Pre- and postnatal bisphenol A treatment results in persistent deficits in the sexual behavior of male rats, but not female rats, in adulthood

Hormones and Behavior

Volumn 59, Issue 2, 2011, Pages 246-251

  Jones, Bryan A ^a   Shimell, Jordan J ^a   Watson, Neil V ^a  

^a SIMON FRASER UNIVERSITY   (Canada)

Author keywords

Behavior; Bisphenol A; Endocrine disruptor; Estrogen; Reproduction

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; BREEDING; CONTROLLED STUDY; FEMALE; FEMALE SEXUAL DYSFUNCTION; LACTATION; MALE; MALE SEXUAL DYSFUNCTION; NONHUMAN; PERINATAL PERIOD; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; SEXUAL BEHAVIOR;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ENDOCRINE DISRUPTORS; FEMALE; MALE; PHENOLS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SEXUAL BEHAVIOR, ANIMAL; SEXUAL DYSFUNCTION, PHYSIOLOGICAL;

EID: 79851508903     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2010.12.006     Document Type: Article

References (35)

1. Adewale H.B., Todd K.L., Mickens J.A., Patisaul H.B. The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat. Neurotoxicology 2010, Epub ahead of print.
2. Aikawa H., Koyama S., Matsuda M., Nakahashi K., Akazome Y., Mori T. Relief effect of vitamin A on the decreased motility of sperm and the increased incidence of malformed sperm in mice exposed neonatally to Bisphenol A. Cell Tissue Res. 2004, 315:119-124.
3. Akingbemi B.T., Sottal C.M., Koulova A.I., Klinefelter G.R., Hardy M.P. Inhibition of testicular steroidogenesis by the xenoestrogen bisphenol A is associated with reduced pituitary steroidogenic enzyme gene expression in rat Leydig cells. Endocrinology 2004, 145:592-603.
4. Auger A.P., Tetel M.J., McCarthy M.M. Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. PNAS 2000, 97:7551-7555.
5. Balthazart J., Absil P., Gerard M., Appeltants D., Ball G.F. Appetitive and consummatory male sexual behavior in Japanese quail are differentially regulated by subregions of the preoptic medial nucleus. J. Neurosci. 1998, 18:6512-6527.
6. Calafat A.M., Ye X., Wong L.-Y., Reidy J.A., Needham L.L. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ. Health Perspect. 2008, 116:39-44.
7. Corbier P., Kerdelhue B., Picon R., Roffi J. Changes in testicular weight and serum gonadotropin and testosterone levels before, during, and after birth in the perinatal rat. Endocrinology 1978, 103:1985-1991.
8. Della Seta D., Farabollini F., Dessì-Fulgheri F., Fusani L. Environmental-like exposure to low levels of estrogen affects sexual behavior and physiology of female rats. Endocrinology 2008, 149:5592-5598.
9. Dodds E.C., Lawson W. Synthetic oestrogenic agents without the phenanthrene nucleus. Nature 1936, 137:996.
10. Dolinoy D.C., Huang D., Jirtle R.L. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. PNAS 2007, 104:13056-13061.
11. Ema M., Fujii S., Furukawa M., Kiguchi M., Ikka T., Harazono A. Rat two-generation reproductive toxicity study of bisphenol A. Reprod. Toxicol. 2001, 15:505-523.
12. Farabollini F., Porrini S., Della Seta D., Bianchi F., Dessi-Fulgheri F. Effects of perinatal exposure to bisphenol A on sociosexual behavior of female and male rats. Environ. Health Perspect. 2002, 110:409-414.
13. Gould J.C., Leonard L.S., Maness S.C., Wagner B.L., Conner K., Zacharewski T., Safe S., McDonnell D.P., Gaido K.W. Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol. Mol. Cell. Endocrinol. 1998, 142:203-214.
14. Henley C.L., Nunez A.A., Clemens L.G. Estrogen treatment during development alters adult partner preference and reproductive behavior in female laboratory rats. Horm. Behav. 2009, 55:68-75.
15. Herath C.B., Jin W., Watanabe G., Suzuki A.K., Taya K. Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats. Endocr. 2004, 25:163-172.
16. Kuiper G.G.J.M., Carlsson B., Grandien K., Enmark E., Haggblad J., Nilsson S., Gustafsson J.-A. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors ? and ?. Endocrinology 1997, 138:863-870.
17. Lopez H.H., Olster D.H., Ettenberg A. Sexual motivation in the male rat: the role of primary incentives and copulatory experience. Horm. Behav. 1999, 36:176-185.
18. McEwen B.S., Lieberburg I., Chaptal C., Krey L.C. Aromatization: important for sexual differentiation of the neonatal rat brain. Horm. Behav. 1977, 9:249-263.
19. Monje L., Varayoud J., Munoz-de-Toro M., Luque E.H., Ramos J.G. Neonatal exposure to bisphenol A alters estrogen-dependent mechanisms governing sexual behavior in the adult female rat. Reprod. Toxicol. 2009, 28:435-442.
20. Moriyama K., Tagami T., Akamizu T., Usui T., Saijo M., Kanamoto N., Hataya Y., Shimatsu A., Kuzuya H., Nakao K. Thyroid hormone action is disrupted by bisphenol A as an antagonist. J. Clin. Endocrinol. Metab. 2002, 87:5185-5190.
21. Nagao T., Saito Y., Usumi K., Yoshiura S., Ono H. Low-dose bisphenol A does not affect reproductive organs in estrogen-sensitive C57BL/6N mice exposed at the sexually mature, juvenile, or embryonic stage. Reprod. Toxicol. 2002, 16:123-130.
22. Nagel S.C., vom Saal F.S., Thayer K.A., Dhar M.G., Boechler M., Welshons W.V. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ. Health Perspect. 1997, 105:70-76.
23. National Toxicology Program, 2008. NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. NTP CERHR MON. (22), i-III1.
24. Patisaul H.B., Fortino A.E., Polston E.K. Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV. Neurotoxicol. Teratol. 2006, 28:111-118.
25. Pfaus J.G., Phillips A.G. Role of dopamine in anticipatory and consummatory aspects of sexual behavior in the male rat. Behav. Neurosci. 1991, 105:727-743.
26. Rabedeau R.G., Whalen R.E. Effects of copulatory experience on mating behavior in the male rat. J. Comp. Physiol. Psychol. 1959, 52:482-484.
27. Rissman E.F., Wersinger S.R., Taylor J.A., Lubahn D.B. Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects. Horm. Behav. 1997, 31:232-243.
28. Roof R.L. Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats. Behav. Brain Res. 1993, 53:1-10.
29. Ryan B.C., Hotchkiss A.K., Crofton K.M., Gray L.E. In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility and anatomy of female LE rats. Toxicol. Sci. 2010, 114:133-148.
30. Salian S., Doshi T., Vanage G. Perinatal exposure of rats to bisphenol A affects the fertility of male offspring. Life Sci. 2009, 85:742-752.
31. Salian S., Doshi T., Vanage G. Neonatal exposure of male rats to bisphenol A impairs fertility and expression of Sertoli cell junctional proteins in the testis. Toxicology 2009, 265:56-67.
32. Sohoni P., Sumpter J.P. Several environmental oestrogens are also anti-androgens. J. Endocrinol. 1998, 158:327-339.
33. Tando S., Itoh K., Yaoi T., Ikeda J., Fujiwara Y., Fushiki S. Effects of pre- and neonatal exposure to bisphenol A on murine brain development. Brain Dev. 2007, 29:352-356.
34. Ward I.L., Weisz J. Maternal stress alters plasma testosterone in fetal males. Science 1980, 207:328-329.
35. Welshons W.V., Thayer K.A., Judy B.M., Taylor J.A., Curran E.M., vom Saal F.S. Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ. Health Perspect. 2003, 111:994-1006.