-generation reproduction study in Crl:CD BR rats with 17 ß-estradiol. Toxicol. Sci. 44, 116-142.
4. Biel, W. C. (1940). Early age differences in maze performance in the albino rat. J. Genetic Psychol. 56, 439-453.
5. Chapin, R. E., Adams, J., Boekelheide, K., Gray, L. E., Jr., Hayward, S. W., Lees, P. S., McIntyre, B. S., Portier, K. M., Schnorr, T. M., Selevan, S. G., et al. (2008). NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A. Birth Defects Res. B Dev. Reprod. Toxicol. 83, 157-395.
6. Crofton, K. M., Foss, J. A., Hass, U., Jensen, K. F., Levin, E. D., and Parker, S. P. (2008). Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 266-287.
7. Dekant, W., and Völkel, W. (2008). Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol. Appl. Pharmacol. 228, 114-134.
8. Domoradzki, J. Y., Pottenger, L. H., Thornton, C. M., Hansen, S. C., Card, T. L., Markham, D. A., Dryzga, M. D., Shiotsuka, R. N., and Waechter, J. M., Jr. (2003). Metabolism and pharmacokinetics of bisphenol A (BPA) and the embryo-fetal distribution of BPA and BPA-monoglucuronide in CD Sprague-Dawley rats at three gestational stages. Toxicol. Sci. 76, 21-34.
9. Ema, M., Fujii, S., Furukawa, M., Kiguchi, M., Ikka, T., and Harazono, A. (2001). Rat two-generation reproductive toxicity study of bisphenol A. Reprod. Toxicol. 15, 505-523.
10. European Food Safety Authority (EFSA). (2006). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-bis(4-hydroxyphenyl)propane. EFSA J. 428, 1-75.
11. European Union (EU). (2010). European Union Risk Assessment Report: 4,4'-Isopropylidenediphenol (Bisphenol-A). Available at: http://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-Chemicals/RISK_ASSESSMENT /ADDENDUM/bisphenola_add_325.pdf. Accessed February 22, 2010.
12. Ferguson, S. A., Scallet, A. C., Flynn, K. M., Meredith, J. M., and Schwetz, B. A. (2000). Developmental neurotoxicity of endocrine disruptors: focus on estrogens. Neurotoxicology. 21, 947-956.
13. Food and Drug Administration (FDA). (2008). Draft Assessment of Bisphenol A for Use in Food Contact Applications Available at: http://www.fda.gov. Accessed August 14, 2008.
14. Gad, S. C. (1982). A neuromuscular screen for use in industrial toxicology. J. Toxicol. Environ. Health 9, 691-704.
15. Haggerty, G. C. (1989). Development of tier I neurobehavioral testing capabilities for incorporation into pivotal rodent safety assessment studies. J. Am. Coll. Toxicol. 8, 53-69.
16. Health Canada. (2008). Screening Assessment for the Challenge, Phenol, 4,4'-(1-methylethylidene)bis (Bisphenol A), Chemical Abstracts Service Registry Number 80-05-7, Environment Canada, Health Canada. October 18, 2008. Available at: http://www.ec.gc.ca/substances/ese/eng/challenge/batch2/batch2_80-05-7_e n.pdf. Accessed February 22, 2010.
17. Holson, R., Freshwater, L., Maurissen, P. J., Moser, V. C., and Phang, W. (2008). Statistical issues and techniques appropriate for developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 326-348.
18. Howdeshell, K. L., Furr, J., Lambright, C. R., Wilson, V. S., Ryan, B. C., and Gray, L. E., Jr. (2008). Gestational and lactational exposure to ethinyl estradiol, but not bisphenol A, decreases androgen-dependent reproductive organ weights and epididymal sperm abundance in the male Long Evans hooded rat. Toxicol. Sci. 102, 371-382.
19. Irwin, S. C. (1968). Comprehensive observational assessment: Ia. A systematic quantitative procedure for assessing the behavioral physiological state of the mouse. Psychopharmacologia. 13, 222-256.
20. Korenbrot, C. C., Huhtaniemi, I. T., and Weiner, R. I. (1977). Preputial separation as an external sign of pubertal development in the male rat. Biol. Reprod. 17, 298-303.
21. LaKind, J. S., and Naiman, D. Q. (2008). Bisphenol A (BPA) daily intakes in the United States: estimates from the 2003-2004 NHANES urinary BPA data. J. Expo. Sci. Environ. Epidemiol. 18, 608-615.
22. Makris, S. L., Raffaele, K., Allen, S., Bowers, W. J., Hass, U., Alleva, E., Calamandrei, G., Sheets, L.,Amcoff, P.,Delrue,N., et al. (2009).Aretrospective performance assessment of the developmental neurotoxicity study in support of OECD Test Guideline 426. Environ. Health Perspect. 117, 17-25.
23. Moser, V. C. (1997). Neurobehavioral screening methods. Neurotoxicology. 18, 925-1101.
24. Moser, V. C., McCormick, J. P., Creason, J. P., and MacPhail, R. C. (1988). Comparison of chlordimeform and carbaryl using a functional observational battery. Fundam. Appl. Toxicol 11, 189-206.
25. Moser, V. C., McDaniel, K. L., and Phillips, P. M. (1991). Rat strain and stock comparisons using a functional observational battery: baseline values and effects of Amitraz. Toxicol. Appl. Pharmacol. 108, 267-283.
26. National Research Council. (1996). Guide for the Care and Use of Laboratory Animals. Institute of Laboratory Animal Resources, Commission on Life Sciences; National Academy Press, Washington, DC.
27. O'Donoghue, J. L. (1989). Screening for neurotoxicity using a neurologically based examination and neuropathology. J. Am. Coll. Toxicol. 8, 97-115.
28. Organization for Economic Cooperation and Development (OECD). (1998). OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring, No. 1, OECD Principles of Good Laboratory Practice. OECD, Environment Directorate, Paris, France. Available at: http://www.olis.oecd.org/olis/1998doc.nsf/LinkTo/env-mc-chem(98)17. Accessed February 22, 2010.
29. Organization for Economic Cooperation and Development (OECD). (2002). OECD Series on Principles of Good Laboratory Practice and Compliance Monitoring, No. 13. The Application of the OECD Principles of GLP to the Organization and Management of Multi-Site Studies. OECD Environment Directorate, Paris, France. Available at: http://www.olis.oecd.org/olis/2002doc.nsf/LinkTo/env-jm-mono(2002)9. Accessed February 22, 2010.
30. Organization for Economic Cooperation and Development (OECD). (2007a). OECD Guidelines for the Testing of Chemicals. Test No. 426: Developmental Neurotoxicity Study. OECD Environment Directorate, Paris, France. Available at: http://oberon.sourceoecd.org/vl=692122/cl=21/nw=1/rpsv/ij/oecdjournals/1 607310x/v1n4/s26/p1. Accessed February 22, 2010.
31. Organization for Economic Cooperation and Development (OECD). (2007b). OECD Guidelines for the testing of Chemicals. Test No. 440: Uterotrophic Bioassay in Rodents: A short-term screening test for oestrogenic properties. OECD Environment Directorate, Paris, France. Available at: http://oberon.sourceoecd.org/vl=692122/cl=21/nw=1/rpsv/ij/oecdjournals/1 607310x/v1n4/s34/p1. Accessed February 22, 2010.
32. Paretto, P., Merighi, A., Fasolo, A., and Bonfanti, L. (1999). The subependymal layer in rodents: a site of structural plasticity and cell migration in the adult mammalian brain. Brain Res. Bull. 49, 221-243.
33. Paxinos, G., and Watson, C. (1998). In The Rat Brain in Stereotaxic Coordinates, 4th ed. Academic Press, New York.
34. Ryan, B. C., Hotchkiss, A. K., Crofton, K. M., and Gray, L. E., Jr. (2010). In utero and lactational exposure to Bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility and anatomy of female LE rats. Toxicol. Sci. 114, 133-148.
35. Snyder, R. W., Maness, S. C., Gaido, K. W., Welsch, F., Sumner, S. C., and Fennell, T. R. (2000). Metabolism and disposition of bisphenol A in female rats. Toxicol. Appl. Pharmacol. 168, 225-234.
36. Tyl, R. W., Crofton, K., Moretto, A., Moser, V., Sheets, L. P., and Sobotka, T. J. (2008a). Identification and interpretation of developmental neurotoxicity effects: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints. Neurotoxicol. Teratol. 30, 349-381.
37. Tyl, R. W., Myers, C. B., Marr, M. C., Castillo, N. P., Seely, J. C., Sloan, C. S., Veselica, M. M., Joiner, R. L., Van Miller, J. P., and Simon, G. S. (2006). Three-generation evaluation of dietary para-nonylphenol in CD (Sprague-Dawley) rats. Toxicol. Sci. 92, 295-310.
38. Tyl, R. W., Myers, C. B., Marr, M. C., Castillo, N. P., Veselica, M. M., Joiner, R. L., Dimond, S. S., Van Miller, J. P., and Hentges, S. G. (2008b). One-generation reproductive toxicity study of dietary 17ß-Estradiol (E2; CAS No. 50-28-2) in CD-1® (Swiss) mice. Reprod. Toxicol. 25, 144-160.
39. Tyl, R. W., Myers, C. B., Marr, M. C., Sloan, C. S., Castillo, N., Veselica, M. M., Seely, J. C., Dimond, S. S., Van Miller, J. P., Shiotsuka, R. S., et al. (2008c). Two-generation reproductive toxicity evaluation of dietary 17ß-estradiol (E2; CAS No. 50-28-2) in CD-1® (Swiss) mice. Toxicol. Sci. 102, 392-412.
40. Tyl, R. W., Myers, C. B., Marr, M. C., Sloan, C. S., Castillo, N., Veselica,M. M., Seely, J. C., Dimond, S. S., Van Miller, J. P., Shiotsuka, R. S., et al. (2008d). Two-generation reproductive toxicity study of dietary bisphenol A (BPA) in CD-1® (Swiss) mice. Toxicol. Sci. 104, 362-384.
41. Tyl, R. W., Myers, C. B., Marr, M. C., Thomas, B. F., Keimowitz, A. R., Brine, D. R., Veselica, M. M., Fail, P. A., Chang, T. Y., Seely, J. C., et al. (2002). Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Toxicol. Sci. 68, 121-146.
42. U.S. Environmental Protection Agency (EPA). (1989). Good Laboratory Practice Standards (40 CFR Part 792), 18 September 1989. EPA, Washington, DC. Available at: http://www.epa.gov/lawsregs/search/40cfr.html. Accessed February 22, 2010.
43. U.S. Environmental Protection Agency (EPA). (1998). Health Effects Test Guidelines: OPPTS 870.6300, Developmental Neurotoxicity Study. EPA 712-C-98-239. August 1998. EPA, Washington, DC. Available at: http://www.epa.gov/oppts/pubs/frs/publications/Test_Guidelines/series870 .htm. Accessed February 22, 2010.